Showing posts from July, 2022

Methylene Blue: Benefits, Dosage and Side Effects 2022

Methylene blue (MB), also known as methylthioninium chloride, is a bioactive substance and a blue dye. Methylene blue (MB), as the first fully man-made medicine, has a wide range of clinical applications. Apart from its well-known FDA approved applications in surgical staining, malaria, and methemoglobinemia, the anti-oxidative properties of MB recently brought new attention to this century-old drug. Some researchers believe that it can directly improve cellular and mitochondrial function and decrease the production of proteins linked to Alzheimer’s. It is also being studied for its potential to inhibit monoamine oxidase (MAO), nitric oxide (NO) synthase, and guanylate cyclase [ Rojas, 2013 ,  Tucker, 2017 ]. Mitochondrial Mechanisms During brain aging, mitochondrial dysfunction has been associated with neuronal loss. It has also been observed in many brain diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and brain injuries [ Nitzan,

Are You Prepared for Food and Energy Shortages?

While it’s difficult to predict just how bad it will get in any given area, it seems safe to say that everyone should prepare for some degree of food and energy shortages, regardless of where you live, as we’re staring at a perfect storm of confounding factors that are global in nature and therefore can cause far-reaching and somewhat unpredictable ripple effects. So, if you still haven’t begun preparations, I urge you to reconsider. Those who fail to prepare are likely to find themselves in an incredibly difficult situation this fall and next year. I was a member of the Boy Scouts in middle school and it was one of the best experiences of my life. Their motto is to “Be Prepared,” which has served me well most of my life, and I encourage you to consider it. Prepare With Shelf-Stable Foods Many say they feel unsure about how to prepare for food shortages and famine, having no real experience with that sort of thing. Modern life has also

CFU-f 101: To Be an Orthobiologics Expert You MUST Learn This

Chris Centeno - The blind leading the blind is one of my favorite expressions. As one of the founders of this field of interventional orthobiologics, the fact that this statement applies to much of our existing orthobiologics education is concerning to me. Nowhere is this more true than the concept of stem cell dose and CFU-f assays. Hence, this morning let’s dive into this topic. The Game of Telephone There’s a saying in medicine, “See one, do one, teach one”. Meaning, in medical school, internship, and residency, there’s a lot to learn, so that uptake had better be quick. While that may sound scary that doctors are educated in that way, when you have strict educational criteria where student physicians are the brightest of the brightest and you surround them with a tough didactic curriculum and then wrap that in formalized hands-on education, it kind of works. However, there is no such standard curriculum in orthobiologics. While  I founded an organization called IOF that is slowly b

What Does the ‘Best Evidence’ Say About Antidepressants?

In June 2022, 22.4% of American adults reported symptoms of depression, compared to 7.1% in 2017. 1   When the numbers were broken down in April 2022, half of young adults ages 18 to 24 reported feeling depressed; 22% ages 45 to 64 had depression symptoms; 9% of people age 65 or over reported feeling depressed. 2   While the rapid rise in depression has been attributed to the COVID-19 pandemic, the symptoms of depression have not changed. Depression can interfere with personal and work relationships, reduce work or academic performance and affect physical health by impairing your ability to properly care for yourself and make good health decisions, including decisions about nutrition and sleep. Imbalances in nutrition, weight fluctuations and poor sleep habits may in turn compromise your immune function. 3 The condition can also be lethal, as depression is a contributing factor in up to 70% of all suicides. 4  In 2016, 44,965 Americans committed suici


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