The Medical Advisor

Updated October 8, 2026 · Evidence reviewed and expanded Creatine monohydrate is one of the most extensively studied dietary supplements for improving high-intensity exercise performance and supporting gains in lean mass when combined with resistance training. Increasing research is also examining creatine's role in brain energy metabolism, memory, cognition, aging and mental health . But the evidence is not equally strong for every proposed benefit. The strongest evidence remains around exercise performance and muscle-related outcomes. Brain and mental-health applications are promising but more heterogeneous, and the 2024 finding linking brain creatine levels with recovery from traumatic stress was an observational study in only 25 U.S. veterans—not a clinical trial showing that taking creatine treats PTSD. Bottom line: For most healthy adults interested in strength, training adaptation or maintaining muscle with aging, 3–5 g/day of creatine m...

Creatine is a substance naturally found in muscle cells and the brain. It helps your muscles produce energy during high-intensity exercise or heavy lifting. Most of the body's creatine is stored in muscles, where it’s used for quick bursts of energy. As such, creatine is commonly used by athletes to improve performance, as it's immediately used by your body to convert adenosine diphosphate (ADP) to adenosine triphosphate (ATP) — the main energy currency of cells — and supply energy muscles need for contraction. However, creatine also helps provide energy to your brain and research suggests it may play an important role in recovery from traumatic stress. Unraveling the Neurobiological Reasons Why Some Develop PTSD — and Others Don’t While creatine is well-known for its benefits in physical performance and muscle health, its potential advantages for brain health are becoming increasingly recognized. In a study involving U.S. veterans, researchers with the University of Utah Schoo...

Parkinson’s disease, a progressive neurodegenerative disorder, affects millions worldwide, causing debilitating symptoms like tremors, rigidity, and cognitive decline. As researchers continue to explore innovative treatments, one unexpected candidate has emerged: ivermectin, a drug traditionally used to treat parasitic infections. Recent studies have sparked curiosity about its potential neuroprotective effects, prompting questions about whether this widely available medication could offer hope for managing or even slowing the progression of Parkinson’s disease. In this article, we delve into the science behind ivermectin’s potential role in Parkinson’s treatment, examining the latest research, mechanisms of action, and what this could mean for patients seeking new therapeutic options. Can Ivermectin play a key role in treating Parkinson's Disease? Two peer-reviewed papers—one by Warnecke et al. (2020) and another by Wadsworth et al. (2024)—along with a 2021 PhD thesis by ...