Fenbendazole and Ivermectin for Prostate Cancer? A Case Series of 38 Patients (October 2025 Edition)

AbstractBackground: Advanced prostate cancer, including metastatic hormone-sensitive and castration-resistant forms, often develops resistance to standard androgen deprivation therapies, highlighting the need for novel adjunctive strategies. Repurposed antiparasitic agents such as fenbendazole and ivermectin have garnered attention for their potential anticancer properties, supported by preclinical studies demonstrating microtubule disruption, apoptosis induction, and metastasis inhibition.
Methods: This compilation reviews 37 case reports from 2024–2025, sourced from peer-reviewed publications, social media platforms, and personal testimonials. Protocols typically involved fenbendazole (222–2000 mg/day) and ivermectin (1–2 mg/kg/day), often combined with adjuncts like ketogenic diets, high-dose intravenous vitamin C, CBD oil, melatonin, berberine, curcumin, and artemisinin. Dosing was tailored to disease stage, with monitoring via prostate-specific antigen (PSA) levels, imaging (PET/CT, MRI, bone scans), and clinical symptoms. Cases included early-stage, recurrent, and metastatic disease, with some integrating conventional treatments.
Results: Remarkable responses were observed, including rapid PSA reductions (e.g., from 2093 to 39 in 2 months, 800 to 18 in 3 months) and tumor regressions leading to no evidence of disease in multiple instances. Metastatic cases showed resolution of bone and lymph node lesions, with sustained remissions up to 26 months. Early-stage patients achieved PSA normalization and avoided invasive interventions. No severe toxicities were reported, though transient fatigue or initial PSA spikes occurred in some rapid responders.
Conclusions: These case reports suggest fenbendazole and ivermectin as promising, low-cost adjuncts for prostate cancer management, potentially enhancing standard therapies with minimal side effects. However, evidence is anecdotal and lacks randomized controlled trials. Further rigorous clinical studies are essential to establish efficacy, optimal dosing, and safety under supervised conditions.
Keywords: Fenbendazole, Ivermectin, Prostate Cancer, Antiparasitic, Case report, Repurposed drug, Benzimidazoles, Advanced cancer, Cancer regression

Introduction

Prostate cancer remains a significant health challenge globally, particularly in its advanced stages where treatment resistance and disease progression limit patient outcomes. Despite advances in targeted therapies, hormone therapies, and immunotherapies, many patients with metastatic or recurrent prostate cancer face a need for new, more effective treatment options.

Testosterone suppressant drugs such as leuprolide injections and apalutamide pills are used until the cancer no longer responds to hormone suppression, a state referred to as loss of hormone sensitivity. One of the most significant side effects of leuprolide injections is bone demineralization, which can occur at a high rate of up to 11% per year.

Enzalutamide and abiraterone are commonly used to treat various subtypes of prostate cancer, with treatment and monitoring tailored to each specific subtype. The primary subtypes treated with these agents are metastatic hormone-sensitive prostate cancer (mHSPC) and metastatic castration-resistant prostate cancer (mCRPC). Androgen Receptor (AR) splice variant (AR-V7) is a specialized test for circulating tumor cells (CTCs) to detect the AR-V7 mutation, a known mechanism of resistance to enzalutamide.

However, treatment options remain limited for patients with other subtypes of stage 4 prostate cancer, particularly those with resistant or aggressive disease not amenable to current targeted therapies.

Repurposing existing drugs, such as antiparasitics fenbendazole, ivermectin, and mebendazole, offers a promising and cost-effective strategy in oncology. These agents have demonstrated multiple anticancer mechanisms in preclinical models, including disruption of cancer cell division, induction of apoptosis, and modulation of the tumor microenvironment. Early clinical observations and accumulating case reports suggest these drugs might improve tumor control and patient quality of life when used as adjuncts to standard therapies.


This compilation presents a collection of recent case reports and peer-reviewed studies highlighting the potential of fenbendazole, ivermectin, and mebendazole in managing prostate cancer. By reviewing these evidences alongside mechanistic insights, the article aims to provide a comprehensive overview of these repurposed drugs’ emerging roles in prostate cancer treatment.

Note: The case reports below offer detailed, practical information on fenbendazole, ivermectin, and cancer that clinicians can find both useful and actionable.

Fenbendazole and Ivermectin Prostate Cancer Case Series Compilation and Presentations

We have compiled a list of fenbendazole and/or ivermectin and prostate cancer case reports below.

This compilation features several case reports from multiple sources involving the use of ivermectin and/or fenbendazole for prostate cancer.

Tables 1 - 3 below provide a summary of the information for the cases presented in this paper, including therapies used, dosage, outcome, and prior treatments. The cases are organised into tables grouped by primary drug emphasis (FBZ-focused (Table 1), IVM-focused (Table 2), or combinations (Table 3)). Each table includes key details: case number, patient demographics, cancer details, protocol, outcomes, and notes. Due to volume, only high-detail cases are prioritized. For details of each case report, refer to the case # and see the full case report below the tables.

Table 1: Fenbendazole (FBZ)-Focused Cases



Table 2: Ivermectin (IVM)-Focused Cases


Table 3: Combination (IVM + FBZ, Often with Adjuncts) Cases






Case 38 - 2025: 69 year old Canadian man with Stage 4 Prostate Cancer

Dr William Makis shared on X.com in October 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 69 year old Canadian man with Stage 4 Prostate Cancer has major improvement after 4 months! STORY: 69 year old Canadian man with Stage 4 Prostate Cancer On April 7, 2025 he started: Ivermectin 1.5mg/kg/day Fenbendazole 1500mg/day Results after 4 months: “liver metastases have improved significantly from previous exam” 
“I am feeling a great improvement in energy, sleeping and overall well-being”


Case 37 - 2025: 68 year old California paraplegic man with Stage 4 Prostate Cancer

Dr William Makis shared on X.com in October 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 68 year old California man with Stage 4 Prostate Cancer was abandoned by Oncology as a paraplegic, after the cancer destroyed his vertebrae. He now walks.

Do you folks have any idea how many cancer patients have come to me after they were ABANDONED by their highly paid, licensed Oncologist? No one ever talks about that... 68 year old California man with Stage 4 Prostate Cancer was abandoned by Oncology as a paraplegic, after the cancer destroyed his vertebrae "I believe the hospital has written me off. The last time I saw the Oncologist in May, she was thinking I was "full of cancer" and hospice was probably next. So those were her plans, and she's never contacted me again". So he reached out to me. After we talked, on April 22, 2025 he started: Ivermectin 1mg/kg/day Fenbendazole 2000mg/day Results after 5 months: He went from being a paraplegic to walking PSA dropped 217 to 0.19 His metastatic bone pain has disappeared. "I'd always seen her in a wheelchair, and I walked into her office with a walker. I am currently back to walking.


Case 36 - 2025: 66 year old Australian man with Stage 4 Prostate Cancer

Dr William Makis shared on X.com in October 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 66 year old Australian man with 5 small children and Stage 4 Prostate Cancer sees "profound" improvement according to his urologist after 5 months Prostate Cancer patients are having incredible success with Ivermectin and Fenbendazole combination: 66 year old Australian man with 5 small children and Stage 4 Prostate Cancer His PSA was 736 In late March 2025 he started: Ivermectin 1mg/kg/day Fenbendazole 1776mg/day He had 2 Goserelin injections (hormone suppression) His PSA now is 15.1 and he is now a candidate for TURP and PAE Procedures He is working on getting an MRI. What have his doctors said about all this? That his treatment response has been "profound".


