Fenbendazole, Ivermectin and Mebendazole for Breast Cancer Success Stories

Fenbendazole, Ivermectin and Mebendazole for Breast Cancer Success Stories – 35 Case Reports (June 2025)

By Editorial Team - June 04, 2025

Can Fenbendazole, Ivermectin and Mebendazole play a key role in treating Stage 4 Breast Cancer?

Several peer-reviewed papers and case studies (below) suggest that it might.

In this article, we examine case studies of fenbendazole, ivermectin and mebendazole and its possible role as an adjunct treatment in managing breast cancer. Could these repurposed drugs offer new hope for patients seeking additional treatment options? Let’s take a closer look.

Breast Cancer Success Stories

Case 35 - 2025: 26-year-old UK female with Stage 4 Breast Cancer Triple Negative with brain metastases

Dr. William Makis shared on X (Twitter) in June 2025:

IVERMECTIN and MEBENDAZOLE Testimonial - 26 year old UK woman with Stage 4 Breast Cancer Triple Negative with brain metastases responds incredibly well after 4 weeks (shrinking lung mets & brain mets) One of my youngest breast cancer patients has seen tremendous success! This 26 year old UK woman, Stage 4 Breast Cancer Triple Negative (TNBC) patient was progressing on numerous conventional Cancer Treatments: - Initially diagnosed Feb.2023 - completed Capecitabine chemo Feb.2024 - May 2024 diagnosed with Lung metastases (Stage 4) - was on Olaparib (Lynparza, PARP Inhibitor) May 2024 to March 2025 - April 2025 5cm brain metastasis was diagnosed, and she came to me. After 4 weeks of Ivermectin + Mebendazole + Trodelvy, her lung metastases and brain metastasis are shrinking. "Hey guys, just wanted to share some great news!" "In 4 weeks my brain tumor has gone from 5cm to 3cm and the huge cyst attached has halved in size!" "Also my my 5 lung mets have massively shrank! So very positive!!" "Thank you so much for all your help! Looking forward to seeing what the future brings with my results! Best wishes..."

Related: Ivermectin and Mebendazole (Compounded Formula) from The Wellness Company.

Case 34 - 2025: 49 year old woman in Puerto Rico with Stage 3 Breast Cancer

Dr. William Makis shared on X (Twitter) in June 2025:

IVERMECTIN, FENBENDAZOLE, MEBENDAZOLE and DMSO Testimonial - 49 year old woman in Puerto Rico with Stage 3 Breast Cancer has >50% tumor shrinkage in 4 weeks! Oncologist left speechless... I love shocking Oncologists around the world, but this one is special. STORY: 49 year old woman from Puerto Rico was diagnosed with aggressive Stage 3 Breast Cancer She started:

Ivermectin paste
Fenbendazole
DMSO

She reached out to me and we made an adjustment:

Ivermectin 1.5mg/kg/day
Mebendazole 1500mg/day

RESULTS after 4 weeks: Description of Oncologist: “He started the exam…His face dropped in surprise when he noticed how much smaller the tumor was” “He used words like “surprising” and “unbelievable” and “incredible” to describe the change "He believes it has shrunk by more than half." “Then he just kind of stood there, laughing for a few moments” You can almost picture it. He was so shocked, all he could do is stand there and laugh. "Your decision to keep fighting for your patients means that, all the way from Canada, you are giving hope to a family in Puerto Rico".

Cases 25 - 33: A phase I/II study evaluating the safety and efficacy of ivermectin in combination with balstilimab in patients with metastatic triple negative breast cancer

Abstract e13146 (2025 ASCO Annual Meeting) is a phase 1/2 study of ivermectin in combination with balstilimab after 1-2 prior lines of therapy for triple negative breast cancer:

Background: Despite recent FDA approval of immune checkpoint inhibitor (ICI) and antibody-drug conjugates (ADCs), therapeutic options for metastatic triple negative breast cancer (mTNBC) remain limited. Preclinical data showed that ivermectin induces robust T cell infiltration into breast tumors and turning “cold” tumors “hot” in mouse model of TNBC. Balstilimab is a fully humanized IgG4 anti-PD-1 agent with proven safety and efficacy in metastatic cervical cancer. The current phase I/II trial is designed to test the safety and efficacy of the combination of ivermectin and balstilimab in patients with mTNBC.

Methods: Key eligibility criteria include patients with unresectable or metastatic TNBC; progressed on 1-2 prior chemotherapies including an ICI-containing regimen; ECOG 0-1; RECIST 1.1 measurable disease. Eligible patients receive balstilimab 450 mg, IV, on Day 1 and ivermectin (30, 45 or 60 mg po daily), PO, Days 1-3, 8-10, 15-17 of each 21 days cycle till disease progression or intolerance. The primary objective of the phase 1 portion of the study is to determine the recommended phase 2 dose of ivermectin in combination with balstilimab using NCI-CTCAE v5.0. The primary objective of the phase II portion of the study is to determine the efficacy of the combination using the objective response rate (ORR). Secondary objectives are progression free survival (PFS), overall survival (OS), clinical benefit rate (CBR), and patients’ quality of life (QOL) by EORTC QLQ-C30.

Results: This study has accrual 9 patients to-date. Median age was 52 years (IQR 47-56, range 38-68), 4 (44.4%) were non-Hispanic white, 3 (33.3%) were Hispanic, and 2 were other (22.2%). Median lines of metastatic chemo or targeted therapy prior to the start of trial registration was 5 (IQR 2-5, range 1-7). Dose level 1 and 2 were completed with only 1 serious adverse event (AE) attributed to disease related anemia. All grades treatment related AEs are: 2 maculo-papular rash (grade 1), 1 patient each for anemia (grade 3), diarrhea (grade 1), dysgeusia (grade 1), generalized muscle weakness (grade 1), hypothyroidism (grade 2), and vomiting (grade 1). The initial ECOG value was 0 among 8 patients and 1 patient had ECOG of 1. Six (66.7%) patients had prior immune checkpoint inhibitors, 6 (66.7%) had positive tumor PD-L1 expression. The study will continue to accrual of dose level 3. Of 8 evaluable patients, 1 had SD, 6 had PD, and 1 had PR. The median PFS was 2.5 month (95% CI 66 – Not reached). The 4-month clinical benefit rate was 37.5% (95% CI 15.3%-91.7%). OS is too early to be assessed.

