Why Dr. Sinclair takes NMN instead of NR
Dr. Sinclair recently said he takes NMN instead of NR based on research he did that found NR did not work at all, while NMN increased the endurance in older mice such that they were able to run twice as far as those on placebo. He is referencing this research , but unfortunately, they did not publish the results they found with NR. NMN has much stronger record of benefit to humans in clinical studies Over the last few years there have been several human clinical trials published with NR, while those with NMN have lagged behind, leading some people to conclude that NR is the “safer” bet. In 2021, that narrative was turned upside down, as 3 clinical studies were published with NMN. One was a safety trial only ( r ). The other 2 were successful in showing some benefit to humans ( r , r ). Although there have been more than 11 clinical trials now published with NR, nearly all have failed to show any benefit in humans. The one possible exception being this 2021 research showing a ...