Ivermectin and Mebendazole for Brain Cancer Success Stories (2025)

Ivermectin and mebendazole, traditionally used as antiparasitic agents, have recently gained attention for their potential roles in brain cancer treatment. Emerging success stories from 2025 highlight promising patient outcomes when these repurposed drugs are integrated into therapeutic regimens. This introduction explores the growing body of anecdotal and observational evidence supporting mebendazole and ivermectin as adjuncts in brain cancer management, setting the stage for further research and clinical validation.

Case Presentations (7 cases)

Case No. 7 - 2025: 66 year old Ontario man with Glioblastoma (unmethylated)*

Dr William Makis shared on X/Twitter (June 2025):

IVERMECTIN and MEBENDAZOLE Testimonial - 66 year old Ontario man with Glioblastoma (unmethylated) reports after 5 months - no recurrence. A Glioblastoma success story! 66 year old Ontario man with Glioblastoma (unmethylated). For 5 months, the patient was on:

• Ivermectin 168 mg/day
• Mebendazole 1500 mg/day
• Melatonin 500 mg/day

RESULT: No recurrence on follow-up imaging!

Glioblastoma (GBM) is a lethal disease. At least in part, the recurrence of GBM is caused by cancer stem cells (CSCs), which are resistant to chemotherapy. Ivermectin targets and kills Cancer Stem Cells! The question is whether we can completely prevent recurrence of Glioblastoma (unmethylated) over the long term. I believe we can. But we have to prove it with long term studies. That's next.

*Note: Glioblastoma is otherwise known as Stage IV Astrocytoma. Unmethylated glioblastoma refers to a glioblastoma (GBM) tumor where the MGMT promoter is unmethylated, which is a poor prognostic indicator. The unmethylated state means the tumor is resistant to temozolomide (TMZ), a standard chemotherapy drug for GBM, leading to a worse prognosis compared to methylated tumors. Therefore, patients with unmethylated GBM require alternative treatment strategies, such as other chemotherapy, immunotherapy, targeted therapies, or novel approaches like CRISPR-based epigenetic editing, to improve outcomes.

Case No. 6 - 2025: 74 year old Canadian man with Glioblastoma

Dr William Makis shared on X/Twitter (June 2025):

IVERMECTIN and MEBENDAZOLE - 74 year old Canadian man with Glioblastoma gives an exciting update after 3 months! Do you want to hear a brain cancer success story? Of course you do! 74 year old Canadian man with Glioblastoma In early March 2025 we started:

• Ivermectin 1.5mg/kg/day
• Mebendazole 1500mg/day
• CBD Oil 100mg/day

The patient was on this regimen for 3 months (and if you count the Ivermectin and Fenbendazole they started on their own in early February, then 4 months). From the patient: "he recently had his first MRI since chemo and radiation begun - there were no abnormal changes - no abnormalities - no new artifacts Overall, both our family and the oncologists were extremely happy to not see any visible growth or changes." "First off, thank you for your work and services, I have zero doubt that the results would have been different if we didn’t have your guidance." I do believe that Glioblastoma recurrence could be eliminated with a repurposed drug regimen that includes Ivermectin and Mebendazole. Of course, now we have to prove it with long term follow-up and publish it. Remember, this patient was quoted a life expectancy as low as 6 months as Glioblastomas are notorious for recurrence despite best conventional cancer treatment. We are 4 months in and the patient is CANCER FREE.

Case 5 - 2025: Brain Cancer Testimonial from Brazil

"We applied your protocol plus methylene blue to a friend with brain cancer...started in beginning of February 2025...she is cancer free now!

"Getting more details...story developing.

Ivermectin. Mebendazole. Methylene Blue.

