Ivermectin and Mebendazole for Brain Cancer Success Stories: 112 Case Reports (December 2025)

By Editorial Team -
Brain cancer, particularly aggressive forms like glioblastoma multiforme (GBM), remains one of the most formidable challenges in oncology, with limited treatment options, high recurrence rates, and dismal survival prognoses despite advances in surgery, chemotherapy, and radiation. 

In recent years, however, a paradigm shift has emerged through the repurposing of established antiparasitic medications—ivermectin and mebendazole—as potential adjunctive therapies. These drugs, long proven safe for human use against parasitic infections, are now drawing attention for their anticancer properties, including the ability to target cancer stem cells, disrupt tumor metabolism, and cross the blood-brain barrier to combat intracranial malignancies. 

Drawing from a surge of compelling success stories documented from 2019 (METRICS study) to 2025, this article explores more than 100 real-world case reports of patients achieving remarkable outcomes, such as tumor stabilization, shrinkage, and even remission, when incorporating high-dose ivermectin and mebendazole into their regimens—often alongside or in lieu of conventional treatments.

Backed by insights from preclinical studies and mechanisms, these anecdotes offer a beacon of hope while underscoring the urgent need for rigorous clinical trials. As we delve into these inspiring narratives, dosages, and protocols, readers are reminded that these approaches should complement, not replace, standard care under professional medical guidance.

In This Article:

  • Case 111: 57 year old Quebec woman with Glioblastoma
  • Case 110: 50 year old woman with Glioblastoma
  • Case 109: 55 year old New Jersey woman with GLIOBLASTOMA
  • Case 108: 7 year old boy in Siberia, Russia, with Cervicomedullary Ganglioglioma
  • Case 107: 35 year old Canadian woman with Grade 4 ASTROCYTOMA
  • Case 106: 5 year old Boy from SWITZERLAND with a brain tumor (Diffuse Intrinsic Pontine Glioma, or DIPG)
  • Case 105: 61 year old Kentucky woman with Oliogodendroglioma (Grade 2)
  • Case 104: 57 year old Florida man with Glioblastoma Brain Tumor
  • Case 103: 51 year old Toronto man with Glioblastoma
  • Case 102: 66 year old Ontario man with Glioblastoma (unmethylated)*
  • Case 101: 74 year old Canadian man with Glioblastoma
  • Case 100: Brain Cancer Testimonial from Brazil
  • Case 99: 36 year old California woman with multifocal Grade 4 Astrocytoma
  • Case 98: Stage 4 brain cancer terminal and on radiation and chemo
  • Case 97: 41 year old Canadian man with Grade 3 Oligodendroglioma Brain Cancer
  • Case 96: Male with Glioblastoma (Oct 2024)
  • Case Series 1 - 95 (METRICS study)


Case Presentations (112 cases)


Case 112: 69 year old Kentucky man with Glioblastoma

Dr William Makis shared on X.com (December 2025):

IVERMECTIN and MEBENDAZOLE Testimonial - 69 year old Kentucky man with Glioblastoma reports after being on Protocol for 12 months.
A 12 month Glioblastoma success story!! (Oncologists don't have these) STORY: 69 year old Kentucky man with a 4.5cm Glioblastoma In October 2024 he Started: Ivermectin 2mg/kg/day Mebendazole 1500mg/day CBD Oil 75mg/day In January 2025 he started: Ivermectin 2mg/kg/day Mebendazole 2000mg/day Fenbendazole 1000mg/day CBD Oil 100mg/day His brain tumor has consistently shrunk over the past 12 months!! The MRIs are read right to left "Doc was very happy and asked me to take the treatments exactly how I have been doing" Glioblastoma is not easy to deal with so to see a shrinking Glioblastoma over a course of 12 months is incredible!!


