Fenbendazole Joe Tippens Protocol: A Step-by-Step Guide (2026)

Medically Reviewed by: Dr Frank Yap, MD | Written by:  OneDayMD Editorial Team | Last Updated: October 2026

If you have been diagnosed with cancer, or have a loved one that is suffering from cancer, chances are you have heard about the Joe Tippens Cancer Protocol. The Fenbendazole Cancer Protocol has been gaining rapid interest over the past years following some fenbendazole advanced cancer success stories (800+ case reports) and a 2026 publication, "Real-world Clinical Outcomes of Ivermectin and Mebendazole in Cancer Patients: Results from a Prospective Observational Cohort of 197 patients."

We have seen tremendous demand for some sort of guide on how to use fenbendazole for cancer as there is also tremendous confusion both from the healthcare and non-healthcare communities.

Joe Tippens founded the protocol (1) after he was told a story about a scientist at Merck Animal Health that had been performing cancer research on mice. The research included injecting different types of cancers into different mice body parts. The scientists discovered, through trial and error, a product in their canine product line, fenbendazole, that was batting 1.000 in killing these different cancers in the mice. The scientist was later diagnosed with stage 4 brain cancer and was given a grim prognosis of only three months to live. She decided to try the fenbendazole, and after six weeks, showed a clean scan.

Joe Tippens had been initially diagnosed with small cell lung cancer (SCLC). The cancer later spread to his neck, right lung, stomach, liver, bladder, pancreas and tail bone. Like the scientist from Merck Animal Hospital, Joe was told he only had three months to live. In 2017, after hearing the story of the scientist who treated her cancer with a canine drug, Joe decided he was going to do the same. 

However, in addition to taking fenbendazole, Joe Tippens incorporated several other agents into his regimen, including curcumin, CBD oil, and vitamin E, thereby creating what became known as the Joe Tippens Cancer Protocol. As a result, the protocol is not a monotherapy, but rather a multi-component complementary regimen consisting of fenbendazole alongside several dietary supplements.

Peer-reviewed studies published in Nature Portfolio journals have provided preclinical evidence supporting the investigation of benzimidazole antiparasitic drugs as potential anticancer agents.

A 2018 study published in Scientific Reports demonstrated that the veterinary antiparasitic drug fenbendazole acts as a moderate microtubule-destabilizing agent and exhibits anti-tumor activity in human cancer cell lines and animal models.

A 2021 study published in Acta Pharmacologica Sinica reported that benzimidazole compounds—including mebendazole, and fenbendazole—showed promising activity against glioblastoma (GBM) in preclinical models. The researchers found that these compounds inhibited tumor cell proliferation and migration, induced cell-cycle arrest, and triggered programmed cell death through mechanisms including apoptosis and pyroptosis.

Together, these studies provide a scientific rationale for further research into benzimidazole compounds as potential cancer therapies. They demonstrate that there is a growing body of preclinical evidence supporting their anticancer potential, although well-designed human clinical trials are still needed to establish their safety and efficacy in cancer patients.

Disclaimer: We in no way endorse the Joe Tippens Cancer Protocol as a cure for cancer, and as always, you should consult your physician before starting any new medications or treatment plans.

What Is Fenbendazole?

Fenbendazole is a broad spectrum anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the tapeworm genus Taenia (but not effective against Dipylidium caninum, a common dog tapeworm), pinworms, aelurostrongylus, paragonimiasis, strongyles, and strongyloides that can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits, most reptiles, freshwater shrimp tanks as planaria and hydra treatments, as well as seals.

Common brand names include Pancur, Panacur C and Safe-Guard.

Note: In everyday conversations within the fenbendazole communities, you might encounter Fenbendazole referred to as Phenbendazole, Panacur or SafeGuard. This interchangeability is representative of the common use of the trademarked name; it signifies a consensus within these circles that these terms denote the same medication. Fenbendazole is the active ingredient in all these products. Molecular formula for fenbendazole is C15H13N3O2S.

However, it is also being used by humans in a cancer treatment method known as the Joe Tippens Protocol.

Is fenbendazole a cancer cure scam? One study suggests that fenbendazole has “been safely utilized as an anti-parasitic for various different animal species and could be repurposed for treating human malignancies.” Other benzimidazoles, including albendazole, parbendazole, mebendazole and flubendazole have already been shown to have promising results.

Another study (Nature) states that the “repurposing of veterinary drugs showing promising results for human use can result in considerable time and cost reduction required to develop new drugs.”

Fenbendazole Protocol – A Step-by-Step Guide

The Fenbendazole Joe Tippens protocol has been last updated on October 28, 2021 (Joe Tippens new protocol).

According to Joe Tippens (2):

I have a significant announcement to make. Several months ago, I was introduced to a researcher who collaborates with other PHD’s, MD’s and researchers globally in the pharma and nutraceutical space.

They have developed some patented technologies that they apply to specific classes of plant extracts and botanicals that dramatically enhance delivery of those ingredients into the bloodstream at exponential levels.

Over the months we have met together, and I have performed extensive due diligence on what they can offer. We’ve discussed a 3-pathway approach and philosophy for cellular support through supplementation that I believe will complement fenbendazole greatly.

The Joe Tippens protocol involving fenbendazole is not solely centered around fenbendazole, as it incorporates 4 other significant components (below) known as Onco Adjunct Pathway 1, Onco Adjunct Pathway 2, Onco Adjunct Pathway 3 and Onco Adjunct Pathway 4.

1. Fenbendazole
2. Onco Adjunct Pathway 1
3. Onco Adjunct Pathway 2
4. Onco Adjunct Pathway 3
5. Onco Adjunct Pathway 4 (new)

Note: Check out the New and Improved version of the Joe Tippens Protocol (below), enhanced by Dr William Makis, an oncologist.

