Ivermectin for Parkinson's Disease and Dementia: Can Ivermectin play a key role in treating Parkinson's Disease and Dementia?
Parkinson's disease is a neurological disorder in which neurons and dopamine-producing cells in your brain begin to die. Symptoms progress over time and include tremors, slow movements, rigid limbs, shuffling gait, stooped posture and an inability to move. Patients may also experience a reduced ability to make facial expressions.
While patients suffer significant physical disability, the condition may also trigger depression, speech impediments and personality changes. There is also an association with dementia. Parkinson’s affects as many as 7 million to 10 million adults worldwide, and approximately 60,000 Americans are diagnosed with Parkinson's every year.
Although incidence of the disease increases with age, an estimated 4% of those with Parkinson's are diagnosed before the age of 50. Men are 1.5 times more likely to have Parkinson's than women, and treatment can be expensive. Medications can an average $2,500 a year, while therapeutic surgery may cost up to $100,000 per patient.
Although incidence of the disease increases with age, an estimated 4% of those with Parkinson's are diagnosed before the age of 50. Men are 1.5 times more likely to have Parkinson's than women, and treatment can be expensive. Medications can an average $2,500 a year, while therapeutic surgery may cost up to $100,000 per patient.
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What is Ivermectin?
Ivermectin is an anti-parasite drug used to treat various parasite infections in humans, but it can also be used to treat other health conditions like river blindness, onchocerciasis, intestinal strongyloidiasis, and onchocerciasis.Ivermectin is often recognized – 2nd to penicillin – for having the greatest impact on human health. And its discovery won the Nobel Prize in 2015. Ivermectin has an increasing list of indications due to its antiviral and anti-inflammatory properties, and is included on the WHO’s Model List of Essential Medicines.
Several studies reported antiviral effects of ivermectin on RNA viruses such as dengue, Zika, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency virus type 1, and COVID 19 virus.
Can Ivermectin play a key role in treating Parkinson's Disease?
Two peer reviewed papers (2020 paper by Warnecke et al, 2024 paper by Wadsworth et al) and a 2021 PhD Thesis by Dongwook Wi strongly suggest it can. This is all new research in the past 3 years.
Here are some highlights.
“The present study found that Ivermectin significantly altered rotational behavior in male and female mice using a mouse model of DA-depletion demonstrating significant differences based on sex." "The findings implicate the potential use of Ivermectin as a lead candidate for use as a novel adjunct therapy in combination with L-DOPA for Parkinson's Disease patients.”
“The possible application of Ivermectin (IVM) in conjunction with L-DOPA for PD patients was introduced as a new treatment therapy in this study. By showing the efficacy of IVM on two PD animal models, including MPTP and 6-OHDA, IVM’s function to modulate DA mediated behaviors in PD would suggest as a new therapeutic for neurodegenerative disease in the future.” "new therapeutic for neurodegenerative disease in the future"
“Importantly, when IVM was co-applied with L-DOPA, there was a greater amount of DA release than with L-DOPA alone.” “Ivermectin itself increases DA release in the DS through cholinergic mechanisms, which could potentially benefit those with dysfunction in DA circuity, including those with Parkinson’s Disease, mood disorders, or attention deficit disorder.”
Ivermectin and Dementia
Case 2
Dr Dr William Makis shared a case testimonial of ivermectin and dementia on X/Twitter (January 2025):
IVERMECTIN and DEMENTIA Testimonial - 93 year old Grandma recovers dramatically with low dose Ivermectin!
"My Grandmother (93 years old) was beginning to show signs of dementia...telling me stories & then forgetting that she had told me...she began to become confused and focused on negative thoughts & emotions"
The grand-daughter saw one of my articles (testimonials) on Ivermectin and Dementia and decided to try the same Ivermectin 24mg dose, as what she had read.
The Result:
"Within 2 days she was back to acting like the Grandma I remembered. She was back to her smart and very mentally coherent self" "I was shocked at the difference it made"
"I left the country for 2 weeks and when I came back she was still very much improved despite no extra doses" (durable response!) "
My father was very skeptical...even he has no words, as he can see how stark the contrast is from before and after giving her Ivermectin. The change is night and day"
And my favorite part..
"Thank you for your work. I wouldn't have seen that information had it not been for you"
You're welcome!
I love testimonials like this.
This is my 3rd Ivermectin and Dementia testimonial in a very short period of time.
I continue to be shocked at how much difference a small dose of Ivermectin makes in patients with dementia."
Case 1
Dr William Makis shared a case testimonial of ivermectin and dementia on X/Twitter (November 2024):
IVERMECTIN and DEMENTIA Testimonial - 97 year old patient begins to remember with IVERMECTIN - one of the most touching stories I've received!
"I gave him 24mg of Ivermectin on day 1. I continued with IVM for 4 days"
"His eyes lit up and he recognized me" - I froze when I was reading this.
"Each day when I visited, he became more of the father I knew decades prior. We had wonderful conversations, his confusion was gone and he was laughing and talking".
What an incredibly touching story.
I am currently helping 4 Parkinson’s Disease patients with Ivermectin, two Multiple Sclerosis, one ALS and one Seizure.
This is in addition to hundreds of Cancer patients.
But I was not aware of literature on Ivermectin and Dementia.
There IS some evidence for the use of Ivermectin in Dementia, except it looks like it has been scrubbed from GOOGLE and the file is conveniently “not available”.
“Ivermectin can be used as a therapeutic candidate in Alzheimer disease which will need more studies to support that” - 2021.
Related: Autophagy, The Gut's Role and Ivermectin in Parkinson's Disease (2024)
Ivermectin and Fenbendazole for White Matter Disease
Rachel Coffenberry shared on X/Twitter (Dec 2024):"8 weeks of low dose Ivermectin & 5 weeks of fenbendazole 222mg have almost alleviated every bit of neuro/cognitive symptoms that I have suffered with for over 2 years!! They said that my Moderate/Severe White Matter Disease was mimicking a Rapid Progressive Dementia!"
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