Case 111: 57 year old Quebec woman with Glioblastoma

Dr William Makis shared on X.com (November 2025):

IVERMECTIN and MEBENDAZOLE Testimonial - 57 year old Quebec woman diagnosed with Glioblastoma in Dec.2024, reports after 8 months.
A Canadian Glioblastoma success story? STORY: 57 year old Canadian woman diagnosed with Glioblastoma in Dec.2024, after 3 COVID-19 mRNA Vaccines (1 Moderna, 2 Pfizer May 2021 to Jan.2022) Had chemo & radiation January / February 2025 In March 2025 she started:
  • Ivermectin 1.5mg/kg/day
  • Mebendazole 1500mg/day (sometimes takes Fenbendazole 1500mg/day)
Results after 8 months: NO RECURRENCE! "More good news! My oncologist had me undergo another MRI, and once again, there's no progression."


Case 110: 50 year old woman with Glioblastoma

Dr William Makis shared on X.com (November 2025):

IVERMECTIN and MEBENDAZOLE (and Dr. Thomas Seyfried) Testimonial - 50 year old woman with Glioblastoma shares her story after given 7 months to live - 16 months later, 4 MRIs, NO RECURRENCE.
"My wife who is 50 years old, diagnosed with a glioblastoma multiforme brain tumor in April 2024 had a 6 hour surgery and given 7 months to live" When you have Glioblastoma and your Oncologist gives you 7 months to live, there is very little hope there. Except... "2 months of radiation and chemo...she couldn't handle the radiation and chemo and quit the treatment half way through" (June 2024) "We found ivermectin and mebendazole protocol as well as Dr. Thomas Seyfried's work with ketogenic diets". "The last 4 MRIs have been clear and no growth. She is feeling great with no deficits" Let all this sink in. 16 months on Ivermectin and Mebendazole. Was supposed to be dead after 7 months. Instead, she has 4 clear MRIs, no growth. No chemo. No radiation. No Oncology treatments. Go ahead, tell me again how Oncologists can justify NOT OFFERING this to dying cancer patients. If this cancer patient relied on her Oncologist, she would have been DEAD 9 months ago!!!


Case 109: 55 year old New Jersey woman with GLIOBLASTOMA

Dr William Makis shared on X.com (November 2025):

IVERMECTIN and MEBENDAZOLE Testimonial - 55 year old New Jersey woman who developed GLIOBLASTOMA after 2 Pfizer Vaccines reports after 3 months - 46% tumor shrinkage!!
A Glioblastoma shrinks almost 50% with Ivermectin and Mebendazole!! Wow!! STORY: 55 year old New Jersey woman who developed GLIOBLASTOMA after 2 Pfizer Vaccines (very likely Turbo Cancer) In late June / early July 2025 she started:
  • Ivermectin 1.5mg/kg/day
  • Fenbendazole 1776mg/day (then switched to Mebendazole 1500mg/day)
Results after 3.5 months: 46% tumor shrinkage! Radiologists called it "mildly decreased in size". This is a fantastic result. With brain cancers, we're usually very happy to see tumors stop growing or stop them from coming back. But almost 50% brain tumor shrinkage over 3 months is incredible!! Remember, Johns Hopkins has a 2021 PATENT on Mebendazole for the treatment of Glioblastoma!! They know something mainstream Oncologists don't!


Case 108: 7 year old boy in Siberia, Russia, with Cervicomedullary Ganglioglioma

Dr William Makis shared on X.com (November 2025):

IVERMECTIN and MEBENDAZOLE Testimonial - 7 year old boy in Siberia, Russia, with Cervicomedullary Ganglioglioma reports after 3 months
You never think you're going to be able to help a 7 year old boy in the middle of Siberia, Russia. STORY: 7 year old boy in Siberia, Russia, with Cervicomedullary Ganglioglioma (a rare brain tumor at the junction of the brainstem and spinal cord, composed of both neuronal and glial cells) In early August 2025 he started:
  • Ivermectin 1mg/kg/day
  • Mebendazole 1000mg/day
Result: “Ivermectin + Mebendazole gave us our son back” Stable tumor In Pediatric tumors especially brain tumors, halting tumor growth is a success, as is any clinical improvement. These are very difficult tumors.


Case 107: 35 year old Canadian woman with Grade 4 ASTROCYTOMA

Dr William Makis shared on X.com (November 2025):

IVERMECTIN and MEBENDAZOLE Testimonial - 35 year old Canadian woman with Grade 4 ASTROCYTOMA reports after 7 months. No recurrence!

