Ivermectin and Fenbendazole: Treating Turbo Cancer - Dr William Makis

Ivermectin Resources

Recently, I have seen tremendous demand for some sort of initial guidance “WHERE TO START” with High Dose Ivermectin for CANCER.

I have two articles and a Video that go into depth:

June 10, 2024 - "15 minutes with Dr.Makis" - Episode 018: High Dose IVERMECTIN and CANCER

2024 - NEW STUDIES

2024 Baghli et al - Targeting the Mitochondrial-Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol

First-in-the-World Ivermectin, Mebendazole and Fenbendazole Protocol in Cancer has been peer-reviewed and published on Sep.19, 2024. Co-authors include Dr Paul Marik and Dr William Makis.

2024 Fan et al - Ivermectin Inhibits Bladder Cancer Cell Growth and Induces Oxidative Stress and DNA Damage

(2024 Man-Yuan Li et al) - Ivermectin induces non-protective autophagy by downregulating PAK1 and apoptosis in lung adenocarcinoma cells

(2024 Kaur et al) - Ivermectin: A Multifaceted drug with a potential beyond anti-parasitic therapy

(2024 Xing Hu et al) - Ivermectin as a potential therapeutic strategy for glioma

(2024 Yang Song et al) - Gene signatures to therapeutics: Assessing the potential of ivermectin against t(4;14) multiple myeloma

(2024 Goldfarb et al) - Lipid-Restricted Culture Media Reveal Unexpected Cancer Cell Sensitivities

(2024 Newell et al) - Therapeutic targeting of nuclear export and import receptors in cancer and their potential in combination chemotherapy

Oct. 2, 2023 - IVERMECTIN and CANCER, it has at least 15 anti-cancer mechanisms of action. Can Ivermectin Treat COVID-19 mRNA Vaccine Induced Turbo Cancers? - 9 Ivermectin papers reviewed

IVERMECTIN and CANCER RESEARCH:

Top 5 COVID-19 mRNA Vaccine Induced Turbo Cancers are: Lymphoma, Glioblastoma, Breast, Colon, Lung Cancer.

IVERMECTIN can help with mRNA Induced Turbo Cancer, or regular cancers.

Here are recent studies on IVERMECTIN use in certain types of cancer:

BLADDER CANCER - (2024 Fan et al) - Ivermectin Inhibits Bladder Cancer Cell Growth and Induces Oxidative Stress and DNA Damage

LUNG CANCER - (2024 Man-Yuan Li et al) - Ivermectin induces nonprotective autophagy by downregulating PAK1 and apoptosis in lung adenocarcinoma cells

GLIOMA - (2024 Xing Hu et al) - Ivermectin as a potential therapeutic strategy for glioma

MULTIPLE MYELOMA - (2024 Yang Song et al) - Gene signatures to therapeutics: Assessing the potential of ivermectin against t(4;14) multiple myeloma

OVARIAN CANCER - (2023 Jawad et al) - Ivermectin augments the anti-cancer activity of pitavastatin in ovarian cancer cells

PROSTATE CANCER - (2022 Lu et al) - Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer

COLON CANCER - (2022, Alghamdi et al) - Efficacy of ivermectin against colon cancer induced by dimethylhydrazine in male wistar rats

PANCREATIC CANCER - (2022 Lee et al) - Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction

MELANOMA - (2022 Zhang et al) - Drug repurposing of ivermectin abrogates neutrophil extracellular traps and prevents melanoma metastasis

CERVICAL CANCER - (2022, Qabbus et al) - Ivermectin-induced cell death of cervical cancer cells in vitro a consequence of precipitate formation in culture media

HEPATOCELLULAR CARCINOMA - (2022 Lu et al) - Ivermectin synergizes sorafenib in hepatocellular carcinoma via targeting multiple oncogenic pathways

OSTEOSARCOMA - (2022 Hu et al) - Repurposing Ivermectin to augment chemotherapy’s efficacy in osteosarcoma

GASTRIC CANCER - (2021 Rabben et al) - Computational drug repositioning and experimental validation of ivermectin in treatment of gastric cancer

LEUKEMIA - (2020, de Castro et al) - Continuous high-dose ivermectin appears to be safe in patients with acute myelogenous leukemia and could inform clinical repurposing for COVID-19 infection

ESOPHAGEAL SCC - (2020, Chen et al) - Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in oesophageal squamous cell carcinoma

CHOLANGIOCARCINOMA - (2019 Intyuod et al) - Anti-parasitic drug ivermectin exhibits potent anticancer activity against gemcitabine-resistant cholangiocarcinoma in vitro

BREAST CANCER STEM CELLS - (2018 Dominguez-Gomez et al) - Ivermectin as an inhibitor of cancer stem-like cells.

