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Ivermectin and Cancer: 15 Minutes with Dr. William Makis
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Editorial Team
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Transcription (Video below):
Hi, everyone. Welcome to another
episode of 15 Minutes with Dr. Makis, my new hard-hitting medical podcast. It
is now pretty well established that Pfizer and Moderna COVID-19 mRNA vaccines
cause extremely aggressive cancers called turbocancer. They are gaslighting us
about this. The medical establishment is burying their head in the sand.
They're pretending that this phenomenon doesn't exist.
0:29 - We've got a Wikipedia entry that quotes an oncologist in the States, Dr. David Gorski, who has received funding for his blog from child sex trafficker Jeffrey Epstein. He's written big articles claiming that this is a made-up phenomenon. But what you will find on social media is that thousands of people and their family
0:51 - members are reporting extremely aggressive cancers after taking Pfizer or Moderna COVID vaccines. The top five turbo cancers that I'm seeing, the number one is lymphoma, number two, brain cancers, glioblastomas, and then breast cancers, colon cancers, and lung cancers. We've seen recently the mainstream media starting to acknowledge that extremely aggressive cancers are showing up in young people.
1:19
Of course, they're baffled. They have no idea what's causing it.
They're not allowed to even hint that the COVID vaccines may have
caused these cancers. But it's happening. There's thousands of stories
everywhere. So the question is, how do you treat these cancers? One of
the key feature of turbo cancers is that they are resistant to
conventional chemotherapy,
1:43
radiation therapy, even immunotherapy. The treatments don't work. And
so oncologists will give you the standard treatments. And when
everything fails, they send you home to die. That's basically it. Your
oncologist will not save you. They will not save your family member.
They're going to protect their medical license. They're going to
protect their job. And that's it.
2:05
They will never recommend anything alternative. So it's extremely
important that you have an alternative cancer treatment plan in place.
I have been doing deep dives into alternative cancer treatments on
Twitter and on my sub stack. And so I'm going to be putting out a
series of videos
2:22
in terms of how you can approach these extremely aggressive cancers
and give yourself a fighting chance to cure some of these cancers that
are at stage four that oncologists can't cure. In this episode, I'm
going to talk about high-dose
ivermectin
and treatment of aggressive cancers. Ivermectin has been vilified.
2:46
It is a Nobel Prize winning drug that has been used as an
anti-parasitic for many, many years. Merck had it on patent until
1996. And interestingly enough, Merck said it doesn't work for
COVID-19. Well, we find out now that Merck has a 50-50 partnership
with Moderna on mRNA cancer vaccines.
3:08
Merck is going to be making billions of dollars on cancer and cancer,
mRNA cancer vaccines. So they have no interest in continuing to
investigate
ivermectin
for cancer, for example, because it's cheap, it's off patent, they're
not going to make any money on it. So there is tremendous amount of
evidence that high dose ivermectin is extremely
3:32
effective in treating many types of cancers. And the way I approach
this is I usually look at, okay, what are the mechanisms of action,
for example? What are the mechanisms of action by which ivermectin
treats cancer? So I'm going to show you a couple of papers that will
look at the mechanisms of action,
3:52
what the studies have been done in terms of maybe animal studies or
human studies, looking at ivermectin and cancer, and then Because I
get hundreds of emails and questions about this. What is the dosing?
How do you actually treat cancer with ivermectin? So let's get
started.
4:12
The first paper I want to share with you is a paper from 2022 by an
Iranian group headed by Dr. Loftitizeh. And this is a very interesting
paper because it just summarizes in a nice way the mechanisms of
action of ivermectin in cancer. It acts on these signaling pathways
called PAC1 and ACT and mTOR and WNT pathways.
4:43
These are pathways that are involved in tumor proliferation, tumor
growth. And so ivermectin inhibits multiple of these pathways that
inhibit tumor growth, tumor proliferation, leads to cell cycle arrest,
and it also inhibits metastases and the ability of the tumors to
create blood vessels for themselves. So that is key. Multiple pathways
that inhibit tumor growth, tumor proliferation.