Case 35 - 2025: 60 year old North Carolina man with Stage 4 Prostate Cancer to bones, Gleason 9

Dr William Makis shared on X.com in October 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 60 year old North Carolina man with Stage 4 Prostate Cancer to bones, Gleason 9, has amazing response after 6 months! I have wrapped up my Florida tour which means back to posting Ivermectin Cancer success stories! STORY: 60 year old North Carolina man with Stage 4 Prostate Cancer to bones, Gleason 9 In early November 2024 he started:
  • Ivermectin 108mg/day 
  • Fenbendazole 1332mg/day 
  • His doctor put him on hormone therapy
Results after 6 months:
  • PSA 196 to 0.16
  • 50% reduction in metastatic lymph nodes

Case 34: Retired male civil fraud attorney with metastasized Stage 4 prostate cancer that had spread into his hip bones, lumbar spine, and inguinal lymph nodes (June 2025 update)

Mr. Jeffrey Kramer of Shelby, Ohio, retired as a plaintiff’s civil fraud attorney in 2024 after he was diagnosed with metastasized Stage 4 prostate cancer that had spread into his hip bones, lumbar spine, and inguinal lymph nodes. His Cleveland Clinic oncologist had advised him that the cancer was incurable but probably manageable for a (short) time using testosterone suppressant drugs (leuprolide injections and apalutamide pills) until his body ceased being “hormone sensitive,” at which point he would decline from there.

The side effects of that drug combo would be substantial—and potentially mortal. Most significant was that the leuprolide injection(s) would assuredly demineralize his bones at a high rate (up to 11% per year), leading to hip fracture(s) and loss of mobility.

This was Mr. Kramer’s second bout with serious cancer, as in 2010, he had undergone surgery, then three months of combined chemotherapy and radiation therapy for tonsil cancer that had incapacitated him for a year before he was able to resume his law practice.

Last fall, Mr. Kramer received information about a new cancer protocol that would change his life.

A new peer-reviewed cancer protocol authored by a team of sixteen cancer doctors and medical researchers from the US and several other nations was published in the September 2024 Journal of Orthomolecular Medicine, titled “Targeting the Mitochondrial-Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol.” Its authors were prominent in oncology, and the published protocol was heavily footnoted to 204 medical studies documenting in vivo and in vitro safe and successful use of each and every element of the protocol. The authors of many of the referenced studies are at the top of their profession, i.e., well-known, highly published doctors and medical research professionals.

After carefully reading that report in the Journal of Orthomolecular Medicine, Mr. Kramer contacted three of the U.S./Canadian doctors who were co-authors of the protocol. Because the protocol had not yet been approved for clinical trials and therefore was not FDA approved, they explained that they could not provide assistance without risking discipline, including potential loss of license to practice medicine, by their state/province medical boards. In response to a question about when a clinical trial for this protocol would be approved, their answers were consistent: it typically would take ten to twenty years to get a clinical trial approved, especially where no Big Pharma company would have a profit interest to lobby for a clinical trial of a protocol involving repurposed/off-patent drugs.

Pierrick Martinez, of the Association Cancer et Métabolisme in Nimes, France, a medical researcher and lead author of the protocol, was then contacted by Mr. Kramer. He agreed to provide “long-distance assistance” and supervised administering the entire 15-week protocol, including corresponding with the nurse practitioner who administered the megadose vitamin C intravenous infusions that were one part of the protocol and answering numerous questions along the way. A licensed nutritionist at a Cleveland Clinic oncology center in Mansfield, Ohio, was consulted for advice on how to implement the therapeutic ketogenic diet that was another part of the protocol.

Mr. Kramer completed the 15-week hybrid orthomolecular protocol on June 5, 2025, with no side effects whatsoever. Two weeks later, he received an FDG-PET scan at AVITA Hospital in Galion, Ohio. The radiologist’s report that followed showed no evidence of any active cancer anywhere in his body—not in his head, hip bones, lumbar spine, chest, or lymph glands; nothing—no active cancer anywhere. In fact, it took the radiologist almost a full week to issue that report, for the PET scan was ordered to evaluate metastatic prostate cancer, deemed to be an incurable condition.

Perhaps most amazing, the total cost of the medicines, dietary vitamin/mineral supplements, and vitamin C infusions of this protocol was less than $20,000—a fraction of the cost of even one month’s expense for the cancer “management” medications that a Cleveland Clinic oncologist had previously prescribed as “the standard of care” for cancer treatment.

A mere $20,000 to stave off debilitating cancer and certain death was more than a bargain; it was a godsend to Mr. Kramer.

Source: Keto, Ivermectin, & Fenbendazole for Stage 4 Prostate Cancer: New Cancer Treatment Protocol Gains Momentum (American Greatness)


Case 33 - 2025: 58 year old man from WA, USA, with Stage 4 Prostate Cancer to bones, Gleason 9

Dr William Makis shared on X.com in September 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 58 year old man from WA, USA, with Stage 4 Prostate Cancer to bones, Gleason 9, reports after 3 months From the world's largest Ivermectin Cancer Clientele: STORY: 58 year old man from WA, USA, with Stage 4 Prostate Cancer to bones, Gleason 9 In early March 2025, he started:
  • Ivermectin 1.5mg/kg/day
  • Fenbendazole 2000mg/day 
It’s a little higher of a Fenbendazole dose than most cancer patients start with but this was a Stage 4 Gleason 9 and a young man who can handle these doses with no issues and no side effects. 

Results after 3 months: 
  • PSA 23.2 to below 1
  • Metastatic lymph nodes disappeared
  • Bone metastases healed over (sclerotic) 
From the patient: "Thank you so much. The Lord lead me to your posted protocol early this year. Even though I had many times of fear and doubt, I believe God used your protocol to heal!".


Case 32 - 2025: 76 year old Idaho man cures his Early Stage Prostate Cancer

Dr William Makis shared on X.com in September 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 76 year old Idaho man cures his Early Stage Prostate Cancer in 6 months. No conventional cancer treatment! No hormones. No chemo. No radiation. Nothing. This story cannot exist according to conventional medicine. 76 year old Idaho man diagnosed with early stage Prostate Cancer.

Here is the timeline:
  • June 2024 PSA 25 
  • July 2024 MRI: Prostate Cancer 1.1cm PIRADS 4 
  • Aug 2024 - started Ivermectin 20mg 3/week 
  • Nov 2024 PSA 22.5 
  • Dec 2024 - started Ivermectin 40mg daily, Fenbendazole 444mg 6/7 days 
  • Feb 2025 - PSA 32 and came to me. 
Excellent choice. He started Ivermectin 60mg increasing to 120mg, Fenbendazole 888mg 6/7 days

Aug 2025 MRI - Cancer free, 1.1cm prostate cancer resolved, PSA 11 and dropping.


Case 31 - 2025: 54 year old Physician from Georgia was diagnosed with Prostate Cancer Recurrence

Dr William Makis shared on X.com in August 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 54 year old Physician from Georgia was diagnosed with Prostate Cancer Recurrence, reports after 4 months that he is in remission! Even doctors are quietly coming to me for help! 54 year old Physician from Georgia was diagnosed with Prostate Cancer Recurrence.

In late January 2025 we started:
  • Ivermectin 1.5mg/kg/day
  • Fenbendazole 888mg/day
  • CBD Oil 100mg/day
  • Oncologist: ADT early January 2025 Rad Onc: SBRT Radiotherapy in late February 2025 for pelvic lymph node metastasis 
Results after 4 months: PSA undetectable < 0.01 

From the patient (who is an MD): "I've been on your protocol for four months and have had a miraculous result".
 