Conclusions: The combination of ivermectin and balstilimab is safe and well tolerated. Encouraging CBR (Clinical Benefit Rate) was observed in this heavily pretreated population, which warranted continued investigation. Clinical trial information: NCT05318469

According to the administrative update, the current responsible party has changed from City of Hope Medical Centre to Cedars-Sinai Medical Center. However, the principal investigator remains the same, Yuan Yuan, MD, PhD.

Contact: Clinical Trial Navigator
Phone Number: 310-423-2133 (source).
Email Address: cancer.trial.info@cshs.org

Case 24 - 2025: 80-year-old woman post breast cancer lumpectomy was on maintenance Ivermectin

Dr. William Makis shared on X (Twitter) in May 2025:

IVERMECTIN Testimonial - 80 year old woman post breast cancer lumpectomy was on maintenance Ivermectin - unexpectedly, she defeated Rheumatoid Arthritis and Crohn's Disease complications. 80 year old patient with breast cancer had a lumpectomy. From the patient: "I started taking Ivermectin 12mg daily about 2 months ago because I had breast cancer lumpectomy and wanted to try to avoid another cancer incident" "The side effects from the ivermectin have been unexpected and welcomed" "My RA (Rheumatoid Arthritis) is calmed down, my knees are no longer painful (I was told I needed both replacements)" "I was diagnosed with Crohn's disease...the problems I have experienced since that time are related to the surgeries I had...best of all my bowels have slowed down and I do not experience the constant diarrhea or near dehydration" "At almost 80 years old, I am getting back to gardening, housekeeping and cooking".

Case 23 - 2025: 67 year old Ontario patient with Stage 4 Breast Cancer metastatic to lungs and bones

Dr. William Makis shared on X (Twitter) in May 2025:

IVERMECTIN and MEBENDAZOLE Testimonial - 67 year old Ontario patient with Stage 4 Breast Cancer metastatic to lungs and bones has a stunning turnaround after only 2 months! Up to 99.7% tumor shrinkage Most cancer patients appreciate help in desperate situations. STORY: 67 year old Ontario woman was diagnosed with Stage 4 Breast Cancer metastatic to lungs and bones on Jan.24, 2025. We started on Jan.31, 2025:

Ivermectin 1.5mg/kg/day (120mg)
Mebendazole 1000mg/day

She took Ivermectin and Mebendazole for 2 months and 10 days. Follow-up CT showed: Right Breast mass shrunk in size Lymph nodes shrunk: hilar 1.7cm to 0.6cm, subcarinal 2.2cm to 0.5cm, rt axilla 1.4cm to 0.2cm (99.7% tumor vol shrinkage) Lung nodules shrunk (2.1x1.1cm to 0.8x0.5cm is 92% tumor volume shrinkage!!) Pleural effusions resolved (!!) Bone lesions show new healing (sclerosis) This is an incredible response after just 2 months! Oncologists are usually not capable of getting pleural effusions to resolve. From the patient: "We got the latest CT scan and it shows all tumors have shrunk dramatically and the breast tissue is totally gone!" "Thank you for travelling this road with us!" "Blessings to you and your Team!"

Related: Ivermectin and Mebendazole (Compounded Formula) from The Wellness Company.

Case 22 - 2025: 49 year old Australian woman with Stage 4 Breast Cancer to liver and bones who failed Kisqali

Dr. William Makis shared on X (Twitter) in May 2025:

"IVERMECTIN and FENBENDAZOLE Testimonial - 49 year old Australian woman with Stage 4 Breast Cancer to liver and bones who failed Kisqali, has full metabolic response on PET after only 6 weeks! Incredible Cancer success story from Australia!

I told you I have patients from around the world! STORY: 49 year old Australian woman with Stage 4 Breast Cancer metastatic to bones (sternum, ribs) on Letrozole and Kisqali, reached out to me

We started in mid February:

Ivermectin 1mg/kg/day
Fenbendazole 444mg/day increasing to 1554mg/day

However, by end of February, the cancer had progressed to the liver and her Oncologist switched from Kisqali to Capecitabine 1500mg.

RESULTS at end of April 2025:

"We had our appointment with the oncologist today who shared with us XXX's "miraculous" (her words) PET scan results"

"As you can see 6 weeks ago, before starting your protocol, she had extensive metastasis to her lymph bones and liver."

"Today we were told she has had a "complete metabolic response" with no detectable cancer anywhere in her body"

My favorite part

"We thank you once again for the tireless commitment you have provided to XXX and the other countless cancer suffer(er)s you help on a daily basis"

My Take...
"I don’t always get nice images sent to me, but in this case, I did. This PET scan improvement is impressive! Especially considering the short time frame. Don't forget, this breast cancer patient was on Kisqali, the best that modern Oncology could offer this patient. The cost? Up to $15,000 a month. We completely blew Kisqali out of the water. A useless drug that brings in $15,000 a month from every cancer patient that uses it. The cost of Ivermectin and Fenbendazole? About $200-$300 a month."

Case 21: 56 year old Illinois woman with Stage 4 Breast cancer and spread to bones

Dr. William Makis shared on X (Twitter) in May 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 56 year old Illinois woman with Stage 4 Breast Cancer to bones has excellent response! STORY: 56 year old Illinois woman was diagnosed with Stage 4 Breast cancer to bones.

We started in late January 2025:

Ivermectin 1.5mg/kg/day
Fenbendazole 1000mg/day

Oncologist started Letrozole 2.5mg/day in mid Jan.2025 and Kisqali (targeted therapy) in beginning of March 2025, that had to be stopped due to side effects.

RESULTS (after 2 months): From patient: "I wanted to share some amazing updates on blood markers. The CA 15-3 has dropped by 74% and CA 27-29 has dropped by 73.5% in 2 months!"

