Fenbendazole, Ivermectin and Mebendazole for Colorectal Cancer: 35 Case Reports Compilation (October 2025 Edition)

Introduction

The potential applications of Ivermectin and Benzimidazole (Fenbendazole and Mebendazole) in cancer treatment have sparked significant interest online, with growing communities exploring these compounds for therapeutic use. While both have roots in anti-parasitic medicine, emerging research and anecdotal evidence suggest they may offer benefits in combating colorectal cancers.

The main goal with this article is to provide as much clear information as possible for someone dealing with colorectal cancer. This article deals with the basis and practical approach to using Fenbendazole and Ivermectin for colorectal cancer.

Can Fenbendazole and Ivermectin play a key role in treating Stage 4 Colorectal Cancer?

Several peer-reviewed papers and case studies (below) strongly suggest that it might:

Ivermectin, Fenbendazole and Mebendazole in Cancer: 2024 Peer-Reviewed Protocol in Cancer

Ivermectin and Cancer: 15 Anti-cancer Mechanisms of Action

Fenbendazole and Cancer - 12 Anti-Cancer Mechanisms of Action

AI Predicts Ivermectin and Mebendazole Multimodal Protocol Improved Overall Survival in Non-Mutated, Microsatellite Stable Stage 4 Colorectal Cancer

Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth

Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway

Ivermectin: A Promising Avenue for Research

Ivermectin, a widely used antiparasitic medication, has been the subject of preclinical studies investigating its potential role in cancer treatment. However, there is a notable lack of published clinical research. To support further exploration, we have compiled and categorized case reports by cancer type, providing a centralized resource for researchers and individuals interested in its potential applications. Despite its promise, it is critical to consult with qualified medical professionals before considering any treatment involving Ivermectin.

In 2021 (Zhou et al) - The study results demonstrated that ivermectin dose-dependently inhibited colorectal cancer cell growth, suggesting that ivermectin might be a new potential anticancer drug therapy for human colorectal cancer and other cancers.

Ivermectin also blocks WNT* pathway (one of the main drivers of colon cancer spread) (Loftalizadeh et al, 2022).

*The term "Wnt" in Wnt pathway is a combination of two words, "Wingless" and "int", derived from the name of a gene identified in the fruit fly Drosophila (Wingless) and a gene found in mouse mammary tumors (int-1).

Ivermectin dosage for Cancer in Humans

Fenbendazole: From Parasites to Cancer Therapy

Fenbendazole, often referred to as FenBen, is a broad-spectrum anthelmintic initially developed to eliminate a variety of parasites in animals and humans. It is effective against roundworms, hookworms, whipworms, giardia, and certain tapeworms, among others, and is commonly sold under brand names like Panacur, Panacur C, and Safe-Guard. Beyond its antiparasitic properties, Fenbendazole has gained attention in cancer treatment through the "Joe Tippens Fenbendazole Protocol." Though first introduced in 1961, its potential anti-cancer properties were identified in 2009 during a glioblastoma (GBM) study at Johns Hopkins University. Since then, case reports have suggested Fenbendazole's effectiveness in treating various cancers, including lung, liver, kidney, breast, prostate, melanoma, colon, ovary, bone, and brain tumors.

Fenbendazole, while similar in safety and efficacy to Mebendazole, is not FDA approved for use in humans. Mebendazole plays a crucial role in blocking cancer metabolism through lactate suppression and WNT pathway inhibition (induces TNIK degradation, blocking Wnt/β-catenin signaling in colorectal cancer). (source)

Note: In everyday conversations within the fenbendazole communities, you might encounter Fenbendazole referred to as Phenbendazole, Panacur or SafeGuard. This interchangeability is representative of the common use of the trademarked name; it signifies a consensus within these circles that these terms denote the same medication. Fenbendazole is the active ingredient in all these products. Molecular formula for fenbendazole is C15H13N3O2S.

Fenbendazole dosage for Cancer in Humans

Fenbendazole and Ivermectin Colorectal Case Series Compilation

We have compiled a list of fenbendazole and/or ivermectin and colorectal cancer case reports below.

This compilation features several case reports involving the use of ivermectin and fenbendazole or mebendazole (benzimidazole) for colorectal cancer and related intestinal cancer such as appendix cancer.

Case 35 - 2025: 79 year old Michigan man with Stage 4 Colon Cancer metastatic to peritoneum

Dr. William Makis shared on X.com in October 2025:

IVERMECTIN and MEBENDAZOLE Testimonial - 79 year old Michigan man with Stage 4 Colon Cancer metastatic to peritoneum has a great response after only 2 months!

The combination of Ivermectin + Mebendazole + chemo is extremely powerful. STORY: 79 year old Michigan man with Stage 4 Colon Cancer that was extensively metastatic to the peritoneum. In August and September he took:

• Ivermectin
• Mebendazole
• Chemo 2 cycles

Result: CEA dropped from 304 to 37. He had no side effects and his liver enzymes remained normal. "Ivermectin significantly enhanced the anti-cancer efficacy of chemotherapeutic drugs to tumor cells, especially in the drug-resistant cells." "Thus, ivermectin, a FDA-approved antiparasitic drug, could potentially be used in combination with chemotherapeutic agents to treat cancers and in particular, the drug-resistant cancers" (2019 study in Journal of Experimental & Clinical Cancer Research by Lu Jiang) It makes absolutely no sense to do any kind of chemo without Ivermectin + Mebendazole (or Fenbendazole). This should be the new gold standard of care.

Case 34 - 2025: 47 year old Washington woman with Stage 4 Appendix Goblet Cell Cancer reports

Dr. William Makis shared on X.com in October 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 47 year old Washington woman with Stage 4 Appendix Goblet Cell Cancer reports after 4 months

Appendix cancers can be very aggressive and difficult to deal with but many of them respond to Ivermectin and Fenbendazole combination STORY: 47 year old Washington woman with Stage 4 Appendix Goblet Cell Cancer At start of June 2025 she started:

• Ivermectin 1.0mg/kg/day increasing to 1.5mg/kg/day
• Fenbendazole 1776mg/day

Results after 4 months: CA125 dropped from 500+ to 9. Her Tumors are shrinking. She is having difficulty handling chemotherapy and this is what we sometimes encounter, the chemo is so toxic that patients have severe chemo side effects.

Case 33 - 2025: 49 year old South Carolina woman with Stage 4 Colorectal cancer metastatic to liver

Dr. William Makis shared on X.com in October 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 49 year old South Carolina woman with Stage 4 Colorectal cancer metastatic to liver reports after 5 months, tumors almost completely gone!

Another amazing success story!

