The Medical Advisor

  Niacinamide is a precursor to NAD+ (nicotinamide adenine dinucleotide), a vital signaling molecule that’s believed to play an important role in longevity. In fact, the best single NAD+ precursor is niacinamide, and this is reason alone to educate yourself about its benefits, but niacinamide, also known as nicotinamide (NAM), is also valuable in its own right. Supplementation with NAM has been found to improve insulin sensitivity in models of human diabetes, for instance, and it also decreases oxidative stress and prevents fatty liver. 1  It also shows impressive promise for fighting obesity and associated diseases, including stroke, cardiovascular diseases, diabetes and certain cancers, which have reached epidemic levels worldwide. 2 But the key with NAM is that you need the right “Goldilocks” dose. The most common mistake people make is taking too much and thereby actually sabotaging any metabolic benefits. Niacinamide Reprograms Fat Metabolism, Ameliorates Obesity NAD+ mod...

The latest weight loss craze to hit Hollywood and beyond is semaglutide, more popularly known as Ozempic, the brand name of the drug marketed to improve blood sugar in people with Type 2 diabetes. Semaglutide is also known as Wegovy, which is prescribed to adults interested in weight loss. The weekly injectable drug is available only by prescription — and costs $1,349 a month (1) — but it’s in high demand among those looking to shed a few pounds. Note: Semaglutide is known by the brand names Ozempic, Wegovy, Rybelsus and others. New York dermatologist Dr. Paul Jarrod Frank told People, "It's the drug of choice these days for the 1%."(2) He says he can always spot users due to "Ozempic face," a gaunt appearance that can occur due to fat loss, which may make you appear older, particularly in the face. But this undesirable side effect is the least of your worries if you choose to use semaglutide. The blockbuster drug, slated to bring in more than $10 billion in ann...

Obesity and overweight affect increasing numbers of people, and for some, diet and exercise aren’t enough. A broad range of drug interventions can help. The  2023 report  from the World Obesity Federation estimates that the economic impact of overweight and obesity will surpass $4.3 trillion annually by 2035. In the U.S., the  CDC  reports the prevalence of obesity in adults was 41.9% measured from 2017 to March 2020. This represented an increase from 30.5% from 1999 to 2000. The estimated annual medical costs were roughly $173 billion in 2019 dollars. Prescriptions for semaglutide have doubled since mid-2021, rising to more than 1.2 million. In April 2023, a spokesperson for Novo Nordisk, maker of semaglutide, said the drugs are now available in pharmacies nationwide. Semaglutide is sold under the name Ozempic as a diabetes drug and under the name Wegovy as a weight loss prescription drug. Wegovy has recently boomed in popularity for its use to help people lose...