CA 15-3: 335 to 88.6

CA 27-29: 764 to 203

PET/CT confirmed ongoing healing of bone metastases !

Case 20: 35 year old American woman with Stage 4 Breast cancer metastatic to lymph nodes and bones

Dr. William Makis shared on X (Twitter) in April 2025:

IVERMECTIN and MEBENDAZOLE Testimonial - 35 year old American woman with Stage 4 Breast cancer metastatic to lymph nodes and bones sees dramatic improvement! 35 years old with Stage 4 is a difficult battle but we go to war against cancer with no hesitation! STORY: 35 year old American woman was diagnosed with Stage 4 Breast Cancer metastatic to lymph nodes and multiple bones. She came to me in mid January 2025.

We started:

Ivermectin 1.5mg/kg/day
Mebendazole 1000mg/day

RESULTS after 2.5 months:

- Cancer Blood marker CA15.3 dropped from 50.1 to 26.9

- SIGNATERA (circulating tumor DNA) dropped from 5.1 to 0.07 (!!)

- PET Scan showed decreased metabolic activity in all bone metastases and all lymph node metastases.

The only issue we ran into was an MRI that saw some "larger" bone lesions, which were almost certainly areas of bone healing in previously invisible areas of cancer. This is one of the major advantages that PET/CT has over MRI or CT - it is able to identify “healed bone metastases” which look “larger” due to sclerosis (bone healing) but have lower or no metabolic activity due to cancer cell killing. In this case, we see a dramatic response after only 2.5 months on Ivermectin & Mebendazole! Oncologists have never seen results like this. Sometimes, they'll even admit it.

Case 19: 61-year-old Florida woman with Stage 4 Breast Cancer metastatic to lungs, liver, and bones

Dr. William Makis shared on X (Twitter) in April 2025:

Ivermectin and Mebendazole Testimonial - 61 year old Florida woman with Stage 4 Breast Cancer metastatic to lungs, liver, and bones, has dramatic response in 2 months - 83% tumor shrinkage!

Breast cancer is the most common cancer at my Ivermectin Cancer Clinic. We have so many successes!!

STORY:

61 year old Florida woman was diagnosed with Stage 4 Breast Cancer metastatic to lungs, liver, and bones. Patient started Ivermectin and Fenbendazole 444mg at end of December 2024 but the breast mass continued to grow.The patient then came to me for assistance.

Sometimes you need some guidance from someone with expertise.

In early February 2025, patient started:

Ivermectin 120mg (2mg/kg) and
Mebendazole 1000mg along with
6 cycles of Carboplatin + Paclitaxel.

Within 2 months, the breast tumor shrunk from 8.0x7.0cm to 3.5x2.7cm (83% tumor volume shrinkage!!)
Oncologist: “He is so impressed with her treatment...not aware of the ivermectin and mebendazole"

Patient:
"We are grateful to you for your advice and support. We hope and believe she will make the mass on her breast disappear completely"

"I follow closely on X your case with Alberta health and I root for you!"
Imagine an 8cm tumor shrinking down to 3.5cm in barely two months with Ivermectin & Fenbendazole.

Case 18: 57 year old California female with Stage 4 Breast Cancer and progressing metastases

Dr William Makis updated on X (Twitter) in April 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 57 year old California woman with Stage 4 Breast Cancer goes from progressing metastases to "CANCER FREE" in 3 months!

57 year old Stage 4 Breast Cancer patient with metastatic lymph nodes in the thorax and abdomen.

In August 2024, PET/CT showed progressive metastases that were growing quite quickly. She reached out to me in August 2024 and was one of the first patients in my Ivermectin Cancer Clinic! She started:

Ivermectin 45mg/day and
Fenbendazole 444mg/day

In mid December, 2024 (her Ivermectin order had been confiscated by some evil individuals, so her start was delayed) On Feb.25, 2025, PET/CT showed no evidence of disease. All the metastatic lymph nodes were gone. That’s less than 3 months. When a tumor is very responsive to Ivermectin and Fenbendazole, the results can be absolutely jaw dropping. From the patient: "I started your Ivermectin and Fenbendazole protocol in December 2024, along with targeted therapy Enhertu. I now have "no evidence of disease"!" (email March 20, 2025) “My oncologist is very open to me staying on ivermectin, actually told me to keep taking it, knows it helps chemo work better, and said, “absolutely” when I asked him if he would take it if he had cancer.”

“Thank you for all you do! You and your family are always in my prayers!”

The CEA dropped from 25 to 1.4 from the moment she started taking Ivermectin and Fenbendazole.

Case 17: 51 year old American Woman shrinks her Grade 2, Stage 2 Breast cancer 99% prior to surgery

Dr. William Makis shared on X (Twitter) in April 2025:

IVERMECTIN and MEBENDAZOLE Testimonial - 51 year old American Woman shrinks her Breast cancer 99% prior to surgery!! Breast surgeon hasn't seen this in 30 years of practice! Most cancer patients come to me at Stage 4, once they've exhausted many conventional treatment options. That's just how life is... But what happens if a cancer patient comes to my world leading Ivermectin Cancer Clinic at an early stage? Let's find out...

STORY: 51 year old American woman (wife of a physician) was diagnosed with a 2.1cm Breast Cancer in the left breast, Grade 2, Stage 2

We started:

Ivermectin 1.5mg/kg/day
Mebendazole 1000mg/day

RESULTS: Her primary breast cancer shrunk from 2.1cm to 0.45cm = 99% Volume Shrinkage!!!

From the patient:

“My Breast Surgeon said she had never seen anything like it in her 30 years of practice!”

"My situation is so unique, they are planning to send it to the Cleveland or Mayo Clinic"

So what's my experience with early stage tumors? Ivermectin, Fenbendazole and Mebendazole are often capable of shrinking tumors before surgery. In this case, the tumor shrank 99%. Some of my patients have avoided surgery entirely.