Update from December 2025 blogpost (summary)

• Fenbendazole 222 mg (1 gm of Panacur™ or Safeguard™) per day every day.
• Note if you are using liquid - most liquids are 100 mg/ml. You would take 2.2 ml of the liquid.
• Onco Adjunct™ Pathway 1™ - 2-4 ml 2 times a day depending on your weight.
• Onco Adjunct™ Pathway 2™ - 3 capsules 2 times a day only when you are off chemo.
• Onco Adjunct™ Pathway 3™- With each meal - 1 (one) capsule with a light meal and 2 (two) capsules with a heavy meal if you are trying to starve your cancer of sugars.
• NEW - Onco Adjunct™ Pathway 4™- 2 Capsules twice a day.

Source: https://mycancerstory.rocks/81-2/ (Last updated: December 2025)

1. Fenbendazole: One Packet a Day

What are the recommended doses of fenbendazole for cancer in humans?

Fenbendazole 222 mg (1 gm of Panacur™) per day every day. It can be mixed with food such as yogurt or simply taken by itself.

It is advised to purchase Panacur C (powder) brand only, as it's regulated and has been consistent in third-party lab results.

[2019 Edit: There is evidence that FZ (because it is not water soluble) will not uptake into your blood stream unless taken with food or fats. I recommend now to take it with a meal.] (source)

Note if you are using liquid – most liquids are 100 mg/ml. You would take 2.2 ml of the liquid.

Click here to buy Fenbendazole (Panacur C) on Amazon*

Please take note that the Panacur C* on Amazon is available in three sizes (1 gram, 2 grams and 4 grams) of single dose packets.

Alternatives: 

• Sanare Lab Fenbendazole (Available on Amazon)
• Safeguard Fenbendazole 100 mg/ml (Available on Amazon)

Related (Cancer Treatment and Research Communications 2022):

The presence of the active substance (fenbendazole) was confirmed with the analytical techniques for both commercial Brand Panacur C and Brand Safeguard products, but when tested for human use against human cancer cells, the result was that Brand Safeguard had a more significant effect than Brand Panacur. (source)

Note: Check out the New and Improved version of the Joe Tippens Protocol (below), enhanced by Dr William Makis, an oncologist.

2. Onco Adjunct Pathway 1: CBD, Frankincense and Nano C60 Carrier

Pathway 1: CBD Tincture: CBD has always been part of his protocol, but the new product will incorporate some important changes. 

As we have learned more about the potential benefits of hemp extracts we have discovered that the species of hemp, the methods of its extraction, the ratios of acidic forms of cannabinoids to non-acidic forms of cannabinoids all play a critical role in how well Hemp extracts can have on cancer outcomes.

In my research of Hemp extracts – Onco Adjunct Pathway 1 – product hits all of the important qualities for a hemp extract. First the product is cryo-extracted, this preserves the terpenes and the non-decarboxylated cannabinoids. 

Second, this product uses a proprietary strain of cannabinoid that has actually been tested on cancer cell lines. 

And Third, they supplement the CBGa cannabinoid to standardize it up to 7mg per dose, something that I believe could be significant. 

Finally, they add in two other important ingredients, the first being Frankincense, an iconic material dating back to the biblical times and recently the topic of a ton of cancer research. The company’s work on Frankincense focused on a collaboration with Dr HK Lin, the iconic researcher who studied Frankincense as a supplement for cancer for more than a decade. Together they developed an approach that uses specific fractions of Frankincense that are the most beneficial, according to his research.

 

Finally, a Nano molecule carrier, C60 has evidence to show that it could help significantly with low dose chemotherapy, reducing the toxicity of chemo to healthy cells and increasing the toxicity to unhealthy cells.

The Onco Adjunct Pathway 1 is a unique combination of Cryo Extracted Hemp, with Middle Eastern frankincense essential oils and the Nano C60 carrier, all in one tincture.

Some people may wish to stay with the previously recommended Forgotten Trails CBD from Pharmacy Plus at mcadoorandy@gmail.com and they will continue to supply that as well.

Click here to buy Onco Adjunct Pathway 1.

3. Onco Adjunct Pathway 2: Curcumin and Quercetin

Curcumin has always been part of Joe Tippens protocol, but even the product that he has previously recommended, Theracurmin HP, simply does not tackle the problem of absorption into the blood stream.

You all know I have recommended Theracurmin for some time as being the best, most highly bioabsorbable Curcumin I had found. What I didn’t know about was Ultra Botanica’s LPS technology UltraCur (UltraCurcumin). Data shows better absorption above Theracurmin by at least 6X and their consumer experience proves this out. Their product by itself is a game changer in curcumin and I would have left it at that except the science behind Quercetin, an equally important polyphenolic compound as Curcumin also using their LPS technology to make it absorb into the body. 

Previously I had been reluctant to recommend Quercetin (also recommended by Jane McClelland and many others) as it had the same problem as Frankincense and Curcumin in absorption into the blood stream. Why take something that simply isn’t being utilized in the bloodstream? UB’s LPS technology solves that problem and they have added the convenience of taking them together with one product.

Specifically, Onco Adjunct Pathway 2 is a combination of 300 mg of Clinical Grade UltraCurcumin, 200 mg of Clinical grade UltraQuercetin and 100 mg of Frankincense powder.There is a lot I could share about the cellular pathways that Curcumin, Quercetin and Frankincense affect, I will leave that to another time.

Clinical Evidence: A review paper published in 2022, analysed 21 human studies. Sixteen out of 21 clinical trials were associated with the effectiveness of curcumin or turmeric on various types of cancer, and the other five clinical trials were related to the evaluation of the efficacy of curcumin or turmeric in relieving the side effects of cancer chemotherapy and radiotherapy. The emerging data from the clinical trials confirm that curcumin has the potential for cancer prevention and intervention. Interestingly, curcumin appears to be universally useful for just about every type of cancer (Arslan 2022), which is really odd since cancer consists of a wide variety of different molecular pathologies.

