The Medical Advisor

GLP-1 medicines can be powerful tools for treating obesity and improving metabolic health. But successful weight loss should not be measured only by the number on the scale. When appetite falls and body weight declines, some people also lose lean mass. Bone mineral density can decline during substantial weight loss as well. That does not mean that GLP-1 medicines have been proven to directly cause osteoporosis. Current evidence is mixed, and the effects appear to depend on the drug, diabetes status, magnitude of weight loss, baseline bone health, nutrition and physical activity. The practical goal is therefore not to fear GLP-1 therapy. It is to make sure that fat loss does not come at the expense of muscle, physical function or skeletal health. OneDayMD evidence position: GLP-1 therapy should be viewed as one component of a broader weight-management strategy. Protein adequacy, resistance training, weight-bearing activity, adequate calcium and vitamin D, fall prevention...

If you read this article previously, please reread as there are two important edits that I added. The first is that you need to eat enough protein to achieve muscle growth which is about 0.6 grams/pound or 1.2 grams/kg of body weight. Secondly, I realized that using BFR in constant mode with straps is not as healthy for your muscles as it tends to result in low grade muscle spasms. Fortunately the KAATSU system allows you to do the exercise in a far healthier cycling mode which inflates the cuffs to a safe pressure but only for 30 seconds, and then repeats the process for a total of 8 cycles. Building muscle with BFR is massively important because sarcopenia (age-related muscle loss) threatens your healthy lifespan. One of the reasons I'm committed to exercising lifelong is because both of my parents died from frailty, and I'm determined to avoid sarcopenia, which took them prematurely. With society aging worldwide, the prevalence of sarcopenia increases the urgent need to est...