Case 16: 83-yr-old with Metastatic Breast Cancer

Fenbendazole Testimonial. Full case report: https://www.onedaymd.com/2025/05/metastatic-breast-cancer-age-83.html.

Case 15: 45-year-old with metastatic Stage III triple-negative breast cancer that had spread to her lymph nodes

This Case Report is from a 45 year old woman with metastatic Stage III triple-negative breast cancer that had spread to nearby lymph nodes. According to the Cleveland Clinic, 15% of cases of invasive breast cancer are triple-negative breast cancer (TBNC), which is considered a dangerous subtype of the disease.

Unlike most breast cancers, triple-negative breast cancer cells don’t have receptors for estrogen and progesterone. Because this type of breast cancer doesn’t have the hormone receptors used by the current drugs to attack most breast cancers, the prognosis is very poor using traditional treatments like chemotherapy. Recall that receptors are molecules on cells’ surfaces that determine what substances can attach to cells and affect what the cells do. Triple-negative breast cancer cells don’t have these receptors, so the traditional chemotherapies used to target breast cancer cells by their hormone receptors don’t work. So there is a dire need to find treatments that actually work.

I was diagnosed with Stage III*, Triple Negative Breast Cancer in October of 2022 after noticing some changes on the skin of my breast and some pain in the area. Mammogram, CT scan and biopsy confirmed that it was breast cancer….triple-negative breast cancer. I had stage 3 triple negative breast cancer involving my lymph nodes, the worst one to get, and it (fenbendazole) worked for me.

The cancer had spread to the nearby lymph nodes and was causing the skin on my breast to discolor. I took Safe-Guard (fenbendazole) for 14 weeks, started the 3 days on, 4 days off protocol that I read about for about the first 7 weeks. Then increased from 1 box a week (each box has 3 packets), to a box and a half (about 5 packets of 222 mg each) per week.

The first thing I noticed was my skin clearing up, the small spots on my breast disappeared at about 11 weeks after starting fenbendazole. This was the 222mg dose. No side effects at all.

My advice, take fenben, and don't stop. At least not until it's gone. I’ve been cancer-free for almost 16 months. Best of wishes to all of you!

- L. K. T., Tucson AZ, December 5, 2023

Questions and Answers

Q: Are there any side effects from Fenbendazole?
A: No.

Q: Did you do any other treatments?
A: No.

Q: Did you tell your doctor you were using Fenbendazole?
A: No.

Q: What is your weight?
A: 5’6″ and 145 pounds.

Q: Did you receive any booster shots or COVID-19 shots?
A: None.

Source: https://fenbendazole.substack.com/p/case-report-triple-negative-breast

Case 14: 80-year-old retired nurse with Stage 4 triple negative breast cancer (TNBC)* with lung metastases

Ivermectin, Fenbendazole & Mebendazole Testimonial. (Source: https://t.co/ZTLcEFYc0E)

Description: Shared on March 30, 2025, by @MakisMD , this discusses an 80-year-old retired nurse with Stage 4 triple negative breast cancer with lung metastases. She reportedly became cancer-free after a year on a protocol including fenbendazole.

*Using SEER 5-year survival statistics: Triple-Negative Breast Cancer (TNBC): ~12-20% 5-year survival in Stage III vs. multiple anecdotal remissions in fenbendazole group shared in this case series article.

Case 13: Stage 4 metastatic breast cancer (estrogen and progesterone positive, her2 negative)

Raleigh Williams updated on X (Twitter) in March 2025:

"The scan on the right is from November and showed stage IV breast cancer in my wife’s spine. The scan on the left is from yesterday and shows “No Evidence of Disease.” Following every protocol from the oncologist left my wife exhausted and suicidal (plus the cancer came back anyway) so we started doing our own research and found a protocol that felt good to us and it has worked thus far. The doctor interpreting the PET scan was shocked that the cancer shrunk given the fact that she isn’t on any conventional chemotherapy protocol at the moment."

We get our Ivermectin here (yes it's for horses, we have some friends that get their from a compound pharmacy which we haven't done yet.) And the Fenbendazole here. We've had a lot of questions on dosing and frequency. Dr. Makis has recommended 1mg/kg/day for Ivermectin and 444 mg/day for Fenbendazole on his X account and we have followed that protocol.

Read about their current protocol HERE.

.@RobertKennedyJr Fenbendazole and Ivermectin Responsible In Cancer Success Story.

The testimonial you are about to watch is from an individual who bravely shared her experiences in the hope of inspiring and uplifting others. pic.twitter.com/wwCcpCADnk
— 🦅 Eagle Wings 🦅 (@CRRJA5) April 23, 2025

Case 12: 75 year old patient had breast cancer 10 years ago with 5 new breast masses

Dr. William Makis shared on X (Twitter) in March 2025:

IVERMECTIN and MEBENDAZOLE Testimonial - 75 year old patient with Breast cancer 10 years ago, has 5 new breast masses. They almost completely disappear after 4 months on protocol! Some of the results I get are absolutely jaw dropping. This one is a "must see". STORY: 75 year old patient had breast cancer 10 years ago recently developed multiple breast masses and neck lymph nodes up to 3.6cm. "I do not wish to be treated by the traditional medical system, after a past breast cancer episode and also learning from the COVID pandemic" Fair enough.

We started a protocol in October 2024:

Ivermectin 1mg/kg/day
Mebendazole 1000mg/day

RESULTS after 4 months on the Makis Ivermectin Cancer Clinic Protocol:

Patient: "The comparison is almost unbelievable!"

1.6cm right breast lesion - gone

1.2cm right breast lesion - now 0.9cm

3.6x2.9cm left breast lesion, possible intramammary lymph node - gone

1.7cm left breast lesion - gone 2.9x2.3cm

left breast lesion - gone

Patient: “in addition to these breast improvements, five big lumps in my neck have disappeared!” No biopsy. No surgery. No chemo. No radiation. No other explanation. These breast masses weren’t that small either! When I post these testimonials and the patient also took chemo, many people like to claim the chemo did all the work (and Ivermectin doesn't work). There was no chemo in this case. No radiation. No other treatment of any kind.