Case 4 - 2025: 36 year old California woman with multifocal Grade 4 Astrocytoma

Dr William Makis shared on X/Twitter (May 2025):

IVERMECTIN and MEBENDAZOLE Testimonial - 36 year old California woman with multifocal Grade 4 Astrocytoma is now improving after 2 months! I get asked for Brain Cancer stories ALL THE TIME Here is one! (More are coming soon) STORY: 36 year old California woman was diagnosed with multifocal Grade 4 Astrocytoma (7 brain lesions) in January 2025 In late January 2025 we started:

• Ivermectin 1mg/kg/day
• Mebendazole 1500mg/day

RESULTS after 2 months: "We received results of her MRI yesterday...her oncologist informed us that her tumors are at the very least stable and appear to be shrinking" “They were absolutely shocked as they didn’t seem to have much hope for her prior to this as her cancer was aggressively progressing prior to your treatment”

"If you are unsure how big of a role an Ivermectin/Fenbendazole/Mebendazole protocol plays, always look at the reaction of the Oncologists. They rarely hide their shock. Brain tumors are difficult to treat in general, but the Ivermectin & Mebendazole combination is starting to make a huge impact in this area." - Dr William Makis

Case 3: Stage 4 brain cancer terminal and on radiation and chemo

Doverschoice posted on X/Twitter in April 2025:

My mother had the vaccine and one booster stage 4 brain cancer terminal and on radiation and chemo. Have tried to reach out to William for some time to get some help on what to give her!

Dr William replied (April 2025):

Mebendazole, CBD, Ivermectin would be my top 3.

Case 2: 41 year old Canadian man with Grade 3 Oligodendroglioma Brain Cancer

Dr William Makis shared on X/Twitter (Feb 2025):

IVERMECTIN and FENBENDAZOLE Testimonial - 41 year old Canadian man with Grade 3 Oligodendroglioma Brain Cancer opts out of chemo & radiation - doing extremely well! 

STORY: 

41 year old Ontario man had an aggressive Grade 3 Oligodendroglioma that was mostly resected in early June 2024. After surgery, he opted out of chemo and radiation therapy. Sep.2024 MRI showed “residual parenchymal tumoral component” 4.5x4.1x3.6cm.

We started an aggressive Makis Ivermectin Cancer Clinic Protocol: 

• Ivermectin 1mg/kg/day increasing to 2mg/kg/day 
• Fenbendazole 888mg/day

He had a follow-up MRI 3 months later: RESULTS: The Radiologist couldn’t find the residual tumor! From the patient: 

"Thank you so much. I don't know how else to put it. This is not a big deal...its THE deal. A cure for "terminal" brain cancer. The implications are mind-blowing and its sad so few people know about these options." 

"Keep up the good fight please!"

Case 1: Male with Glioblastoma

Case sharing by Michelle Wright (X/Twitter):

The reading of the results has been posted!! There is a whole lot that I DON’T understand, but I can understand enough to see that THERE HAS BEEN IMPROVEMENT!!  I appreciate all of the prayers and well wishes!  For anyone that isn’t up to date- my Dad was diagnosed with Glioblastoma in April of this year. He had completed one full round of chemo and radiation, and at the beginning of August he was not well. I won’t go into detail. However, I had been doing a lot of research and one of the AWESOME pages I found here was @JohnDParody  I went with a protocol that I felt was best and got my Dad started on a journey with Ivermectin and Fenbendazole. He HAS continued his chemo treatments, but I 100% believe it has been that being used in combination with the Ivermectin and Fenben that has gotten him where he is today. I’ve been here, and I’ve watched him improve daily. I do not have pictures of the scans themselves, because they’re not posted on the portal. But if anyone would like to compare it to any of his previous readings, I can get those as well. I’m going to go celebrate with my Dad.

Note:

Although the fenbendazole and mebendazole are very similar in effectiveness at higher doses, Mebendazole has superior brain cancer cell killing at lower loses compared to Fenbendazole. So for Glioblastoma, it’s Mebendazole if you can get it. Otherwise, you can't go wrong with Fenbendazole. It's still almost as good. (source)

Albendazole is also recommended for brain related cancers or brain spread, as it can cross the blood-brain barrier. (source)

Related: A Glioblastoma Survivor Story | Dr Justus Hope