Fenbendazole in Stage 4 Kidney-Urinary Cancers: 2021 Stanford University Case Series and More (13 Case Reports) (2025)

By Editorial Team -

What is the "Stanford Fenbendazole Protocol"?

I bet you've never heard of the "Stanford Fenbendazole Protocol" for treating Cancer. Yet, it exists. But it's heavily suppressed by search engines and mainstream Oncology, especially in the United States and Canada. In 2021 a group at Stanford University Medical Center, Department of Medicine, published a Case Series (Clin. Oncol. Case Rep 2021)* on a "forbidden" repurposed drug, Fenbendazole.

*Note: Clinical Oncology Case Reports is a peer-reviewed International clinical and medical oncology and cancer research Journal. Clinical Oncology Case Reports (COCR) is a high-impact multidisciplinary journal focus on the area of clinical and medical investigation.


They wrote about 3 cases of Stage 4 Cancer patients who self-treated and cured their cancers.
 
Case 1: 63 year old man with a Stage 4 Renal Cell Carcinoma (clear cell), a 5.3cm mass and mets to pancreas and bone, failed 3 lines of chemo. He achieved remission on 1000mg Fenbendazole 3 times per week and his tumors shrank dramatically. Case 2: 72 year old man with Stage 4 Urothelial Carcinoma of Urethra, developed lung, lymph node and brain metastases. He failed radiotherapy, carboplatin, paclitaxel, pembrolizumab, and 6 cycles of gemcitabine and cisplatin Started 1000mg Fenbendazole orally 3 days per week, Vitamin E 800mg daily, Curcumin 600mg daily and CBD Oil CT scan showed tumor shrinkage of 2cm aortocaval node metastasis until it disappeared (complete radiographic response). Case 3: 63 year old woman with Stage 4 Urothelial Carcinoma of Bladder, with a 7.5cm tumor and extension to pelvic side wall. She took combination of Chemotherapy WITH Fenbendazole 1000mg three times a week. Follow-up CT revealed no evidence of disease. Sources and References:
For more Fenbendazole in Genito-Urinary stage 4 cancer case series, check out the case reports below. 

Kidney Cancer Success Stories (8 cases)

Case No. 8 - 2025: 42 year old Saudi Arabian woman with Stage 4 Renal Cell (Kidney) Cancer

Dr. William Makis shared on X.com in October 2025:

IVERMECTIN and MEBENDAZOLE Testimonial - 42 year old Saudi Arabian woman with Stage 4 Renal Cell Carcinoma sees improvement after 2 months!
I was very happy to learn recently that I shocked an Oncologist at the King Faisal Specialist Hospital in Saudi Arabia! STORY: 42 year old Saudi Arabian woman with Stage 4 Renal Cell Carcinoma metastatic to the lungs On July 9 she started: Ivermectin 1.5mg/kg/day Mebendazole 1500mg/day After only 2 months her lung metastases are shrinking and her kidney tumor is dying (turning necrotic). "The CT showed amazing improvement" "You are our hero and you made my day. My Oncologist was speechless."


Case No. 7 - 2025: 58 year old California CEO with Stage 4 Kidney Cancer recurrence and extensive metastatic disease

Dr. William Makis shared on X.com in September 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 58 year old California CEO with Stage 4 Kidney Cancer recurrence and extensive metastatic disease shows dying tumors after 10 weeks! Yes, I have several CEOs who have come to me for help. A few famous names as well. 58 year old California CEO with Stage 4 Kidney Cancer recurrence and extensive metastatic disease (had partial nephrectomy in 2010 but cancer returned and started spreading exponentially from Dec.2024) From mid April, 2025 he started taking Ivermectin and Fenbendazole. Results are after 2.5 months or 10 weeks, with all tumors showing various degrees of dying off.


Case No. 6 - 2025: 75 year old Southern Florida man with Stage 4 Renal Cell Carcinoma

Dr. William Makis shared on X.com in August 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 75 year old Southern Florida man with Stage 4 Renal Cell Carcinoma sees dramatic improvement after 6 months. He started low doses initially but with some research and peer review based guidance, increased those to more appropriate levels for Cancer. After 6 months on high doses of Ivermectin and Fenbendazole (in combination with Keytruda): - Lung metastasis shrunk from 14cm to 4cm - stomach metastases disappeared "Thank you for your advice and your work with our global community in fighting cancer. God Bless!"