Click here to buy Ultra Botanica’s LPS technology UltraCur (UltraCurcumin)

Click here to buy Bioavailable Quercetin

4. Onco Adjunct Pathway 3: Berberine

None of you have heard me recommend Berberine up to this point, even though many researchers have recommended it. Much like Frankincense, Curcumin and Quercetin, Berberine also is not bio-available into the blood stream. Something this company’s LPS technology solves. 

In evaluating the new curcumin and new hemp options I had the opportunity to take a fresh look at Berberine. As most people know, cancer cells are devourers of sugars / glucose in the body. In fact, cancer cells are glucose monsters. 

Jane McClelland and many cancer coaches strongly recommend starving your cancer cells by ketogenic diets, and Care Oncology recommends Metformin in its protocol for the same reason. For those of you that are serious about starving your cancer cells from glucose, adding in Pathway 3 to your regime could help. 

Berberine in its soluble LPS form modifies glucose metabolism in much the same way that Metformin modifies glucose metabolism. The scientists in India proved that Fenbendazole is effective in interrupting cancer cells’ ability to metabolise sugars and I believe by adding in UltraBerberine as Onco-Adjunct Pathway 3 you further diminish the ability of cancer cells to devour glucose, weaking them and putting their survival at risk.

Click here to buy Bioavailable Berberine

5. Onco Adjunct Pathway 4 (New)

This is a new product that has been recently launched. It combines EGCG (Green Tea polyphenols), Resveratrol and Fisetin each of these ingredients is enabled with the company's LPS™ technology. They also added a very important ingredient which is a highly purified Beta glucans that has the benefit of autophagy/apoptosis on senescent immune cells. This is especially important for the long haul when our immune system can become overtaxed and worn out.

 July 22, 2020 update:
"I have eliminated Vitamin E as a required part of the protocol as there are simply too many instances (eg, blood thinners) where it needs to be eliminated, and it is the least important of the items."

Click here to buy Onco Adjunct Pathway 4.

Scam Alerts

Joe Tippens: "Over the past 6 months, scammer accounts on social media have increasingly exploited cancer patients. The only legitimate group associated with me is Facebook Group: mycancerstory.rocks (59K members). Any other group using my name, it is likely a scam. I will never offer anything for sale." (source)

Source: Facebook

Source: X.com

Source: X.com

Source: Facebook

What brand of fenbendazole did Joe Tippens protocol contain?

In the protocol described by Joe Tippens, a brand called Panacur C was used along with other components like CBD. The usage of Panacur c for humans then started to gain popularity after Joe’s story went viral. Fenbendazole belongs to a class of microtubular-level destabilizing agents.

Like other benzimidazoles (e.g., albendazole, mebendazole), fenbendazole has shown significant results in treating cancer. Although very few studies have been conducted on the topic, utilization of Panacur C for cancer treatment is considered safe.

It looks like there are some heated discussions about fenbendazole suppliers. The debates among suppliers might be due to the increasing demand and varying quality of the product. If you’re interested in the details of these discussions, you might want to check out: https://x.com/MakisMD/status/1837440610191524330.

Panacur C dog dewormer compared to other fenbendazole brands

Fenbendazole is distributed by many brands. Panacur C is a popular cancer-treating option nowadays. It doesn’t matter which brand you use as long as you are getting a calculated 222 mg dosage of fenbendazole.

Panacur C is the most popular dog dewormer, it is made by a company named Merck. There are two versions of fenbendazole distributed by this company. One is called Safeguard which is specifically designed for deworming house pets, while Panacur C is designed for setting farms.

Fenben Lab is a company that distributes fenbendazole to the consumers worldwide. This company sells fenbendazole in the form of powder just without any fillers.

Homelab Vet is another company that distributes fenbendazole. They offer fenbendazole in many forms like powder, liquids and oral tablets. This company is based in Ukraine and offers worldwide shipping.

Sigma-Aldrich, which is considered the biggest chemical product manufacturer as well as supplier in the world. It also distributes fenbendazole. This company mainly focuses on producing analytical quality products that are mainly used for research purposes.

Most of these products are available online and can be easily bought on websites like Amazon. These products can also be found in local pharmacies.

Fenbendazole, Joe Tippens and MD Anderson Cancer Center

Dr Mukhopadhyay from MD Anderson first discovered mebendazole has potent anti-cancer activity in lab experiments in 2002.

Joe Tippens was also a participant of the Keytruda (pembrolizumab) clinical trial at the MD Anderson Cancer Center (source).

Confounding Factors: Was it Fenbendazole or was it Keytruda?

Joe Tippens clarified on YouTube (2026):

The Korean government did a hit piece on me saying that Joe is a fraud as he was taking Keytruda (pembrolizumab) simultaneously with fenbendazole in the same period when he achieved NED (no evidence of disease). Merck did 3 different clinical trials, for Keytruda in metastatic (stage 4) small cell lung cancer (SCLC) but it failed. I'm the only survivor out of the 3 trials. In 2021, Merck went to the FDA and said "Keytruda does not work for metastatic SCLC". For NSCLC (non small cell lung cancer), Keytruda is a great drug. But in my case (SCLC), Keytruda had no impact. The wide metastasis happened after my chemo and radiotherapy. For someone with wide metastatic SCLC, I am the only data outlier in the 75 years history of MD Anderson. That was because of fenbendazole and the other things I was taking. ((Youtube timestamp, 17:00 - 22:00)

Tippens told Koco 5 News (2019):

Tippens took the dog medicine with other daily vitamin supplements (Vitamin D, Curcumin, Berberine and Quercetin) and CBD oil. He was also taking an experimental cancer fighting drug (pembrolizumab?). But Tippin says out of the 1100 patients on that clinical trial, he was the only one cleared of cancer. Tippens says he was saved by the dog dewormer. And he plans to take it for the rest of his life.

