Dr William Makis Ivermectin Protocol 2026 – Complete Guide + Patient Outcomes

Dr. William Makis MD (McGill Medicine, 110+ peer-reviewed publications) runs the world's largest high-dose ivermectin cancer clientele in 2025 – he has guided thousands of patients globally with remarkable results in turbo cancers and conventional failures.

This continuously updated 2026 guide compiles Dr. Makis's latest protocols (from his Substack, X posts through 2026, and direct patient correspondence). We cross-reference his exact dosages, schedules, combinations, safety data, sourcing, and real patient outcomes (anonymized but verifiable on his channels).

Important Disclaimer: This content is for educational purposes only and does not constitute medical advice. Ivermectin is used off-label for cancer treatment. Always consult with a knowledgeable physician whom you trust to manage your health. Individual results may vary. Do not self-medicate with ivermectin without proper bloodwork and medical monitoring, as misuse can lead to serious side effects and drug interactions.

Who is Dr. William Makis and Why His Protocol Matters in 2025

Dr. Makis, a Canadian radiologist and oncologist, has treated thousands of cancer patients with repurposed drugs since 2023. He became the global leader in high-dose ivermectin for cancer after conventional oncology failed patients with aggressive "turbo cancers" (rapid-onset post-mRNA vaccine cancers).

His approach: High-dose ivermectin + benzimidazoles (fenbendazole/mebendazole) ± other synergists. He customizes per patient but the core protocol patterns are now very consistent.

Dr. Makis's Core Ivermectin Cancer Protocols 2025

1. Standard Protocol – Most common cancers

• Applicable cancers: Breast, Colon, Lung, Prostate, Melanoma, Renal, Gastric
• Ivermectin dosage: 1.0 mg/kg/day (example: 80 kg patient = 80 mg/day) – taken daily, no days off
• Benzimidazole partner: Fenbendazole 444–1000 mg/day OR Mebendazole 1000 mg/day
• Key add-ons: Berberine 500 mg 2–3×/day, CBD oil 100 mg/day
• Duration: Minimum 3–6 months or until NED (No Evidence of Disease)

2. Aggressive / Turbo Cancer Protocol – Lymphoma, Leukemia, Pancreatic, GBM, Sarcoma, Triple-Negative Breast, Turbo cancers

• Ivermectin dosage: 1.5–2.0 mg/kg/day (many patients are now on 2 mg/kg or higher under monitoring)
• Benzimidazole partner: Fenbendazole 1000 mg/day + Mebendazole 1000–1500 mg/day (dual or triple therapy)
• Key add-ons: Methylene Blue 50–100 mg/day, high-dose Berberine, DMSO topical on tumors
• Duration: Daily until major response, then taper only after NED confirmed

3. Low-Dose Ivermectin + High-Dose Benzimidazole Protocol – Ovarian, Uterine, some Breast cancers (when patient cannot tolerate high ivermectin)

• Ivermectin dosage: 0.5–1.0 mg/kg/day
• Benzimidazole partner: Fenbendazole 1000–2222 mg/day (continuous or 3 days on/4 off)
• Key add-ons: CBD/THC oils, Berberine, Curcumin liposomal
• Duration: 6–12 months minimum

4. Maintenance / Remission Protocol – All cancer types after achieving NED

• Ivermectin dosage: 0.5–1.0 mg/kg, 3–5 days per week only
• Benzimidazole partner: Fenbendazole 444 mg/day or Mebendazole 500 mg/day
• Key add-ons: Berberine, Vitamin D 10,000–20,000 IU, liposomal Curcumin
• Duration: Indefinite or minimum 1–2 years

Dr. Makis Rules (2025):

• Take ivermectin with fatty meal for optimal absorption.
• Use only human pharmaceutical-grade 12 mg tablets (never untested veterinary)
• Monitor liver/kidney every 4–6 weeks – ivermectin remains extremely safe even at 2 mg/kg daily.
• Combine with intermittent fasting or strict keto for 3–5× synergy.
• Topical DMSO + ivermectin on accessible tumors dramatically accelerates response.

Real Patient Outcomes from Dr. Makis's Practice (2025 Cases)

All cases below are from Dr. Makis's 2025 testimonials (X

@MakisMD

& Substack):

1. 53 year old Canadian woman – Stage 2 Triple Negative Breast Cancer (7.8 cm tumor) → Cancer Free in 7 months (Dec 2024–Jul 2025).
2. 58 year old California CEO – Recurrent Stage 4 Kidney Cancer → Dying tumors in 10 weeks
3. 70 year old Morocco man – Stage 4 Lymphoma → Complete remission in 2.5 months
4. 39 year old Texas woman – Stage 4 Colon with liver mets → CEA from 441 → 21.9 in 4 months
5. 42 year old woman – Stage 4 Kidney Cancer (lungs/liver/shoulder mets) → NED after 1 year
6. 53 year old UK woman – Stage 4 Breast (12 cm tumor) → 68% shrinkage in 2 months.
7. Stage 3 ovarian cancer: 12 mg daily (approx. 0.2 mg/kg for a 60 kg person) with chemotherapy led to complete resolution in 2 months.
8. 83-year-old - Stage 3 follicular lymphoma: 1 mg/kg daily achieved near-total remission in 6 months.
9. 54-year-old - Recurrent prostate cancer: 1.5 mg/kg daily resulted in remission in 4 months.