Case No. 5 - 2025: 42 year old woman with Stage 4 Kidney Cancer to lungs, liver and shoulder

Dr. William Makis shared on X.com in August 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 42 year old woman with Stage 4 Kidney Cancer to lungs, liver and shoulder, is CANCER FREE after one year! STORY: 42 year old woman with Stage 4 Kidney Cancer to lungs, liver and shoulder Started Ivermectin and Fenbendazole Reports back after 1 year: "my scan today showed NED (No Evidence of Disease)." "I cannot thank you enough for what you are doing for people who are being handed a death sentence. You have given so many of us hope! Bless you"



Case No. 4: 63 year old Florida man with Stage 4 Clear cell renal cell carcinoma (ccRCC)* metastatic to chest

Dr. William Makis shared on X (Twitter) in April 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 63 year old Florida man with Stage 4 Renal Cell Clear Cell Cancer metastatic to chest becomes "CANCER FREE" after 3 months! Renal Cancer is a tough one...or...is it? 62 year old man with history of Stage 3 locally advanced Renal Clear Cell Carcinoma had a 3 cm tumor recurrence in the hilum. In early August 2024, this was one of my first patients. We started: Ivermectin 1mg/kg/day increasing to 2mg/kg/day Fenbendazole 1000mg/day July 2024 PET/CT showed: 3cm hilar metastasis Aug 2024 (early): Ivermectin + Fenbendazole Oncologist: immunotherapy Nov.18, 2024 PET/CT: Cancer Free Apr.5, 2024 PET/CT: Cancer Free April 7 patient wrote me: "I promised I would keep you in the loop on my follow-up PET/CT scan. No evidence of cancer! Again, I want to thank you for helping me. " "Most people I talk to, especially those that have cancer or their loved ones have cancer, think I am nuts with the protocol I take but the results speak for themselves!" "I will keep spreading the word and praying for you and your family" PET/CT April 5, 2025: "No evidence of recurrent or residual renal cell cancer". "The most recent PET/CT showed a complete response" "My Oncologist is thrilled". I bet he is! Because he sure as heck didn't do this. My Take... Quick. Easy. Cancer Free. Look, it honestly doesn't have to be complicated. The good news here is that there wasn't much overall tumor burden to deal with. One 3cm lesion. Patient jumped on this quickly before it spread further and he also knew that the Oncologist, having failed once, probably wasn't going to fix this. Remember, he was cancer free, on top of the line treatment that modern Oncology can offer in the United States (immunotherapy) and he STILL developed a 3cm recurrent cancer! I don't know how he found me, but he did. It was Day 3 of my Cancer Clinic. I'm now in the 8th month.

*Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer, making up about 80% of all kidney cancer cases.


Case No. 3: 68 yr old Male with Stage 4 Clear Cell Renal Cell Carcinoma - shrinking lung metastases by 60-70%! 

Dr. William Makis shared on X (Twitter) in March 2025:

Do you think Renal Cell Carcinoma can be beaten? Most doctors will tell you it can't.  Well, they're wrong.  Of course, your local friendly mRNA Vaccinated Oncologist has no chance to even contemplate this. Story: 68 year old man with Stage 4 Clear Cell Renal Cell Carcinoma and lung metastases reached out to my Ivermectin Cancer Clinic.
   Did a 3 month protocol of :
  • Ivermectin 2mg/kg/day
  • Fenbendazole 888mg/day
  • CBD Oil 25mg/day
  • Melatonin 120mg/day
RESULTS: Largest lung metastasis shrunk from 1.3x0.7cm to 1.2x0.3cm. According to Grok, that’s a reduction of 60-70% tumor volume. Another lung nodule shrunk 0.7cm to 0.6cm, a reduction of 37% tumor volume. No chemo. No radiation. No immunotherapy.


Case No. 2: Stage 4 Metastatic Clear Cell Renal Carcinoma (aka Kidney cancer) - July, 2022

Husband diagnosed 7/19/21

Stage 4 Metastatic Clear Cell Renal Carcinoma (aka Kidney cancer).

Surgery 8/2/21 left radical nephrectomy with complications and have colostomy

9/2/21 Start Opdivo

10/2021 colostomy reversal

11/2021 land in ER with sepsis (unknown origin) and have surgery

11/2021 Start Yervoy in addition to Opdivo (and FenBen)

11/2021 (just before Thanksgiving), doctor said ”let’s see if you can make it 5 weeks” when husband asked about prognosis

12/21 Travel to NYC to spend what my husband believes is his last Christmas

1/3/21 ER visit due to lack of lucidity

1/22 Start Cabo (have been off FenBen because of all the hospital visits)

2/4/22 see medical consultant – start FenBen again

5/22 – Cancer is shrinking some totally gone – off nearly all pain meds. Doctor says he’s never seen this much progress in such little time.