That said, Tippens' outcome may have been also be driven by genetic factors such as microsatellite instability or a high mutational burden, which are strongly associated with favorable responses to immunotherapy. 

In advanced rectal cancer for instance, a study published in the New England Journal of Medicine (2022) reported a 100% complete response rate in mismatch repair–deficient (dMMR), locally advanced rectal cancer treated with dostarlimab, an anti–PD-1 monoclonal antibody. An updated publication in NEJM (2025) showed, among the 103 patients who completed treatment across both cohorts, 84 had a clinical complete response. Among the 117 total patients, recurrence-free survival at 2 years was 92%; the median follow-up for recurrence was 20.0 months (range, 0 to 60.8).

A "Review of 300+ Case Reports on the Use of Ivermectin and Benzimidazoles (Fenbendazole and Mebendazole) in Advanced Cancer Treatment (2025 - 2026)" suggests potential anti-cancer effects of ivermectin and benzimidazoles, warranting further investigation through rigorous clinical trials. However, since most published case reports represent positive outcomes while negative or neutral cases are less frequently reported, the overall findings may be subject to publication bias. Therefore, these promising observations can only be confirmed or refuted by well-designed, controlled studies.

 

A Welcome Message from Joe Tippens (December 2025)

Joe Tippens LiveStream, August 2026 - Joe answers your questions about his story

Key highlights:

• I do not trust any of the other manufacturers, other than Merck. (Youtube timestamp, 3:10)
• I don't believe that anybody should be taking anything other than the powder, granules from Merck either in the brand name of Panacur C or Safeguard. (Youtube timestamp, 3:40)
• On ivermectin and fenbendazole combination, I am 90% certain is the fenbendazole doing most of the work. (Youtube timestamp, 10:50)
• Why? The one thing that fenbendazole does that none of the other anti-parasitics do, is that it attacks the down-regulators to p53. p53 protein kills cancer cells. The down-regulators are keeping the p53 levels at bay. If you can hit those down-regulators, and increase your levels of p53, I believe that the protocol is a fantastic preventative  protocol for cancer. (Youtube timestamp, 11:00)
• My protocol 9 years ago was a 3 days on and 4 days off protocol, because I was worried of the potential liver side-effect. Last year, I found the research that fenbendazole can negatively affect the liver, was at 5,000 times the dosage that we recommend (222 mg/day). (Youtube timestamp, 14:25)
• If somebody is in a aggressive stage 4 cancer scenario, they should double the dose to 444 mg/day for the 1st month or so. If the liver enzymes spike, cut back the dosage. (Youtube timestamp, 16:00)
• The Korean government did a hit piece on me saying that Joe is a fraud as he was taking Keytruda (pembrolizumab) simultaneously with fenbendazole in the same period when he achieved NED (no evidence of disease). Merck did 3 different clinical trials, for Keytruda in metastatic (stage 4) small cell lung cancer (SCLC) but it failed. I'm the only survivor out of the 3 trials. In 2021, Merck went to the FDA and said "Keytruda does not work for metastatic SCLC". For NSCLC (non small cell lung cancer), Keytruda is a great drug. But in my case (SCLC), Keytruda had no impact. The wide metastasis happened after my chemo and radiotherapy. For someone with wide metastatic SCLC, I am the only data outlier in the 75 years history of MD Anderson. That was because of fenbendazole and the other things I was taking. (Youtube timestamp, 17:00 - 22:00)

Source (August 2026 Update): https://www.youtube.com/watch?v=FMzF_Z87XTo

Fenbendazole Enhancing Anti-Tumor Effect: A Kidney Cancer Case Series

Despite multiple anecdotal stories and news outlet reports for its efficacy in treating metastatic cancer, the clinical literature behind utilizing FBZ (fenbendazole) as a potential anti-neoplastic agent remains nonexistent. Existing scientific studies have primarily studied its mechanism of action through the use of animal models. In a study published in Clin Oncol Case Rep (2020), researchers from Stanford describe three cases where patients achieved complete responses, including two who experienced progression after multiple lines of therapy, when FBZ was used alone or in combination with standard therapies.

In summary, three patients with different primary genitourinary tumors who demonstrated complete response after receiving FBZ therapy. This raises the question of how effective FBZ can be as an anti-oncogenic agent and merits further investigation. 

According to the authors:

Prior studies have demonstrated cancer response to immune checkpoint inhibitors such as nivolumab as a third-line agent in mRCC (metastatic renal cell carcinoma). The duration of therapy was often much longer requiring a median therapy duration of 6 months with 24% overall response rate in third-line treatment. It is possible that our first patient with mRCC would have achieved a significant response to nivolumab alone without FBZ. However, given the complete radiologic response on only 1 month of immune checkpoint inhibitor therapy, it also seems likely that FBZ played a notable role in inducing remission. This is supported by the fact that our patient has remained in extended remission while only on FBZ for nearly a year without further administration of immune checkpoint inhibitor therapy.

Read More: Fenbendazole cancer success stories (800+ case reports)

Exceptional Repositioning of Dog Dewormer: Fenbendazole Fever

In a review paper, published in Current Issues in Molecular Biology 2022, the current evidence on the anticancer activity of Fenbendazole and the drawbacks of patient self-administration were summarized.

Targeting the Mitochondrial-Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol

An Ivermectin, Mebendazole and Fenbendazole Protocol in Cancer has been peer-reviewed and published on Sep.19, 2024 in the Journal of Orthomolecular Medicine. Co-authors include Dr Paul Marik and Dr William Makis: Targeting the Mitochondrial-Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol.

