Fenbendazole for Humans: Safety and Efficacy Examined (2024)
Fenbendazole is a broad spectrum anthelmintic used against
gastrointestinal parasites including: giardia, roundworms, hookworms,
whipworms, the tapeworm genus Taenia (but not effective against Dipylidium
caninum, a common dog tapeworm), pinworms, aelurostrongylus, paragonimiasis,
strongyles, and strongyloides that can be administered to sheep, cattle,
horses, fish, dogs, cats, rabbits, most reptiles, freshwater shrimp tanks as
planaria and hydra treatments, as well as seals. (Wikipedia)
Joe Tippens founded the protocol after he was told a story about a scientist at Merck Animal Health that had been performing cancer research on mice. The research included injecting different types of cancers into different mice body parts. The scientists discovered, through trial and error, a product in their canine product line, fenbendazole, that was batting 1.000 in killing these different cancers in the mice. The scientist was later diagnosed with stage 4 brain cancer and was given a grim prognosis of only three months to live. She decided to try the fenbendazole, and after six weeks, showed a clean scan.
Joe Tippens had been initially diagnosed with small cell lung cancer. The cancer later spread to his neck, right lung, stomach, liver, bladder, pancreas and tail bone. Like the scientist from Merck Animal Hospital, Joe was told he only had three months to live. In 2017, after hearing the story of the scientist who treated her cancer with a canine drug, Joe decided he was going to do the same. However, in addition to taking the fenbendazole, Joe added his own ingredients to the regimen (curcumin, CBD oil, and vitamin E), thus creating the Joe Tippens Cancer Protocol.
Disclaimer: We in no way endorse the Joe Tippens Cancer Protocol as a cure for cancer, and as always, you should consult your physician before starting any new medications or treatment plans.
This article examines the safety and efficacy of fenbendazole when
applied to human health concerns. We will explore the current research,
potential benefits, and risks associated with human consumption of this
traditionally animal-focused medication. By analyzing available data and
expert opinions, we aim to provide a comprehensive overview of
fenbendazole’s status in human medicine and its possible future
applications.
Contents
- Understanding Fenbendazole: From Veterinary Medicine to Human Use
- Potential Mechanisms of Action in Cancer Treatment
- Why cancer patients use Fenbendazole
- Fenbendazole side effects in humans
- Clinical Evidence and Ongoing Research
- Dosage and Administration Guidelines for Off-Label Use
- Regulatory Status and Legal Implications of Human Consumption
- Q&A
- Find Integrative Oncologists in USA, Mexico, Europe or Asia
Understanding Fenbendazole: From Veterinary Medicine to Human Use
Originally developed as an anthelmintic medication for animals, fenbendazole has garnered attention for its potential applications in human health. This benzimidazole compound, traditionally used to combat parasitic worms in livestock and pets, has piqued the interest of researchers and medical professionals due to its alleged anti-cancer properties. While its primary function remains in veterinary medicine, anecdotal evidence and preliminary studies have sparked discussions about its efficacy in treating various human conditions.The transition from veterinary to human use raises important questions about safety, dosage, and regulation. Fenbendazole’s mechanism of action involves disrupting the cellular structure of parasites, but its effects on human cells, particularly cancer cells, are still under investigation. As interest grows, it’s crucial to consider the following aspects:
- Off-label use: The current status of fenbendazole for human consumption
- Potential benefits: Reported effects on cancer cells and other health conditions
- Safety concerns: Possible side effects and interactions with other medications
- Regulatory landscape: Current stance of health authorities on human use
Potential Mechanisms of Action in Cancer Treatment
Fenbendazole, traditionally used as an anthelmintic in veterinary medicine, has garnered attention for its potential anticancer properties in humans. Several mechanisms have been proposed to explain its potential efficacy in cancer treatment. One key pathway involves the disruption of microtubule formation, which is critical for cell division. By binding to tubulin, fenbendazole may inhibit the polymerization of microtubules, leading to cell cycle arrest and apoptosis in cancer cells. Additionally, this compound has been shown to induce oxidative stress, potentially targeting cancer cells that are already under higher oxidative pressure compared to normal cells.