Case 30 - 2025: 64 year old Nevada man with Stage 4 Prostate Cancer metastatic to lungs and spine

Dr William Makis shared on X.com in August 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 64 year old Nevada man with Stage 4 Prostate Cancer metastatic to lungs and spine - PSA drops 79 to 0.32 after 4 months. 

We have so many prostate cancer testimonials! STORY: 64 year old Nevada man with Stage 4 Prostate Cancer metastatic to lungs and spine Early February 2025 we started:
  • Ivermectin 1.5mg/kg/day
  • Fenbendazole 1500mg/day
  • CBD Oil 100mg/day 
Results after 4 months: PSA 79 to 0.32.


Case 29 - 2025: 63 year old New York man with Stage 4 Prostate Cancer

Dr William Makis shared on X.com in August 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 63 year old New York man with Stage 4 Prostate Cancer reports after 4 months The testimonials will continue... 63 year old New York man with Stage 4 Prostate Cancer.

In early February 2025 we started: 
  • Ivermectin 1.5mg/kg/day 
  • Fenbendazole 1500mg/day 
  • Oncologist put patient on Orgovyx and Nubeqa
RESULTS after 4 months: PSA 64.9 to less than 0.1.

From the patient: "Our May appointment with XXX went well, Oncologist very pleased with latest blood work results. So much so, potential chemo conversations have been postponed to potentially end of Summer"


Case 28: 74-yr-old man with Metastatic Prostate Cancer, Liver and Lymph Node Metastases

Published on Fenbendazole Can Cure Cancer (July 2025):

This is the account of a 74-year-old man, 6-ft, 169 pounds, who faced a dire prognosis of terminal, metastatic prostate cancer but charted an unconventional path to remarkable recovery, primarily through the determined use of fenbendazole. His journey told by his daughter TW, underscores a powerful testament to individual agency in the face of seemingly insurmountable odds.

The Onset of Crisis: A Timeline of Decline

TW’s dad’s battle with prostate cancer began in 2019, a diagnosis initially met with surgical removal of the prostate and an “all clear.” However, the reprieve was short-lived. The timeline of his relapse and subsequent crisis unfolded rapidly in 2024:
  • Early August 2024: Routine blood work delivered alarming news – a PSA of 14.
  • Mid-August 2024: The situation escalated dramatically. His PSA soared to 51, and asubsequent PET scan revealed the devastating spread: metastases to his liver and lymph nodes.
  • Late August 2024: Biopsies of both the liver and lymph nodes unequivocally confirmed the recurrence of prostate cancer.
The diagnosis from his oncologist at a leading cancer center (MDA) was grim: Stage 4 metastatic prostate cancer. He was informed that his liver was “completely consumed” and that medical intervention could offer nothing beyond palliative care. The proposed conventional treatment plan comprised hormone therapy (Lupron) followed by chemotherapy, with a stark prognosis of 12-18 months of life remaining.

A Divergent Path: Embracing Fenbendazole

Faced with this bleak outlook, TW’s dad’s made a pivotal decision. In September 2024, he received the initial Lupron shot as prescribed. However, during this consultation, he inquired about the fenbendazole protocol. His MDA oncologist unequivocally stated that if he chose to pursue fenbendazole, he could no longer be seen as a patient. Despite outwardly agreeing to forgo it, TW’s dad’s, resolute in his conviction, returned home and immediately initiated the fenbendazole protocol, choosing not to inform his oncologist.

His self-directed fenbendazole regimen commenced in late August 2024. He began with 222mg of fenbendazole (from Panacur C powder, meticulously weighed) once daily for seven days, quickly increasing to 222mg twice daily (total 444mg fenbendazole per day), taken after breakfast and dinner with peanut butter to aid absorption.

While fenbendazole was the central therapeutic agent, he adopted a comprehensive adjunctive strategy: a ketogenic diet (resulting in a 30-pound weight loss in three months), daily ivermectin (an eraser-sized amount of horse paste), Vitamin D, Serrapeptase, Soursop tea, TUDCA, Lion’s Mane, Onco Pathways 1-4 from UltraBotanica, high-dose intravenous Vitamin C (50-75 grams, three times a week), and monthly three-day fasts (water and bone broth only). Lupron remained the only conventional medical treatment he had ever received.

Immediate Impact and Astounding Turnaround

The effects of fenbendazole were felt almost immediately. Any existing pain and discomfort abated rapidly upon starting the fenbendazole, a profound and immediate improvement in his quality of life. Despite the grave diagnosis, TW’s dad’s reported feeling remarkably well throughout this period, never experiencing debilitating symptoms often associated with advanced cancer.

The true measure of fenbendazole’s efficacy became undeniably clear within three months.
  • Early November 2024: A follow-up appointment at MDA, initially intended to plan for chemotherapy, delivered astonishing news. A PET scan revealed a 50% reduction in all tumors. His oncologist was, by report, “shocked.”
  • Bloodwork corroborated this stunning reversal: his PSA, which had peaked at 51 in mid-August, had plummeted to just 2 by early November 2024.
  • The chemotherapy scheduled for that very day was promptly cancelled in light of these profoundly positive results.


Sustained Progress and Vigilant Management

TW’s dad’s continues his fenbendazole regimen (222mg twice daily, seven days a week) and the supportive protocols. He proactively monitors his liver enzymes (AST/ALT) through independent lab work, as these showed elevation on two occasions initially after starting fenbendazole. There were no adverse side effects attributed to fenbendazole. TW’s dad’s has not, and will not, disclose his fenbendazole use to his MDA oncologist.

His daughter, T.W., reported a further update from a follow-up visit at MDA on January 7, 2025:

His cancer showed an additional 50% decrease from the November scan. This marked a total 75% reduction in all tumors within just five months (August 2024 to January 2025) of commencing the fenbendazole-centric protocol. As of May 2025 there is no evidence of disease as confirmed by PET/CT scans.

TW’s dad’s speculates his cancer may have been linked to a diet high in sugar, processed foods, and carbohydrates, and potentially to COVID-19 vaccinations (two shots and one booster).

When sharing her Dad’s experience, TW said that reactions range from surprise and intrigue, with many requesting his protocol for loved ones, to indignation that such a potentially effective and accessible option is not offered by mainstream oncology.

“My Dad is doing amazing! He is still following the Joe Tippin's protocol and also uses Ivermectin and does high dose 100g Vit C IV's 3 days a week. His liver enzymes have been wonderful with no issues at all. He's stronger and more active now than he's ever been. He still eats all organic, no antibiotic or hormone foods and follows Keto; he even goes to the gym 4 days a week without question. He has zero size effects from any of the cancer or therapies we're doing. His next appt with MD Anderson is June 2025, we use them so we get the PET/CT scans and can track his progress. Here is a spreadsheet I put together showing his progress to date. To this day he has still had no radiation or chemo and doesn't plan to.”



Q: We are getting ready to publish your Dad’s story, did he happen to be taking aspirin in any form while self-treating with fenbendazole?
A: No aspirin.

““He had a follow up on 6/28 and another 30% reduction from last appointment. His cancer has digressed by 80% now overall. His tumors in the lymph nodes and lungs are now completely gone. MD Anderson is still tapping their foreheads asking “are you doing anything besides the lupron shot we gave you?” Of course we say no because Dad wants to still get the quarterly PET scans to track his progress.””