49 year old South Carolina woman with Stage 4 Colorectal cancer metastatic to liver On April 22, she started Ivermectin 60mg and Fenbendazole 888mg and gradually increased the Fenbendazole dose to 1554mg. Her Oncologist started chemotherapy on April 28. We often see a synergy with Ivermectin + Fenbendazole + Chemo where the tumor shrinkage is dramatic and much more pronounced than chemo alone. MRI after 5 months: "further response to therapy with only 2 tiny 5mm foci within the liver currently" "significant decrease in bulk and extent of the known sigmoid mass" "significant improvement in the masslike fistulization/extension into the mid rectum...previously identified tumor invasion into myometrium also appears significantly decreased"

Case 32 - 2025: 48 year old Philippine man (husband of a physician) with Stage 4 Appendiceal Adenocarcinoma*

*Both appendix cancer and appendiceal cancer refer to the same condition—a rare malignancy originating from cells in the appendix, a small pouch attached to the large intestine.

Dr. William Makis shared on X.com in September 2025:

IVERMECTIN and MEBENDAZOLE Testimonial - 48 year old Philippine man (husband of a physician) with Stage 4 Appendiceal Adenocarcinoma has dramatic results after 2 months!

From half-way around the world, cancer patients have much better results than the biggest Cancer Centers in the United States or Canada can provide!

Do you know why? There is no fighting over who gets to have a "right to try" and who doesn't. "Right to try" is a given. It's automatic. You don't need anyone's "permission". 48 year old Philippine man (husband of a physician) with Stage 4 Appendiceal Adenocarcinoma, terminal condition. "My husband has appendiceal mucinous adenocarcinoma with numerous carcinomatosis on palliative care. Currently we are admitted at the hospital" We've been working together for 2 months: "All the doctors are amazed of his recovery. He is now able to tolerate food after 1 month on TPN, obstruction seems to be resolving..."

Case 31 - 2025: 34 year old man from Slovenia with Stage 4 Colon Cancer

Dr. William Makis shared on X.com in September 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 34 year old man from Slovenia with Stage 4 Colon Cancer reports after 3 months: CEA 679 to 10, up to 50% tumor shrinkage after starting!

I just shocked an Oncologist in former Eastern Europe. Those of you who know me, know I love to do this to Mayo Clinic and MD Anderson Oncologists.  But I have to be careful as their hearts are full of spike protein.... 34 year old man from Slovenia with Stage 4 Colon Cancer In early June 2025, he started Ivermectin and low dose Fenbendazole (444mg) RESULTS after 3 months: CEA 679 to 10 CA19-9 1941 to < 35 (Normal) Liver metastases shrunk up to 50% Possibly a surgical candidate again after given < 1% chance by his Oncologist “My doctor said she has only seen such a good response in the literature, but never with her own eyes” “Now they say I am one of those “extremely rare cases”” NEVER WITH HER OWN EYES. Oncologists can't believe the results and I will tell you why. Ivermectin and Fenbendazole are chemosensitizers! They sensitize tumors to chemo This results in RAPID and EXTENSIVE Cancer cell killing once chemo is introduced. Here is a sample of peer reviewed literature: "Ivermectin enhanced efficacy of paclitaxel..." "Ivermectin augments efficacy of cisplatin..." "Ivermectin strengthens paclitaxel effectiveness..." "Novel strategies to reverse chemoresistance in colorectal cancer..." From the patient: "I feel really good, I am very active. I am able to go hiking or running the same day when I get unplugged from 5FU, it has no effect on me." "I think this whole protocol is really working, with killing tumors, with overall immunity and mood, all the supplements support chemotherapy amazingly".

Case 30 - 2025: 49 year old woman from Slovakia with Stage 3 Rectal Cancer

Dr. William Makis shared on X.com in September 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 49 year old woman from Slovakia with Stage 3 Rectal Cancer sees improvement in 2 months and is eligible for surgery.

Another success from the world's largest Ivermectin Cancer Clientele: STORY: 49 year old woman from Slovakia with Stage 3 Rectal Cancer In early June 2025 she started Ivermectin and Fenbendazole. Results after 2 months: "I am very happy because thanks to your protocol I have a lot of energy for myself and my family, I am able to function and even do sports" "The tumor has shrunk from 12mm to 7mm, the lymph nodes from 5mm to less then 3mm" Two months of Ivermectin and Fenbendazole can mean the difference between containing and shrinking a Stage 3 operable Cancer versus progressing to Stage 4 inoperable metastatic disease. “even the surgeon does not recommend radiotherapy but surgery as soon as possible.” The earlier a cancer patient gets on Ivermectin and Fenbendazole, the better. Time is always major factor.

Case 29 - 2025: Stage 4 Colon and Gastric Cancer patient

Dr. William Makis shared on X.com in September 2025:

IVERMECTIN, FENBENDAZOLE and METHYLENE BLUE Testimonial - Stage 4 Colon and Gastric Cancer patient with 12-19 months to live, is now Cancer Free!

I received a short email today that made me very happy. "In September 2022, I was diagnosed with Stage 4 Colon & Gastric Cancer and given 12-19 months to live. My Oncologist recommended surgery, chemo, radiation" "Instead, I took another path" "in April 2024, I was cancer free" 

Still cancer free as of September 2025.

"You've helped more people than you'll ever know. I'm living proof".

Case 28 - 2025: 59 year old Canadian woman with Stage 4 Colon Cancer metastatic to liver and lymph nodes

Dr William Makis shared on X.com in July 2025 (source):

IVERMECTIN and FENBENDAZOLE Testimonial - 59 year old Canadian woman with Stage 4 Colon Cancer metastatic to liver, lymph nodes, reports after 1.5 months.

Colon Cancer has not been easy to deal with. Some cases respond very well and some don't. We still have a lot of work to do here. STORY: 59 year old Canadian woman with Stage 4 Colon Cancer metastatic to liver, lymph nodes. In mid April 2025 we started:

• Ivermectin 1.5mg/kg/day
• Fenbendazole 1500mg/day
• CBD Oil 100mg/day

Results after 1.5 months “aggregate size of her tumors had shrunk in excess of 20%” "Our Oncologist was thrilled..."

Case 27 - 2025: 57 year old Florida man with Stage 4 Rectal Cancer to liver 

Dr William Makis shared on X/Twitter in July 2025 (source):

IVERMECTIN and FENBENDAZOLE Testimonial - 57 year old Florida man with Stage 4 Rectal Cancer to liver (post 2 Pfizer COVID-19 Vaccines) reports after 5 months: 100% resolution of liver metastases!