Case 11: 35 year old woman with Stage 4 Breast Cancer (triple positive) to lungs and bones

Dr. William Makis shared on X (Twitter) in February 2025:

IVERMECTIN and MEBENDAZOLE Testimonial with TURBO CANCER FROM THE BRINK: 35 year old Stage 4 Breast Turbo Cancer patient with "little time left to live" to "NO ACTIVE DISEASE" - the miracle PET/CT scan at 6 months!

This was one of my first Ivermectin Clinic patients: 35 years old US woman with Stage 4 Breast Cancer to lungs and bones Initially diagnosed in Nov 2023 with triple positive breast cancer. "We suspect that she may have a COVID-19 vaccine induced turbo cancer as she received both doses of the vaccine and a booster. Her husband, 36 years old, who received the same vaccines as her at the same time, was diagnosed with testicular cancer" 2024: “We were recently informed that her cancer is resistant to treatment and very aggressive". It is confirmed to have metastasized to her lungs, sternum and spine” “Her Oncologists have informed her that she has little time left and they are not open to trying any of the drugs you have mentioned like Ivermectin”. When I started my cancer clinic, I was very aggressive in my treatment approach. I still am. We started in mid August 2024.

Ivermectin 1mg/kg/day escalating dose to 2mg/kg/day
Mebendazole 1500mg/day

Why am I aggressive in my dosing? Have a look at the follow-up PET/CT scan done 6 months into Ivermectin/Mebendazole.

Impression:
"Excellent treatment response with interval left mastectomy as well as complete resolution of FDG avid bone metastasis and bilateral hilar FDG avid lymph nodes that were present on prior exam. No findings to suggest active malignant disease at this time".

Case 10: Stage 4 metastatic breast cancer (Jan 2025 Update)

Carla shared on X/Twitter:

"Diagnosed Stage 4 metastatic breast cancer in November of 2022. Started Fenbendazole right away and also switch it up one week a month with ivermectin. I’ve been cancer free for over a year!"

Case 9: IVERMECTIN and MEBENDAZOLE* Testimonial - 69 year old USA Stage 4 Breast Cancer patient with metastases to liver and bones on Enhertu (December 2024)

Dr William Makis shared on X/Twitter:

IVERMECTIN and MEBENDAZOLE* Testimonial - 69 year old USA Stage 4 Breast Cancer patient with metastases to liver and bones on Enhertu 69 year old woman with Stage 4 Breast Cancer to liver and bones Had 2 treatments of Enhertu with Ivermectin 36mg and Mebendazole 500mg a day for 3 weeks CEA dropped from 148.4 to 83.9 (that’s a 43% drop!!) What is Enhertu?

"Enhertu, generically known as fam-trastuzumab deruxtecan-nxki, is an antibody-drug conjugate (ADC) designed for targeted cancer therapy, particularly for cancers expressing the HER2 protein on their cell surface" Grok will tell you that it wasn't Enhertu that did this: "In summary, while there is some indication from patient experiences that Enhertu might lead to reduced CEA levels in some individuals, this is not a guaranteed or direct effect of the drug." That 43% drop in tumor marker CEA was due to the Ivermectin and Mebendazole addition to the treatment regimen.

I share these to show what optimizing Cancer Treatment looks like (especially in Stage 4 Cancer patients). This is cutting edge work not being done at any Cancer Centre in the United States or Canada.

*Note: Although technically mebendazole is not the same as fenbendazole, both mebendazole and fenbendazole are part of a larger group of drugs known as benzimidazole*, which are anthelmintic drugs (i.e., drugs that kill parasitic worms).

*The class of drugs known as benzimidazoles includes fenbendazole, mebendazole, albendazole and flubendazole.

Fenbendazole and mebendazole are similar in that they both eliminate parasitic worms, but there is a difference. Mebendazole is approved for human consumption by the FDA, while fenbendazole is only approved for veterinary use and has not been approved for human use.

Mebendazole is the form that is approved for human use while fenbendazole is approved for veterinary use. The main difference is the cost. Mebendazole is expensive ~$450 per pill (two pills of mebendazole cost just $4 in the UK.), while fenbendazole is inexpensive ~48 cents per 222 mg free powder dose (Williams, 2019). Albendazole is the form used to treat intestinal parasites in India and these cost 2 cents per pill.

While most of the pre-clinical research uses mebendazole, probably because it is the FDA-approved-for-humans form of fenbendazole, virtually most of the self-treating clinical reports involve the use of fenbendazole.

Case 8: Stage 4 Breast Cancer

source: https://substack.com/home/post/p-155091883

Case 7: 70 year old Stage 4 Breast Cancer patient with bone and brain metastases (December 2024)

Dr William Makis shared on X/Twitter:

IVERMECTIN, FENBENDAZOLE and LACTOFERRIN Testimonial - (SPAIN) 70s year old Stage 4 Breast Cancer patient with bone and brain metastases sees dramatic improvements in Quality of Life! 70s year old Stage 4 Breast Cancer patient with bone and brain metastases. Family reached out to me.

We started a protocol:

Ivermectin 1mg/kg/day
Fenbendazole 444mg/day 6 days a week
Lactoferrin 1000mg/day

Sometimes it’s the quality of life improvements you can see right away:

“Pain gradually decreasing” (requiring less pain medications
“Starting to get up and walk around the house” - Increased mobilit
“being able to sleep on her side, which she couldn’t do before”
“willing to do things” (improved mood)
“she can get up alone from bed and sofa” (improved strenght)
“blood test results showing good improvements” (improved blood work)

And my favorite:

“Her Oncologist was very surprised to see her well, with lucidity and with enough mobility”

Case 6: Anaesthesiologist with Breast Cancer (Last Update: November 2024)

Katrina’s November 25, 2024 addendum:

Shortly after doing my October 2024 podcast with Dr. Yoho, I again had a return of liver dysfunction symptoms similar to those I had a few months prior with the ivermectin and fenbendazole combination, even though I had reduced doses of both and taken a 2-week break after that episode. My symptoms were primarily severe laryngopharyngeal Reflux, dry coughing, vomiting intermittently after meals, diarrhea, loss of appetite, and significant fatigue.