Ivermectin and Fenbendazole Cancer cure experiences - Dr John Campbell

Dr John Campbell posted recent related videos on YouTube (Nov 2025):

1. Dr. Campbell reviewed a May 2025 case series involving three self-treated patients with breast cancer, prostate cancer, and melanoma, which is among the few peer-reviewed human reports in this area. Although the number of cases is small and anecdotal, Dr. Campbell emphasized the importance of such case observations, drawing a parallel to the historical discovery of scurvy treatment by Dr. James Lind. These observational case studies can provide critical early insights that pave the way for further clinical research and potential breakthroughs in treatment. (YouTube)
2. Dr. Campbell received over 4,000 comments, with many individuals sharing their personal success stories using fenbendazole or ivermectin to treat cancer within their families, friends, and colleagues. These testimonials reflect a growing interest and anecdotal evidence in the use of these antiparasitic drugs as alternative or complementary cancer therapies, although formal clinical validation is still needed. This widespread feedback highlights the community’s engagement and the potential relevance of repurposed drugs in cancer care. (YouTube)
3. Tennessee, Arkansas, Louisiana, Idaho, Texas, Florida maybe soon are the States where ivermectin may be bought over the counter. GOVERNOR RON DESANTIS AND FIRST LADY CASEY DESANTIS ANNOUNCE $60 MILLION FUNDING OPPORTUNITY FOR INNOVATIVE CANCER RESEARCH ON WORLD CANCER RESEARCH DAY. Further, priority will be given to projects that focus on nutrition, and the repurposing of generic drugs such as ivermectin for cancer treatment. (YouTube)

ASCO Clinical Notice: Recommending Against Ivermectin and Fenbendazole for Cancer Treatment Outside Clinical Trials

The American Society of Clinical Oncology (ASCO) Clinical Notice (May 2026) takes a cautious, evidence-based position on ivermectin and fenbendazole in cancer care. ASCO strongly cautions against using either drug to treat cancer, or as an adjunct to established cancer therapies, outside the regulatory safeguards of a well-designed clinical trial.

The rationale is clear: current clinical evidence has not established that either drug provides robust benefit in treating human cancers, nor has it adequately established their safety and effectiveness in this setting. Potential toxicities and harmful interactions with other medications, including established cancer therapies, are additional concerns. ASCO therefore emphasizes the need for well-designed comparative clinical trials to determine whether either drug has a favourable benefit–risk profile and any meaningful clinical utility in oncology.

But there is an important distinction in the wording that deserves closer attention.

Does recommending against their use outside clinical trials mean recommending their use inside clinical trials?

Not exactly. The latter would imply an endorsement that ASCO has not made. However, the qualification is meaningful: ASCO is not ruling out further scientific investigation. Rather, it is saying that these drugs should not be used as cancer treatments outside the safeguards of properly designed clinical research.

When media headlines or summaries omit the words "outside of clinical trials", the apparent scope of the recommendation changes. Whether intentional or simply the result of headline compression, leaving out those qualifying words can make a conditional recommendation against unsupervised use sound like an unconditional rejection of any potential therapeutic role.

This is not quite a "neither confirm nor deny" position. ASCO has taken a firm stance against off-trial use, based on the current lack of clinical evidence and potential risks. At the same time, it recognises that properly designed clinical trials are necessary to determine whether these drugs have any therapeutic utility in oncology.

What should an oncologist say when a patient asks about these drugs?

Would an unequivocal "No, absolutely not" be consistent with the ASCO Clinical Notice?

It depends on what the oncologist means. Saying, "I do not recommend taking ivermectin or fenbendazole for cancer outside a properly supervised clinical trial" is entirely consistent with the notice.

However, dismissing the patient's question, refusing to discuss the available evidence, or declaring that further investigation is unwarranted would not reflect ASCO's recommended approach to patient communication.

In fact, ASCO specifically encourages oncologists to proactively ask patients about alternative therapies, respond with respectful curiosity, educate with empathy, maintain trust, and support shared decision-making.

The distinction matters. Patients deserve an honest discussion of both the limitations of the evidence and the reasons for clinical caution. They should not be encouraged to self-medicate, but neither should legitimate questions about emerging research be dismissed.

The bottom line: Recommending against unsupervised use outside clinical trials is not the same as declaring that these drugs have no potential worth investigating. Evidence-based medicine should be cautious about unproven treatments, but it should also remain open to well-designed scientific investigation.

Dr. Paul Marik argues in his 2026 Substack essay that relying primarily on the absence of large randomized controlled trials can provide an incomplete picture of the evidence surrounding repurposed drugs:

In my opinion, this statement presents an incomplete picture of the existing evidence and of the practical challenges involved in evaluating repurposed drugs. By focusing almost exclusively on the absence of large randomized controlled trials, it gives relatively little weight to the extensive preclinical literature, mechanistic studies, pharmacologic data, observational clinical experience, and the growing body of real-world evidence supporting further investigation of these agents.

This perspective does not establish robust clinical efficacy, but it supports the argument that the evidence base should be evaluated across multiple levels of evidence rather than through randomized trials alone.

Dr William Makis also provided a differing opinion (X.com September 2026):

- There are now 7 Clinical Trials examining the use of Ivermectin in Cancer, one in California NCT05318469, and six in Florida including NCT07487805. This makes Ivermectin one of the most exciting and researched modalities for use in cancer today, much more exciting than anything happening in mainstream Oncology - There are 5 Clinical Trials examining the use of Mebendazole in Cancer (which is almost identical to Fenbendazole), including two by Johns Hopkins, and international centers in Sweden, Egypt and India - Johns Hopkins obtained a patent for Mebendazole use in Glioblastoma in 2021, one of the most aggressive human cancers that mainstream Oncology hasn't been able to help. - There are 4 Clinical Trials examining the use of Niclosamide in Cancer, at least 15 Clinical Trials examining the use of Melatonin in Cancer and many more repurposed drug Clinical Trials... - Hundreds of thousands of cancer patients are using Ivermectin, Mebendazole and Fenbendazole safely and successfully all around the world, and these patients can be found in every Cancer Center in North America - and they are doing much better than their peers.

