Ivermectin, Fenbendazole and Mebendazole Cancer Treatment Research

Ivermectin and Fenbendazole in Cancer Care: A Functional Medicine Breakthrough

As cancer diagnoses rise globally, the urgency for innovative, effective, and supportive therapies grows stronger. A peer-reviewed study has highlighted a groundbreaking protocol combining ivermectin, fenbendazole, and natural compounds such as Vitamin E, curcumin, and CBD. These elements, when used together, demonstrate significant potential in supporting cancer care. 

The Study: A Synergistic Approach to Cancer Care

The research reveals the combined effects of ivermectin, fenbendazole, and complementary compounds in addressing cancer at multiple levels. While traditionally known as antiparasitic drugs, ivermectin and fenbendazole, when used together, showed potential to modulate cancer pathways and support the body’s natural healing mechanisms.

Key Findings from the Study

1. Immune System Modulation: The protocol enhanced the immune system’s ability to detect and target cancer cells.

2. Cellular Repair: The combination supported cellular repair processes, mitigating damage that contributes to cancer progression.

3. Anti-Cancer Activity: Together, ivermectin and fenbendazole appeared to limit cancer cell proliferation, enhancing the effectiveness of the treatment protocol.

These effects were further amplified by the addition of Vitamin E, curcumin, and CBD, which are known for their anti-inflammatory, antioxidant, and immune-supporting properties. This synergy highlights the importance of combining multiple therapeutic elements to address the complexities of cancer biology.

Read the study here to explore the detailed findings.

The Hybrid Orthomolecular Cancer Protocol: 7 therapeutic recommendations, consisting of orthomolecules, drugs, and additional therapies

1. Intravenous Vitamin C 

Intermediate- and high-grade cancers: Dose of 1.5g/kg/day, 2-3x per week (Fan, et al., 2023). Established as a non-toxic dose for cancer patients (Wang, F., et al., 2019). 

2. Oral Vitamin D 

All cancer grades: Dose of 50,000 IU/day for patients with a blood level ≤ 30ng/mL; 25,000 IU/day for levels 30-60ng/mL; and 5000 IU/day for levels 60-80ng/mL. Established as a non-toxic dose (Cannon, et al., 2016; Ghanaati, et al., 2020; McCullough, et al., 2019). 

It is necessary to reach a blood level of 80 ng/mL of vitamin D (25-hydroxyvitamine D (25(OH) D) (Kennel, et al., 2010; Mohr, et al., 2014; Mohr, et al., 2015). This level is non-toxic (Holick, et al., 2011). Once this level is reached it must be maintained with a reduced daily dosage of ≈ 2000 IU/day (Ekwaru, et al., 2014). The vitamin D blood concentration should be measured every two weeks for high doses and monthly for lower doses. 

3. Zinc 

All cancer grades: Dose of 1 mg/kg/day is established as a non-toxic dose for cancer patients (Hoppe, et al., 2021; Lin, et al., 2006). The reference range for serum zinc concentration is 80 to 120 μg/dL (Mashhadi, et al., 2016; Yokokawa, et al., 2020). Once this level is reached it must be maintained with a reduced daily dosage of 5mg/day (Li, et al., 2022). The zinc blood concentration should be measured monthly.

4. Ivermectin 

• Low-grade cancers: Dose of 0.5mg/kg, 3x per week (Guzzo, et al., 2002). 
• Intermediate-grade cancers: Dose of 1mg/kg, 3x per week (Guzzo, et al., 2002). 
• High-grade cancers: Dose from 1 mg/kg/day (de Castro, et al., 2020) to 2 mg/kg/day (Guzzo, et al., 2002). 

All these doses have been established as tolerable for humans (Guzzo, et al., 2002). 

5. Mebendazole, Fenbendazole and DON (Anti-Glutamine)*

• Low-grade cancers: Mebendazole: Dose of 200 mg/day (Dobrosotskaya, et al., 2011). 
• Intermediate-grade cancers: Mebendazole: Dose of 400 mg/day (Chai, et al., 2021). 
• High-grade cancers: Mebendazole dose of 1,500 mg/day (Son, et al., 2020) or Fenbendazole 1,000 mg 3x per week (Chiang, et al., 2021). 

