Best Ivermectin Dosage for Humans with Cancer or Different Cancer Types (2024)

Introduction

This article discusses dosage considerations and key factors regarding the use of ivermectin in cancer treatment.

Commonly available information about ivermectin dosages is often inaccurate when applied to potential cancer-related uses. Many sources cite standard dosages recommended by Merck for treating parasitic infections, rather than dosages studied specifically in the context of cancer research.

The anti-parasitic dosage is not as effective for people looking for a dosage against cancer. Dosage will need to be adjusted according to cancer type and stage.

Ivermectin dosage should be based on ivermectin cancer studies. Multiple factors are considered including studies including ivermectin for cancer, anecdotal studies and case series, the aggressiveness of the cancer type and the cancer stage.

Cancer dosage estimation can be adjusted based on the time that a person has to beat cancer or its risk to the patient - this includes both the cancer type and whether the cancer has spread or metastasised.

Some cancers provide the patient with less time to beat the cancer e.g. fast growing cancer, and of course; metastasis also means that the time to beat the cancer is shorter than before metastasis.

What Is Ivermectin?

Ivermectin is an anti-parasite drug used to treat various parasite infections in humans, but it can also be used to treat other health conditions like river blindness, onchocerciasis, intestinal strongyloidiasis, and onchocerciasis.

Ivermectin is often recognized – 2nd to penicillin – for having the greatest impact on human health. And its discovery won the Nobel Prize in 2015. Ivermectin has an increasing list of indications due to its antiviral and anti-inflammatory properties, and is included on the WHO’s Model List of Essential Medicines

Several studies reported antiviral effects of ivermectin on RNA viruses such as dengue, Zika, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency virus type 1, and COVID 19 virus.

Ivermectin vs Conventional Cancer Treatments

Taking conventional cancer treatments should involve a detailed analysis of the normally complex treatments and its cost-benefit e.g. immunotherapy cost-benefit.

The Big Pharma Strategy of promoting new on patent, less safe and less effective drugs versus drugs which are off patent.

On the hand, taking ivermectin requires far less analysis as it provides other additional health benefits and is something every cancer patient could take.

Ivermectin is effective against cancer as a treatment but also as a cancer preventive drug.

It can be taken without much issue in general for long period for both purposes i.e. to prevent cancer and to minimize cancer recurrence.

Ivermectin has extremely low side effects compared to any conventional cancer treatment - while conventional cancer chemotherapy are some of drugs with the highest side effects.

The cost of ivermectin versus conventional cancer treatments are low.


Ivermectin vs Other Non-Conventional Cancer Treatments

Ivermectin is one of the top non-standard or non-conventional drug for cancer.

A close second would be fenbendazole - which also happens to be an anti-parasitic drug that works against cancer through some difference mechanisms than ivermectin - which we cover in the article here: 
Fenbendazole Joe Tippens Protocol.

Best Ivermectin Dosage for Humans

Is there any study for Ivermectin and Fenbendazole for Cancer?

Yes. There is now a peer-reviewed research study where patients with cancer successfully took all three drugs Fenbendazole, Mebendazole and Ivermectin. Experts believe this combination attacks the mitochondrial support for cancer stem cells.

According to oncologist Dr William Makis:

This paper is the FIRST peer-reviewed and Published paper in the world to propose a Cancer Treatment Protocol based on the incredible properties of IVERMECTIN, MEBENDAZOLE and FENBENDAZOLE. This was truly a labor of love.

My thanks to lead authors Ilyes Baghli and Pierrick Martinez for their incredible inspired work, FLCCC’s Dr. Paul Marik for his extensive work on repurposed drugs and every co-author who worked hard to bring this paper to life.

I hope that this paper lays the groundwork for a brand new future for Cancer Treatment”.



The Hybrid Orthomolecular Cancer Protocol: 7 therapeutic recommendations, consisting of orthomolecules, drugs, and additional therapies

1. Intravenous Vitamin C 

Intermediate- and high-grade cancers: Dose of 1.5g/kg/day, 2-3x per week (Fan, et al., 2023). Established as a non-toxic dose for cancer patients (Wang, F., et al., 2019). 

2. Oral Vitamin D 

All cancer grades: Dose of 50,000 IU/day for patients with a blood level ≤ 30ng/mL; 25,000 IU/day for levels 30-60ng/mL; and 5000 IU/day for levels 60-80ng/mL. Established as a non-toxic dose (Cannon, et al., 2016; Ghanaati, et al., 2020; McCullough, et al., 2019). 

It is necessary to reach a blood level of 80 ng/mL of vitamin D (25-hydroxyvitamine D (25(OH) D) (Kennel, et al., 2010; Mohr, et al., 2014; Mohr, et al., 2015). This level is non-toxic (Holick, et al., 2011). Once this level is reached it must be maintained with a reduced daily dosage of ≈ 2000 IU/day (Ekwaru, et al., 2014). The vitamin D blood concentration should be measured every two weeks for high doses and monthly for lower doses. 