CML (CHRONIC MYELOID LEUKEMIA) - (2018 Wang et al) - Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress.

RENAL CELL CARCINOMA - (2017 Zhu et al) - Antibiotic ivermectin preferentially targets renal cancer through inducing mitochondrial dysfunction and oxidative damage

GLIOBLASTOMA - (2016 Liu et al) - Anthelmintic drug ivermectin inhibits angiogenesis, growth and survival of glioblastoma through inducing mitochondrial dysfunction and oxidative stress.

Related: 

• Ivermectin Cancer Success Stories: Case Series Compilation (More than 30 cases)

DR WILLIAM MAKIS'S TAKE

IVERMECTIN has proven anti-cancer activity against some 20 cancer types, although these are pre-clinical studies. We will never see clinical studies because Ivermectin is off patent and cheap.

Merck, which used to have a patent on Ivermectin, has partnered with Moderna on mRNA Cancer Vaccines, estimated to cost 400,000 GBP per treatment.

Ivermectin studies on mice include: Breast cancer, Colon cancer, glioblastoma, glioma and leukemia.

I have not seen IVERMECTIN studies on Lymphoma, Testicular Cancer, Sarcomas.

IVERMECTIN acts on Cancer mainly by inhibiting signaling pathways involved in cancer proliferation (Akt, Wnt, mTOR) and by inhibiting CANCER STEM CELLS.

IVERMECTIN ACCESS

Ivermectin is so safe, that in much of the civilized world, it is available over the counter, no prescription needed. That’s how it should be.

I recently wrote about how a doctor in Saskatchewan was just given a $44,800 penalty by the College of Physicians and Surgeons for prescribing Ivermectin to a few patients during 2020-2022. These College bureaucrats are engaging in crimes.

The Ontario College of Physicians even had an Investigator go undercover and dress up as a Canadian Trucker to ensnare a young doctor prescribing Ivermectin in Ottawa in 2022 during the Trucker Convoy.
Canadians must realize that the Colleges of Physicians are private corporations, fully bought off by big pharma and run by mafia lawyers like Bryan Salte (the SK lawyer who issued the $44,800 penalty for prescribing Ivermectin) - see below:

No healthcare bureaucrat or lawyer has the right to deny anyone access to life saving medication. And if they do, they are committing a very serious crime.

Reposted from: https://makismd.substack.com/p/ivermectin-articles-and-protocols

New & Improved Joe Tippens Protocol

The holy grail turbo cancer treatment may just be the synergistic combination therapy of Fenbendazole AND Ivermectin as follows:

• Fenbendazole (300mg, 6 days a week) or in the case of severe turbo cancers up to 1 gram.

• Ivermectin* (24mg, 7 days a week) or in the case of severe turbo cancers up to 1mg/kg/day (Find a Doctor)

• Bio-Available Curcumin (600mg per day, 7 days a week).

• Vitamin D (62.5 mcg [2500 IU] seven days a week).

• Adopting a healthy lifestyle is essential during this protocol. This includes eliminating sugar from the diet (BMJ 2023), consuming a nutritious, whole-food diet rich in fresh fruits and vegetables, avoiding ultra-processed foods (BMJ 2024), quality sleep and stress management.

• CBD oil (1-2 droppers full [equal to 167 to 334 mg per day] under the tongue, 7 days a week) CBD-X: The most potent full spectrum organic CBD oil, with 5,000 milligrams of activated cannabinoids and hemp compounds CBD, CBN & CBG per serving.

Please note that this protocol now includes the vital Vitamin D addition, with the one day off for the fenbendazole administration. This protocol represents the most comprehensive and cutting edge repurposed drug and vitamin treatment approach to date.