5:13
Then ivermectin also acts on cancer stem cells. It inhibits cancer
stem cells. And cancer stem cells are extremely important because they
are involved in the aggressiveness of cancers. They're involved in
metastases, and they're also involved in cancer recurrence. So imagine
you get chemotherapy, you think you've been cured, but cancer stem
cells tend to be resistant to chemo,
5:37
and then your cancer comes roaring back because these cancer stem
cells start proliferating again. So it inhibits cancer stem cells.
Very important. Ivermectin also stimulates cancer cell death,
stimulates apoptosis, autophagy, other kinds of cancer cell death.
Ivermectin also reverses multidrug resistance. So if you develop
resistance to certain chemotherapy, Ivermectin will reverse it.
6:02
And Ivermectin acts in combination with chemo or radiation therapy. So
it has those additional benefits as well. Another great paper is a
paper by Guzzo from 2002. And this was basically a safety study on
ivermectin. What kind of a dose of ivermectin can you take safely? So
in this paper,
6:26
they looked at 30 or 60 milligrams three times a week or 90 or 120
milligrams as a single dose. And basically, the conclusion was that
ivermectin was generally well-tolerated with no indication of CNS
toxicity. So this is neurological toxicity. For doses up to 10 times
the highest FDA-approved dose of 0.2 milligrams per kilogram.
6:53
So 10 times that would be 2 milligrams per kilogram. Remember this
number. This is... They've shown... that ivermectin is well tolerated
up to two milligrams per kilogram per day. And the approved dose is,
of course, as an anti-parasitic. It's 200 micrograms per kilogram or
0.2 milligrams per kilogram. Well, you need a higher dose for cancer
effects.
7:18
So again, ivermectin generally well tolerated at these higher doses
and more frequent regimens. So very important study showing safety of
ivermectin at higher doses. Next, you want to look at whether
ivermectin has actually been used in cancer patients at the higher
doses and whether those doses were safe.
7:44
So great paper on this is a paper by Claudio Castro back in 2020. And
this paper looked at using high dose of ivermectin in children who had
leukemia. One of the children was an 11-year-old boy diagnosed with an
extremely aggressive leukemia. And they gave him one milligram per
kilogram once daily, so per day, with chemotherapy.
8:11
And what they showed was that he started feeling better and the
blasts, which were the leukemic cells, were cleared from his blood.
Now, they only gave it for a short time with the chemo. Then, you
know, he eventually started getting worse again. So they resumed
ivermectin one milligram per kilogram for another six months.
8:31
And then he had stable disease for a surprisingly long period of time.
So this 11-year-old boy... was taking one milligram per kilogram of
ivermectin daily for six months and he had no side effect. His only
therapy related complaint was that he didn't like the smell. So no
side effects whatsoever at one milligram per kilogram.
8:53
This is very important because this actually gives you an idea of what
doses should be used. Here's an article that was published in 2023.
Now, this is not a peer-reviewed article. This was on
thedesertreview.com. And it features experiences of doctors around the
world who have used ivermectin at
9:14
high doses and with certain cancer patients and how those cancer
patients did. Very important was a report by Dr. Tess Laurie from the
World Council for Health. who reported on a case she had of an ovarian
metastatic cancer patient who took a fairly low dose, only 12
milligrams per day, and her tumor markers, her CA-125 levels,
9:38
dropped from 288 down to 22. Now, this patient was taking ivermectin
with chemo, but had a shocking response to therapy. Then there's a
report by Dr. Landrito who reported a doctor colleague of his who had
terminal gallbladder cancer. She was dying from gallbladder cancer and
she just started taking a high dose of
10:03
daily ivermectin for 14 months and her terminal gallbladder cancer
completely resolved and disappeared. And so when you go into the
details of this case, you find out that she took an extremely high
dose for the first few months of two milligrams per kilograms per day.
So here we have again that dose, two milligrams per kilograms per day,
10:27
which we saw from the Gutso article that this is a safe dose to take.
She experienced the visual side effects for a few days, but they
quickly resolved. So this was well tolerated at this very high dose.