3. Zinc 

All cancer grades: Dose of 1 mg/kg/day is established as a non-toxic dose for cancer patients (Hoppe, et al., 2021; Lin, et al., 2006). The reference range for serum zinc concentration is 80 to 120 μg/dL (Mashhadi, et al., 2016; Yokokawa, et al., 2020). Once this level is reached it must be maintained with a reduced daily dosage of 5mg/day (Li, et al., 2022). The zinc blood concentration should be measured monthly.

4. Ivermectin 
  • Low-grade cancers: Dose of 0.5mg/kg, 3x per week (Guzzo, et al., 2002). 
  • Intermediate-grade cancers: Dose of 1mg/kg, 3x per week (Guzzo, et al., 2002). 
  • High-grade cancers: Dose from 1 mg/kg/day (de Castro, et al., 2020) to 2 mg/ kg/day (Guzzo, et al., 2002). 
All these doses have been established as tolerable for humans (Guzzo, et al., 2002). 

5. Benzimidazoles and DON*
  • Low-grade cancers: Mebendazole: Dose of 200 mg/day (Dobrosotskaya, et al., 2011). 
  • Intermediate-grade cancers: Mebendazole: Dose of 400 mg/day (Chai, et al., 2021). 
  • High-grade cancers: Mebendazole dose of 1,500 mg/day (Son, et al., 2020) or Fenbendazole 1,000 mg 3x per week (Chiang, et al., 2021). 
All these doses have been established as tolerable for humans (Chai, et al., 2021; Chiang, et al., 2021; Son, et al., 2020). Benzimidazoles can be replaced or combined with DON, administered without toxicity; intravenously or intramuscularly: 0.2 to 0.6 mg/kg once daily; or orally: 0.2 to 1.1 mg/kg once daily (Lemberg, et al., 2018; Rais, et al., 2022). Benzimidazole are much easier to obtain than DON. However, for metastatic cancers, which rely heavily on glutamine (Seyfried, et al., 2020), a combination of DON and Benzimidazoles should be considered (Mukherjee, et al., 2023). 

*DON (6-diazo-5-oxo-L-norleucine) is a glutamine-specific antagonist more potent than Benzimidazoles.

6. Dietary Interventions 

All cancer grades: Ketogenic diet (low carbohydrate-high fat diet, 900 to 1500 kcal/day) (Weber, et al., 2020). 

Ketone metabolic therapy consists of approximately 60- 80% fat, 15-25% protein and 5-10% fibrous carbohydrates. Adequate hydration and single-ingredient whole food ketogenic meals are necessary to achieve a glucose ketone index (GKI) score of 2.0 or below (Meidenbauer, et al., 2015; Seyfried, Shivane, et al., 2021). GKI should be measured 2–3 hours postprandial, twice a day if possible (Meidenbauer, et al., 2015; Seyfried, Shivane, et al., 2021). 

Intermediate- and high-grade cancers: The ketogenic diet should be coupled with a water fast for 3 to 7 consecutive days in advanced cancers (Phillips, et al., 2022; Arora, et al., 2023). The water fast should be repeated several times (≈ every 3-4 weeks) throughout the treatment (Nencioni, et al., 2018), but fasting needs to be undertaken cautiously in individuals using certain drugs and those with < 20 BMI, to prevent loss of lean body mass. 

For patients who can not fast, the FastingMimicking Diet (300 to 1,100 kcal/day of broths, soups, juices, nut bars, and herbal teas) can be used (Nencioni, et al., 2018). 

7. Additional Therapeutics 

All cancer grades: Moderate physical activity, 3x per week. Increased heart and respiratory rate for a period of 45 to 75 minutes (Bull, et al., 2020) with activities such as cycling, running, swimming, etc.
 
Intermediate- and high-grade cancers or individuals who are unable to engage in physical activity: Hyperbaric oxygen therapy (HBOT), 1.5 to 2.5 ATA for 45 to 60 minutes 2-3x per week (Gonzalez, et al., 2018; Poff, et al., 2015).

New & Improved Joe Tippens Protocol

If you or a loved one has been diagnosed with cancer, you may have come across the Joe Tippens Cancer Protocol. In recent years, the Fenbendazole Cancer Protocol has gained significant attention, fueled by reports of advanced cancer success stories. Below is a modified version of the Joe Tippens protocol, as recommended by Canadian oncologist Dr. William Makis.
  • Fenbendazole* (300 mg, 6 days a week) or in the case of severe turbo cancers up to 1 gram.
  • Ivermectin (24 mg, 7 days a week) or in the case of severe turbo cancers up to 1mg/kg/day.
  • Diet and Lifestyle: Removing sugar from one’s diet is crucial during this protocol (as highlighted in BMJ 2023). Maintaining a nutritious diet rich in fresh, whole foods, including fruits and vegetables, while avoiding ultra-processed foods (as highlighted in BMJ 2024), along with adopting a healthy, low-stress lifestyle, is essential for overall well-being.
  • Bio-Available Curcumin (600 mg per day, 2 pills per day 7 days a week).
  • Vitamin D (62.5 mcg [2500 IU] seven days a week).
  • Tocotrienol and Tocopherol forms (all 8) of Vitamin E (400-800mg per day, 7 days a week). A product called Gamma E by Life Extension.
*Alternatives to Panacur C: 

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