Another intriguing aspect of fenbendazole’s potential anticancer activity
is its ability to modulate various signaling pathways. Research suggests
that it may:
- Inhibit glucose uptake in cancer cells, starving them of essential energy
- Reduce the expression of hypoxia-inducible factor 1-alpha (HIF-1α), a protein involved in tumor angiogenesis
- Activate p53, a crucial tumor suppressor gene
- Downregulate the STAT3 signaling pathway, which is often overactive in cancer cells
Why cancer patients use Fenbendazole
Developing new drugs requires a lot of time, effort, and money, and
generating a promising drug can take years. Fenbendazole is already an
established drug showing promising results for human use with a very low
level of toxicity. It has been shown to stabilize WT p53, provide moderate
microtubule disruption, interfere with cancer cells’ glucose metabolism,
and target cell cycle arrest. These factors have led to a decrease in
cancer cells both in laboratory environments as well as in live subjects
with minimal side effects and toxicity. In addition, Fenbendazole has been
shown to kill cancerous cells and promote regression in cancer patients
with large B-cell lymphoma that had metastasized, as well as other
metastatic malignancies, bladder cancer, renal cell carcinoma, and more.
According to a study available from the European Medicine Agency, doses up to 500 mg per person did not result in serious adverse effects. Moreover, single doses of up to 2,000 mg per person were reported to cause no serious adverse effects over the course of ten days.
* Mild diarrhoea
* Mild stomach discomfort
* Elevated liver enzymes
Therefore, patients should get a blood panel that includes the liver enzymes of AST, ALT, Alkaline Phosphatase, before taking Fenbendazole.
Liver enzymes may be elevated from cancer treatments, alcohol use, certain medications, and cancer itself.
Elevated liver enzymes indicate a liver that is stressed and inflamed, and adding to its burden with Fenbendazole would not be recommended.
Given that acetaminophen is metabolized in the liver, and the effects of fenbendazole on human liver metabolism are not well-documented, using these in combination requires careful monitoring.
If you decide to continue using this combination, closely monitor for potential side effects, such as gastrointestinal issues from metoclopramide or liver problems from acetaminophen.
In conclusion, while there is no specific evidence of harmful interactions between metoclopramide, acetaminophen, and fenbendazole, the experimental nature of fenbendazole’s use in humans necessitates caution and vigilant monitoring of the patient’s health. Be sure to regularly check liver enzyme levels to manage any emerging issues effectively.
The fenbendazole protocol was designed to keep the liver in optimal health, therefore the schedule of weekly 3 days on, 4 days off was previously suggested. However, more and more people are using fenbendazole on a daily basis without problems.
We would still recommend taking at least 1 day off per week to avoid over stressing the liver if the medication is to be used for prolonged periods of time (like months or years).
To keep the liver health optimal, we advise you to take 250 mg capsules of Milk Thistle or 150 mg of Silymarin daily as a supportive supplement for keeping it in great shape.
Panacur-C for Cancer
* Please take note that the Panacur C on Amazon is available in
three sizes (1 gram, 2 grams and 4 grams) of single dose packets.
Fenbendazole side effects in humans
Although safety data exists for various animals, the safety and tolerability of Fenbendazole in humans for sustained periods of time have not been thoroughly studied yet. Nevertheless, many patients have decided not to wait for the lengthy bureaucratic process of scientific data to be published; they are following the protocol at their own risk. Most of these people report taking Fenbendazole without any side effects.According to a study available from the European Medicine Agency, doses up to 500 mg per person did not result in serious adverse effects. Moreover, single doses of up to 2,000 mg per person were reported to cause no serious adverse effects over the course of ten days.
According to the product description on Amazon, fenbendazole
is "Safe for all Dogs 6 weeks and older, including pregnant Dogs".
Based on toxicology studies, benzimidazoles such as
Fenbendazole, Mebendazole or Albendazole seem to be safe drugs.