Summary

This Case Report documents the extraordinary turnaround of a 74-year-old man diagnosed in August 2024 with Stage 4 metastatic prostate cancer, with extensive liver and lymph node involvement, and given a palliative prognosis of 12-18 months. Forsaking further conventional treatment beyond an initial Lupron injection, he independently initiated a daily regimen of fenbendazole (444mg total). He experienced an immediate abatement of all pain and discomfort. Within three months, his PSA plummeted from 51 to 2, and imaging confirmed a 50% reduction in all tumors, leading to the cancellation of planned chemotherapy. After five months on fenbendazole, his total tumor burden had decreased by an astounding 75%, now NED in liver at 11 months. This remarkable outcome, primarily attributed by TW’s dad to fenbendazole, underscores the profound anti-cancer effects he experienced with fenbendazole.


Case 27: 75-year-old man with recurrent stage IV prostate cancer and extensive bone metastases

Published peer-reviewed paper on Case Reports in Oncology (May 2025):

A 75-year-old man was diagnosed in December 2021 with recurrent stage IV prostate cancer and extensive bone metastases. Initially diagnosed 10 years earlier and treated surgically, he had undetectable PSA levels for 18 months before a gradual rise indicated recurrence of prostate cancer. The diagnosis of metastatic cancer was confirmed through imaging studies and elevated PSA levels. Bone scans and CT scans revealed metastases in the spine, pelvic bones, and right humeral head, along with significant lymph node involvement. On a CT abdomen/pelvis with and without IV contrast performed on December 16, 2021, prominent left periaortic lymph nodes were identified, with a representative lymph node measuring 0.8 cm, which was not seen in previous studies.

In December 2021, the patient initiated androgen deprivation therapy with Orgovyx and Erleada, complemented by Xgeva to support bone health. He also added repurposed medications and supplements: vitamin D (5,000–10,000 IU/day) with K2 and magnesium, melatonin (10–40 mg/day), berberine, curcumin, artemisinin, cimetidine, and other compounds with potential anticancer effects. He started taking FBZ in December 2021 (dose range: 222–444 mg/day), usually daily, with occasional dose reductions. 

In December 2022, after 1 year of follow-up, regression of bone lesions was observed, and lymph node involvement had fully resolved. In January 2024, after 2 years of follow-up, imaging confirmed significant regression of bone lesions with no new metastatic sites. The use of FBZ coincided with continued regression of metastatic lesions and sustained undetectable PSA levels. No increase in liver enzymes or any other side effects attributable to FBZ were reported. 

In April 2024, a PSMA-PET/CT whole body scan revealed that the vast majority of the sclerotic bone lesions demonstrated no abnormal radiopharmaceutical accumulation. A large left renal cortical cyst deforming the kidney had a SUV of 0.5, and no abnormal radiopharmaceutical accumulation was observed within lymph nodes. PSA levels remained undetectable for over 2 years (<0.05 ng/mL). 

After 26 months of sustained regression and no new progression, the patient remains in near-complete response and continues FBZ with conventional therapy (androgen deprivation therapy with Xgeva). A summary timeline is provided in Figure 2 below.




Case 26 - 2025: 61 year old NC man with Gleason 8 Prostate Cancer

Dr William Makis shared on X.com in July 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 61 year old NC man with Gleason 8 Prostate Cancer has no spread on surgery and drops to Gleason 7, as PSA also drops!

Repurposed drugs will often limit the spread of cancer and leave shocking results on pathology. I have many testimonials now of "unexpected" results on pathology after a few months of Ivermectin, Fenbendazole or Mebendazole and I will be posting these in the coming weeks. 61 year old NC man with Gleason 8 Prostate Cancer On Feb.12, 2025 we started:
  • Ivermectin 1.5mg/kg/day
  • Fenbendazole 1000mg/day (eventually increased to 2000mg/day after 2 months, after PSA stayed stable)
  • CBD Oil 100mg/day
Results after 3.5 months:
  • PSA 6.3 to 4.5
  • No spread of Cancer
  • Gleason 8 to Gleason 7
From patient: "Prostate removed - pathology report shows no sign of spread, all contained within the prostate. Gleason score reduced from 4+4 to 3+4" 

That's a full two degrees less in aggressiveness. The cancer went from 4+4 to 4+3 to 3+4.


Case 25 - 2025: 65 year old Florida man with new Prostate Cancer sees improvement after 4 months

Dr William Makis shared on X/Twitter in July 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 65 year old Florida man with new Prostate Cancer sees improvement after 4 months We have so many Prostate Cancer successes! 65 year old Florida man with new Prostate Cancer PIRADS-4. 

In late January 2025 we started:
  • Ivermectin 1.5mg/kg/day
  • Fenbendazole 888mg/day
  • CBD Oil 100mg/day
Results after 4 months:
  • PIRADS-4 to PIRADS-3 and smaller lesion. 

  • Sometimes we celebrate big successes, sometimes we celebrate small successes. But the reality is that the risk of trying repurposed drugs in Cancer is minimal. And the risk/benefit calculation almost always weighs heavily in the direction of "benefit".


Case 24 - 2025: Alberta man with Prostate cancer, avoids radical prostatectomy and full pelvic radiation

Dr William Makis shared on X/Twitter in June 2025:

Ivermectin and Fenbendazole Testimonial - Alberta man avoids radical prostatectomy and full pelvic radiation, PSA 9.0 to 1.7 and doing great! An Alberta man was diagnosed with Prostate Cancer. He was offered the best options Modern Oncology has to offer: radical prostatectomy and full pelvic radiation.
These treatments are 50+ years old...

His Alberta doctors also told him there was a 50% chance he would be "normal" after one of these procedures.

"I am in the risk business and this seemed unacceptable to me". 

So he started Ivermectin and Fenbendazole, went to Seattle for Proton Therapy, and then continued Ivermectin and Fenbendazole with MCT Oil for 3 months. He did the opposite of what Modern Oncology recommended. How did he do?

"My PSA registered 1.7 (from a high of 9)...My prostate is still intact. All my bodily health functions are normal".


Case 23 - 2025: 77 year old North Carolina man with Stage 4 Prostate Cancer metastatic to lungs and bones

Dr William Makis shared on X/Twitter in June 2025:

IVERMECTIN and FENBEDAZOLE and CBD Oil Testimonial - 77 year old North Carolina man with Stage 4 Prostate Cancer metastatic to lungs, bones, has almost complete resolution of cancer after 5 months!!

Want to see an incredible Prostate Cancer testimonial? According to vocal pharma shills, these don't exist 77 year old North Carolina man with Stage 4 Prostate Cancer metastatic to bones.

End of Nov. 2024 we started:
  • Ivermectin 1.5mg/kg/day
  • Fenbendazole 888mg/day
  • CBD Oil 50mg/day
His Oncologist put him on chemo.

RESULTS after 5 months: 

PET/CT done May 4, 2025 showed almost complete resolution of cancer!

Prostate: Previously near entirety of the gland was involved with intense radiotracer activity prostate adenocarcinoma. Single focus of radiotracer activity remains within the apex of the prostate gland SUVmax 4.8

Pelvic nodes - Single node in right external iliac nodal station SUVmax 2.6 measures less than 5mm. (Previously enlarged 10mm node with SUVmax 45).

Periaortic nodes - Resolution of previously seen periaortic retroperitoneal nodes (previous 13mm SUVmax 39.9 and 10mm SUV 44.6max, now gone)

Bones: only 3 foci remain in the skeleton. Interval resolution of previously described activity within the pelvis and lumbar spine. (previous sternoclavicular joint SUVmax 64.2, now SUVmax 8.3)

Lungs: resolution of left upper lobe pulmonary nodule (previous 4mm SUVmax 6.3)

From the patient:

"I am elated to write to you to express my gratitude for your help. My father got his results this week. The stage 4 prostate cancer is practically gone. The scan only shows 2-3 tiny spots on his bones and they’re not sure if that’s even cancer."