Then we have another report of a man named Oscar Nasu with a huge neck
tumor and cannonball-sized lung metastases.
10:52
He took high-dose ivermectin of 2.4 milligrams per kilograms per day
for three months. The lung metastases shrank and he no longer needed
pain medication. He is now on 2.45 milligrams per kilogram per day,
and not showing any sign of overdosing or toxicity. This is the
highest dose I've seen any person use.
11:14
So this is an extremely high dose, but again, an anecdotal report of
success on this dose. Then there's one more case here in this article,
a 70-year-old man with prostate cancer that was taking 45 milligrams a
day, so not a very high dose. This would be about less than one
milligram per kilogram a day.
11:36
And his PSA dropped from 89 down to 10. So I get hundreds of
questions. What kind of ivermectin formulation should you take for
cancer? Well, if you can get the tablets, get the tablets. People are
importing them from India. They're getting them from Mexico. In the
United States, you can get them fairly easily.
12:00
In Canada, it's extremely difficult to get. The border agents will
actually confiscate it at the border. I would recommend or I would
suggest 12 milligrams tablets because 6 milligram tablets, you're
going to have to take quite a few of them. So if you can get your
hands on 12 milligram tablets, that's probably the best scenario.
12:19
If you're in a desperate situation and you cannot get the tablets and
you've basically been sent home to die, there are liquid versions of
ivermectin. I never recommend veterinary products, but if I had a
family member who was dying, well, this is something that I may
consider.
12:36
you will find with the liquid versions is that each ml contains 10
milligrams of ivermectin so you can think of it as each ml is almost
like a 12 milligram pill one pill one ml one pill right now these come
in 250 ml or 500 ml and they're not very
12:54
expensive maybe 100 to 150 bucks a bottle so It ends up being very
economical, especially people who don't have a lot of money. This is a
very, very economical way of getting ivermectin. But the concentration
is very crucial. Each ml contains 10 milligrams of ivermectin. In
terms of the various types of paste formulations, again,
13:18
I do not recommend veterinary products, even something like this. They
may have other additives that are not safe for human use. And in terms
of the concentration, the concentration gets really complicated. You
may have to take half a tube or even an entire tube a day Once you
convert the concentration,
13:42
so I would really not recommend this again, you know, people may end
up in desperate situations. And so, you know, you do what you have to
do. So we now come to the most important graph that I've put together
in the past year, and it is the dosing schedule for ivermectin.
14:03
I would suggest for most cancers, you want to be looking at one
milligram per kilogram per day. That would be my starting dose for
most cancers. And cancers that have been shown to work with
ivermectin, there's many different kinds of cancers. You've got breast
cancer, colon cancer, lung cancer. You've got pancreatic, renal cell
carcinomas, gastric cancers.
14:30
You know, there's many different cancers that you can try ivermectin
with, leukemias, of course. The one cancer I have not seen almost any
research on with ivermectin is lymphomas. I just have not seen any
papers. talking about lymphoma and ivermectin. That doesn't mean it
doesn't work. It just means that there aren't any studies looking at
lymphomas.
14:57
This is the dose that I would start with. Dr. Shankara Chetty had that
prostate cancer patient whose PSA dropped from 89 to 11. He used 45
milligrams of ivermectin per day. So when you think about the dosing,
one milligram per kilogram, typical person is 60 kilograms.
15:18
That means you're going to be using 60 milligrams of ivermectin per
day. That's five pills of 12 milligrams each or six ml of the liquid
ivermectin. And six ml is basically one teaspoon. That is the way to
think about it per day. One teaspoon per day, once a day.
15:42
And there's been no report of long-term side effects with one
milligram per kilogram. And there was that study by Castro looking at
children who are taking one milligram per kilogram. They had leukemia
over the long-term with no side effects. You can start lower. Dr.
Tesolori reported a case with a much lower dose.
16:05
This dose was actually 0.2 milligrams per kilogram. And there was
still an improvement in ovarian cancer with the blood markers, the
CA-125 levels dropping from 288 to 22 after two months. So there is
anti-cancer effect. It is dose dependent. There is evidence that the
anti-cancer effect of ivermectin is dose dependent.