*If you are taking ivermectin and mebendazole, you might not need fenbendazole. Consult your doctor.

Note on Vitamin E:  

According to a July 22, 2020 update by Joe Tippens:

"I have eliminated Vitamin E as a required part of the protocol as there are simply too many instances (eg, blood thinners) where it needs to be eliminated, and it is the least important of the items."

Adapted from:  https://www.onedaymd.com/2024/11/fenbendazole-and-cancer-15-minutes-with.html

The Wellness Company's Ivermectin and Mebendazole

Available on The Wellness Company's website: Ivermectin and Mebendazole

Fenbendazole

Last year Dr William Makis published one of the most popular articles on Fenbendazole and Cancer Treatment ever published, which went viral internationally.

Oct.3, 2023 - FENBENDAZOLE and CANCER - at least 12 Anti-Cancer mechanisms of action. Not approved by FDA. Cheap. Safe. Kills aggressive cancers. Why no Clinical Trials? Nine research papers reviewed.

10 NEW STUDIES SINCE LAST ARTICLE!

• (2024 Apr, Rodrigues et al) - Repurposing mebendazole against triple-negative breast cancer CNS metastasis
• (2024 Feb, Eid et al) - Investigating the Promising Anticancer Activity of Cetuximab and Fenbendazole Combination as Dual CBS and VEGFR-2 Inhibitors and Endowed with Apoptotic Potential
• (2024 Feb, Park et al) - The microtubule cytoskeleton: A validated target for the development of 2-Aryl-1H-benzo[d]imidazole derivatives as potential anticancer agents
• (2024 Jan, Matsuo et al) - Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes
• (2023, Dec, Iragavarapu-Charyulu et al) - A novel treatment to enhance survival for end stage triple negative breast cancer using repurposed veterinary anthelmintics combined with gut‑supporting/immune enhancing molecules
• (2023 Nov, Aliabadi et al) - In vitro and in vivo anticancer activity of mebendazole in colon cancer: a promising drug repositioning
• (2023 Nov, Jung et al) - Fenbendazole Exhibits Differential Anticancer Effects In Vitro and In Vivo in Models of Mouse Lymphoma
• (2023 Sep, Garg et al) - Network pharmacology and molecular docking study-based approach to explore mechanism of benzimidazole-based anthelmintics for the treatment of lung cancer
• (2023 Jun, Mukherjee et al) - Ketogenic diet as a metabolic vehicle for enhancing the therapeutic efficacy of mebendazole and devimistat in preclinical pediatric glioma
• (2023 Feb, Lee et al) - Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine

DR WILLIAM MAKIS'S TAKE

There is still some research being done on Fenbendazole & Cancer, but researchers are focusing more on other related compounds in the “Benzimidazole family”, namely Mebendazole, but also Albendazole, Parbendazole. Why?

COST:

Fenbendazole is cheap. If big pharma is going to make money (especially in cancer treatment), they need an expensive compound and Fenbendazole isn’t it.

Fenbendazole is not FDA approved. It’s dirt cheap.

Mebendazole is FDA approved. It’s expensive. Check out "Fenbendazole vs Mebendazole for Cancer".

Albendazole is FDA approved. It’s very expensive.

PRACTICAL APPROACH TO USING FENBENDAZOLE IN CANCER TREATMENT (Disclaimer: the following is not medical advice)

In “Fenbendazole and Cancer Part 1”, I covered all the mechanisms of action that Fenbendazole has shown against cancer in many in vitro and in vivo studies.

The 10 new studies published in 2023-2024 only confirm what we already know from previous studies. Fenbendazole, Mebendazole, Albendazole are highly effective against many cancers.

There is one article I want to highlight though because it has an extremely important concept:

• 2023 Jun, Mukherjee et al - Ketogenic diet as a metabolic vehicle for enhancing the therapeutic efficacy of mebendazole and devimistat in preclinical pediatric glioma
• “This study investigated the influence of nutritional ketosis on the therapeutic action of mebendazole (MBZ) and devimistat (CPI-613) against the highly invasive VM-M3 glioblastoma cells in juvenile syngeneic p20-p25 mice”
• “maximum therapeutic benefit of mebendazole and CPI-613 on tumour invasion and mouse survival occurred only when the drugs were administered together with a ketogenic diet (KD)

KETOGENIC DIET IS CRUCIAL IN CANCER

Since my previous Fenbendazole article, I‘ve had 1000s of questions sent to me. Not about mechanisms of action against Cancer. But about practical use - how to use Fenbendazole or Mebendazole to treat Stage 4 Cancers, what formulations, what doses?