6/22 – Cancer is still shrinking – off almost every pain med (1 10MG Oxy a day)

7/22 – Cancer still shrinking!! PTL


Case No. 1: Stage 4 Kidney Cancer (December, 2021)

In 2016 I was diagnosed with stage 4 cancer in my kidney and abdomen alongside a secondary diagnosis of follicular lymphoma. The Oncologist predicted that if I am lucky I will have 6 months left to spare.

I declined any medical help that came my way and decided with dedication and faith to take the natural path to healing from the very beginning of my cancer journey.

It has been a challenging journey for me the last year and I thought I might not make it at one point. But, then, everything started to change and my symptoms were fading slowly but surely from using various methods and eventually ended up taking fenbendazole and following the protocol religiously. I started off on a dose of 150mg and kept on increasing it from there over a period of four months. I showed symptoms when I hit the 600mg dosage and was very concerned that it might not be the best approach and even though I kept on increasing the dose over a reasonable amount of time and took a break off of it for a couple of days before I would continue on it again.

Over the last month the swelling in my face seems to have decreased and I don’t experience anymore pain in my eye, and the lymph nodes were busy disappearing up to the point of not being visible anymore. My persistence and belief in the protocol paid off, this is the least I can say!

I still have a long journey to walk, but I am more motivated than ever and I attribute all the success to the use of this protocol and encourage everyone to give it a go! Do not lose hope.

See also Bladder (Urinary) Cancer success story below. 

Stage 4 Urinary Bladder Cancer Success Stories

Case No. 2: 57 year old Chicago man with Stage 4 Small Cell Carcinoma of the Bladder

Dr. William Makis shared on X (Twitter) in September 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 57 year old Chicago man with Stage 4 Small Cell Carcinoma of the Bladder - cancer free after 2 months! We have been particularly successful with bladder cancers of all types. 57 year old Chicago man with Stage 4 Small Cell Carcinoma of the Bladder (very aggressive type) End of May 2025 he started:
  • Ivermectin 1.5mg/kg/day
  • Fenbendazole 1500mg/day
He also had pelvic radiation Results after 2 months: "Today's PET examination demonstrates complete interval resolution of previous hypermetabolic pelvic tumor" "Complete metabolic response to therapy. No FDG avid tumor currently" "Signatera CT DNA bloodwork...is back at zero" From the patient: "This is clearly a success story after starting the protocol with a very aggressive form of cancer. We cannot thank you enough" "They said he is cancer free"


Case No. 1 - 2025: Stage 4 Urothelial Bladder Cancer


Description: Shared on March 24, 2025, by @MakisMD, this details a 75-year-old man with Stage 4 urothelial bladder cancer with metastases to multiple organs. He reportedly showed dramatic improvement on PET/CT scans after using ivermectin and fenbendazole.

TREATMENT 
  • Padcev and Keytruda 12/23/2024 to 3/10/2025 
  • Fenbendazole 222mg/d 1/3/2025 to 2/19/2025 
  • Ivermectin 30mg/d 1/20/2025 to 2/19/2025 
  • Fenbendazole 1500mg/d (Makis Protocol) 2/19/2025 - 3/10/2025 
  • Ivermectin 1mg/kg/d (Makis Protocol) 2/19/2025 - 3/10/2025

Enfortumab Vedotin and Pembrolizumab in Untreated Advanced Urothelial Cancer (EV-302/KEYNOTE-A39) - NEJM 2024

A combination of Keytruda and Astellas and Pfizer’s Padcev won full FDA approval as a first-line treatment for advanced bladder cancer—regardless of the patient’s eligibility for chemotherapy. The approval came after the phase 3 EV-302 trial linked the Keytruda-Padcev combo to a 53% reduction in the risk of death compared with chemo. (EV-302/KEYNOTE-A39)

But the EV-302 readout was viewed as more of a success for Padcev and the antibody-drug conjugate modality, especially given Keytruda’s previous stumbles (KEYNOTE 361) in first-line bladder cancer as a monotherapy and as part of a combination with traditional chemotherapy.