However,
a drug without any side-effects does not exist. Scientific data
reports do not reveal significant adverse reactions from taking
fenbendazole. Despite the fact, there are anecdotal reports of
potential toxicity: Up to 5 % of people can experience stomach
discomfort or diarrhea when taking large quantities of fenbendazole
with no breaks.
People with severe liver or kidney failure have lower medication
excretion rates, therefore, fenbendazole can accumulate and cause
unexpected side-effects. Doses should be divided accordingly in this
situation.
When used in large quantities for a long period of
time without breaks, fenbendazole can cause an asymptomatic liver
enzyme increase due to the fact of the substance being mainly
metabolized in the liver. This is reversible with the help of a couple
week pause from the medication.
The protocol was designed
to keep the liver in optimal health, therefore the schedule of weekly
3 days on, 4 days off was previously suggested. However, more and more
people are using fenbendazole on a daily basis without problems.
We
would still recommend taking at least 1 day off per week to avoid over stressing the liver if the medication is to be used for prolonged
periods of time (like months or years).
To keep the liver
health optimal, we advise you to take 250 mg capsules of Milk Thistle
or 150 mg of Silymarin daily as a supportive supplement for keeping it
in great shape.
References:
- Lacey, E. (1979). Mode of action of benzimidazoles
- Blanchard, P., & Villard, J. (2008). Toxicological profile of benzimidazole derivatives: Fenbendazole and mebendazole
- Morris, G. M., & Keppler, D. (2019). The role of anthelmintic drugs in the treatment of cancer
- Lacey, E., & Morrell, A. (2013). Benzimidazoles in cancer therapy: repurposing anthelmintics for oncology
- Drug-Induced Liver Injury in a Patient with Nonsmall Cell Lung Cancer after the Self-Administration of Fenbendazole Based on Social Media Information (2021)
Side Effects of Fenbendazole Reported:
Most people have NO side effects. The main complaints of the small group of people who did experience side effects were:* Mild diarrhoea
* Mild stomach discomfort
* Elevated liver enzymes
Who May Be At Greater Risk of Side Effects?:
- People who use Fenbendazole in high doses.
- Use of medications and supplements that use the same pathways for metabolism as Fenbendazole
- Those taking treatments/medications that increase liver enzymes
- One research suggests that those who are weak from chemotherapy may experience more side effects than those not receiving conventional cancer treatment, particularly in elevated liver enzymes.
Does fenbendazole cause liver damage?
Although fenbendazole is generally well tolerated, there have been reports of elevated liver enzymes from the use of Fenbendazole, as well as the similar human medications mebendazole and albendazole.Therefore, patients should get a blood panel that includes the liver enzymes of AST, ALT, Alkaline Phosphatase, before taking Fenbendazole.
Liver enzymes may be elevated from cancer treatments, alcohol use, certain medications, and cancer itself.
Elevated liver enzymes indicate a liver that is stressed and inflamed, and adding to its burden with Fenbendazole would not be recommended.
There is a report documenting the effect of fenbendazole on liver function as measured by the enzymes aspartate transaminase (AST) and alanine aminotransferase (ALT). A search using Google of “fenbendazole and cancer” returns this case report as the first result: Teppei Yamaguchi, Junichi Shimizu, Yuko Oya, Yoshitsugu Horio, Toyoaki Hida. Drug-Induced Liver Injury in a Patient with Nonsmall Cell Lung Cancer after the Self-Administration of Fenbendazole Based on Social Media Information. Case Rep Oncol 1 September 2021; 14 (2): 886–891. https://doi.org/10.1159/000516276
Elevated liver enzymes may actually be a good sign for a cancer patient taking fenbendazole. Those liver enzyme (AST, ALT) values may spike for one or two months as the liver is stressed by the influx of dead cancer cells as it filters and processes the cellular debris from those dead cancer cells. AST and ALT increasing is a sign of hepatic stress (work), not necessarily disease, in the context of fenbendazole use. These liver enzymes usually normalize after the cancer is eradicated by fenbendazole.
