The Medical Advisor

Abstract: The exploration of alternative and metabolic interventions in cancer therapy has garnered significant attention in recent years. This review critically examines various non-conventional treatments, including dietary modifications, repurposed pharmaceuticals, and lifestyle adjustments, assessing their potential roles in cancer prevention and management. Emphasis is placed on evidence-based strategies that may complement traditional oncological approaches, aiming to provide a comprehensive understanding for clinicians and researchers. Diverse cancer hallmarks targeted by repurposed non-oncology drugs. This figure was created with Biorender.com. Source:  Nature 2024 Keywords: Alternative cancer treatments, complementary therapies, cancer, herbal supplements, integrative medicine, clinical evidence, oncology, cancer care, fenbendazole, mebendazole, ivermectin, vitamin D 1. Introduction Cancer remains one of the leading causes of morbidity and mortality worldwide. While conven...

Medically Reviewed by: OneDayMD Editorial Team Last Updated: April 2026 Abstract Background: Repurposed antiparasitic agents, including ivermectin and benzimidazoles (fenbendazole and mebendazole), have gained attention for their potential anticancer properties, particularly in colorectal cancer. Preclinical studies suggest these agents may exert antitumor effects through mechanisms such as inhibition of cell proliferation and disruption of key oncogenic pathways, including Wnt/β-catenin signaling. Objective: To summarize and evaluate a compilation of case reports describing the use of ivermectin and benzimidazole-based regimens in patients with colorectal cancer, with a focus on advanced-stage disease. Methods: This review analyzes a curated series of 56 case reports involving patients with colorectal or related gastrointestinal cancers treated with ivermectin in combination with fenbendazole or mebendazole, often alongside standard therapies such as chemotherapy. Reported outc...