"My family is sooo happy. My dad is sleeping soundly now for the first time since the diagnosis back in August, 2024. I’m sure it’s because he doesn’t have the anxiety that comes with such a terrible diagnosis"

"I will never be able to repay you for saving my dad’s life. Thank you for your dedication to saving lives all over the world! Much love and respect!"


Case 22 - 2025: 78 year old Australian man with Stage 4 Prostate Cancer

Dr William Makis shared on X/Twitter in June 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 78 year old Australian man with Stage 4 Prostate Cancer sees PSA 385 drop to 1.2 and tumors shrinking!

I have many Stage 4 Prostate Cancer success stories, although this is where I recently faced sabotage. After all, Prostate Cancer means big money for Big Pharma, and they will send anyone, along with an entire army of bots to protect their profits. 

STORY: 78 year old Australian man with Stage 4 Prostate Cancer started chemotherapy (Docetaxel) and Hormone Therapy (Goserelin) But he also came to me for help and started:
  • Ivermectin 1mg/kg/day
  • Fenbendazole 1000mg/day
After not even 2 months: PSA 385 to 1.2

Metastatic disease shrinking on PET/CT There are some prostate cancers, however, that are completely resistant to Ivermectin and Fenbendazole. Why they are resistant, I don’t know. There isn’t a particular identifiable feature. This remains one of the challenges. Many respond, but some don't. When they do respond, the response is very impressive.


Case 21 - 2025: 87 year old WA man with Stage 4 Prostate Cancer metastatic to bones & spine

Dr William Makis shared on X/Twitter in June 2025 

IVERMECTIN and FENBENDAZOLE TESTIMONIAL - 87 year old WA man with Stage 4 Prostate Cancer metastatic to bones & spine, has dramatic response, PSA 2093 to 39, shocks Oncologist.

STORY: 87 year old WA man with Stage 4 Prostate Cancer metastatic to bones, with bone pain and severely reduced mobility. We started in late March 2025:
  • Ivermectin 1mg/kg/day
  • Fenbendazole 1000mg/day

RESULTS after 2 months:

PSA 2093 to 39

From patient: 

April 4: "My father got his bloodwork done and the good news is his testosterone & PSA is way down. He says the pain in his legs is a lot better as well. Things are looking up!" 
April 13: "His PSA was 2093, now it is 83 on 4/1/25.
He didn’t use his walker or cane when I took him for his healthy IVs. Just a little bit of pain in his legs, but much better." 
April 18: "My father’s numbers are getting better so all is well. Just did more bloodwork on Thursday, April 17th and his PSA went from 85 down to 39." 
May 21: "the good news is, the soon to be fired oncologist, was very surprised on how well my father is doing. He told my father whatever he was doing to keep doing it. He was VERY impressed." "Last time he went to see the doctor he was using his walker and now he isn’t using his cane or walker!! So, my father is doing better thanks to you and my father’s diligent efforts in following the protocol."


Case 20 - 2025: Stage 4 Prostate Cancer

Dr. Peter McCullough shared (May 2025) a stunning anecdote: a patient with metastatic prostate cancer saw his PSA drop from 200 to 2 after trying ivermectin.

IVERMECTIN AND CANCER

Dr. Peter McCullough shares a stunning anecdote: a patient with metastatic prostate cancer saw his PSA drop from 200 to 2 after trying ivermectin.


Case 19 - 2025: 93 year old male with Stage 4 prostate cancer that has metastasized to the hip bone

Testimonial shared by @1FidLaf in May 2025 (source): 

"Well thanks to a miracle drug. That is very inexpensive. My 93 year old father is alive today. In just 2 months he was cured of a prostate cancer that has metastasized to the hip bone. IVERMECTIN is that miracle drug. It cost less that $80 dollars for the cure. No chemo no radio."






Case 18: Stage 4 prostate cancer

Dr. Kathleen Ruddy reported on a case of stage 4 prostate cancer:

He worked for the government, and he was going to lose his job and his pension if he wasn’t vaccinated. Two months after his second Pfizer shot, he was diagnosed all at once with stage 4 prostate cancer. He tells a very compelling, melodramatic story about that 24-hour period of time in his life.

He went through the traditional protocols; radiation, chemotherapy, pharmacologic, castration, all of it, over a period of nine months. His name is Paul Mann. His doctor said, “There’s really nothing else we can do. He said, “Can’t you give me more radiation? Can’t you give me more chemo? Aren’t there any other drugs? Are there any clinical trials? The answer was, “No, there’s nothing. There is only hospice. Send for the priest.”

A friend of his knew me and said, “Would you give Paul a call? He just needs some moral support.” I began calling him and we spoke about once a week for three weeks. The poor guy was suffering and had cancer in 11 bones in his body. His right leg was completely swollen and obstructed with a tumor. He was miserable.

I said, “Paul, I don’t know if this is going to help you, but I know it’s not going to hurt you. I just can’t imagine based on my judgment and understanding of the scientific literature and all of the work that Doctors Kory and Marik have done that ivermectin would hurt you. It might help, but I can’t say.”
He said, “I'll give it a try.” He drove to Tennessee where you could get it without a prescription. He drove from where he lives in New York to Tennessee and paid cash for his ivermectin. He didn’t submit it to an insurance company. He didn’t tell his oncologist back in Missouri.

His ivermectin prescriptions were listed in his medical chart. How did that information get from the pharmacy in Tennessee to his chart in Missouri? They don’t know. But actually, somebody does know, and I'd like to know myself.

Anyway, he starts taking ivermectin. He doesn’t have any problems with it. I talk to him every week, “How are you feeling? How’s your leg? How’s the pain? He says, “No change. But I don’t know. It’s not quite as swollen. There’s pain everywhere. Maybe it’s getting a little bit better. It’s not necessarily getting worse.”

Fast forward to a two-month follow-up appointment at the clinic. They didn’t expect to see him. He’s feeling a little bit better. They do a PSA [Prostrate-Specific Antigen Test], which in the beginning was off the charts, maybe 700 or 800. At the time, they recommended him to hospice.
Mr. Jekielek: What exactly do those numbers mean, for the layperson?

Dr. Ruddy: Over four would be abnormal. What are we talking about here? Prostate cells normally secrete a protein, a prostate-specific antigen. It’s one of the things that they do. Cancer cells that originate in the prostate that are dividing rapidly and growing fast are spitting out PSA. It’s not that they’re contributing to the body economy in any way. It’s just they just want to multiply and divide. That’s the end of the story.

Your PSA levels start to rise, which is a screening marker. They will say, “Your PSA was four, and now it’s eight. Let’s do a prostate ultrasound.” The PSA can be a screen for the emergence of a tumor, but it can also be used, particularly at high levels, as evidence for cancer, response to cancer, or recurrence of cancer. His was supposed to be four, but it’s in the hundreds.

He goes back for a two-month appointment and it’s 1.3. They said, “You’re in biochemical remission.” He was not in complete remission, because he still had the bone metastasis, but this was good news. Slowly, he begins to improve. There is less pain and the swelling is down. He has a lot of other vaccine injuries, but he’s getting better.


Case 12 - 17: February 2025



Cases shared by Dr William Makis (X/Twitter) in February 2025: 

Case 01: 78 year old man with Prostate Cancer Gleason 9 post prostatectomy, halted recurrence with "your low dose protocol" "So there you have it. My PSA has stopped rising, still 1.2 and my annual scan and MRI in December were still clear after 3 months on the low dose protocol".