16:27
So higher dose, you may get better efficacy. Now, if you have
extremely aggressive cancers like leukemia, pancreatic cancers are
extremely aggressive and brain cancers. Now, there is some question
about, you know, does the ivermectin cross the blood brain barrier? It
does because you do get neurological side effects, but it doesn't
cross it very well.
16:51
So you may, for brain cancers, you actually may need a higher dose,
like two milligrams a kilogram. And again, you know, this is the case
of Dr. Landrido's colleague, doctor colleague who had that terminal
gallbladder cancer. She took two milligrams a kilogram a day for 14
months and her cancer disappeared.
17:12
She had some visual side effects, but then those went away after a few
days. Now, the highest dose that I've seen is 2.5 milligrams per
kilogram. Mainstream oncologists will not even offer you ivermectin.
So this is as far as some people have pushed the dosing, 2.5
milligrams per kilogram. Again, Dr. Shankar Chetty.
17:35
had a patient on up to 2.5 milligrams per kilogram per day without any
long-term side effects. So at 2 milligrams per kilogram or 2.5
milligrams per kilogram, you might get some visual effects. but they
don't seem to last long-term. They only seem to last a few days.
17:56
I would suggest for most people to start at one milligram per
kilogram, and then depending on your personal situation, adjust from
there. You can always adjust upwards. So that pretty much covers it.
Using ivermectin in cancer is honestly very straightforward. One
milligram per kilogram per day is your typical starting dose.
18:23
If you're using the pills for a 60-kilogram person, that's 60
milligrams a day. That's five 12-milligram pills a day. If you're
using the liquid version for whatever reason, that's six mL per day. A
teaspoon is 5 ml, right? So that's basically a teaspoon a day of the
liquid ivermectin. And that's it.
18:47
It is a very, very safe drug. It is off patent. You can get generic
versions of ivermectin. No one's going to make any money off it. And
there are no clinical trials right now looking at ivermectin in cancer
because there's no money in it. So I really strongly suggest if you
are struggling with cancer.
19:11
look into ivermectin at a starting dose of one milligram per kilogram
per day. You take it as long as there is evidence of active tumor. You
can take it for months. In the Castro study, those children with
leukemia were taking it for six months.
19:33: There are anecdotal reports of people taking it over a year on a
daily basis without any long-term toxicity or side effects. So that'll be it
for this video. I'm going to have an extensive series of videos on the
treatment of cancer. So thank you very much for listening and for your
interest and for all your comments.
New & Improved Joe Tippens Protocol
The holy grail turbo cancer treatment may just be the synergistic
combination therapy of Fenbendazole AND Ivermectin as follows:
Fenbendazole (300mg, 6 days a week) or in the case of severe turbo cancers
up to 1 gram.
Ivermectin* (24mg, 7 days a week) or in the case of severe turbo cancers up
to 1mg/kg/day (Find a Doctor)
Adopting a healthy lifestyle is essential during this protocol. This
includes eliminating sugar from the diet (BMJ 2023), consuming a nutritious, whole-food diet rich in fresh fruits and
vegetables, avoiding ultra-processed foods (BMJ 2024), quality sleep and stress management.
Please note that this protocol now includes the vital Vitamin D addition,
with the one day off for the fenbendazole administration. This protocol represents the most comprehensive and
cutting edge repurposed drug and vitamin treatment approach to date.
*If you are taking ivermectin and mebendazole, you might not need
fenbendazole. Consult your doctor.
"I have eliminated Vitamin E as a required part of the protocol as there
are simply too many instances (eg, blood thinners) where it needs to be
eliminated, and it is the least important of the items."