All these doses have been established as tolerable for humans (Chai, et al., 2021; Chiang, et al., 2021; Son, et al., 2020). Benzimidazoles can be replaced or combined with DON, administered without toxicity; intravenously or intramuscularly: 0.2 to 0.6 mg/kg once daily; or orally: 0.2 to 1.1 mg/kg once daily (Lemberg, et al., 2018; Rais, et al., 2022). Benzimidazole are much easier to obtain than DON. However, for metastatic cancers, which rely heavily on glutamine (Seyfried, et al., 2020), a combination of DON and Benzimidazoles should be considered (Mukherjee, et al., 2023). 

*DON (6-diazo-5-oxo-L-norleucine) is a glutamine-specific antagonist more potent than Benzimidazoles.

6. Dietary Interventions 

All cancer grades: Ketogenic diet (low carbohydrate-high fat diet, 900 to 1500 kcal/day) (Weber, et al., 2020). 

Ketone metabolic therapy consists of approximately 60- 80% fat, 15-25% protein and 5-10% fibrous carbohydrates. Adequate hydration and single-ingredient whole food ketogenic meals are necessary to achieve a glucose ketone index (GKI) score of 2.0 or below (Meidenbauer, et al., 2015; Seyfried, Shivane, et al., 2021). GKI should be measured 2–3 hours postprandial, twice a day if possible (Meidenbauer, et al., 2015; Seyfried, Shivane, et al., 2021). 

Intermediate- and high-grade cancers: The ketogenic diet should be coupled with a water fast for 3 to 7 consecutive days in advanced cancers (Phillips, et al., 2022; Arora, et al., 2023). The water fast should be repeated several times (≈ every 3-4 weeks) throughout the treatment (Nencioni, et al., 2018), but fasting needs to be undertaken cautiously in individuals using certain drugs and those with < 20 BMI, to prevent loss of lean body mass. 

For patients who can not fast, the FastingMimicking Diet (300 to 1,100 kcal/day of broths, soups, juices, nut bars, and herbal teas) can be used (Nencioni, et al., 2018). 

7. Additional Therapeutics 

All cancer grades: Moderate physical activity, 3x per week. Increased heart and respiratory rate for a period of 45 to 75 minutes (Bull, et al., 2020) with activities such as cycling, running, swimming, etc.

 

Intermediate- and high-grade cancers or individuals who are unable to engage in physical activity: Hyperbaric oxygen therapy (HBOT), 1.5 to 2.5 ATA for 45 to 60 minutes 2-3x per week (Gonzalez, et al., 2018; Poff, et al., 2015).

Notes:

No single drug is a miracle cure for all cancers. Taking a particular drug or adopting a particular protocol as a stand alone strategy cannot replace an unhealthy lifestyle i.e. heavy smoker, alcoholic, a very stressful and non-active lifestyle, overweight and obesity. All these cancer promoting factors need to be removed.

The best way to fight cancer is to utilise a menu of strategies by maintaining good health, like from eating a nutritious whole-food diet with lots of fruits and vegetables, avoid ultra processed foods and a healthy lifestyle. Each strategy might produce an incremental improvement in results for some cancers when added to existing treatment regimens.

Everyone’s situation is different, however, it is important to arm yourself with medical knowledge that cancer doctors (Oncologists) may simply not give you.

Whether you’re living with cancer or a survivor, talk to your doctor to determine the best treatment for you.

How Functional Medicine Supports Cancer Care

1. Immune Optimization: Strengthening the immune system is central to our functional medicine protocols. The study’s emphasis on immune modulation reflects the importance of this approach in cancer prevention and recovery.

2. Personalized Treatment Plans: We tailor protocols to each patient, incorporating research-backed therapies like ivermectin and fenbendazole alongside dietary changes, lifestyle adjustments, and advanced supplements.

