Thyroid Cancer Concerns Raised Regarding Active Ingredient in Popular Drugs Ozempic and Wegovy?

The European Medicines Agency (EMA) has issued a drug safety signal ( pdf ) regarding the potential risk of thyroid cancer associated with certain classes of medications that include semaglutide , the active ingredient in the widely used drugs Ozempic, approved for Type 2 diabetes, and Wegovy, approved for obesity. The medications in question are glucagon-like peptide-1 (GLP-1) receptor agonists. Their manufacturers, including Novo Nordisk, AstraZeneca, Eli Lilly, and Sanofi Winthrop, must submit supplementary information by July 26, 2023. A safety signal does not necessarily imply a direct causal relationship between a medicine and the reported adverse event. The purpose of assessing safety signals is to determine whether such a causal link exists between the medication and the reported adverse event. “Novo Nordisk is aware of the signal and the request by EMA and will deliver a thorough assessment of all relevant data to elucidate this topic,” Lars Otto Andersen-Lange, media relation