57 year old Florida man with Stage 4 Rectal Cancer to liver (post 2 Pfizer COVID-19 Vaccines)

In Mid Jan.2025 we started: 

• Ivermectin 1.5mg/kg/day 
• Fenbendazole 1000mg/day 
• CBD Oil 100mg/day 

Results (after 5 months) 

Liver metastases (largest 4.7cm) resolved completely (100% resolution) !! 

From patient: 

"I am writing to you in utter shock" 

"You are an incredible man that is saving lives and giving people hope and courage." 

This time we helped out the Cleveland Clinic and Moffitt Cancer Center. 

Case 26 - 2025: 61 year old Florida man with Stage 4 Appendix Cancer

Dr William Makis shared on X/Twitter in June 2025 (source):

IVERMECTIN and MEBENDAZOLE Testimonial - 61 year old Florida man with Stage 4 Appendix Cancer has an incredible response after only 2 months! 68% tumor volume reduction We help cancer patients who have all types of rare cancers. Here is a success story with a Primary Appendix Adenocarcinoma. 61 year old Florida man with Stage 4 Primary Appendix Adenocarcinoma, metastatic to peritoneum and omentum. In early March 2025 we started:

• Ivermectin 1.5mg/kg/day 
• Mebendazole 1500mg/day

Oncologist started chemo and immunotherapy. RESULTS after 2 months on PET/CT: “Decreased size with significant decrease in metabolic activity of the omental and bilateral peritoneal lymphadenopathy.” “Index omental lesion in the midline anterior abdomen extending through and in the umbilicus into the skin surface now has an SUV max of 2.06, previously 8.4” “Index implant medial to the inferior aspect of the spleen now has an SUV max of 2.4, previously 5.3” “Left upper quadrant peritoneal implant adjacent to the ascending colon now measures 1.1 cm with SUVmax 1.38. This lesion previously measured 1.6 cm with SUV max 8.02” (68% tumor volume reduction - Grok 3) It's incredibly difficult to achieve results like this with chemotherapy and immunotherapy alone. Peritoneal metastases are very hard to treat, you simply never see these kinds of results.

Related: Adan Canto: X-Men and Designated Survivor star dies of appendix cancer at 42 (Epoch Times)

Case 25 - 2025: Male with stage 4 colon cancer which had spread to his liver

@doringtoon shared on X/Twitter in July 2025 (source):

My wife's cousin was diagnosed with stage 4 colon cancer which had spread to his liver. Treatment included chemo but also Ivermectin (dosage sounds like 24mg for 4 days every 3 weeks). Post-chemo scan this past Saturday - no sign of any cancer at all.

Case 24 - 2025: 35 year old UK woman with Stage 4 Colorectal Cancer and metastatic to lungs

Dr William Makis shared on X/Twitter in June 2025 (source):

Ivermectin and Fenbendazole Testimonial - 35 year old UK woman with Stage 4 Colorectal Cancer metastatic to lungs has improvement after 2.5 months! 

STORY: 35 year old UK woman with Stage 4 Colorectal cancer metastatic to lungs, came to me in early March 2025.

We Started:

• Ivermectin 1mg/kg/day
• Fenbendazole 1000mg/day
• MCP 15g/day (Modified Citrus Pectin)

RESULTS after 2.5 months: Sometimes we get a “mixed response”, where most findings are improving but one or two seem to be getting worse. In this case, most lung nodules improved but one got a bit worse:

• RUL 5mm to 3.5mm (66% volume reduction)
• RLL 6mm to 5mm (42% reduction)
• LUL 5mm to 4mm (49% reduction)
• RLL 22 to 24.7mm 

Although it is possible that one nodule actually got worse while all others improved, this worsening could also be due to inflammation. This is where a PET/CT scan would be very helpful in giving us metabolic information on the metastases. However, in countries like the UK, PET/CT is much harder to get. Same in Canada.

Case 23 - 2025: 62 year old USA man with Stage 4 Colorectal Cancer has recurrence after 6 years in remission

Dr William Makis shared on X/Twitter in May 2025 (source):

IVERMECTIN and FENBENDAZOLE Testimonial - 62 year old USA man with Stage 4 Colorectal Cancer has recurrence after 6 years in remission, has fantastic results on Protocol + Radiation (no chemo) What happens where there is no chemo? STORY: 62 year old USA man had been battling Colorectal Cancer since 2018. After chemo, radiation and surgery he was in remission until late 2024 when extensive recurrence was diagnosed. We started in mid March 2025:

• Ivermectin 1mg/kg/day
• Fenbendazole 1000mg/day
• He also had Radiation Therapy but no chemo

RESULTS after 1.5 months: Coloanal anastomosis mass 5.0x4.0cm shrunk to 1.8x1.3cm (96% tumor volume shrinkage) Perineal mass 5.0x4.0cm shrunk to 3.0x2.7cm (74% vol shrinkage) IVERMECTIN and FENBENDAZOLE are RADIOSENSITIZERS and there are at least two papers that support this hypothesis: 2020 Mudassar et al - Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas.

2019 Le Zhang et al - Mebendazole Potentiates Radiation Therapy in Triple-Negative Breast Cancer.  "Mebendazole sensitizes Triple Negative Breast Cancer cells to ionizing radiation in vitro and in vivo, resulting in improved tumor control in a human xenograft model of TNBC" How can tumors shrink up to 96% with no chemo? Shouldn't be possible, according to modern Oncology.

Case 22: 64 year old female with Stage 3B Colon Cancer with no chemotherapy

Dr William Makis shared on X/Twitter in May 2025 (source):

IVERMECTIN and MEBENDAZOLE Testimonial - 64 year old woman with Stage 3B Colon Cancer did not want chemo, and was declared "Cancer Free" 3 months later!

Oncologists will push chemo on you in vast majority of cases but do you always need it? 

This patient didn't think so. 

A 64 year old patient with Stage 3B Colon Cancer had surgery in January 2025 which found involvement of two lymph nodes. After surgery she was also found to have a suspicious lung nodule on CT. Possibly Stage 4. 

We started on Feb.27, 2025: 

• Ivermectin 1.0mg/kg/day 
• Mebendazole 1000mg/day 

RESULTS (May 20, 2025):

 
"I had my appointment with my oncologist today. After reviewing my second Signatera test and my PET results, he pronounced me "CANCER-FREE!" 

"Even though he had recommended chemo, he was aware that I had chosen an alternative protocol using repurposed drugs...and he supported me in my decision" 

And the best part:
 "I cannot begin to adequately express my heartfelt gratitude for your expertise and dedication in helping successfully fight cancer for patients such as me. Truly, you have made a life-altering impact, in the best of ways, for me and my family" 

Cancer Free. Avoided chemo. Oncologist supported patient's decision.