3. Synergistic Interventions: Functional medicine thrives on integrative solutions. The study’s use of Vitamin E, curcumin, and CBD exemplifies how combining therapies enhances overall effectiveness and supports whole-body healing.

The Role of Complementary Compounds in the Protocol

The study’s protocol emphasizes the importance of complementary compounds, which work alongside ivermectin and fenbendazole to enhance therapeutic outcomes:

• Vitamin E: Reduces oxidative stress and protects cells from damage.
• Curcumin: Offers anti-inflammatory and antioxidant properties, with emerging evidence of its role in slowing cancer progression.
• CBD (Cannabidiol): Supports immune health, reduces inflammation, and alleviates pain.

Together, these elements create a comprehensive approach, addressing cancer at multiple levels while supporting the patient’s overall well-being.

Find Integrative Oncologists in USA, Mexico, Europe or Asia

While the potential anti-cancer properties of fenbendazole, ivermectin and mebendazole are intriguing, it’s crucial to approach with caution.

Consulting with an integrative healthcare expert is key to crafting a protocol tailored to your unique health requirements. 

To find integrative oncologists, check out "find integrative oncologists".

Conclusion

Ivermectin, Fenbendazole and Mebendazole offer promising, yet experimental, cancer treatment options.

While clinical trials remain limited, emerging studies suggest promising applications across multiple cancer types.

Patients should consult healthcare professionals before considering this protocol.

Read More: This article is part of the Winning the War on Cancer series.

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Joe Tippens Protocol Fenbendazole

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Integrative Medicine Expert Reveals Links Between Gut Health, Immunity, and Wellness - Dr Heather Moday

New & Improved Joe Tippens Protocol

In 2016, Joe Tippens was diagnosed with non-small-cell lung cancer with extensive metastatic disease. At the advice of a veterinarian friend, he took Fenbendazole together with nanocurcumin, and three months after starting these drugs his PET scan was completely clear.

Below is a modified version of the Joe Tippens protocol, a synergistic combination of fenbendazole, ivermectin and nutraceuticals, updated based on the ivermectin and mebendazole based protocol published in the Journal of Orthomolecular Medicine (2024):

• Ivermectin (24 mg, 6 days a week) or in the case of severe aggresive cancers up to 1mg/kg/day (6 days a week).
• Mebendazole (Dose of 200 - 400 mg/day) or Fenbendazole, commonly taken at 300 mg for six days a week, with doses increasing to up to 1 gram in cases of aggressive cancers.
• Vitamin D (62.5 mcg [2500 IU] seven days a week).
• Bio-Available Curcumin (600 mg per day, 7 days a week). 
• Enhanced absorption Berberine (500 mg per day) to starve your cancer of sugar.
• Diet and Lifestyle: Eliminate sugar consumption as supported by the BMJ 2023 umbrella review, which recommends reducing free and added sugars to below 25 g/day and limiting sugar-sweetened beverages to less than one serving per week to reduce adverse health effects. Adopt a whole-food diet and avoid ultra-processed foods, as recommended by the BMJ 2024 guidelines. Additionally, prioritise adequate quality sleep and effective stress management to support overall health.

*Notes:

• Please note that this protocol now includes the vital Vitamin D addition, with the one day off for the fenbendazole administration. This protocol represents the most comprehensive and cutting edge repurposed drug and vitamin treatment approach to date.
• If you are taking ivermectin and mebendazole, you might not need fenbendazole. Consult your doctor.
• Vitamin E: Removed from the protocol (Joe Tippens, July 22, 2020) due to interactions (e.g., with blood thinners).

The Wellness Company's Ivermectin and Mebendazole

Ivermectin and mebendazole, both approved for human use, are now available in the U.S.

Researched and approved by Dr. Peter McCullough.

• Prescribed by licensed medical professionals
• Compounded and dispensed by a licensed US-based pharmacy
• Approved for human use

Where to buy Ivermectin and Mebendazole Formula: Available on The Wellness Company's website. Here is the link: Ivermectin and Mebendazole.