We are pleased to announce that the first-of-its-kind protocol utilizing Ivermectin, Mebendazole, and Fenbendazole for cancer treatment has been peer-reviewed and officially published on September 19, 2024. Spearheaded by leading researchers like Dr. Ilyes Baghli, Dr. Pierrick Martinez, and the FLCCC’s Dr. Paul Marik, this groundbreaking protocol harnesses the untapped power of Ivermectin, Mebendazole, and Fenbendazole, known for their effectiveness against parasites. Now, these drugs are showing potential to battle cancer, marking the dawn of a new treatment evolution. This trio of repurposed drugs has been shown to disrupt the growth of cancer cells, particularly by targeting microtubules, the essential structures that allow cancer to multiply uncontrollably. What makes this protocol even more potent is the synergistic effect when these drugs are used together, creating a powerful new affordable weapon against cancer. According to oncologist Dr William Makis: “ This paper is the FI...
Ivermectin Resources Recently, I have seen tremendous demand for some sort of initial guidance “WHERE TO START” with High Dose Ivermectin for CANCER. Editor's Note: Dr Makis proposes four distinct cancer protocols for using Ivermectin in cancer treatment, specifically for patients who have developed turbo cancer or aggressive cancers. These protocols, referred to as the “Dr. Makis Ivermectin Cancer Protocols,” are categorized based on dosage and the severity of the cancer. I have an article and a video that go into depth: June 10, 2024 - "15 minutes with Dr.Makis" - Episode 018: High Dose Ivermectin and Cancer . 2025 studies on ivermectin for cancer Yuan Yuan et al (Cedars-Sinai Medical Center) - A phase I/II study evaluating the safety and efficacy of ivermectin in combination with balstilimab in patients with metastatic triple negative breast cancer (ASCO 2025) Yuwen et al - A Review of Ivermectin Use in Cancer Patients: Is it Time to Repurpose the Ivermectin in Cance...
If you have been diagnosed with cancer, or have a loved one that is suffering from cancer, chances are you have heard about the Joe Tippens Cancer Protocol. The Fenbendazole Cancer Protocol has been gaining rapid interest over the past years following some fenbendazole advanced cancer success stories . We have seen tremendous demand for some sort of guide on how to use fenbendazole for cancer as there is also tremendous confusion both from the healthcare and non-healthcare communities. Joe Tippens founded the protocol (1) after he was told a story about a scientist at Merck Animal Health that had been performing cancer research on mice. The research included injecting different types of cancers into different mice body parts. The scientists discovered, through trial and error, a product in their canine product line, fenbendazole, that was batting 1.000 in killing these different cancers in the mice. The scientist was later diagnosed with ...
Introduction This article discusses dosage considerations and key factors regarding the use of ivermectin in cancer treatment. Commonly available information about ivermectin dosages is often inaccurate when applied to potential cancer-related uses. Many sources cite standard dosages recommended by Merck for treating parasitic infections, rather than dosages studied specifically in the context of cancer research. The anti-parasitic dosage is not as effective for people looking for a dosage against cancer. Dosage will need to be adjusted according to cancer type and stage. Ivermectin dosage should be based on ivermectin cancer studies. Multiple factors are considered including studies including ivermectin for cancer, anecdotal studies and case series, the aggressiveness of the cancer type and the cancer stage. Cancer dosage estimation can be adjusted based on the time that a person has to beat cancer or its risk to the patient - this includes both the cancer type and whether the ca...
Table of Contents: Editor's Preface Introduction Fenbendazole Case Series Compilation (alphabetical) Breast Cancer Success Stories (35 cases) Brain Cancer (including Glioblastoma) (3 cases) Bile Duct Cancer (Cholangiocarcinoma) Bladder Cancer Success Stories (7 cases) Cervical Cancer (2 cases) Colorectal Cancer (23 cases) Esophageal and Stomach cancer (6 cases) Endometrial Cancer (6 cases) Gastric (Stomach) cancer (3 cases) Head and Neck Cancer (10 cases) Kidney Cancer Case Series (10 cases) Liver Cancer (2 cases) Lung Cancer (18 cases) Leukemia (2 cases) Lymphoma (8 cases) Melanoma (Skin Cancer) Multiple Myeloma (2 cases) Myelodysplastic Syndrome Oral Cancer Ovarian Cancer (4 cases) Pancreatic Cancer (16 cases) Prostate Cancer (19 cases) Sarcoma (3 cases) Skin C...