Case 21: 52 year old California man diagnosed with Stage 4 Colon Cancer metastatic to liver and lung

Dr William Makis shared on X/Twitter in May 2025 (source):

IVERMECTIN and FENBENDAZOLE Testimonial - 52 year old California man diagnosed with Stage 4 Colon Cancer metastatic to liver and lungs has a dramatic response on PET/CT after only 2 months!

Another wonderful cancer success story! Sometimes patients come to me as soon as they're diagnosed. And we get to work right away! 

STORY: 52 year old California man was diagnosed with Stage 4 Colon Cancer metastatic to liver and lungs on Jan.3, 2025. 

We started in late January 2025:

• Ivermectin 1.5mg/kg/day
• Fenbendazole 888mg/day

Oncologist started: mFOLFOXIRI 

RESULTS on PET/CT (after 2 months): 

Rectal Primary Tumor: SUV* 27.76 to SUV* 5.89 (“almost complete response”)

 
Liver metastases:

• SUV 8 to 4.63 
• SUV 8.9 to 5.11 SUV 8.8 to 3.55 
• SUV 7.77 to 4.35 
• SUV 7.24 to 3.24 
• Right Inguinal nodes  SUV 3.35 to 1.6 
• Left Inguinal nodes SUV 4.18 to 2.15 

MY TAKE…For now, I’m mostly sharing results obtained after 2 or 3 months of Ivermectin and Fenbendazole or Mebendazole. Why? 

It takes 2-3 months to start seeing results on imaging scans. 

In this case, there was a very impressive metabolic response on PET/CT after only 2 months, which indicates cancer cell killing happening before the tumors start shrinking. 

On a CT, many of these lesions would still appear to be the same size after 2 months, but on PET/CT most metastases show a drop in metabolism by over 50% with the rectal primary showing a drop of 80%. 

You will notice in these stories that the patients are described as feeling great, and doing “better” than similar patients who are strictly following their Oncologist’s advice and not taking Ivermectin or any other repurposed drugs. 

“They can’t explain why he is doing much better than all the other patients”

*Note: SUV in PET scans stands for 'Standardized Uptake Value'. It's a semiquantitative measurement that indicates the concentration of a radiotracer, like FDG (fluorodeoxyglucose), in a specific area of a PET scan image. Essentially, it measures how much of the radioactive substance is absorbed by a particular tissue or organ, relative to the total amount injected. SUV reflects the metabolic activity of tissues and organs. Higher SUV values generally indicate increased metabolic activity, which can be associated with various conditions, including cancer, infection, or inflammation.

Case 20: 52-year-old Colorado patient with Stage 4 Colorectal cancer

Dr William Makis shared on X/Twitter in May 2025 (source):

IVERMECTIN and FENBENDAZOLE Testimonial - 52 year old Colorado patient with Stage 4 Colorectal cancer almost completely clears his cancer. Oncologist said there was only 1% chance of this outcome!! What an incredible story this is!! Sometimes, patients take matters into their own hands, use my Ivermectin protocols and have huge success that completely floors their Oncologist. 

STORY: This 52 year old Colorado patient with Stage 4 Colon Cancer did something incredible. His CEA peaked at 1700! I have rarely seen a number this high. He was progressing rapidly. He took 160mg Ivermectin and 1000mg Fenbendazole along with his 13 rounds of chemo. His CEA went from 1700 to 4 and his CT showed complete resolution of Colon tumor and almost complete resolution of liver metastases. His Oncologist said it was 1% chance of getting these results!! He has been on Ivermectin & Fenbendazole for 11 months (160mg IVM & 1000 Fenben).

We are now working together to get him to “CANCER FREE”. 

From the patient: 

"My CEA numbers jumped to 1700 and my oncologist urged me to start chemo. Around the same time found you on X and have been following your recommendations for my body weight"

"I have had 13 rounds of chemo while continuing your protocol and my numbers have dropped to 4!!! My CT scans have came back with no detectable tumor in my colon and only a couple small spots in the liver" "He can't comment or discuss anything not approved by the FDA. He did not expect these results at all!!! He gave me a 60% chance of having any response at all, just to slow it down" 

"I was told that I had a very low chance of chemo getting me down to these number and here I am. He told me at 1% get down to CEA 4 with my diagnosis"

Case 19: 52-year-old Arizona female with Stage 4 Rectal Cancer with liver metastases.

Dr William Makis shared on X/Twitter in May 2025:

IVERMECTIN and FENBENDAZOLE Protocol - 52 year old Arizona patient with Stage 4 Rectal Cancer responds dramatically after 3 months! 

This patient discovered our world's first published Ivermectin and Fenbendazole Cancer Protocol, and started on their own! 52 year old woman was diagnosed with Stage 4 Rectal Cancer with liver metastases. She started the Protocol in our peer-reviewed paper but then she came to me for fine-tuning. 

For two months we did: 

• Ivermectin 84mg/day 
• Fenbendazole 1500mg/day 
• 108mg CBD Oil 

RESULTS: 

CEA dropped from 25.3 to 7.9 (70% drop!) Next step in these cases is always imaging follow-up, ideally PET/CT but CT with contrast works as well. 

From the patient: 

"We were very happy seeing CEA levels drop dramatically".

Case 18: 58-year-old male diagnosed with metastatic colon adenocarcinoma with liver metastasis, resistant to conventional treatments

Aydin et al (Frontiers in Oncology 2024) - Case report: Precision guided reactive cancer management: molecular complete response in heavily pretreated metastatic CRC (Colo-Rectal Cancer) by dual immunotherapy and mebendazole.

• Nivolumab (anti-PD-1) was given at a monthly dose of 400 mg, 
• Ipilumab (anti-CTLA-4) was administered every two months at a dose of 50 mg, 
• Lenvatinib (Lenvima) was prescribed at a daily dosage of 10 mg, and 
• Mebendazole was used twice daily at a dose of 100 mg each time.

Case 17: 6-year-old Canadian Man with Stage 4 Neuroendocrine Cancer of small bowel

Dr William Makis shared on X/Twitter in April 2025:

IVERMECTIN and MEBENDAZOLE Testimonial - 63 year old Canadian Man with Stage 4 Neuroendocrine Cancer of small bowel has great response after 1 month! I'm often told that chemo does all the work, not the repurposed drugs. 

Well then, here is a NO CHEMO, NO RADIATION testimonial! 63 year old Canadian Man with Stage 4 Neuroendocrine Cancer of small bowel metastatic to liver and pancreas. 

Came to me a couple of months ago: 

5 weeks of Ivermectin 48mg and Mebendazole 500mg daily. 

No chemo. No radiation. 

RESULTS on CT: 

Smallest tumors will shrink the fastest: 

10mm to 3mm is 97.3% volume shrinkage 

16mm to 12mm doesn’t seem like that much but it is 58% shrinkage 

23mm to 19mm is 44% shrinkage 

36mm to 32mm is 30% shrinkage. 