FYI, liver enzymes will also fluctuate with other non-cancerous sicknesses/recoveries as dead cellular debris enters the bloodstream and is processed by the liver for removal. This is part of a normal physiological process. Temporary liver enzyme fluctuation should be expected to occur as a matter of course when using fenbendazole as fenbendazole kills the cancer cells.
If a patient has elevated liver enzymes, liver damage, liver metastasis, or liver diseases, it is important to work with a health professional who is familiar with the use of Fenbendazole and can advise whether it can be used and/or monitor lab values. A typical dose of 250mg of Fenbendazole usually does not cause side effects, but vigilance is key due to the lack of extensive studies on its effects in humans.
Generally, for those with normal lab values, after one month of Fenbendazole treatment, patients should get a comprehensive metabolic panel (CMP). This standard blood test will check the liver and kidney function to assure that the patient is tolerating Fenbendazole without any concerning impacts on the vital organs.
Elevated liver enzymes may actually be a good sign for a cancer patient taking fenbendazole. Those liver enzyme (AST, ALT) values may spike for one or two months as the liver is stressed by the influx of dead cancer cells as it filters and processes the cellular debris from those dead cancer cells. AST and ALT increasing is a sign of hepatic stress (work), not necessarily disease, in the context of fenbendazole use. These liver enzymes usually normalize after the cancer is eradicated by fenbendazole.
FYI, liver enzymes will also fluctuate with other non-cancerous sicknesses/recoveries as dead cellular debris enters the bloodstream and is processed by the liver for removal. This is part of a normal physiological process. Temporary liver enzyme fluctuation should be expected to occur as a matter of course when using fenbendazole as fenbendazole kills the cancer cells.
If a patient has elevated liver enzymes, liver damage, liver metastasis, or liver diseases, it is important to work with a health professional who is familiar with the use of Fenbendazole and can advise whether it can be used and/or monitor lab values. A typical dose of 250mg of Fenbendazole usually does not cause side effects, but vigilance is key due to the lack of extensive studies on its effects in humans.
Generally, for those with normal lab values, after one month of Fenbendazole treatment, patients should get a comprehensive metabolic panel (CMP). This standard blood test will check the liver and kidney function to assure that the patient is tolerating Fenbendazole without any concerning impacts on the vital organs.
Additionally, you might consider incorporating supplements like milk thistle to help maintain normal liver enzyme levels.
If you decide to continue using this combination, closely monitor for potential side effects, such as gastrointestinal issues from metoclopramide or liver problems from acetaminophen.
In conclusion, while there is no specific evidence of harmful interactions between metoclopramide, acetaminophen, and fenbendazole, the experimental nature of fenbendazole’s use in humans necessitates caution and vigilant monitoring of the patient’s health. Be sure to regularly check liver enzyme levels to manage any emerging issues effectively.
We would still recommend taking at least 1 day off per week to avoid over stressing the liver if the medication is to be used for prolonged periods of time (like months or years).
To keep the liver health optimal, we advise you to take 250 mg capsules of Milk Thistle or 150 mg of Silymarin daily as a supportive supplement for keeping it in great shape.
Clinical Evidence and Ongoing Research
Researchers have been exploring the potential applications of fenbendazole in human health, with several studies focusing on its anticancer properties. In vitro experiments have demonstrated the drug’s ability to inhibit cancer cell growth and induce apoptosis in various types of tumors. However, it’s important to note that these findings are preliminary and require further investigation through rigorous clinical trials. Currently, there are ongoing studies evaluating the safety and efficacy of fenbendazole in human subjects, with a particular emphasis on its potential as an adjunct therapy for cancer treatment.While the veterinary use of fenbendazole is well-established, its application in human medicine remains experimental. Researchers are investigating its potential benefits in treating parasitic infections in immunocompromised individuals and exploring its possible synergistic effects when combined with traditional cancer therapies. Some key areas of focus include:
- Assessing the optimal dosage and administration schedule for human use
- Evaluating potential side effects and drug interactions
- Investigating its effectiveness against drug-resistant parasites
- Exploring its impact on the human gut microbiome
As of now, there are limited clinical trials exploring the use of
fenbendazole in humans. Research is primarily in preclinical stages.