Case 02: "Stage 4 Prostate fighter/survivor. On Iver and Fenben for 19 months. Cancer undetectable for past 12 months".

Case 03: Brig Gen (Ret) USAF: "my prostate cancer was eradicated using IVM, Fenben and Doxy".

Case 04: "I have more positive results to report!" "My husband got his PSA results back today. When he was diagnosed with prostate cancer his PSA was 5.8 now it is down to 4.1 after 32 days on Ivermectin and Fenbendazole".

Case 05: "I was told by one local oncologist that I had 2 months to 2 years max" "This past summer moved to high dose Ivermectin and I feel a huge improvement. I take 48-60mg daily and that had the affect of depressing my PSA significantly. But again, the real measure is I feel so much better".

Case 06: "Praise the Lord for Dr.Makis and his wisdom, kind compassionate heart and generosity!! Wonderful start to a Happy New Year!".
"My husband has recently been diagnosed with Prostate Cancer. We started: Daily IVM 96mg 3x/week fenben 888mg LDN Orgovyx PSA 538 (12/6/24) down to 290 (12/30/24).
"God Bless you and your beautiful family Dr.Makis!".


Case 11: Stage 4 Prostate Cancer

Testimonial shared by Jaquar-2014- (HealthUnlocked) in 2024:

I was diagnosed with stage four prostate cancer at the end of January 2024, with a PSA of 143 and a 9 on the Gleason score. It had metastasized to several parts of my bones. I immediately started the Joe Tippens protocol.

Two months later, my PSA dropped to 26. For the last four months, my PSA has been zero. My doctor says I don’t need an MRI or PET scan because I have no evidence of cancer. I do have to undergo some radiation for the cancer on the bones.

So, on the dog medicine, I am cancer-free. This is the truth—no side effects and feeling good. If you’re interested in beating any kind of cancer at any stage, the Joe Tippens story was my cure.


Case 10: 79 year old Canadian man with Stage 4 Prostate Cancer to Lymph nodes (December 2024)

Case shared by Dr William Makis (X/Twitter): 

IVERMECTIN and FENBENDAZOLE Testimonial - 79 year old Canadian man with Stage 4 Prostate Cancer to Lymph nodes - everything is shrinking 4 months later! 79 year old British Columbia, Canada man diagnosed with Prostate Cancer, Gleason 8, “pushing against bladder wall, in lymph nodes, diagnosed late 2022 with a PSA peaking at 19.72. Completed 28 treatments of radiation. Was currently on hormone blockers (and Abiraterone) but tumor hasn’t shrunk. Came to me for help and we got to work right away:

We started the following protocol:
  • Ivermectin 1mg/kg/day
  • Fenbendazole 444mg/day
  • Melatonin 120mg/day
  • IP6
  • Artemisia
RESULTS: 
“approaching 4 months on Ivermectin plus the other products” 
“the oncologist report is that there is shrinkage in all areas (prostate, bladder wall and lymph nodes. He is not in remission as yet”. 

The answer to the question is: continue Protocol until remission.







Case 9: 60s year old Early Stage Prostate Cancer (December 2024)

Case shared by Dr William Makis (X/Twitter): 

IVERMECTIN and FENBENDAZOLE Testimonial - 60s year old Early Stage Prostate Cancer patient, Gleason 7, PSA drop 4.6 to 2.46 in 35 days!

60s year old Prostate Cancer patient, new diagnosis, Gleason 7 (3+4 and 4+3) with bilateral disease. Major US Cancer Center gave this assessment: 

“Overall, I think you will eventually come to need treatment of your prostate and because you appear to have bilateral disease, whole gland treatment is likely the best cancer strategy. Whether undergoing treatment now, or observing for a bit longer is the best route depends on your goals. We can consider radical prostatectomy…I’m less enthusiastic about radiation treatment as you are very young and likely to experience the secondary effects of radiation on your normal tissue as you age.”

Pretty standard stuff from a famous large US Cancer Centre that is stuck in the “Big Pharma guidelines” era with zero creative thought. 

Patient did about a month of Fenbendazole 222mg Joe Tippens Protocol, then I got involved. 

We started a high dose Ivermectin/Fenbendazole Protocol: 
  • 1 mg/kg/day Ivermectin working up to 2 mg/kg/day 
  • 888 mg/day Fenbendazole.
Results one month later: PSA went: 4.4 to 3.6 to 2.46 (lowest PSA level in 2 years!) 44% drop in PSA in about one month! Transient visual symptoms affect some patients at Ivermectin doses above 60mg. They tend to go away with time. Why the high dose Ivermectin/Fenbendazole regimen? - young patient - “A Gleason Score of 4+3 represents a moderately aggressive form of prostate cancer.” - “bilateral disease at the prostate apex plus an additional region with cancer at the base.” I find that Ivermectin and Fenbendazole are well tolerated and it’s very rare to see any issues on bloodwork.



Case 8: Stage 4 Prostate Cancer patient - PSA drops 1533 to 968 in 12 days (November 2024)

Case shared by Dr William Makis (X/Twitter): 

IVERMECTIN and FENBENDAZOLE Testimonial - Stage 4 Prostate Cancer patient - PSA drops 1533 to 968 in 12 days - is fatigue and bone pain normal?
Stage 4 Prostate Cancer patient: Started Ivermectin 1mg/kg and Fenbendazole 1000mg 3 days on 4 days off. In 12 days PSA drops 1533 to 968 (37% drop). Abdominal cancer lymph nodes disappeared.

To be honest, that’s a lot of cancer cell killing over a very short period of time!! That will cause a great deal of FATIGUE. That’s to be expected. Bone pain? Also. As cancer cells in bone get killed, the inflammation can also cause bone pain. That will heal over time This gentleman is on his way to becoming cancer free.



Case 7: November 2024

Case sharing by Dr William Makis (X/Twitter):

IVERMECTIN and FENBENDAZOLE Testimonial - Stage 4 Prostate Cancer patient from Ecuador, Gleason 8, goes on Protocol and PSA drops from 800 to 18 in 3 months!

Patients from around the world (hello Ecuador!) are benefiting from Ivermectin and Fenbendazole repurposed drug combination Protocols. 

This was an Intermediate Dose Protocol, with a starting dose of Ivermectin of 1mg/kg/day and a Fenbendazole dose of 222mg to 444mg a day. 

Additional benefit with a ketogenic diet! Now this is only 3 months in, but I think PSA 800 to 18 is good progress so far.



Case 6: Stage 4 Prostate Cancer (October 2024)

According to Dr William Makis (X/Twitter):

IVERMECTIN & FENBENDAZOLE in very aggressive Stage 4 Prostate Cancer 

"We reached our goal of bringing my PSA Score down to 0.02 quite quickly. Doctors were surprised at how quickly this happened."




Case 5: December 2022 (Updated August 2023)

I wish to share more good news. Since our texts, December 2022/January 2023, my husband has had two more PSA tests. Here is the recap of his tests . Lenny’s PSA continues to drop, as he continues to take the Panacur C daily.

Lanny – PSA Test Results

8.0 = Lanny’s PSA upon being diagnosed with prostate cancer, August 2021 Before Lanny ‘started’ radiation therapy, he had THREE WHOLE MONTHS of Panacur C daily. Lanny’s doctor said any PSA under 1.0 is considered CANCER-FREE.

0.8 = Lanny’s PSA after 3 months of Panacur C — BEFORE radiation therapy, October 2021 Lanny told his doctor about taking Panacur C, when the doctor told Lanny that his PSA was 0.8 (according to that very doctor, this PSA denotes cancer-free; however, this same doctor gaffed off the Panacur C and cancer-free PSA with NO explanation).