DMSO is a medical abbreviation for DiMethyl SulfOxide. Modern medicine often sidelines "miracle" drugs that work too well. Despite decades of evidence showing that the naturally occurring chemical Dimethyl Sulfoxide (DMSO) is a remarkably safe and versatile treatment for a range of challenging conditions — such as strokes, head trauma, spinal cord injuries, dementia, and even Down Syndrome (63) — it has been largely overlooked. This sidelining is particularly remarkable as DMSO is also one of the most effective treatments for acute and chronic pain, musculoskeletal injuries, and chronic degenerative conditions (e.g., arthritis). DMSO, Nature’s Healer DMSO is a powerful, natural compound with several unique properties that make it an incredibly versatile healing agent: Rapid absorption — When applied to the skin or ingested, DMSO quickly spreads throughout the body. ...
Fenbendazole is an established broad spectrum anti-parasitic used against intestinal parasites including: giardia, roundworms, hookworms, whipworms, the tapeworm genus Taenia (but not effective against Dipylidium caninum, a common dog tapeworm), pinworms, aelurostrongylus, paragonimiasis, strongyles, and strongyloides that are administered to sheep, cattle, horses, fish, dogs, cats, rabbits, most reptiles, freshwater shrimp tanks as planaria and hydra treatments, as well as seals. Common brand names include Pancur, Panacur C and Safe-Guard. One such study found unexpected tumor growth inhibition in a group of mice treated with a combination of Fenbendazole and vitamins. As more studies emerge – some already published, some currently ongoing – a rapidly growing number of human patients are taking Fenbendazole to treat their cancer. A cancer treatment method known as the Joe Tippens Fenbendazole Cancer Protocol has been gaining rapid interest over the past years following some fenbe...
Fenbendazole is a broad spectrum anti-parasitic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the tapeworm genus Taenia (but not effective against Dipylidium caninum, a common dog tapeworm), pinworms, aelurostrongylus, paragonimiasis, strongyles, and strongyloides that can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits, most reptiles, freshwater shrimp tanks as planaria and hydra treatments, as well as seals. (1) Fenbendazole, has garnered attention for its potential use in humans. The Fenbendazole Cancer Protocol gained rapid interest over the past years following some fenbendazole advanced cancer success stories . Joe Tippens founded the protocol after he was told a story about a scientist at Merck Animal Health that had been performing cancer research on mice. The research included injecting different types of cancers into different mice body parts. The scientists...
Abstract Cancer continues to pose a significant global health burden, particularly with the rise of aggressive and treatment-resistant malignancies such as triple-negative breast cancer, pancreatic adenocarcinoma, and glioblastoma. In response to the limitations of current therapies, there is growing interest in the repurposing of antiparasitic agents—specifically fenbendazole, mebendazole, and ivermectin—for oncological applications. This review synthesizes recent preclinical and emerging clinical evidence on the anticancer mechanisms and therapeutic potential of these drugs. Fenbendazole, a benzimidazole compound, demonstrates anticancer activity through microtubule destabilization, cell cycle arrest, and inhibition of glucose metabolism, though its clinical application is challenged by poor solubility and bioavailability. Mebendazole, a structurally related benzimidazole with better human pharmacokinetics, similarly disrupts microtubule function and induces apoptosis, showing effica...
What is Fenbendazole used for in humans? Fenbendazole (also known as fenben) is a veterinary medication used to treat parasites and worms such as tapeworms, hookworms, roundworms, and whipworms, in animals. It is commonly used under brand names like Panacur C and Safe-Guard. If you have been diagnosed with cancer, or have a loved one that is suffering from cancer, chances are you have heard about the Joe Tippens Cancer Protocol. The Fenbendazole Cancer Protocol has been gaining rapid interest over the past years following some fenbendazole advanced cancer success stories. Joe Tippens founded the protocol after he was told a story about a scientist at Merck Animal Health that had been performing cancer research on mice. The research included injecting different types of cancers into different mice body parts. The scientists discovered, through trial and error, a product in their canine product line, fenbendazole, that was batting 1.000 in killing these di...
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