Miraculously, I got an earlier appointment with Dr. Lucy Kerr in Brazil via telehealth, and she gave me the correct dose of ivermectin to use indefinitely based on my weight - 1.5 mg/kg (Kat weighs 140 pounds or 64 kg. Her new dose of ivermectin is 95 mg. She told me that only 10% of ivermectin is metabolized by the liver, with 90% of its metabolism occurring in the intestine. She is so knowledgeable about this drug, and she said I must stop the fenbendazole immediately and never use it again, as it is too toxic. I was desperately ill last year, and so many websites had papers extolling the anti-cancer activity of fenbendazole, but as with so much in the complementary alternative cancer world, people are just trying to sell stuff, and nobody really knows what each individual person needs for their cancer. That is why I am becoming increasingly humble and careful and have cut out almost all supplements. I still take vitamin D, and - vitamin A is essential if you are on ivermectin high dose, and of course, magnesium, dandelion tea, green tea, and a keto diet. See the amazing YouTube video interview of Dr. Thomas Seyfried on cancer and diet, and you will understand the crucial importance of diet with a cancer diagnosis. And I do continue PEMF and chlorine dioxide.

Dr. Lucy Kerr is in Brazil and can only be contacted via from the USA via WhatsApp. She does prescribe a lot of supplements, but I think that is because some of the alternative cancer treatments are not available in Brazil as they are in the USA. She is one of the few trustworthy integrative cancer physicians in the world. I know this from how she helped me in 2022. I should have listened to her then and never lowered my ivermectin dose, but I had gotten so swept up in the hype on supplements, etc, for cancer that I did not know what was working for my cancer healing. Just one of the dangers of too many supplements!!

Original Post (Oct 2024)

I found a breast cancer lump in my left breast in 2016. I stupidly allowed my doctor to biopsy the lesion, which broke the capsule around it. This may have permitted the cancer to spread to the nodes, making me Stage 2 with three positive lymph nodes. The doctors had said the lump was too big to do a lumpectomy. I should have done cryotherapy to treat the nodule but chose instead to have a bilateral mastectomy with reconstruction in one procedure to avoid repeated MRIs and constant worry. After surgery, they recommended tamoxifen, chemo, and radiation. I refused it all and was treated with diet, DIM supplements, vitamin D, stress reduction, psychological counseling, and spiritual work.

In early 2022, I began to have a cough and shortness of breath. My chest x-ray showed a large right pleural eﬀusion (fluid around my lung), and when it was sampled using a needle, it contained malignant breast cancer cells. My scans showed mediastinal lymph nodes (in the chest’s center), a nodule in the right upper lung lobe, and a lymph node in each armpit.

To breathe, I was forced for a time to have the fluid around my lungs extracted with a needle every two weeks. This was despite using hyperbaric oxygen therapy, a detox supplement regimen, and other treatments, including green tea, vitamin C infusions, ozone therapy, high-dose melatonin, green tea capsules, ketogenic diet, infrared sauna, and quantum biofeedback. Quantum biofeedback is an advanced system. It is different from other biofeedback that works on arousal states. Instead, it works on frequencies using a complex computer algorithm program that can be used diagnostically and therapeutically. I also began daily ivermectin (IVM) and beta-carotene supplements.

Within four months of starting IVM, the fluid stopped forming around my lungs. My PET scan six months after beginning ivermectin showed no active cancer in any fluid, no nodule in the lung, and just a couple of lymph nodes that were below the active cancer metabolic threshold.

I then (stupidly) tapered the ivermectin dose to 30 mg twice a week. I was taking so many supplements and foods that I could not tell what was working. The pleural effusion recurred about three to four months after reducing the ivermectin. It was in my left lung this time, and the mediastinal lymph nodes reappeared. I had missed the importance of ivermectin in my overall treatment plan.

In August 2023, I visited the Hope 4 cancer clinic in Cancun, but it was an expensive disaster that did nothing to help me. I again started requiring weekly pleural taps and eventually needed a Pleurex catheter to drain the fluid daily. My left lung was my only normal lung after damage to my right lung in 2022 from the constant fluid and subsequent lung collapse.

From September 2023 until July 2024, I took 120mg of IVM daily plus fenbendazole 444mg daily. Six months later, fluid stopped forming around my left lung. However, I started developing teeth staining, and after about five months, my blood enzymes showed liver dysfunction. After a 10-day break from both medications and restarting them at lower doses, I felt better. My PET/CT scans in March 2024 and July 2024 showed no cancer metabolic activity and no evidence of cancer or lymph nodes anywhere, and my follow-up scans are planned for October 2024. I now take 45mg of ivermectin five days a week, none on the weekend, and fenbendazole 440 mg twice a week.

Level One recommendations

★ Ivermectin is crucial and should be taken with food for proper absorption. I use only the compounded variety, not tablets, because the bioavailability and quality may not be assured with much of what is available online. I use 90 mg capsules from Evergreen Compounding Pharmacy and West Cocoa Pharmacy. These require prescriptions from licensed providers.

Optimal dosing is unknown, but I believe it depends upon your cancer stage. If you are stage 4 or are given only a few months to live, I would consider 1-2 milligrams per kilogram daily. Doses this high must be taken with beta carotene supplementation to avoid eye problems, the main issue with high doses of IVM taken daily for extended periods. I have always responded within a few weeks, and a friend with pancreatic cancer noted decreasing pain within a week. Complete remission may take 4-6 months. IVM must be taken with food for best absorption...

Read More: High Dose IVERMECTIN for Breast Cancer AND TIPS FOR OTHER CANCERS - DR KATRINA LEWIS

Case 5: Stage 4 Breast Cancer with spread to bones (Last Update: September 2024)

Description: Shared on September 11, 2024, by @MakisMD, this post highlights Denise Pane’s experience with metastatic breast cancer that spread to her bones. After using fenbendazole, she reportedly became cancer-free, having previously been hospitalized and unable to walk without assistance.