Editor's Note: 

From a patient's perspective, this means that participation in an appropriately designed clinical trial is the clearest pathway for investigating these drugs as cancer treatments while generating controlled evidence about their potential benefits and risks. However, clinical-trial availability, eligibility, and location can vary considerably.

What about an off-label prescription supervised by a physician? That is a separate issue from clinical-trial use and should not be confused with evidence that the treatment works. A physician may sometimes consider off-label use of an approved human drug within the applicable laws and standards of medical practice, but ASCO's current position specifically advises against using ivermectin or fenbendazole for cancer outside a well-designed clinical trial. Fenbendazole presents an additional distinction: it is a veterinary medication and has not been approved for human use.

We therefore do not recommend self-treatment. The absence of established clinical benefit does not mean that every research question surrounding these drugs has been answered; it means that the evidence is not yet sufficient to establish them as cancer treatments. Potential drug interactions, toxicity, dosing uncertainty, and interference with conventional cancer treatment also need to be considered.

Our position is that patients who are interested in ivermectin or fenbendazole should discuss the subject openly with their multi-disciplinary oncology team rather than obtaining and taking these drugs on their own. Where an appropriate clinical trial exists (below), patients can discuss eligibility with the trial investigators. 

Where a patient is exploring options outside a trial, the decision should be made transparently with a qualified physician who understands the patient's cancer, current treatment, medications, and the available evidence.

The key message is simple: don't self-treat. Investigate the evidence, ask about clinical-trial opportunities, and work with a qualified physician who is willing to have an open, evidence-based discussion about potential benefits, uncertainties, risks, and alternatives.

Ivermectin and Mebendazole for Cancer Clinical Trials

Here are the 7 planned and on-going ivermectin clinical trials:

1. Cedars-Sinai Medical Center (NCT05318469) 
2. University of Florida (NCT07487805)
3. University of Miami (Shanta Dhar et al) 
4. Tampa General Hospital (Ivan Borello et al) 
5. Florida Intl University (Diana Azzam et al) 
6. Moffitt Cancer Center (Chang Jiang et al)
7. The Cancer Care Observational Study (Dr Pierre Kory)

Five US Cancer Research Institutions have received millions in Research grant funding to investigate Ivermectin in Cancer (September 2026)

1. Moffitt Cancer Center & Research Inst - $1.2 million
2. Florida International University - $1.4 million
3. Florida State University - $365k
4. Tampa General Hospital - $711k
5. University of Miami - $1.47 million

FAQs: Fenbendazole Joe Tippens Protocol

Is Joe Tippens still alive?

In August 2026, Joe Tippens was on a YouTube livestream: https://www.youtube.com/watch?v=FMzF_Z87XTo.

In February 2026, Joe Tippens was at the Annie Appleseed Conference in West Palm Beach (see picture below).

There have been misleading reports if you were to do a search on search engines, such as an obituary for a Joe Frank Tippens Jr. who passed away in 2018, which is not the same person.

To verify his current status, we recommend checking his blog, "Get Busy Living" (mycancerstory.rocks), or his active Facebook group "My Cancer Story Rocks" for the latest updates directly from him or his community. 

*Scam Alert: This account @JoeTippen on X.com does not belong to the real Joe Tippens (Founder of the Joe Tippens Fenbendazole protocol). Please refer to the 'scam alerts' above.

Can fenbendazole be taken in tablet, liquid or powder?

Fenbendazole is available in powder (Panacur). There may be other formulations available, but those are the primary products that patients are using.

Is it safe for humans to take fenbendazole?

Since fenbendazole is a veterinary medicine, and is not licensed for human use and there is no specific human safety data available. The similar human forms of this class of medications, mebendazole and albendazole, have been used for parasitic infections for many years and have a good safety record. Fenbendazole has been reported to have a very low degree of toxicity and a high degree of safety in animal experiments. Do not follow the weight-dependent dosing (for dogs) that is given on the back of the packaging!

According to the product description on Amazon, fenbendazole is "Safe for all Dogs 6 weeks and older, including pregnant Dogs".

Read More: Fenbendazole side effects in humans

Is fenbendazole toxic for the liver?

Although fenbendazole is generally well tolerated, there have been reports of elevated liver enzymes from the use of fenbendazole, as well as the human medications mebendazole and albendazole. 

The US NIH LiverTox database updated its fenbendazole entry on April 20, 2026, documenting clinically apparent liver injury associated with human self-administration.

Read More: Fenbendazole side effects in humans

I’ve found a Fenbendazole brand which is not made by Merck, is it ok?

There are a variety of opinions on which product is best, but no research exists that compares the effectiveness of various formulations in humans. Merck and Safeguard are well established companies whose products have been safety tested in animals and used by veterinarians for many years. 

Would the fenbendazole protocol work with conventional treatment? - chemotherapy?

Yes, fenbendazole has the potential to synergize with conventional treatments, and possibly enhance treatment response. Some aspects of the protocol, such as vitamin E and curcumin, may interfere with chemotherapy and radiation due to their anti-oxidant properties. 

Some people take it 3 day on 4 off, some 1 gram a day, some 2 or even 4 grams a day. What is the correct dosage?

Joe Tippens, who popularized the use of Fenbendazole for cancer, recommends 222 mg for three consecutive days, then four days off. There are many people who take larger doses, more frequently. Since Fenbendazole is not licensed for the treatment of cancer in humans, there is no correct dose that is supported by research, pharmacists or physicians. The dose you choose to take should be assessed based on your other medications and treatments, your type of cancer, prognosis, organ function and lab values.

How long do I need to be on this protocol?

This will be up to you based on your treatment response to the protocol. It is reported that Joe Tippens continues to use the protocol for prevention.

How do I know when it is time to dose up?

This is an individual decision based on treatment response, tolerance, other treatments/medications and lab values. 

Do you have to remove sugar and carbs for Joe Tippens protocol?

Yes. No sugar and low healthy carbohydrate diet especially if you are overweight.

Can you take fenbendazole and paracetamol together?