However, the Fenbendazole Cancer Protocol gained rapid interest over
the past years following some fenbendazole advanced cancer success stories.
Fenbendazole dosage for humans
Protocol (the initial version) – complimentary treatment of cancer
- Fenbendazole 222 mg. Consume one capsule 3 days weekly, once time daily after eating a fatty dinner. * Then do not take any for 4 days. Replicate this cycle each week.
- Vitamin E 800 U/I. Consume one capsule or another form once daily after eating without any waiting.
- Bio-Available Curcumin 600 mg. Consume one capsule twice daily after eating breakfast and lunch without waiting.
- CBD oil 25 milligrams. Consume one to two drops (total ~25 milligram) under your tongue daily before bedtime.
Protocol (the altered, stronger version) – complimentary cancer treatment
- Fenbendazole 222 milligrams. Consume one capsule daily after eating a fatty dinner without waiting. **
- Vitamin E 800 U/I. Consume one capsule or some other version daily without waiting.
- Bio-Available Curcumin 600 mg. Consume one capsule twice daily after eating breakfast and lunch without waiting.
- CBD oil 25 milligrams. Consume one to two drops (total ~25 milligrams) under your tongue daily before bedtime.
Avoiding cancer relapse – prophylactic procedure
- Fenbendazole 222 milligrams. Consume one capsule 3x weekly, once daily after eating a fatty dinner. Then don’t take it for 4 days. Replicate this cycle each week.
- Vitamin E 800 U/I. Consume one capsule or some other version daily after eating without stopping.
- Bio-Available Curcumin 600 milligrams. Consume one capsule twice daily after you eat breakfast and lunch without stopping.
- CBD oil 25 milligrams. Consume one to two drops (a total of~25 milligrams) under your tongue daily prior to bedtime.
- Tumour marker steady checks every few months, routine annual cancer imaging tests. If there’s not any cancer relapse after five years, reduce the test frequency.
Avoiding cancer for somebody who was always free of cancer – prophylactic procedure
- Fenbendazole 222 milligrams. Consume one capsule 3x weekly, once daily after eating a fatty dinner. Then don’t take it for 4 days. Duplicate this for ten weeks. Halt for ten weeks. Then replicate the cycle once more.
- Vitamin E 800 U/I. Consume one capsule or some other kind daily after eating without stopping.
- Bio-Available Curcumin 600 milligrams. Consume one capsule twice daily after eating breakfast and lunch without stopping.
- CBD oil 25 milligrams. Consume one to two drops (a total of ~25 milligrams) under your tongue daily prior to bedtime.
Regulatory Status and Legal Implications of Human Consumption
The use of fenbendazole in humans exists in a regulatory gray area. While approved for veterinary applications, it lacks formal endorsement from major health authorities for human consumption. The FDA has not granted approval for its use in people, citing insufficient clinical data and potential risks. Despite this, some individuals choose to self-administer the drug, often sourcing it from animal supply stores or online marketplaces.Legal implications of human fenbendazole use vary by jurisdiction. In some countries, possession and consumption may be considered off-label drug use, potentially leading to legal consequences. Healthcare providers face ethical dilemmas when patients request guidance on its use, as recommending unapproved treatments could result in professional repercussions. Consumers should be aware of potential legal risks, including:
- Importation restrictions
- Liability issues in case of adverse effects
- Possible regulatory action against suppliers
Fenbendazole for Humans Q&A
Q: Is fenbendazole approved for human use?A: No, fenbendazole is not currently approved by regulatory agencies for human use.
Q: Are there any human studies on fenbendazole?
A: There are limited human studies on fenbendazole. Most research has been conducted in laboratory settings or animal models. However, the Fenbendazole Cancer Protocol gained rapid interest over the past years following some fenbendazole advanced cancer success stories.
Q: What are the potential risks of using fenbendazole in humans?
A: Potential risks include unknown side effects, drug interactions, and the possibility of ineffective treatment for the intended condition.
Q: Can fenbendazole be legally obtained for human consumption?
A: Fenbendazole is not legally marketed for human use. It is only available as a veterinary medication in most countries.