This is very impressive for such a short period of time with no conventional therapy! No chemo. No rad.

From Patient: 

"Using volume reduction the tumors shrinkage was between 30% and 97%!! I hope to report more good news to you in the future" 

This is why I design my protocols for 3 months, the smallest tumors will often shrink significantly enough to be seen on CT as shrinking, or will disappear altogether! The largest tumors can take a bit longer and sometimes they appear “stable” or “unchanged” even when many of the cancer cells have died. That's why PET/CT is a much superior follow-up imaging modality as it will also show the metabolic activity of the tumors. Wasn't an issue here, all tumors shrunk 30% up to 97%.

Case 16 - 2025: 57 year old man with Stage 4 Colorectal Cancer

Dr William Makis shared on X/Twitter in April 2025:

IVERMECTIN and MEBENDAZOLE Testimonial - 57 year old man with Stage 4 Colorectal Cancer (TURBO CANCER) sees dramatic improvement in 3 months! CEA* drops from 96 to 3.3, liver metastasis shrinks 88%

Today's Ivermectin success story is Stage 4 Colorectal Cancer.

STORY: 57 year old man with Stage 4 Colorectal Cancer metastatic to liver "my beloved husband is 57 years old and just diagnosed with Stage 4 Colon and liver cancer. A doctor told us he is inoperable and incurable...the only thing i can attribute this to is that stupid vaccination"

They reached out to my Ivermectin Cancer Clinic in January 2025 He started 120mg Ivermectin and 1000mg Mebendazole on Jan.13, 2025, along with chemo on Jan.19, 2025. After exactly 3 months:

CEA dropped from 96 to 48 to 16.9 to 7.1 to 5.0 to 3.3 (normal)

“Oncologist was extremely surprised” by the dramatic drops in CEA. 3.6cm Liver segment II metastasis shrunk to 1.8cm (87.5% shrinkage in tumor volume, according to Grok-3)

Always look for the Oncologist’s surprised reactions which will tell you what can be attributed to the chemo and what can be attributed to Ivermectin, Fenbendazole or Mebendazole.

*Note: The CEA (CarcinoEmbryonic Antigen) is a marker often used to monitor certain cancers (like colorectal or breast cancer), but it can also rise due to inflammation, infections, or other non-cancerous conditions. At times, cancer cells breakdown or immune activation could also cause a transient elevation in markers like CEA before they normalize.

Case 15: Stage 4 Rectal Cancer patient (small cell Neuroendocrine) with metastases to the liver and bones (April 2025)

Dr William Makis shared on X/Twitter:

IVERMECTIN and FENBENDAZOLE Testimonial - Stage 4 Rectal Cancer patient (small cell Neuroendocrine) with metastases to the liver and bones has a dramatic response to therapy!

"My mother has Stage 4 Colorectal Cancer - spread to liver and bones. Please help us! Dear Dr.Makis, a friend from work told me about your protocol using Fenbendazole and Ivermectin. My mother is in the hospital and I'm afraid for her life".

Let's say I made a few small suggestions. 

And not even 3 months later:

"We received some incredible news from her oncologist. The doctor said the scans were AMAZING! He is very, very happy. The tumor has shrunk more than half and changed density for the better. The liver and all the other places it was going are practically undetectable"

And of course my favorite part:  "We are overwhelmed with gratitude for this progress, especially after being told this cancer was likely terminal. Your protocol has given us both hope and healing, and we thank God for leading us to you." These beautiful emails fill my heart with joy.

Small Cell Cancer like this is much more aggressive than its Colorectal adenocarcinoma counterpart and chemo response isn't all that great.

Unless you add repurposed drugs.

• Ivermectin 80mg/day
• Fenbendazole 888mg/day

Initially, she had started with Ivermectin 24mg and Fenbendazole 444mg. I use higher doses and have higher rates of success than anyone else!

Case 14: 84-yr-old Colon Cancer patient

Dr William Makis shared on X/Twitter (Dec 2024):

"IVERMECTIN and FENBENDAZOLE Testimonial - 84 year old Colon Cancer patient from Argentina "essentially on his deathbed" sees significant improvement with low doses!" 

"I am from Argentina...My father is very ill; he is bedridden and weak at 84 years old, and he may have colon cancer. He has received the COVID Vaccine five times" (Turbo Cancer?) 

"Refuses to go to the hospital because he is so weak and is essentially on his deathbed." 

"I gave him 500mg of Fenbendazole once, along with a very low dose of 12mg of Ivermectin, and he showed significant improvement" 

"Please continue your important work; you are making a difference" 

"I am sharing this because it is a reminder that even in the most dire situations, you can have a significant impact on someone’s quality of life! Don’t underestimate the impact that Ivermectin and Fenbendazole can have, even in the short term."

Case 13: Female with Stage 4 Colon and Liver Cancer

source: https://substack.com/home/post/p-155091883

Case 12: Male with Rectal Tumor

source: https://substack.com/home/post/p-155091883

Case 11: Stage 3 rectal cancer (Nov 2024)

Dr William Makis shared a testimonial of stage 3 rectal cancer on lower dose of ivermectin: 

IVERMECTIN Testimonial - Stage 3 Rectal Cancer responds incredibly to lower dose of Ivermectin! 

90% drop in CEA after Oncologist said "don't take Ivermectin" and patient did the opposite God bless all of you who share your success stories with me! 

Sometimes, a low dose of Ivermectin works! 24mg/day in this case is a relatively low dose but it worked. It worked without chemo, and then it worked with chemo! A 90% CEA drop!

Case 10: Stage 4 Colorectal Cancer with liver metastases (Oct 2024)

A success case study from Dr William Makis (X/Twitter)

IVERMECTIN & FENBENDAZOLE Testimonial in Stage 4 Colorectal Cancer with liver metastases - Patient in his 60s - dropping CEA and chemo side effects disappear completely! 

Sometimes a patient is taking chemotherapy when I get consulted for assistance. So when I suggest a high dose Ivermectin and Fenbendazole Protocol, it comes with two confident predictions: 

1. You’ll have a better outcome than chemo alone 

2. You’ll have less chemo side effects 

Sometimes cancer patients give me a look. It's that "are you sure?" Look. And I just smile. Because I get to see testimonials like this. And I absolutely love seeing it! And yes, within a month we had the CEA levels dropping like a rock too...

Case 9 - 2024: Advanced Colorectal Cancer (October 2024) 

Case study from Dr William Makis (X/Twitter)

IVERMECTIN and FENBENDAZOLE in Advanced Colorectal Cancer.

Another great testimonial.