This is a Game Changer with Brain Tumors!
35 year old Canadian woman with Grade 4 ASTROCYTOMA

In February 2025 she started:

Ivermectin 1.5mg/kg/day
Mebendazole 1500mg/day

MRI Report after 7 months:

“No acute change at site of previously debulked left temporal tumor”

“No evidence of disease progression”

From patient:
“we are very happy!”

Imagine if we could stop aggressive brain tumors dead in their tracks! Stop them from coming back!

I believe it can be done.

This is one of MANY areas to research with allocated government funding. Florida leads the way...

Case 106: 5 year old Boy from SWITZERLAND with a brain tumor (Diffuse Intrinsic Pontine Glioma, or DIPG)

Dr William Makis shared on X/Twitter (November 2025):

IVERMECTIN, MEBENDAZOLE and FENBENDAZOLE Testimonial - 5 year old Boy from SWITZERLAND with a brain tumor (Diffuse Intrinsic Pontine Glioma, or DIPG) reports after 4 months with tumor shrinkage!

Pediatric cancer cases are hard but pediatric cancer success stories are the best.

STORY:
5 year old boy from SWITZERLAND with a brain tumor (Diffuse Intrinsic Pontine Glioma, or DIPG)

In early June they started:

Ivermectin 1mg/kg/day
Mebendazole 1500mg/day
Fenbendazole 1500mg/day

With pediatric cases, we are always cautiously optimistic and pray for our little angels.

From Dad:
“the most recent MRI showed that the brainstem tumor has been reduced by 26% compared to the last scan”

With pediatric cases, we are always cautiously optimistic and pray for our little angels.

DIPG is a fast-growing and aggressive type of brain tumor that starts in the part of the brain stem called the pons.

The pons controls many vital functions such as breathing, heart rate, and blood pressure, and the nerves and muscles used in seeing, hearing, walking, talking, and eating.

How many children with cancer are we helping?

We’ve now surpassed 100 kids.


Case 105: 61 year old Kentucky woman with Oliogodendroglioma (Grade 2)

Dr William Makis shared on X/Twitter (October 2025):


IVERMECTIN and FENBENDAZOLE Testimonial - 61 year old Kentucky woman with Oliogodendroglioma (Grade 2) reports brain tumor shrinkage after 5 months!
Very interesting story here! 61 year old Kentucky woman with Oliogodendroglioma (Grade 2) In early May 2025 she started: Ivermectin 36mg/day Fenbendazole 1500mg/day Results after 5 months on MRI: "Mild decrease in hyperintense non-enhancing mass" "She (the Oncologist) was very excited and pleased and didn't expect the tumor to shrink a bit" Of course she didn't. This is a very interesting story because many people falsely claim that Ivermectin and Fenbendazole don't cross the blood brain barrier. Except that's false. They do. Not well, but they do.


Case 104: 57 year old Florida man with Glioblastoma Brain Tumor

Dr William Makis shared on X/Twitter (October 2025):

IVERMECTIN and MEBENDAZOLE Testimonial - 57 year old Florida man with Glioblastoma Brain Tumor gives incredible report after 3 months!

Read it for yourself. 

"I am clear at month 4 and that gives me hope and it will give other people hope"

"Both of my oncologists DID NOT expect this. All my doctors told me I should prepare to die after my surgery in June. They said my diagnosis was very aggressive, and it most certainly would grow back" 

"Most recent MRI shows that the tumor and all signs of cancer are gone"

"One of my oncologists even told me that I should expect to possibly have to go into HOSPICE LATER IN THE FALL if their standard of care did not work"

Read his incredible story. It only takes a few minutes.



Case 103: 51 year old Toronto man with Glioblastoma

Dr William Makis shared on X/Twitter (October 2025):

IVERMECTIN and MEBENDAZOLE Testimonial - 51 year old Toronto man with Glioblastoma reports after 6 months - has tumor shrinkage that baffles Oncologists!
This time, I'm baffling Oncologists in my old home town, Toronto, Canada! And I love it because Toronto doctors are particularly arrogant! STORY: 51 year old Toronto man with Glioblastoma In Late February 2025 he started: Ivermectin 1.5mg/kg/day Mebendazole 1500mg/day After 6 months, his tumor is shrinking but his Oncologists believe it is from Radiation and chemo he finished in October 2024. "since there is progress in tumor shrinkage...they are attributing the shrinkage to the chemo and radiation of last year this time" "We feel that the real shift began once we started your protocol but they are not aware of what we're doing".