Q: What do medical professionals say about using fenbendazole in humans?
A: Most medical professionals advise against using fenbendazole for human conditions due to lack of clinical evidence and potential safety concerns.
Q: Are there any ongoing clinical trials for fenbendazole in humans?
A: As of now, there are limited clinical trials exploring the use of fenbendazole in humans. Research is primarily in preclinical stages. However, the Fenbendazole Cancer Protocol gained rapid interest over the past years following some fenbendazole advanced cancer success stories.
Sources and References:
- FENBENDAZOLE and CANCER - at least 12 Anti-Cancer Mechanisms of Action - Dr William Makis
- Targeting the Mitochondrial-Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol
- https://healnavigator.com/fenbendazole-cancer-success-stories-and-testimonials
- https://www.fenbendazole.org/category/case-reports/
- https://fenben.pro/fenbendazole-for-humans-safety-and-efficacy-examined/
Find Integrative Oncologists in USA, Mexico, Europe or Asia
While the potential anti-cancer properties of fenbendazole are intriguing, it’s crucial to approach with caution.Consulting with an integrative healthcare expert is key to crafting a Fenbendazole protocol tailored to your unique health requirements.
To find integrative oncologists, check out "find integrative oncologists".
Notes and Disclaimers:
- Please do not consider this guide as personal medical advice, but as a recommendation for use by professional providers. Consult with your doctor and discuss with her/him.
- Our aim here isn't to replace your doctors' advice. It is intended as a sharing of knowledge and information. Do take note that most treatments are not 100% protective or curative against cancer. It's a continuous struggle between the immune system and the cancer cells. Cancer treatments are meant to assist the immune system in this battle.
- Cancer treatment should be part of a multi-modal approach in order to provide the best possible outcome. Diet and lifestyle changes are meant to run alongside conventional treatment. They are complementary, not alternative.
Fenbendazole Protocol (Joe Tippens)
1. Fenbendazole: One Packet a Day
Fenbendazole 222 mg (1 gm of Panacur™ or Safeguard™) per day every
day. It can be mixed with food such as yogurt or simply taken by
itself.
* Please take note that the Panacur C on Amazon is available in
three sizes (1 gram, 2 grams and 4 grams) of single dose packets.
2. Onco Adjunct Pathway 1: CBD, Frankincense and Nano C60 Carrier
Pathway 1: CBD Tincture: CBD has always been part of his protocol, but
the new product will incorporate some important changes.
3. Onco Adjunct Pathway 2: Curcumin and Quercetin
Curcumin has always been part of Joe Tippens protocol, but even the
product that he has previously recommended, Theracurmin HP, simply
does not tackle the problem of absorption into the blood stream.
4. Onco Adjunct Pathway 3: Berberine
Read More: Joe Tippens Protocol Fenbendazole
New & Improved Joe Tippens Protocol
- Fenbendazole (300 mg, 6 days a week) or in the case of severe turbo cancers up to 1 gram.
- Ivermectin (24 mg, 7 days a week) or in the case of severe turbo cancers up to 1mg/kg/day.
- Removing sugar from one’s diet is crucial during this protocol. (BMJ 2023)
- Eating a nutritious fresh whole-food diet with fruits and vegetables, avoid ultra processed foods (BMJ 2024) and a healthy lifestyle with less stress.
- Bio-Available Curcumin (600mg per day, 2 pills per day 7 days a week).
- Vitamin D (62.5 mcg [2500 IU] seven days a week) and Omega-3 (1 g per day). (Nutrients 2024, Frontiers in Aging 2022)
- Tocotrienol and Tocopherol forms (all 8) of Vitamin E (400-800mg per day, 7 days a week). A product called Gamma E by Life Extension.
Note:
It looks like there are some heated discussions about fenbendazole
suppliers. The debates among suppliers might be due to the increasing
demand and varying quality of the product. If you’re interested in the
details of these discussions, you might want to check out: https://x.com/MakisMD/status/1837440610191524330.
Read More: This article is part of the Winning the War on Cancer series.
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