We can see results as early as 3-4 weeks on bloodwork.

Case 8: February, 2023

Praise report: His colonoscopy ( her husband) is done and the doctor said not even 1 polyp! He said he won’t need to see him for 3 years. we feel beyond blessed and will continue the low dose maintenance fenben protocol. I just want to express how grateful I am to have found this group ( and all the amazing support that comes along with it! You are all amazing and in my daily prayers!

Case 7: Stage IV colon cancer (January, 2023)

Success story! My husband had stage IV colon cancer detected from first colonoscopy at age 50. He is a very disciplined ex- Marine and once he wrapped his head around the fact that he had cancer and his health was in his control he HIT IT as hard as he could from all angles and it has thus far worked!

He is NED 8 months after initial diagnosis. I have snippets of what he did to get to NED from stage IV colon cancer. We continue to change the protocols as we learn from everyone, as well as other sources. Best wishes to everyone!

Case 6: Inoperable colon cancer. Wild type KRAS but BRAF mutated. Positive for CDX2 CK20 Negative CK7.

I was diagnosed on the 13th sept 2018 with inoperable carcinoma colon cancer. Wild type KRAS but BRAF mutated. Positive for CDX2 CK20 Negative CK7.

I was give a bleak 12-18 months with the hope of making it through Christmas 2018. I was offered palliative chemotherapy for end of life pain management, but decided to start taking a number of alternative methods alongside the palliative chemotherapy and continued to take until I finally reached remission.

What I took to get to remission after palliative chemo was all on offer (palliative chemo finished on the 25th March 2019).

Scott Davis protocol –
– 2000 mg cbd oil 4 capsules (18-20 drops) x a day 🌱
– THC oil 4 capsules (18-20 drops) x a day (feco 1:1 mct) 65-75% thc. 🌱 I do this ‪‪at 08:00- 12:00‬‬ – ‪‪16:00 – 20:00‬
– Milk thistle twice a day. (2000mg)💊
– Vitamin d3 twice a day. (4000iu)💊 – Curcumin twice a day. (4000mg)💊
– Vitamin c once a day. (1000mg)💊
– Vitamin b12 once a day 💊
– Cod liver oil. 💊
– Vitamin e once a day 💊
– Berbine. (1000mg) x 2💊
– B17 apricot seeds. (22 mg) x 4💊 – Aspirin (1/2) a day💊
– Cellfood supplement in my water. 💧 – 4.5 gram a day everyday of panacur (999mg fenbendozle) (started on the 22nd May 2019 finished January 2020. ) 🐶 ‬

I reduced my sugar and dairy intake as much as possible and tried to eat a healthy plant based diet with the occasional bit of chicken or turkey. I also drink 5 cups of green tea a day and added berbine (1000mg x 2 a day) and added turkey tail mushrooms and lions mane mushrooms.

After remaining stable and contained from January 2019 for over 12 months I finally got the PET scan results I’d dreamed of. “no active cancer”. (February 2020.) CT scan in August 2020 continued to show improvement and only shows scare tissue where the inoperable Tumour once was.

Case 5: stage 4 colon cancer with multiple Mets to the liver (August, 2022)

Hi everybody. I just wanted to share my story with you. On June 11, 2021 I was diagnosed with stage 4 colon cancer with multiple Mets to the liver … I am labeled, “incurable “. When I had a colonoscopy, they couldn’t get the camera past a certain point because the cancer was so thick. 2 months later I had a couple of blockages and had a colon resection done. At this point the cancer took me from 210 pounds down to 165 pounds. I was so scared that I was on my way out. I started the Joe Tippens protocol at this time. Fast forward to today, and the cancer is gone from my colon and we are focusing on the liver. My blood test have come back perfect the last 4 blood test. My oncologist is so excited that he order a CT scan in a couple of weeks. The first photo is when I felt I was on my way out. It’s still hard to see myself like that. The second photo is a couple of weeks old of me camping in the mountains. I really feel that Joe Tippens protocol helped save my life. I’m so thankful for being here and I’m blessed to have each day. Thank you for listening.

Case 4: Female with stage 4 Colon Cancer. Mets to base of skull, adrenal glands. (July, 2022)

Positive Results!
My wife was diagnosed with stage 4 Colon Cancer on 3/15/22 just 4 months ago. Mets to base of skull, adrenal glands. Before she had terrible pain at the base of her skull and was on Endone and other pain killers. We found out about Joe Tippens story and started Fenbendazole immediately at 222mg twice a day and then gathered other supplements. 5 days after Fenben her pain was gone. We watched Joes videos and also came across Jane McLelland’s Book “how to starve cancer”. From that we enrolled in her online course to gain better insights and from there we got in touch with the Care Oncology Clinic.

My wife has had only 5 chemo sessions and 1 cycle of treatment radiation over 10 days for 10mins each

Today her Cancer is all but GONE!! in just 4 months. She was given between 6 months and 2 yrs to live and is now basically NED. We would 1st like to thank The Lord Jesus Christ our healing Saviour, Joe for having the guts to try something which and face the ridicule of the public and the medical profession. We would like to thank Jane for her tenacity in overcoming her own battle but much more in researching and publishing the info so that the avg person can understand and beat this insidious disease. Also we are very grateful and would like to thanks the Care Oncology Clinic in UK for their help in refining our protocol for My wife’s particular type of cancer.

Also our Surgeon who put in a stoma called today and will now reverse the operation to remove her colostomy bag as the tumour is all but gone.

We are aware that it’s possible the Cancer may return but it’s now like treating a chronic disease such as diabetes rather than a death sentence. With regular blood tests and scans we can now stay on top of this instead of being a slave to it.

Below is a copy of her results with names and places cut out. If you have been told that Cancer is a death sentence don’t believe it as there is hope. You just have to get the right info.

Case 3: August 2024

William David Krawsczyn shared on a Facebook Group:

I was diagnosed 9 years ago with stage 4 colon cancer! Colon, liver, lymph nodes! 44 chemotherapy treatments, 6 surgeries, 3 recurrences of cancer! I have taken fenbendazole and ivermectin off and on during last 9 years! Now have a recurrence of cancer and need to know dosage (ml.’s orally) of each and frequency! I have oral goat dewormer (fenbendazole) and injectable cattle dewormer (ivermectin)! Need to know how much of each to take orally and frequency??

Case 2: Colorectal Cancer and Ivermectin

Dr Justus Hope reported on a case of Stage IV Colon Cancer that appeared hopeless. The gentleman, Rick, had widespread metastatic disease affecting the liver and lymph nodes and was told his cancer was “unsurvivable.” At most, he had six months left, according to his oncologist.