Case 102: 66 year old Ontario man with Glioblastoma (unmethylated)*

Dr William Makis shared on X/Twitter (June 2025):

IVERMECTIN and MEBENDAZOLE Testimonial - 66 year old Ontario man with Glioblastoma (unmethylated) reports after 5 months - no recurrence.

A Glioblastoma success story! 66 year old Ontario man with Glioblastoma (unmethylated). For 5 months, the patient was on:
  • Ivermectin 168 mg/day
  • Mebendazole 1500 mg/day
  • Melatonin 500 mg/day
RESULT: No recurrence on follow-up imaging!
Glioblastoma (GBM) is a lethal disease. At least in part, the recurrence of GBM is caused by cancer stem cells (CSCs), which are resistant to chemotherapy. Ivermectin targets and kills Cancer Stem Cells! The question is whether we can completely prevent recurrence of Glioblastoma (unmethylated) over the long term. I believe we can. But we have to prove it with long term studies. That's next.

*Note: Glioblastoma is otherwise known as Stage IV Astrocytoma. Unmethylated glioblastoma refers to a glioblastoma (GBM) tumor where the MGMT promoter is unmethylated, which is a poor prognostic indicator. The unmethylated state means the tumor is resistant to temozolomide (TMZ), a standard chemotherapy drug for GBM, leading to a worse prognosis compared to methylated tumors. Therefore, patients with unmethylated GBM require alternative treatment strategies, such as other chemotherapy, immunotherapy, targeted therapies, or novel approaches like CRISPR-based epigenetic editing, to improve outcomes.


Case 101: 74 year old Canadian man with Glioblastoma

Dr William Makis shared on X/Twitter (June 2025):

IVERMECTIN and MEBENDAZOLE - 74 year old Canadian man with Glioblastoma gives an exciting update after 3 months!
Do you want to hear a brain cancer success story? Of course you do! 74 year old Canadian man with Glioblastoma In early March 2025 we started:
  • Ivermectin 1.5mg/kg/day
  • Mebendazole 1500mg/day
  • CBD Oil 100mg/day
The patient was on this regimen for 3 months (and if you count the Ivermectin and Fenbendazole they started on their own in early February, then 4 months). From the patient: "he recently had his first MRI since chemo and radiation begun - there were no abnormal changes - no abnormalities - no new artifacts Overall, both our family and the oncologists were extremely happy to not see any visible growth or changes." "First off, thank you for your work and services, I have zero doubt that the results would have been different if we didn’t have your guidance." I do believe that Glioblastoma recurrence could be eliminated with a repurposed drug regimen that includes Ivermectin and Mebendazole. Of course, now we have to prove it with long term follow-up and publish it. Remember, this patient was quoted a life expectancy as low as 6 months as Glioblastomas are notorious for recurrence despite best conventional cancer treatment. We are 4 months in and the patient is CANCER FREE.


Case 100: Brain Cancer Testimonial from Brazil

"We applied your protocol plus methylene blue to a friend with brain cancer...started in beginning of February 2025...she is cancer free now!

"Getting more details...story developing.

Ivermectin. Mebendazole. Methylene Blue.




Case 99: 36 year old California woman with multifocal Grade 4 Astrocytoma

Dr William Makis shared on X/Twitter (May 2025):

IVERMECTIN and MEBENDAZOLE Testimonial - 36 year old California woman with multifocal Grade 4 Astrocytoma is now improving after 2 months! I get asked for Brain Cancer stories ALL THE TIME Here is one! (More are coming soon) STORY: 36 year old California woman was diagnosed with multifocal Grade 4 Astrocytoma (7 brain lesions) in January 2025 In late January 2025 we started:
  • Ivermectin 1mg/kg/day
  • Mebendazole 1500mg/day
RESULTS after 2 months: "We received results of her MRI yesterday...her oncologist informed us that her tumors are at the very least stable and appear to be shrinking" “They were absolutely shocked as they didn’t seem to have much hope for her prior to this as her cancer was aggressively progressing prior to your treatment”