0.09 = Lanny’s 30-DAY POST RADIATION PSA TEST, WHI CH DENOTES WAAAY CANCER-FREE, February 2022 Still no comment from any doctor . . . and I’m not anticipating one.

PSA Updates: 0.08 = February 2023
0.06 = June 2023

December 2022

Lanny was diagnosed with prostate cancer August 2021.
8.0 = Lanny’s PSA upon being diagnosed with prostate cancer.

Lanny’s doctor said any PSA under 1.0 is considered CANCER-FREE.

Before Lanny started radiation therapy, he had THREE MONTHS of Panacur C daily.

0.8 = Lanny’s PSA after 3 months of Panacur C — BEFORE radiation therapy.

Lanny told his doctor about taking Panacur C, when the doctor told Lanny that his PSA was 0.8 (which, according to that very doctor, this PSA denotes cancer-free; however, his doctor gaffed off the Panacur C and cancer-free PSA with NO explanation).

0.09 = Lanny’s 30-DAY POST RADIATION PSA TEST, WHICH DENOTES WAAAY CANCER-FREE.

Still no comment from any doctor and I’m not expecting any.

BTW, Lanny made a personal decision to continue using Panacur C as cancers are notorious for returning.



Case 4


Case 3: September , 2022

My husband was diagnosed 8 months ago.. Feb 1st of this year,, with a aggressive form of prostate cancer that had already metastasized into his lymph nodes and bones. He had fractures throughout his spine, ribs and pelvis. Adams bone scan showed cancer in his bones from his skull,, facial bones, clavicle, sternum right rib cage and most of his spine and pelvis.. His oncologist (we’ve since changed) waited 7 weeks to start any hormone therapy or chemotherapy and told us radiation wasn’t even an option. Only 6 rounds of doxi. He sat at our first office visit Feb 2nd and told my family that the #1 man in our lives would be gone within 18 months. His psa was 140, Gleason score of 9. He was diagnosed full blown stage 4-5 cancer. This was completely unacceptable. Absolutely devastating to our world. My husband is 55 yrs old.. We have 8 children and 8 grandchildren. Our last 2 kids had just moved out a year before.. this was our time.. We had always talked about IF cancer ever came about for either of us we would research alternative treatments. We fear medical poison as much as the cancer itself..

Thank God my husband’s cousin connected us with a angel that gave us all the information we needed on a product meant for animals, fenbendazole and even sent us 2 bottles of fenbendazole. Has since supplied us with bottles when needed.

So week 2 post diagnosis Adam started his 222mg of fenben.


Case 2: Prostate Cancer refused surgery (March, 2022)

I received the awful news two years ago from my Urologist that I have prostate cancer. The doctor wanted to prepare me for surgery immediately, but I refused to go for surgery. I was very afraid and gave up hope at some point till I discovered the fenbendazole protocol. Thanks to reaching out to a couple of people who have been on the course before and after sharing their stories with me I decided to take the protocol on with full commitment.


Case 1: Stage 1 prostate cancer (June, 2022)

After having two scans and a biopsy and being told that I have stage 1 prostate cancer. I was told by a friend about Fenbendazole. After taking it for a year I had another M.R.I. and biopsy and the cancer is gone. Like a miracle.
Used: Fenbendazole , Vitamin E


Looking for more case reports? Explore additional cases for other cancer types in our Fenbendazole Cancer Case Series

Discussion

The compilation of case reports and emerging clinical data reviewed in this article highlight the promising potential of fenbendazole and ivermectin as adjunctive agents in prostate cancer management, including advanced and metastatic cases. These repurposed antiparasitic drugs exhibit multiple anticancer mechanisms, such as microtubule disruption, induction of cancer cell apoptosis, inhibition of metastasis, and immune modulation. These biological activities align with the substantial tumor regressions and PSA reductions reported in numerous patients with recurrent or treatment-resistant prostate cancer.

This evidence is especially compelling considering these agents’ favorable safety profiles and broad accessibility, offering a cost-effective supplemental strategy alongside standard therapies like androgen deprivation therapy (ADT) and radiotherapy. Several patients achieved remarkable biochemical and radiologic responses, including near-complete remissions, sustained over months without significant adverse effects.

Studies have shown Fenbendazole could be used for prostate cancer by targeting microtubules, which are structures involved in cell division. Fenbendazole interferes with microtubule function, disrupting the ability of cancer cells to divide and proliferate. This could potentially slow down tumor growth and progression in prostate cancer.

In a 2011 study, researchers from Boston and Maryland looked at benzimidazoles, which is the group of drugs Fenbendazole falls under. The study discovered that certain benzimidazoles, including Fenbendazole, can target aggressive prostate cancer cells without harming normal cells. These drugs work by stopping cancer cells from growing and causing them to die, both in the lab and in animals.

When tested in mice with prostate cancer that had spread to the lungs, benzimidazoles helped the mice live longer and slowed down the cancer’s growth in their bones. Even more impressive, these drugs still worked against prostate cancer cells that were resistant to standard chemotherapy. The study suggested that benzimidazoles could be a promising treatment for men with advanced prostate cancer that has spread to other parts of the body.

According to the study (ResearchGate):

Benzimidazoles significantly extend the lifespan of tumor metastases-bearing mice, without severe toxicity to the host. Notably, these anti-tumor effects are comparable if not more effective than paclitaxel. The selective cytotoxicity to the metastatic cells is mediated partly by inhibition of the microtubulin polymerization, leading to mitotic arrest and subsequently cell death. These cytotoxic effects are also observed in cancer cells with paclitaxel or multi-drug resistance, both in vitro and in vivo. The benzimidazoles may possess significant anti-tumor effects and a good safety profile that are desired in the long term treatment of men with late-stage prostate cancer and failed both hormone-deprivation and taxane-based therapies.

However, it is critical to interpret these observations with caution due to their largely anecdotal and case-report nature, coupled with a current lack of large-scale randomized controlled trials (RCTs). RCTs evaluating fenbendazole and ivermectin, alone and in combination with standard prostate cancer treatments, are urgently needed to establish efficacy, optimal dosing, and long-term safety.

The resistance often observed in advanced prostate cancer, including metastatic castrate-resistant disease, demands innovative multimodal approaches. Repurposed drugs like fenbendazole and ivermectin might fill critical therapeutic gaps—either by direct cytotoxic effects or through sensitizing tumors to existing treatments. Their incorporation into integrative oncology protocols illustrates how conventional and complementary therapies may converge to improve patient outcomes.

As research progresses, collaboration between conventional oncologists, integrative medicine practitioners, and researchers will be crucial. Shared decision-making and patient-centered care remain paramount when integrating repurposed treatments, ensuring transparent risk-benefit discussions and careful clinical monitoring.

President Biden’s Prostate Cancer Diagnosis

On May 18, 2025, former President Joe Biden’s personal office announced that he had been diagnosed with an "aggressive form" of prostate cancer, which had metastasized to his bones, with a Gleason score of 9, indicating a high level of aggressiveness . This diagnosis has fueled speculation and conspiracy theories, including claims that mRNA vaccines may have contributed to his condition. Web searches confirm the diagnosis, with multiple sources like NBC News and The New York Times reporting the details, noting that Biden and his family are reviewing treatment options (NBC News, The New York Times).

X Post by Scott Adams: Prostate Cancer Update

Scott Adams posted on X in May 2025:

UPDATE 1: 

Please don’t recommend I take Ivermectin and Fenben. 