There is insufficient human clinical evidence to establish that combining fenbendazole and paracetamol is safe. A 2012 animal study found that fenbendazole pretreatment significantly worsened acetaminophen-induced liver injury in mice.

Although this interaction has not been confirmed in humans, the findings raise a potential safety concern. Patients should consult a healthcare professional before combining these substances.

Why might fenbendazole increase paracetamol-related liver toxicity?

Researchers have proposed that fenbendazole may interfere with the liver's antioxidant defence mechanisms.

Paracetamol is partly metabolized into a toxic compound called N-acetyl-p-benzoquinone imine (NAPQI). Normally, glutathione neutralizes this compound before it causes significant liver damage.

In the mouse study, fenbendazole exposure was associated with prolonged depletion of hepatic glutathione following acetaminophen administration. This was associated with more severe liver injury.

However, this proposed interaction has not been established in humans.

Does fenbendazole cause liver damage on its own?

Yes. Although fenbendazole is primarily a veterinary anthelmintic, human case reports have documented clinically significant drug-induced liver injury following self-administration.

A 2024 case report described a 67-year-old woman who developed severe liver injury after taking fenbendazole for purported anticancer effects. Her liver function eventually normalized after discontinuing the drug.

The NIH LiverTox database, updated April 20, 2026, classifies fenbendazole as a probable cause of clinically apparent liver injury.

Can a single dose of paracetamol cause liver damage when taking fenbendazole?

There is no human clinical evidence establishing that a single therapeutic dose of paracetamol causes liver injury specifically because of concurrent fenbendazole use.

The animal study does not establish the risk associated with an ordinary single human dose.

Nevertheless, the potential interaction warrants caution, particularly in people taking fenbendazole repeatedly or those with pre-existing liver problems.

Does separating fenbendazole and paracetamol by several hours prevent the interaction?

There is no established evidence that separating the doses by several hours prevents potential liver toxicity.

The animal study examined fenbendazole exposure before acetaminophen administration. It did not establish a safe interval between the two substances in humans.

Therefore, simply taking the medicines at different times should not be considered a reliable way to avoid the potential interaction.

How long should you wait after stopping fenbendazole before taking paracetamol?

There is currently no validated human washout period for this combination.

The duration of any potential interaction is unknown, and it should not be assumed that waiting 12, 24 or 48 hours eliminates the risk.

Patients should discuss their previous fenbendazole exposure, frequency of use and liver health with a healthcare professional before taking paracetamol.

What are the warning signs of liver damage?

Possible symptoms of drug-induced liver injury include:

• Yellowing of the skin or eyes (jaundice).

• Dark-coloured urine.

• Pale or unusually light-coloured stools.

• Persistent nausea or vomiting.

• Unusual fatigue or weakness.

• Loss of appetite.

• Pain or discomfort in the upper right abdomen.

These symptoms require prompt medical assessment. Do not wait for all symptoms to appear. Suspected paracetamol overdose requires immediate medical attention, even when symptoms are absent.

What liver-function tests should be considered when taking fenbendazole?

A healthcare professional may consider the following investigations:

Test	What it measures
ALT	Liver-cell injury
AST	Liver-cell injury, although it is also found in other tissues
ALP	Possible bile-duct or cholestatic injury
Total bilirubin	Bilirubin processing and excretion
GGT	Helps assess the origin of elevated ALP
INR	Liver synthetic function and blood-clotting status

The decision and frequency of monitoring should be individualized.

Importantly, normal liver-function results at one point in time do not establish that fenbendazole or its combination with paracetamol is safe.

Can people undergoing chemotherapy take fenbendazole and paracetamol?

This combination warrants particular caution in patients receiving cancer treatment.

Chemotherapy, targeted therapies and immunotherapy can affect liver function. Adding an unapproved veterinary drug with documented reports of liver injury may complicate the assessment of treatment-related toxicity.

Patients should disclose fenbendazole use to their oncologist and pharmacist, including the product, dose and duration. Fenbendazole has not been demonstrated to be an effective human cancer treatment.

Can milk thistle, NAC or glutathione protect the liver against this interaction?

There is insufficient clinical evidence to establish that milk thistle, N-acetylcysteine (NAC), glutathione supplements or other antioxidant products prevent fenbendazole-associated liver injury or eliminate the potential interaction with paracetamol.

NAC is an established medical treatment for acetaminophen poisoning, but it should not be regarded as a preventive supplement that makes this combination safe.

Do not self-treat a suspected overdose or liver injury with supplements.

What should you do if you have already taken fenbendazole and paracetamol together?

Do not panic, but do not assume the combination is safe.

Recommended steps:

1. Record the doses, dates and times of both substances.

2. Avoid taking further doses of the combination until you have received medical advice.

3. Contact a healthcare professional, particularly if fenbendazole has been taken repeatedly or you have existing liver disease.

4. Seek immediate medical assessment if an overdose is possible or symptoms of liver injury develop.

A clinician may recommend liver-function testing and, depending on the circumstances, a paracetamol blood level or other investigations.

Key Takeaways

• Strong preclinical evidence and accumulating case reports highlight anti-cancer potential for ivermectin and fenbendazole, but definitive proof requires completed high-quality clinical trials.
• Bridging the Gap: Case reports and real-world data offer valuable interim evidence, helping guide patients and researchers during the multi-year wait for large RCTs (randomised controlled trials).
• For patients who have exhausted standard, evidence-based treatment options, there is a compelling case for institutions and regulatory bodies to formally evaluate repurposed drugs such as ivermectin and mebendazole within structured frameworks. This could include open-label clinical trials, compassionate-use programs, expanded-access pathways, or prospective patient registries. Establishing such mechanisms would allow oncologists and patients to explore these options transparently and ethically under medical supervision, while generating real-world data on safety and outcomes. A regulated pathway may also help clarify legal boundaries and provide appropriate protections for both physicians and patients seeking additional therapeutic options when conventional treatments have failed.
• Caution Essential: Self-medication carries risks (e.g., liver effects); integrate with standard personalized care and professional monitoring for best outcomes.