"I had metastatic breast cancer that spread to my bones. I was in the hospital most of Jan/Feb of this year. Couldn't walk without assistance and was in excruciating pain" "I had heard about Fenben through a friend and decided to finally give it a try" "My markers were dropping and my PET scans were showing significant improvements" "I never would have expected to hear No active cancer this soon"

Sep.6, 2024: "Just found out that I am Cancer Free today!!"

Source: https://t.co/R26UcS5bkU

Source: Facebook

Case 4: Dichloroacetate, Omeprazole (plus tamoxifen), and Ivermectin for Invasive Breast Cancer

A 69-year-old female was diagnosed with invasive breast cancer in October 2015. She underwent left breast partial mastectomy, but bone metastases and pleural dissemination appeared (Figure 1). She responded to chemo-endocrine therapy, but it soon became less effective, and intolerable side effects appeared. We gave up conventional therapy and started treatment with dichloroacetate, omeprazole, and tamoxifen from October 2021: weekly use of three tablets of 333 mg dichloroacetate per day (on Day 1), three tablets of 40 mg omeprazole per day (on Day 1), along with a tablet of 20 mg tamoxifen every day. This relieved her symptoms (bone pain, shortness of breath, and general fatigue) instantly but not completely. Hence, we added a tablet of 12 mg ivermectin per day (on Day 1), which stabilized pleural effusion and induced tumor marker reduction (CEA or carcinoembryonic antigen), which went down from 12.9 to 7.3, and cancer antigen 15-3 (CA15-3), which went down from 302.3 to 229.4 in three months).

Source: Ishiguro et al., 2022

Case 3: Stage 4 ER+PR+HER2- Metastatic Breast Cancer to bones (December, 2022)

Condition: Stage 4 ER+PR+HER2- Metastatic Breast Cancer to bones

A friend told me about the Joe Tippens Protocol and ivermectin the day after I got my diagnosis for a third bout with breast cancer. I started both immediately. I saw my oncologist a week later. She added Faslodex, Kisqali, and Femara. She supported me added the JTP and the ivermectin. In 8 weeks I was in remission as measured by my CA2729. At week 11, a PET scan showed NED.

Which of the protocol components did you use? Fenbendazole , Curcumin, CBD/ cannabis Oil, Berberine, Other

Other supplements used: 12 mg ivermectin daily

Which conventional treatments did you do? Hormone therapy

Case 2: Stage 4 metastatic breast cancer Mets to lymph nodes, liver and bone in my upper shoulder (March, 2022)

In 2018, I experienced heavy fatigue most of the time. It almost felt as if I got weaker and weaker as the days went by. I felt this lump on the side of my breast and got it checked out right away. I received the news that I have stage 4 metastatic breast cancer Mets to lymph nodes, liver and bone in my upper shoulder.

Case 1: Stage 4 breast cancer with Mets to lymph nodes, bones, and bone marrow (June, 2021)

Three years ago I received a lumpectomy, which is when the cancer gets removed from a part of the breast tissue. The surgery was successful and I was declared free of any cancer back then, till about two years later I was diagnosed with stage 4 breast cancer with Mets to lymph nodes, bones, and bone marrow. It basically spread all over my body. This was terrifying at the time and I felt there was no way to win this battle.

With no options left, I decided to go onto the Joe Tippens protocol, and followed it for a whole good year before I received my PET scan results stating that I am cancer free! And to make this even more insane to think of – I wasn’t receiving any form of chemo or radiation ever during the recovery process, the only medication I consumed alongside following this protocol was hormone blockers.

I however got very sick in the beginning stages of using this protocol and started using Serrapeptase (an enzyme) along with it, which seems to have taken all side effects away. I gained my strength back and my blood tests were normalized on every account. After being only 6 months on the protocol more than half of my cancer disappeared. Here is a brief idea of what my protocol looked like:

Serrapeptase (as I wake up)
Fenben, Vit D and Vit K, Quercetin with Zinc (at noon)
Turkey tail mushrooms & Letrozole (also at noon)
RSO (before bedtime, but a very little amount)

I only removed refined sugars and corn syrup from my daily diet and other than that, I just continued with my activities of daily living. This combination of supplements along with the fenben really did the magic and I will continue to follow this lifestyle to prevent any evidence of disease to show up!

Video Testimonial of Breast Cancer (Triple Negative Breast Cancer) Recovery with Fenbendazole Protocol

Looking for more case reports? Explore additional cases for other cancer types in our Fenbendazole Cancer Case Series.

Fenbendazole and Breast Cancer

In a 2022 study, researchers from Greece and Switzerland looked at the cytotoxic effect of fenbendazole and its commercially available formulations (Panacur and Safeguard), which is used for its antihelmintic properties. The formulation was tested for its efficacy as well as the determination of the ingredients with proliferation assays and analytical techniques. Dissolution studies were performed to simulate the ability of fenbendazole to dissolve adequately in the fluids of the Gastrointestinal tract, be absorbed in the circulation and reach certain areas of the human body. However, dissolution studies showed that both brands possess issues in their distribution. The in vitro drug screening exhibited potential cytotoxic effect in different types of human cancer cell lines and MDA-MB-231 human breast adenocarcinoma cells appeared to be the most sensitive.

Interestingly, among all the cancer cell types that were tested, human breast cancer cells seemed to be the most responsive to treatment. In particular, a type called MDA-MB-231, which is a tough-to-treat form of breast cancer known as triple-negative, showed the strongest reaction. Another type, called MCF7, which responds to hormones like estrogen and progesterone, was less affected.

The MDA-MB-231 cells rely mostly on sugar (glucose) for energy, even when oxygen is available—this is often seen in more aggressive cancers. In contrast, MCF7 cells mainly use oxygen to produce energy, switching to sugar-based energy only when oxygen is low.

MDA-MB-231 cells also tend to be more aggressive and resistant to many drugs, while MCF7 cells behave in a more controlled, less invasive way. Researchers aren’t exactly sure why, but it seems that the specific characteristics of MDA-MB-231 cells—how they look, how they function, and how they produce energy—make them more sensitive to the effects of fenbendazole.