Following adding Ivermectin, his tumor markers dropped from 1489 to 4.7, and his metastases calcified and shrunk. This was believed due to the anti-metastatic effect of Ivermectin as it suppresses the WnT Pathway, which cancer stem cells rely upon.

Read More: Ivermectin for Large Intestine Cancer

Case 1: Colorectal Cancer and Ivermectin

Source: https://www.brightworkresearchtreatment.com/testimonials/

Are there more case reports? For more Fenbendazole and Ivermectin case series in other cancer types, check out 'Ivermectin, Fenbendazole, and Mebendazole Cancer Case Series' (more than 200 case reports).

Colon Cancer and Vitamin D

A comprehensive analysis published in the journal Nutrients in April 2025 has discovered a fascinating but substantial link between vitamin D and colorectal cancer (CRC). The researchers reviewed and analyzed data from 50 separate studies involving over 1.3 million participants to determine how much vitamin D impacts your risk of developing colorectal cancer.

• This large-scale 2025 review looked at diverse populations — The data covered various groups and nationalities, including women in the U.S. Midwest, Danish adults with a family history of cancer and Canadians living in high-altitude areas. The participants had different health statuses as well — some had colorectal cancer, or a documented vitamin D deficiency. Others were also given a vitamin D supplement.
• While the participants varied in health status and genetic risk, a consistent pattern emerged — The researchers found that the lower your vitamin D levels, the higher your risk of developing colon cancer. On the flip side, people with adequate or optimal levels of vitamin D had dramatically lower rates of cancer.
• Unfortunately, majority of people today have very low levels of this vital nutrient — A recent study that looked at the vitamin D status of more than 5,600 adults found that 37.6% had vitamin D insufficiency (blood levels between 20 and 30 ng/mL), while 42% were severely deficient (blood levels lower than 20 ng/mL) in this nutrient.

This new research makes it clear that if you're not paying attention to your vitamin D status, you're missing out on one of the simplest and most powerful tools available to reduce your risk of colon cancer. Below are some of the compelling findings from the featured analysis that point to vitamin D as a key factor in reducing your risk of colorectal cancer.

• A landmark 1996 study found that women with the highest vitamin D intake had a 58% lower risk than those with the lowest intake.
• A 2021 meta-analysis found a 39% lower risk of colorectal cancer in people with higher blood levels of vitamin D. The researchers also noted that when vitamin D levels were monitored over time, those who maintained higher levels had a 20% lower chance of developing colorectal cancer down the line.
• A Canadian study found that supplementing with vitamin D reduced the incidence of precancerous polyps — by 33% for all polyps and 43% for high-risk ones. These polyps often go on to become cancer if not addressed early, so this kind of intervention has massive implications.
• The Iowa Women's Health study found that women who took vitamin D with calcium saw a 15% drop in colorectal cancer risk compared to those who didn't take any supplements.
• The Danish "Diet, Cancer and Health" study (one of the major ones included) found that vitamin D offered even stronger protection in people with a high genetic risk of colon cancer. That means if you've got a family history of this disease, optimizing your vitamin D status isn't just helpful — it could be life-saving.

Cruciferous Vegetables Cut Colon Cancer Risk: 2025 Study

In a paper published in BMC Gastroenterology, researchers combined data from 17 studies involving 639,539 people. Out of these, 97,595 had colon cancer. The analysis showed that those who ate more cruciferous vegetables (e.g. brocolli) had significantly lower odds of developing colon cancer. The overall reduction in risk was 17%, which is meaningful when you think about preventing a disease that kills over 900,000 people each year.

• The "sweet spot" was surprisingly modest — The strongest protection occurred when people ate about 40 to 60 grams of cruciferous vegetables daily, roughly half a cup of cooked broccoli. Eating more than 60 grams didn't appear to provide much additional benefit, which suggests that your body reaches a point of saturation — where the cancer-fighting compounds do their job and more isn't necessarily better. Importantly, this threshold makes prevention achievable because it doesn't require extreme dietary changes.
• Specific chemicals in the vegetables drive the effect — Cruciferous vegetables contain glucosinolates, which break down into compounds such as sulforaphane and indole-3-carbinol when the vegetables are chopped or chewed. These compounds support your body in several ways:
• Detoxification — They activate enzymes that help your liver process and eliminate carcinogens.
• Apoptosis — They trigger programmed death in damaged or pre-cancerous cells.
• Cell cycle regulation — They slow down cell division, reducing the chance of runaway growth that leads to tumors.

Simple Strategies to Strengthen Your Gut and Cut Colon Cancer Risk

If your goal is to lower your risk of colon cancer, you need to start with the root cause: the health of your gut and how your body produces energy. When your gut microbes are balanced and your colon lining is strong, you're in a far better position to stop abnormal cells before they take hold. On the other hand, when your diet and environment disrupt that balance, your risk climbs fast. These steps give you clear, practical actions that help you rebuild resilience and protection — starting with your plate.

1. Cut out vegetable oils and packaged junk — When you eat restaurant food, fried snacks, or packaged meals, you load your body with linoleic acid (LA) from vegetable oils. This fat poisons your mitochondria — the engines inside your cells — and creates a gut environment that favors harmful bacteria. Swap these foods for fresh, unprocessed choices you cook yourself. Use stable fats like ghee, tallow, or grass fed butter, and keep LA below 5 grams per day — closer to 2 grams is even better. Using an app like Food Buddy in my Health Coach, which is coming out this year, is an easy way to track where hidden vegetable oils are sneaking into your diet.
2. Fuel your cells with the right carbs — Your gut and mitochondria work best when they get a steady flow of glucose. For most adults, that means 250 grams of healthy carbohydrates daily, with higher amounts if you're very active. Start simple with white rice and fruit, especially if your gut is unhealthy. This approach gives your cells the energy they need while allowing your gut bacteria to stabilize before you add more complex foods.
3. Introduce more fiber step by step — Fiber feeds the good microbes in your gut, helping them produce butyrate, a short-chain fatty acid that acts like fuel for your colon lining. But too much fiber too soon backfires if your gut is inflamed. Once you've done well with fruits and white rice, add in root vegetables, then branch out to cruciferous and other vegetables, beans, legumes, and whole grains. Cooked and cooled potatoes or rice are especially useful because the resistant starch they form is perfect food for butyrate-producing bacteria. By pacing your fiber intake, you allow your gut to heal and build strength without triggering irritation.
4. Bring in cruciferous vegetables for extra defense — Once your gut tolerates carbs well, make cruciferous vegetables part of your regular diet. Whether you prefer roasted Brussels sprouts, lightly steamed broccoli, or sauerkraut, your choices matter and directly influence whether cancer takes hold in your colon. These foods contain compounds that help your liver clear carcinogens, repair damaged DNA, and strengthen your colon lining. Aim for 40 to 60 grams a day — roughly half a cup of cooked broccoli — to get the best protection. Rotate different crucifers through your meals to diversify the compounds your gut microbes have to work with. This variety keeps your microbiome healthier and gives your colon more layers of defense.
5. Limit toxins, prioritize daily movement and restore your microbiome — Environmental toxins — from plastics, pesticides, and synthetic estrogens to constant exposure to electromagnetic fields — undermine your gut health, allowing the wrong microbes to take over. Switch to glass containers, avoid heating food in plastic, and cut down on wireless signals at home where possible. Movement is another tool that lowers your risk of colon cancer. 2024 Research shows that exercising in the morning around 8 a.m. and again in the evening around 6 p.m. reduces colorectal cancer risk by 11%, with this two-peak pattern outperforming other exercise schedules. Antibiotics are another disruptor, wiping out beneficial species. Use them only when truly necessary, and then rebuild your microbiome with fermented foods. Once your gut is healthy, supporting beneficial microbes like Akkermansia, which help maintain your gut lining, keeps your colon protected from cancer-triggering toxins.