"If you are unsure how big of a role an Ivermectin/Fenbendazole/Mebendazole protocol plays, always look at the reaction of the Oncologists. They rarely hide their shock. Brain tumors are difficult to treat in general, but the Ivermectin & Mebendazole combination is starting to make a huge impact in this area." - Dr William Makis


Case 98: Stage 4 brain cancer terminal and on radiation and chemo

Doverschoice posted on X/Twitter in April 2025:

My mother had the vaccine and one booster stage 4 brain cancer terminal and on radiation and chemo. Have tried to reach out to William for some time to get some help on what to give her!

Dr William replied (April 2025):

Mebendazole, CBD, Ivermectin would be my top 3.


Case 97: 41 year old Canadian man with Grade 3 Oligodendroglioma Brain Cancer

Dr William Makis shared on X/Twitter (Feb 2025):

IVERMECTIN and FENBENDAZOLE Testimonial - 41 year old Canadian man with Grade 3 Oligodendroglioma Brain Cancer opts out of chemo & radiation - doing extremely well! 

STORY: 

41 year old Ontario man had an aggressive Grade 3 Oligodendroglioma that was mostly resected in early June 2024. After surgery, he opted out of chemo and radiation therapy. Sep.2024 MRI showed “residual parenchymal tumoral component” 4.5x4.1x3.6cm.

We started an aggressive Makis Ivermectin Cancer Clinic Protocol: 
  • Ivermectin 1mg/kg/day increasing to 2mg/kg/day 
  • Fenbendazole 888mg/day
He had a follow-up MRI 3 months later: RESULTS: The Radiologist couldn’t find the residual tumor! From the patient: 
"Thank you so much. I don't know how else to put it. This is not a big deal...its THE deal. A cure for "terminal" brain cancer. The implications are mind-blowing and its sad so few people know about these options." 
"Keep up the good fight please!"


Case 96: Male with Glioblastoma

Case sharing by Michelle Wright (X/Twitter) in October 2024:

The reading of the results has been posted!! There is a whole lot that I DON’T understand, but I can understand enough to see that THERE HAS BEEN IMPROVEMENT!!  I appreciate all of the prayers and well wishes!  For anyone that isn’t up to date- my Dad was diagnosed with Glioblastoma in April of this year. He had completed one full round of chemo and radiation, and at the beginning of August he was not well. I won’t go into detail. However, I had been doing a lot of research and one of the AWESOME pages I found here was @JohnDParody  I went with a protocol that I felt was best and got my Dad started on a journey with Ivermectin and Fenbendazole. He HAS continued his chemo treatments, but I 100% believe it has been that being used in combination with the Ivermectin and Fenben that has gotten him where he is today. I’ve been here, and I’ve watched him improve daily. I do not have pictures of the scans themselves, because they’re not posted on the portal. But if anyone would like to compare it to any of his previous readings, I can get those as well. I’m going to go celebrate with my Dad.



Note:

Although the fenbendazole and mebendazole are very similar in effectiveness at higher doses, Mebendazole has superior brain cancer cell killing at lower loses compared to Fenbendazole. So for Glioblastoma, it’s Mebendazole if you can get it. Otherwise, you can't go wrong with Fenbendazole. It's still almost as good. (source)

Albendazole is also recommended for brain related cancers or brain spread, as it can cross the blood-brain barrier. (source)


Case Series 1 - 95 (METRICS study)

The Care Oncology Clinic in the UK, which is now doing clinical trials on glioblastoma, published their preliminary retrospective data from the METRICS study (NCT02201381) in Frontiers in Pharmacology (2019) about the combination standard treatment and repurposed drugs in 95 patients. 

Full inclusion and exclusion criteria and further methodological details can be found at https://clinicaltrials.gov/ct2/show/NCT02201381:

Subjects will take the following treatments (adjunctive) and have their data collected from their medical records every 3 months.
  • Oral Mebendazole 100 mg once a day, for study duration.
  • Oral atorvastatin up to 80 mg once a day, for study duration.
  • Oral metformin up to 1000 mg once a day, increased to bid if tolerated after 2 weeks, for study duration.
  • Oral doxycycline 100 mg once a day, for study duration.
The retrospective analysis consisted of 95 patients with advanced GBM (brain cancer) stage IV (GBM) who attended the clinic between 2013 and 2016.

