The Medical Advisor

OneDayMD Master Evidence Guide • Updated September 2026 Semaglutide, tirzepatide, oral GLP-1 medicines, retatrutide and the next generation of metabolic therapies have changed the obesity and cardiometabolic treatment landscape. But the phrase “GLP-1 drug” can hide major differences in mechanism, indication, dose, study population and clinical evidence. This master guide organizes the most important clinical trials into an ebook-style reference—from the landmark STEP and SURMOUNT obesity trials to SELECT , FLOW , SUMMIT , ESSENCE , OASIS 4 , ATTAIN-1 , TRIUMPH, SURPASS  and the emerging CagriSema program. 2026 update: The field has moved beyond injections alone. Oral semaglutide (Wegovy tablets) and orforglipron (Foundayo) are now U.S. FDA-approved options for weight management, while higher-dose semaglutide (Wegovy HD) has also ...

A OneDayMD Ebook Guide · Part of the Nutrition, Vitamins & Supplements Hub A 12-chapter, evidence-reviewed reference — from macronutrients to a full A–Z supplement directory REVIEWED & UPDATED BY ONEDAYMD EDITORIAL TEAM · October 2026 · Medically Reviewed by Dr. Frank Yap, MD Quick Answer For most healthy adults, the supplement foundation stack with the broadest evidence base is Vitamin D3 + K2, magnesium glycinate, omega-3 EPA/DHA, vitamin C, zinc, a strain-specific probiotic, and CoQ10/ubiquinol — but evidence quality varies considerably by nutrient and by the outcome claimed (see the Evidence Tier notes throughout this guide). Supplements should always add to , never replace, a whole-food diet. This ebook organizes 200+ evidence-reviewed vitamins and supplements across 12 chapters: the science of why nutrition matters, how to judge supplement quality, an A–Z ingredient directory, a categorized directory by health condition, and a chapter on using AI...