When the comparison was made between the compounds, commercial Brand S (Safeguard) exhibited greater cytotoxic effect against most of the human cancer cell lines. The presence of the active substance (fenbendazole) was confirmed with the analytical techniques for both commercial Brand P (Panacur) and Brand S (Safeguard) products, but when tested for human use against human cancer cells, the result was that Brand S had a more significant effect than Brand P.

Notes:

No single drug is a miracle cure for all cancers. Taking a particular drug as a stand alone strategy cannot replace an unhealthy lifestyle i.e. heavy smoker, alcoholic, a very stressful and non-active lifestyle, overweight and obesity. All these cancer promoting factors need to change.

The best way to fight cancer is to utilise a menu of strategies by maintaining good health, like from eating a nutritious whole-food diet with lots of fruits and vegetables, avoid ultra processed foods and a healthy lifestyle. Each strategy might produce an incremental improvement in results for some cancers when added to existing treatment regimens.

Everyone’s situation is different, however, it is important to arm yourself with medical knowledge that cancer doctors (Oncologists) may simply not give you.

Whether you’re living with cancer or a survivor, talk to your doctor to determine the best treatment for you.

Clinical Trials

Clinical Trials of Metastatic Triple Negative Breast Cancer

There are more than 800 clinical trials of ClinicalTrials.gov on metastatic triple negative breast cancer.

Related:

A phase I/II study evaluating the safety and efficacy of ivermectin in combination with balstilimab in patients with metastatic triple negative breast cancer. (2025 ASCO Annual Meeting)

Clinical outcomes of patients with stage I triple-negative breast cancer (TNBC) treated with or without chemotherapy: The Mayo Clinic experience. (2025 ASCO Annual Meeting)

Merck’s Keytruda Combined with Gilead’s Trodelvy Reduces Breast Cancer Risk by 35% in Clinical Trial. (2025 ASCO Annual Meeting)

Sacituzumab govitecan (SG) + pembrolizumab (pembro) vs chemotherapy (chemo) + pembro in previously untreated PD-L1–positive advanced triple-negative breast cancer (TNBC): Primary results from the randomized phase 3 ASCENT-04/KEYNOTE-D19 study. (2025 ASCO Annual Meeting)

Immune checkpoint inhibitor (ICI) efficacy in triple-negative breast cancer (TNBC) patients with liver metastases (LM): A meta-analysis. (2025 ASCO Annual Meeting)

Real-world use of carboplatin-containing chemotherapy in early triple negative breast cancer (TNBC). (2025 ASCO Annual Meeting)

Find Integrative Oncologists in USA, Mexico, Europe or Asia

While the potential anti-cancer properties of fenbendazole are intriguing, it’s crucial to approach with caution.

Consulting with an integrative healthcare expert is key to crafting a Fenbendazole protocol tailored to your unique health requirements.

To find integrative oncologists, check out "find integrative oncologists".

Conclusion and Key Takeaway

Keep in mind that these references are based on case reports, which offer preliminary evidence. Critics may dismiss them as pseudoscience or low-quality data or even misinformation. However, these testimonials could represent just the tip of the iceberg—an emerging frontier that science is only beginning to explore.

For a more comprehensive understanding, it's worth looking into additional research studies and clinical trials. As always, consult with your healthcare provider(s) before making any treatment decisions, as close monitoring and personalised care are essential.

Disclaimers:

Statements on this website have not been evaluated by the Food and Drug Administration. The contents of this website is for educational and informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis or treatment.
Please do not consider this guide as personal medical advice, but as a recommendation for use by professional providers. Consult with your doctor and discuss with her/him. Our aim here isn't to replace your doctors' advice. It is intended as a sharing of knowledge and information. Do take note that cancer is a continuous struggle between the immune system and the cancer cells. Cancer treatments are meant to assist the immune system in this battle. Any potential treatment—whether conventional or complementary—must be evaluated on a case-by-case basis, with careful consideration of the benefit-risk ratio to ensure both safety and efficacy.
The case reports presented reflect the real-life experiences and opinions of other readers or users of the website. The experiences of those readers or users are personal to those particular readers/users and may not necessarily be representative of all readers/users. We do not claim, and you should not assume, that all other readers/users will have the same experiences. Do you own research, consult with relevant medical professionals before attempting to self-treat for any condition.
Cancer treatment should be part of a multi-modal approach in order to provide the best possible outcome. Diet and lifestyle changes are meant to run alongside conventional treatment. They are complementary, not alternative.
Cancer care is a team effort with the patient at the centre. Care should be supervised and coordinated by a primary healthcare provider. Patients with cancer should consult with their regular oncologist as well as an integrative provider/oncologist, in addition to their primary care provider and the supporting nurses, dieticians and other allied healthcare professionals.
While the term 'alternative' might imply opposition to conventional oncology, we prefer 'complementary,' 'integrated,' or 'holistic.' These terms better reflect the role of these strategies as part of a personalized value-added menu of strategies, ensuring the most effective and safe solutions for patients.
Integrating a repurposed drug doesn't mean rejecting modern medicine — It enhances it and offers a more comprehensive approach to wellness and healing. By combining conventional cancer management with root-cause resolution, this model creates a path to sustained recovery and resilience.

References:

Looking for more case reports? Explore additional cases for other cancer types in our Fenbendazole Cancer Case Series.
Top Repurposed Drugs and Metabolic Interventions for Cancer Treatment

Mebendazole vs fenbendazole for cancer

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The Wellness Company's Ivermectin and Mebendazole

Ivermectin and mebendazole, both approved for human use, are now available in the U.S.

Researched and approved by Dr. Peter McCullough.
Prescribed by licensed medical professionals
Compounded and dispensed by a licensed US-based pharmacy
Approved for human use
Where to buy Ivermectin and Mebendazole Formula: Available on The Wellness Company's website. Here is the link: Ivermectin and Mebendazole.

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