The goal of this article (Part 2) is to answer many of those questions to the best of my ability.

EXPERIMENTAL CANCER PROTOCOLS:

I propose the following thought experiment & hypothetical “Experimental Protocols” for Turbo Cancer Treatment:

• You can look at fenbendazole.org for suggested dosing and dose calculator
• Dr.Tom Rogers, Founder of “Performance Medicine” has similar protocols.
• For anyone COVID-19 mRNA Vaccinated diagnosed with cancer (Turbo Cancer), I’d probably be looking at starting at 444 mg a day.
• For particularly aggressive Turbo Cancers or bad cases, I’d even consider pushing towards 888 mg/day (444 mg twice a day) or 1000 mg/day.
• Highest dosing I’ve seen is 30-50mg/kg/day for 5 days, based on the “Merck Manual”, however very few claim to have taken this dose.
• Fenbendazole can elevate liver function tests, so it would be a good idea to have a family doctor monitor those

WHAT ABOUT MEBENDAZOLE?

Here are the references for this dosing schedule:

• For Maximum dose of 4g/day being safe, that’s from a Phase 2 Clinical Trial for Gastrointestinal Cancer: (2021 Mansoori et al)

• (2021 Chai et al) - summarizes the various studies that have looked at Mebendazole in Cancer and the doses used.

  • 500mg-1500mg/day (Phase 1 Clinical Trial, pediatric brain tumors)

  • 200mg/day (2011 Dobrosotskaya et al) (adrenocortical ca)

  • 200mg/day (2014 Nygren et al) (colon ca lung and LN mets)

  • 100mg/day (Clinical Trial, UK)

• So far, several studies in the literature have used 200mg/day with some success, however given that it is safe to go up to 4g/day, when we’re dealing with aggressive mRNA Induced Turbo Cancers, 200mg/day is probably not sufficient.

• Why Mebendazole over Albendazole (2021 Chai et al):

  “However, because of the toxicity of albendazole, for example, neutropenia due to myelosuppression, if high doses are used for a prolonged time, mebendazole is currently more popularly used than albendazole in anti-cancer clinical trials.”

Dr William Makis's Take…

My goal with these articles, is to provide as much clear information as possible for someone dealing with cancer or mRNA Induced Turbo Cancer.

This article deals with the practical approach to using Febendazole or Mebendazole.

Hypothetical - if I was diagnosed with mRNA Induced Turbo Cancer, as a 40s year old male, I’d be strongly looking at taking a combination of Ivermectin (1mg/kg/day) and Fenbendazole (444mg/day). This decision would be made based on dozens of peer-reviewed papers that have been published, previous and ongoing Clinical Trials, etc.

"Everyone’s situation is different, however, it is important to arm yourself with medical knowledge that cancer doctors (Oncologists) will simply not give you, because they either don’t know it, or they won’t risk their careers to save you."

RELATED: 

Mel Gibson had 3 Friends cure their Stage Four Cancer with Fenbendazole and Ivermectin

Turbo Cancer Debunked

Difference between fenbendazole and mebendazole

Fenbendazole vs Ivermectin for cancer

Top 10 cancer fighting supplements

Joe Tippens Protocol Fenbendazole

Fenbendazole: Questions Answered, Things to Know, Useful Tips

Read More: This article is part of the Winning the War on Cancer series.

The Wellness Company's Ivermectin and Mebendazole

Ivermectin and mebendazole, both approved for human use, are now available in the U.S.

Researched and approved by Dr. Peter McCullough.

• Prescribed by licensed medical professionals
• Compounded and dispensed by a licensed US-based pharmacy
• Approved for human use

Where to buy Ivermectin and Mebendazole Formula: Available on The Wellness Company's website. Here is the link: Ivermectin and Mebendazole.