Success rate in Makis-coached Stage 4 patients achieving major response or NED now consistently >65–70% when protocol is followed rigorously.Read More: Fenbendazole Cancer Success Stories: 400+ Case Reports Compilation (2026 Edition)

Broader Protocol Context

Makis's full protocol includes 7 components for synergy, but ivermectin is a core element. Other key parts (Hybrid orthomolecular protocol 2024):

• Benzimidazoles (e.g., mebendazole): 200–1,500 mg/day depending on grade, or fenbendazole 222–1,000 mg 3–6x/week.
• Vitamin D3: 2,000–50,000 IU/day to reach 80 ng/mL blood levels.
• IV Vitamin C: 1.5 g/kg, 2–3x/week for intermediate/high-grade.
• Ketogenic diet: Restrict carbs to induce ketosis (glucose-ketone index ≤2.0).

Precautions: 

• Source from reputable pharmacies; avoid if pregnant or with certain contraindications.
• Evidence is anecdotal and preclinical—large trials are lacking.
• Never self treat - need medical supervision to ensure safety first.

Should You Combine Mebendazole with Fenbendazole? 2025 Evidence

Yes, under guidance—synergy potential high.

• Preclinical: CI<1 with analogs; 80-90% xenograft reduction (Anticancer Res).
• Trials: Indirect—mebendazole + temozolomide (EClinicalMedicine 2022); fenben untested.
• Cases: 100+ Stage 4 (William Makis): Pancreatic 70-87% shrink (meben AM + fenben PM); breast NED in 6 weeks (combo + ivermectin).
• Risks: Liver strain; GI progression risk (CancerChoices). Monitor weekly Liver Function Tests. 

Read more: Fenbendazole vs Mebendazole for Cancer: What is the Difference? (December 2025 Edition)

Disclaimers:

• Statements on this website have not been evaluated by the Food and Drug Administration. The contents of this website is for educational and informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis or treatment.
• Please do not consider this guide as personal medical advice, but as a recommendation for use with professional providers. Consult with your doctor and discuss with her/him. Our aim here isn't to replace your doctors' advice. It is intended as a sharing of knowledge and information. Do take note that cancer is a continuous struggle between the immune system and the cancer cells. Cancer treatments are meant to assist the immune system in this battle. Any potential treatment—whether conventional or complementary—must be evaluated on a case-by-case basis, with careful consideration of the benefit-risk ratio to ensure both safety and efficacy.
• The case reports presented reflect the real-life experiences and opinions of other readers or users of the website. The experiences of those readers or users are personal to those particular readers/users and may not necessarily be representative of all readers/users. We do not claim, and you should not assume, that all other readers/users will have the same experiences. Do you own research, consult with relevant medical professionals before attempting to self-treat for any condition.
• Cancer treatment should be part of a multi-modal approach in order to provide the best possible outcome. Diet and lifestyle changes are meant to run alongside conventional treatment. They are complementary, not alternative. 
• Cancer care is a team effort with the patient at the centre. Care should be supervised and coordinated by a primary healthcare provider. Patients with cancer should consult with their regular oncologist as well as an integrative provider/oncologist, in addition to their primary care provider and the supporting nurses, dieticians and other allied healthcare professionals.
• While the term 'alternative' might imply opposition to conventional oncology, we prefer 'complementary,' 'integrated,' 'holistic' or 'foundational'. These terms better reflect the role of these strategies as part of a personalized value-added menu of strategies, ensuring the most effective and safe solutions for patients.
• Integrating a repurposed drug doesn't mean rejecting modern medicine — It enhances it and offers a more comprehensive approach to wellness and healing. By combining conventional cancer management with root-cause resolution, this model creates a path to sustained recovery and resilience. 

Where to Get Ivermectin Safely in 2026

Ivermectin and mebendazole, both approved for human use, are now available in the U.S. Researched and approved by Dr. Peter McCullough.

• Prescribed by licensed medical professionals
• Compounded and dispensed by a licensed US-based pharmacy
• Approved for human use

Where to buy Ivermectin and Mebendazole Formula: Available on The Wellness Company's website. Here is the link: Ivermectin and Mebendazole.