I tried that last year, via Dr. Makis, to no effect. There are claims of it working, but I am aware of no patient who benefitted from it. Neither are you. 

Please don't recommend fasting or any diet-related system. Someone credible would have noticed if that worked. 

Please don't recommend any cocktail of vitamins and minerals. I very much appreciate your caring, but assume I've heard about all of the above. 

I'm overwhelmed with those same suggestions all day long.

Dr William Makis explained in his Substack article:

Scott supposedly tried Ivermectin and Fenbendazole, for a total of 1 month. 

Scott never completed my Ivermectin Protocol, which is a minimum of 3 months with follow-up. 

So we will never know if Ivermectin and Fenbendazole would have worked for him or not. Trying it for one month and then stopping, is not sufficient to make any sort of conclusion. 

It is the equivalent of doing one chemo cycle, stopping and declaring chemo doesn’t work. 

It takes approximately 3 months to see significant changes on blood cancer markers and imaging. During that time, PSA may go up due to cancer cell killing and release of cancer antigens. 

So for the hundreds of Twitter posts which had the same identical language: “he tried it, it didn’t work”, all of these posts were entirely false. 

Scott didn’t try Ivermectin and Fenbendazole in any proper shape or form and we will never know if it would have worked for him or not.

Dr William Makis posted a related post on X.com in October 2025:

I tried to bring Pluvicto (177Lu-PSMA) to Canada and have been targeted by the Canadian Federal government ever since. They destroyed my medical license over it. First Trudeau, then Carney. I hope Scott Adams gets Pluvicto and it works for him. However, Pluvicto would be far more effective when taken with Ivermectin due to Ivermectin's ability to radiosensitize tumors. So Scott will not get the best treatment or Cancer care from his Oncologist and that is always sad to see.

X Post by Barking Mad MD

BarkingMadMD (@3GHtweets) posted in May 2025 on X:

Not when metastatic to bone. While @MakisMD and others have reported success with IVM and Febendazole in a number of cases https://onedaymd.com/2025/04/fenbendazole-ivermectin-prostate-cancer.html…, the only treatment typically provided for metastatic prostate cancer is Leuprolide or other androgen blockers to slow progression. The most effective treatment for early stage cancer conformal proton beam radiation therapy. It is criminal that Biden's cancer was not detected earlier and can only be a consequence of neglected medical care on the part of his physicians who look to have been as incompetent as the rest of the crew surrounding Biden.

Conclusion and Key Takeaway

In conclusion, fenbendazole and ivermectin represent promising adjuncts in prostate cancer treatment, particularly for patients with limited therapeutic options. However, it is important to recognize that much of the current evidence is based on case reports, which provide preliminary insights but may be dismissed by some as anecdotal or of low scientific quality. Despite skepticism, these encouraging testimonials could signify the early stages of a scientific frontier worthy of rigorous exploration.

Given the urgent need for new prostate cancer treatments, the U.S. Department of Health and Human Services should consider expediting well-designed human clinical trials and enabling access to these therapies under medical supervision, classifying them as “experimental” where appropriate and ensuring proper legal safeguards.

For a more comprehensive understanding, patients and clinicians are encouraged to review emerging research and participate in ongoing clinical trials. As always, treatment decisions should be made in close consultation with healthcare providers, with individualized monitoring and personalized care to optimize safety and efficacy.


Disclaimers:
  • Statements on this website have not been evaluated by the Food and Drug Administration. The contents of this website is for educational and informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis or treatment.
  • Please do not consider this guide as personal medical advice, but as a recommendation for use by professional providers. Consult with your doctor and discuss with her/him. Our aim here isn't to replace your doctors' advice. It is intended as a sharing of knowledge and information. Do take note that cancer is a continuous struggle between the immune system and the cancer cells. Cancer treatments are meant to assist the immune system in this battle. Any potential treatment—whether conventional or complementary—must be evaluated on a case-by-case basis, with careful consideration of the benefit-risk ratio to ensure both safety and effectiveness.
  • The case reports presented reflect the real-life experiences and opinions of other readers or users of the website. The experiences of those readers or users are personal to those particular readers/users and may not necessarily be representative of all readers/users. We do not claim, and you should not assume, that all other readers/users will have the same experiences. Do you own research, consult with relevant medical professionals before attempting to self-treat for any condition.
  • Cancer treatment should be part of a multi-modal approach in order to provide the best possible outcome. Diet and lifestyle changes are meant to run alongside conventional treatment. They are complementary, not alternative. 
  • Cancer care is a team effort with the patient at the centre. Care should be supervised and coordinated by a primary healthcare provider. Patients with cancer should consult with their regular oncologist as well as an integrative provider/oncologist, in addition to their primary care provider and the supporting nurses, dieticians and other allied healthcare professionals.
  • While the term 'alternative' might imply opposition to conventional oncology, we prefer 'complementary,' 'integrated,' or 'holistic.' These terms better reflect the role of these strategies as part of a personalized value-added menu of strategies, ensuring the most effective and safe solutions for patients.
  • Integrating a repurposed drug doesn't mean rejecting modern medicine — It enhances it and offers a more comprehensive approach to wellness and healing. By combining conventional cancer management with root-cause resolution, this model creates a path to sustained recovery and resilience. 



References:
  1. Top 10 Prostate Cancer Fighting Supplements
  2. Fenbendazole as an Anticancer Agent? A Case Series of Self-Administration in Three Patients - (Case Reports in Oncology 2025)
  3. Ivermectin, Fenbendazole and Mebendazole in Cancer: 2024 Peer-Reviewed Protocol in Cancer (Journal of OrthoMolecular Medicine 2024)
  4. Ivermectin and Cancer: 15 Anti-cancer Mechanisms of Action
  5. Fenbendazole and Cancer: 12 Anti-Cancer Mechanisms of Action
  6. Ivermectin, Mebendazole, Metformin, High-Dose Vitamin C, Vitamin D, Curcumin, Diet/Lifestyle, and Standard Therapies for Non-BRCA-Mutated Stage 4 Prostate Cancer: A Simulated Double-Blind Randomized Controlled Trial (Grok 2025)
  7. Fenbendazole vs Mebendazole for Cancer (OneDayMD 2025)
  8. Fenbendazole vs Ivermectin for Cancer (OneDayMD 2025)
  9. Ivermectin, Fenbendazole, and Mebendazole for Stage 4 Prostate Cancer: Case Reports Compilation (2025)
  10. Turbo Cancer Debunked: What You Need to Know (2025)
  11. Top 10 cancer fighting supplements
  12. Joe Tippens Protocol Fenbendazole
  13. Best Fenbendazole Dosage for Humans: Safety, Side Effects and Efficacy Examined
  14. Best Ivermectin Dosage for Humans with Cancer or Different Cancer Types
  15. Fenbendazole and Ivermectin for Cancer: The Ultimate 2025 Guide (OneDayMD 2025)
  16. The Great Prostate Hoax & Supplements (Urologist 2025)


Like and Follow us for more updates on X/TwitterOne Day MD on X.com.

Ivermectin and mebendazole, both approved for human use, are now available in the U.S.

Researched and approved by Dr. Peter McCullough.
  • Prescribed by licensed medical professionals
  • Compounded and dispensed by a licensed US-based pharmacy
  • Approved for human use
Where to buy Ivermectin and Mebendazole Formula: Available on The Wellness Company's website. Here is the link: Ivermectin and Mebendazole.

Comments

  1. Is 34 a good number? I feel like it should be higher, hundreds of people or thousands even. Less than 100 seems so small :(

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