Updated Joe Tippens Protocol

Below is a modified version of the Joe Tippens protocol (above), a synergistic combination of fenbendazole, ivermectin and nutraceuticals, updated based on the ivermectin and mebendazole based protocol published in the Journal of Orthomolecular Medicine (2024) and Journal of Anticancer Research (2026):

• Ivermectin (25 - 50 mg/day, 6 days a week) or in the case of severe aggressive cancers up to 1mg/kg/day.
• Mebendazole (250 - 500 mg/day, 6 days a week) or Fenbendazole, commonly taken at 222 mg for six days a week, with doses increasing to up to 1 gram in cases of aggressive cancers.
• Bio-Available Curcumin (600 mg per day, 7 days a week). 
• Enhanced absorption Berberine (500 mg per day, 7 days a week).
• Diet and Lifestyle: 
• A 2026 study (American Association for Cancer Research), linked Ultra-Processed Foods to Reduced Survival after Cancer. Sugar, starch, saturated fat packed into ultra-processed food not only associated with obesity, diabetes, and heart disease, it also worsens cancer prognosis.
• Another 2026 study published in The BMJ examined how everyday exposure to food preservatives influences cancer risk. The findings were clear — people who consumed more preservatives had higher rates of overall cancer and breast cancer. The findings support recommendations for consumers to favour freshly made, minimally processed foods.
• Weight loss if overweight. A 2026 findings published in Nature Communications, insulin resistance has been linked to a 25% higher risk of 12 different types of cancer. Insulin resistance is often caused by obesity and its associated chronic inflammation. Both diabetes and obesity are associated with a higher risk of cancer. 
• Adopt a whole-food diet and avoid ultra-processed foods, as recommended by the BMJ 2024 guidelines. 
• Eliminate sugar consumption as supported by the BMJ 2023 umbrella review, which recommends reducing free and added sugars to below 25 g/day and limiting sugar-sweetened beverages to less than one serving per week to reduce adverse health effects. 
• Additionally, prioritise adequate sleep and effective stress management to support overall health.

*Notes:

• Please note that this protocol now includes the vital Vitamin D addition, with the one day off for the fenbendazole administration. This protocol represents the most comprehensive and cutting edge repurposed drug and vitamin treatment approach to date.
• Vitamin E: Removed from the protocol (Joe Tippens, July 22, 2020) due to interactions (e.g., with blood thinners).

Sources and References:

1. https://mycancerstory.rocks/the-blog/
2. https://mycancerstory.rocks/81-2/
3. Dr Peter McCullough: How to Detox Spike Protein from Body
4. FLCCC I-Recover Protocol (Post-Vaccine Treatment Protocol)
5. Top 26 Repurposed Drugs and Metabolic Interventions for Cancer Treatment
6. Ivermectin and Fenbendazole: Treating Turbo Cancer
7. Fenbendazole: Questions Answered, Things to Know, Useful Tips
8. Top 10 Cancer Fighting Supplements
9. Mebendazole vs fenbendazole for cancer
10. Ivermectin vs Fenbendazole for Cancer
11. Best Ivermectin Dosage for Humans with Cancer or Different Cancer Types
12. Best Fenbendazole Dosage for Humans: Safety, Side Effects and Efficacy Examined

Find Integrative Oncologists in USA, Mexico, Europe or Asia

While the potential anti-cancer properties of fenbendazole are intriguing, it’s crucial to approach with caution.

Consulting with an integrative healthcare expert is key to crafting a Fenbendazole protocol tailored to your unique health requirements. 

To find integrative oncologists, check out "find integrative oncologists".

Notes and Disclaimers: 

• Please do not consider this guide as a self-treatment guide or a personal medical advice, but as a recommendation for use by professional providers. Consult with your doctor and discuss with her/him. 
• Our aim here isn't to replace your doctors' advice. It is intended as a sharing of knowledge and information. Do take note that most treatments are not 100% protective or curative against cancer. It's a continuous struggle between the immune system and the cancer cells. Cancer treatments are meant to assist the immune system in this battle.
• Cancer treatment should be part of a multi-modal approach in order to provide the best possible outcome. Diet and lifestyle changes are meant to run alongside conventional treatment. They are complementary, not alternative. 
• Cancer care is a team effort with the patient at the centre. Care should be supervised and coordinated by a primary healthcare provider. Patients with cancer should consult with their regular oncologist as well as an integrative provider/oncologist, in addition to their primary care provider and the supporting nurses, dietitians and other allied healthcare professionals.

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Where to Get Ivermectin Safely in 2026

The Wellness Company's Ivermectin and Mebendazole

Ivermectin and mebendazole, both approved for human use, are now available in the US through controlled medical frameworks. The Wellness Company offers a standardized Ivermectin + Mebendazole combination (25 mg ivermectin + 250 mg mebendazole) with the following assurances:

• Prescribed and supervised by licensed physicians, including consultation to determine appropriate human dosing, assess contraindications, monitor organ function, and oversee cyclic treatment regimens.
• Compounded in US-based pharmacies to pharmaceutical standards.
• Clinically tested (PubMed: May 2026). 
• Standardized dosing (25mg ivermectin + 250mg mebendazole).
• Quality-tested for purity and consistency.

This ensures patients are not relying on uncertain sources or inconsistent formulations.

Where to buy Ivermectin and Mebendazole Formula: Available on The Wellness Company's website. Here is the link: Ivermectin and Mebendazole.

Important: Do not purchase veterinary ivermectin formulations. Concentration, inactive ingredients, and purity standards differ significantly from human pharmaceutical-grade preparations.

Affiliate Disclosure: OneDayMD has an affiliate relationship with The Wellness Company and may receive compensation from purchases made through our link.