Simply adding metformin, doxycycline, atorvastatin, and mebendazole in addition to optimal standard of care can increase GBM (Glioblastoma) average survival from 15 to 27 months, almost a doubling.




Are there more case reports? For more Fenbendazole and Ivermectin case series in other cancer types, check out 'Ivermectin, Fenbendazole, and Mebendazole Cancer Case Series' (more than 300 case reports).

Conclusion

In conclusion, the array of more than 100 compelling case reports from 2025, primarily shared by Dr. William Makis and the METRICS study, illuminates the transformative potential of ivermectin and mebendazole as repurposed adjunctive therapies for aggressive brain cancers such as glioblastoma multiforme and astrocytoma—conditions notorious for their resistance to standard treatments and high recurrence rates.

These antiparasitic agents, often administered at high doses (e.g., ivermectin 1-2 mg/kg/day and mebendazole 1500 mg/day) alongside chemotherapy, radiation, or supportive elements like CBD and melatonin, have demonstrated remarkable abilities to target cancer stem cells, stabilize tumors, induce shrinkage, and achieve sustained remission in patients facing dire prognoses. Protocols inspired by these successes, including alternatives like fenbendazole or albendazole for enhanced blood-brain barrier penetration, underscore a multifaceted approach that complements conventional care and offers renewed hope where options were once limited. 

Nevertheless, while these anecdotal triumphs—backed by MRI evidence and oncologist astonishment—signal a paradigm shift in brain cancer management, they remain observational and demand robust, long-term clinical trials to confirm efficacy, safety, and optimal integration. That said, it may take years before these anti-cancer agents get into mainstream medical journals, as bold results often trigger powerful pushback. The biggest confirmation may not come from top journals but from a grassroots movement of patients and doctors who have proven results.

Patients and caregivers are encouraged to collaborate closely with healthcare experts to tailor these strategies, fostering informed, personalized paths toward overcoming this formidable disease.

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In this Article: Overview of Ivermectin Dosage | Ivermectin Dosage for Adults | Ivermectin Dosage for Children | Ivermectin dosage restrictions | How to take ivermectin | Ivermectin dosage FAQs The prescribed dosage for ivermectin oral tablets depends on the type of parasitic infection you have and your body weight. Ivermectin is typically taken as a single dose. Repeat doses may be needed in some cases. Specifically, ivermectin oral tablet is approved by the Food and Drug Administration (FDA) to treat the following conditions in adults and certain children: a parasitic infection in the intestinal tract called strongyloidiasis a parasitic infection of the eyes and skin called onchocerciasis  (River Blindness) Ivermectin oral tablet is a generic medication and belongs to a drug class called antiparasitic medications. It is also available in a brand-name version called Stromectol. This article describes the dosages of ivermectin oral tablets, as well as the medication’s streng...
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Fenbendazole and Ivermectin for Cancer: The Ultimate 2025 Guide

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In This Article: Introduction Chapter 1: Conventional, Standard Cancer Treatments and the Search for New Solutions Chapter 2: Repurposing Existing Drugs for Cancer Chapter 3: Ivermectin for Cancer Ivermectin Mechanisms of Action in Cancer Preclinical Evidence of Ivermectin (Cell and Animal Studies) Ivermectin Clinical Evidence and Anecdotal Reports Protocols and Dosing Strategies of Ivermectin Chapter 4: Fenbendazole or Mebendazole for Cancer Fenbendazole and Mebendazole Mechanisms of Action in Cancer Preclinical Evidence of Fenbendazole and Mebendazole (Cell and Animal Studies) Fenbendazole and Mebendazole Clinical Evidence and Anecdotal Reports Protocols and Dosing Strategies of Fenbendazole and Mebendazole Fenbendazole and Mebendazole Safety, Side Effects, and Toxicity Conclusion and Future Directions Introduction In 2016, Oklahoma businessman Joe Tippens was diagnosed with small-cell lung cancer, an aggressive form that had already metastasized to his pancreas, ...
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