Ivermectin for Parkinson’s & Dementia: Exploring Its Potential as an Adjunct Neuroprotective Therapy (2025)
Can Ivermectin play a key role in treating Parkinson's Disease?
Two peer-reviewed papers—one by Warnecke et al. (2020) and another by Wadsworth et al. (2024)—along with a 2021 PhD thesis by Dongwook Wi, strongly suggest that it might. All of this research has emerged within the past three years.
Here are some highlights.
“The present study found that Ivermectin significantly altered rotational
behavior in male and female mice using a mouse model of DA-depletion
demonstrating significant differences based on sex." "The findings implicate
the potential use of Ivermectin as a lead candidate for use as a novel adjunct
therapy in combination with L-DOPA for Parkinson's Disease patients.”
“The possible application of Ivermectin (IVM) in conjunction with L-DOPA for
PD patients was introduced as a new treatment therapy in this study. By
showing the efficacy of IVM on two PD animal models, including MPTP and
6-OHDA, IVM’s function to modulate DA mediated behaviors in PD would suggest
as a new therapeutic for neurodegenerative disease in the future.” "new
therapeutic for neurodegenerative disease in the future"
“Importantly, when IVM was co-applied with L-DOPA, there was a greater amount
of DA release than with L-DOPA alone.” “Ivermectin itself increases DA release
in the DS through cholinergic mechanisms, which could potentially benefit
those with dysfunction in DA circuity, including those with Parkinson’s
Disease, mood disorders, or attention deficit disorder.”
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| Image credit: Grok 2 |
Can Ivermectin play a key role in treating Neurological Disease?
Three peer reviewed pre-clinical papers (below) suggest it might.
1. Anti-Inflammatory Effects
A 2023 study published in Inflammation demonstrated that ivermectin mitigates neuroinflammatory damage in a mouse model of experimental autoimmune encephalomyelitis. The compound reduced pro-inflammatory cytokines such as IL-17A and IFN-Îł and promoted regulatory T cell activity (Springer, 2023). These mechanisms are relevant to Alzheimer’s disease, where microglial activation and cytokine dysregulation contribute to neuronal degeneration.
2. Synaptic Modulation and Inhibitory Neurotransmission
Ivermectin potentiates glutamate-gated chloride channels (GluClRs), enhancing inhibitory postsynaptic currents. A 2019 study in PLOS Pathogens found that ivermectin increased tonic inhibitory currents and prolonged synaptic inhibition, possibly restoring balance in neural circuits disrupted by neurodegeneration (PMC6368337).
3. Cholinergic Enhancement and Dopaminergic Crosstalk
A 2024 study published in Cell & Bioscience reported that ivermectin increased activity of striatal cholinergic interneurons, thereby enhancing dopamine release via nicotinic receptor modulation (PMC11025261). Since cholinergic deficits underlie many cognitive symptoms in Alzheimer’s, ivermectin’s indirect cholinergic enhancement may complement standard therapies.
Ivermectin and Dementia (6 Case Reports)
Can Ivermectin play a key role in treating Dementia?
6 case series suggest ivermectin may help treat dementia. Dr William Makis shared 6 case testimonials of ivermectin and dementia on X/Twitter (February 2025):
Case 01: Vascular Dementia
"my father has been taking Ivermectin for Vascular Dementia now for 5 days...he seems much calmer, less agitated"
"we have noticed significant change in my father...he seems more tranquil, less rebellious and frustrated...only 1 week on Ivermectin so far but very positive so far"
Case 02: Alzheimer's Dementia
"I gave my mother in law Ivermectin 12mg x 5 days. She is 84 and suffers with dementia. She slept almost all night those 5 nights. That is a HUGE improvement over wandering around the house all night."
Case 03: Cognitive Decline & End of Life
"I have seen phenomenal results recently with my fathers (82yo) health specifically with his cognitive improvements but also his energy levels and his appetite.
Began giving him Ivermectin and the results were fast and absolutely remarkable. His ability to speak and hold a conversation and actually be humorous with us generated a wave of emotion for our family as we went from a near death diagnosis to hospice care dropping him from their program within just a few weeks. What an incredible gift we have been given!"
Case 4: (Brazil) - Memory loss
"My father...82 years old...major loss of memory...we managed to get him to agree to use a daily dose of 24mg...we felt a little improvement, with more words in his vocabulary, a better sense of time and sense, knowing that he has a bond with us"
Case 5: New Onset Dementia
Dr William Makis shared a case testimonial of ivermectin and dementia
on X/Twitter (January 2025):
IVERMECTIN and DEMENTIA Testimonial - 93 year old Grandma recovers dramatically with low dose Ivermectin!
"My Grandmother (93 years old) was beginning to show signs of
dementia...telling me stories & then forgetting that she had told
me...she began to become confused and focused on negative thoughts &
emotions"
The grand-daughter saw one of my articles (testimonials) on Ivermectin
and Dementia and decided to try the same Ivermectin 24mg dose, as what she
had read.
The Result:
"Within 2 days she was back to acting like the Grandma I remembered. She
was back to her smart and very mentally coherent self" "I was shocked at
the difference it made"
"I left the country for 2 weeks and when I came back she was still very
much improved despite no extra doses" (durable response!) "
My father was very skeptical...even he has no words, as he can see how
stark the contrast is from before and after giving her Ivermectin. The
change is night and day"
And my favorite part..
"Thank you for your work. I wouldn't have seen that information had it not
been for you"
You're welcome!
I love testimonials like this.
This is my 3rd Ivermectin and Dementia testimonial in a very short period
of time.
I continue to be shocked at how much difference a small dose of
Ivermectin makes in patients with dementia."
Case 6: Dementia and End of Life
Dr William Makis shared a case testimonial of ivermectin and dementia
on X/Twitter (November 2024):
IVERMECTIN and DEMENTIA Testimonial - 97 year old patient begins to
remember with IVERMECTIN - one of the most touching stories I've
received!
"I gave him 24mg of Ivermectin on day 1. I continued with IVM for 4
days"
"His eyes lit up and he recognized me" - I froze when I was reading
this.
"Each day when I visited, he became more of the father I knew decades
prior. We had wonderful conversations, his confusion was gone and he was
laughing and talking".
What an incredibly touching story.
I am currently helping 4
Parkinson’s Disease patients with Ivermectin, two Multiple Sclerosis, one
ALS (Amyotrophic Lateral Sclerosis) and one Seizure.
This is in addition to hundreds of Cancer patients.
But I was not aware of literature on Ivermectin and Dementia.
There IS some evidence for the use of Ivermectin in Dementia, except it
looks like it has been scrubbed from GOOGLE and the file is conveniently
“not available”.
“Ivermectin can be used as a therapeutic candidate in Alzheimer disease
which will need more studies to support that” - 2021.
Related:
Autophagy, The Gut's Role and Ivermectin in Parkinson's Disease
(2024)
Ivermectin and Fenbendazole for White Matter Disease
Rachel Coffenberry shared on X/Twitter (Dec 2024):"8 weeks of low dose Ivermectin & 5 weeks of fenbendazole 222mg have almost alleviated every bit of neuro/cognitive symptoms that I have suffered with for over 2 years!! They said that my Moderate/Severe White Matter Disease was mimicking a Rapid Progressive Dementia!"
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