Fenbendazole and Other Stage 4 Cancer Types

The compilation includes over 150 stage 4 cancer case reports across 17 cancer types. Full details are provided in the following: https://www.onedaymd.com/2025/06/ivermectin-fenbendazole-mebendazole-stage-4-cancer.html.


Notes:

No single drug is a miracle cure for all cancers. Taking a particular drug as a stand alone strategy cannot replace an unhealthy lifestyle i.e. heavy smoker, alcoholic, a very stressful and non-active lifestyle, overweight and obesity. All these cancer promoting factors need to change.

The best way to fight cancer is to utilise a menu of strategies by maintaining good health, like from eating a nutritious whole-food diet with lots of fruits and vegetables, avoid ultra processed foods and a healthy lifestyle. Each strategy might produce an incremental improvement in results for some cancers when added to existing treatment regimens.

Everyone’s situation is different, however, it is important to arm yourself with medical knowledge that cancer doctors (Oncologists) may simply not give you.

Whether you’re living with cancer or a survivor, talk to your doctor to determine the best treatment for you.


Disclaimers: 
  • Please do not consider this guide as personal medical advice, but as a recommendation for use by professional providers. Consult with your doctor and discuss with her/him. 
  • Our aim here isn't to replace your doctors' advice. It is intended as a sharing of knowledge and information. Do take note that most treatments are not 100% protective or curative against cancer. It's a continuous struggle between the immune system and the cancer cells. Cancer treatments are meant to assist the immune system in this battle.
  • Cancer treatment should be part of a multi-modal approach in order to provide the best possible outcome. Diet and lifestyle changes are meant to run alongside conventional treatment. They are complementary, not alternative. That said, there is no miracle diet or treatment that can cure all cancers.

Find Integrative Oncologists in USA, Mexico, Europe or Asia

While the potential anti-cancer properties of fenbendazole are intriguing, it’s crucial to approach with caution.

Consulting with an integrative healthcare expert is key to crafting a Fenbendazole protocol tailored to your unique health requirements. 

To find integrative oncologists, check out "find integrative oncologists".

New & Improved Joe Tippens Protocol

In 2016, Joe Tippens was diagnosed with non-small-cell lung cancer with extensive metastatic disease. At the advice of a veterinarian friend, he took Fenbendazole together with nanocurcumin, and three months after starting these drugs his PET scan was completely clear.

Below is a modified version of the Joe Tippens protocol, a synergistic combination of fenbendazole, ivermectin and nutraceuticals, updated based on the ivermectin and mebendazole based protocol published in the Journal of Orthomolecular Medicine (2024):
  • Ivermectin (24 mg, 7 days a week) or in the case of severe aggressive cancers up to 1mg/kg/day.
  • Mebendazole (Dose of 200 - 400 mg/day) or Fenbendazole, commonly taken at 300 mg for six days a week, with doses increasing to up to 1 gram in cases of aggressive cancers.
  • Vitamin D (62.5 mcg [2500 IU] seven days a week).
  • Bio-Available Curcumin (600 mg per day, 7 days a week). 
  • Enhanced absorption Berberine (500 mg per day) to starve your cancer of sugar.
  • Diet and Lifestyle: Eliminate sugar (BMJ 2023), adopt a whole-food diet, avoid ultra-processed foods (BMJ 2024) and a healthy lifestyle with quality sleep and proper stress management. 
*Notes:
  • Please note that this protocol now includes the vital Vitamin D addition, with the one day off for the fenbendazole administration. This protocol represents the most comprehensive and cutting edge repurposed drug and vitamin treatment approach to date.
  • If you are taking ivermectin and mebendazole, you might not need fenbendazole. Consult your doctor.
  • Vitamin E: Removed from the protocol (Joe Tippens, July 22, 2020) due to interactions (e.g., with blood thinners).

References:
Related: Enfortumab Vedotin and Pembrolizumab in Untreated Advanced Urothelial Cancer (EV-302/KEYNOTE-A39) - NEJM 2024

Read More: This article is part of the Winning the War on Cancer series.

Source: Reddit




Ivermectin and mebendazole, both approved for human use, are now available in the U.S.

Researched and approved by Dr. Peter McCullough.
  • Prescribed by licensed medical professionals
  • Compounded and dispensed by a licensed US-based pharmacy
  • Approved for human use
Where to buy Ivermectin and Mebendazole Formula: Available on The Wellness Company's website. Here is the link: Ivermectin and Mebendazole.

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