New & Improved Joe Tippens Protocol

In 2016, Joe Tippens was diagnosed with non-small-cell lung cancer with extensive metastatic disease. At the advice of a veterinarian friend, he took Fenbendazole together with nanocurcumin, and three months after starting these drugs his PET scan was completely clear.

Below is a modified version of the Joe Tippens protocol, a synergistic combination of fenbendazole, ivermectin and nutraceuticals, updated based on the ivermectin and mebendazole based protocol published in the Journal of Orthomolecular Medicine (2024):

• Ivermectin (24 mg, 7 days a week) or in the case of severe aggressive cancers up to 1mg/kg/day.
• Mebendazole (Dose of 200 - 400 mg/day) or Fenbendazole, commonly taken at 300 mg for six days a week, with doses increasing to up to 1 gram in cases of aggressive cancers.
• Vitamin D (62.5 mcg [2500 IU] seven days a week).
• Bio-Available Curcumin (600 mg per day, 7 days a week). 
• Enhanced absorption Berberine (500 mg per day) to starve your cancer of sugar.
• Diet and Lifestyle: Eliminate sugar (BMJ 2023), adopt a whole-food diet, avoid ultra-processed foods (BMJ 2024) and a healthy lifestyle with quality sleep and proper stress management. 

*Notes:

• Please note that this protocol now includes the vital Vitamin D addition, with the one day off for the fenbendazole administration. This protocol represents the most comprehensive and cutting edge repurposed drug and vitamin treatment approach to date.
• If you are taking ivermectin and mebendazole, you might not need fenbendazole. Consult your doctor.
• Vitamin E: Removed from the protocol (Joe Tippens, July 22, 2020) due to interactions (e.g., with blood thinners).

AI Predicts Ivermectin and Mebendazole Multimodal Protocol Improved Overall Survival in Non-Mutated, Microsatellite Stable Stage 4 Colorectal Cancer

This simulated RCT showed that a multimodal protocol (Arm 1) outperforms chemotherapy (Arm 2, p=0.03 for PFS, p=0.04 for OS) and ivermectin/mebendazole alone (Arm 3, p=0.006 for PFS, p=0.008 for OS) in non-mutated, MSS stage 4 CRC. Arm 1 achieved a median OS of 23.8 months and 82% 12-month OS rate, compared to 21.0 months and 76% for Arm 2, and 18.2 months and 70% for Arm 3. Secondary outcomes (tumor inhibition, apoptosis, CSC reduction) favoured Arm 1, reflecting synergy from mEHT, ketogenic diet, and fasting. Arm 3’s modest efficacy (PFS 6.8 months, OS 18.2 months, p=0.12 and p=0.15 vs. Arm 2) is limited by low tumor drug concentrations and lack of adjunctive therapies. The KEYNOTE-177 study provided a robust chemotherapy benchmark, adjusted for MSS CRC (OS ~21 months).

Conclusion

In conclusion, the compelling compilation of 34 case reports, alongside emerging preclinical studies and AI-simulated trials, underscores the promising potential of fenbendazole, ivermectin, and mebendazole as adjunctive therapies in the fight against colorectal cancer—particularly in advanced stages where traditional treatments alone often fall short. 

These repurposed antiparasitic drugs demonstrate remarkable abilities to inhibit tumor growth, enhance chemotherapy and radiation efficacy, and improve survival outcomes through mechanisms like WNT pathway disruption, metabolic interference, and synergy with immunotherapy. When integrated into protocols such as the updated Joe Tippens regimen, complemented by vitamin D optimization, dietary shifts, and lifestyle modifications, patients have reported dramatic remissions and quality-of-life improvements. 

However, while these anecdotal successes offer hope and warrant immediate exploration, they are not substitutes for standard medical care; rigorous clinical trials are essential to validate safety, optimal dosing, and long-term efficacy. Individuals facing colorectal cancer should consult qualified healthcare professionals to personalize these approaches, ensuring informed decisions in their journey toward remission and beyond.

Read More: This article is part of the Colorectal Cancer and Winning the War on Cancer series.

References:

1. Exercise is Better at Preventing Colon Cancer Recurrence than Chemotherapy - New England Journal of Medicine (2025) 
2. Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer (JAMA Oncology 2025)
3. Second-Line Treatment Strategies for Right-Sided, RAS/RAF Wild-Type Colorectal Cancer (JAMA June 2025)
4. Early ctDNA and Survival in Metastatic Colorectal Cancer Treated With Immune Checkpoint Inhibitors (JAMA June 2025)
5. Ivermectin, Fenbendazole and Mebendazole for Stage 4 ColoRectal Cancer: 24 Case Reports Compilation (2025)
6. Challenging the Status Quo in Colorectal Cancer: YouTube Channel’s dedicated playlist. (OncoDaily 2024)
7. Top 10 Cancer Fighting Supplements
8. Best Alternatives to Cancer Treatment
9. Experts Say Doing This 1 Thing Can Lower Your Risk Of Colon Cancer — And It’s Easier Than You Think (HuffPost 2025)
10. Yes, Aspirin Does Prevent Cancer. Just Not Fast Enough (Medscape 2025)

The Wellness Company's Ivermectin and Mebendazole

Ivermectin and mebendazole, both approved for human use, are now available in the U.S.

Researched and approved by Dr. Peter McCullough.

• Prescribed by licensed medical professionals
• Compounded and dispensed by a licensed US-based pharmacy
• Approved for human use

Where to buy Ivermectin and Mebendazole Formula: Available on The Wellness Company's website. Here is the link: Ivermectin and Mebendazole.