Fenbendazole: Side Effects, Safety and Dosage in Humans (2024)
According to Wikipedia, Fenbendazole is a broad spectrum anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the tapeworm genus Taenia (but not effective against Dipylidium caninum, a common dog tapeworm), pinworms, aelurostrongylus, paragonimiasis, strongyles, and strongyloides that can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits, most reptiles, freshwater shrimp tanks as planaria and hydra treatments, as well as seals.
One such study found unexpected tumor growth inhibition in a group of mice treated with a combination of Fenbendazole and vitamins. As more studies emerge – some already published, some currently ongoing – a rapidly growing number of human patients are taking Fenbendazole to treat their cancer.The Fenbendazole Cancer Protocol has been gaining rapid interest over the past years following some fenbendazole advanced cancer success stories.
Joe Tippens founded the protocol after he was told a story about a scientist at Merck Animal Health that had been performing cancer research on mice. The research included injecting different types of cancers into different mice body parts. The scientists discovered, through trial and error, a product in their canine product line, fenbendazole, that was batting 1.000 in killing these different cancers in the mice. The scientist was later diagnosed with stage 4 brain cancer and was given a grim prognosis of only three months to live. She decided to try the fenbendazole, and after six weeks, showed a clean scan.
Joe Tippens had been initially diagnosed with small cell lung cancer. The cancer later spread to his neck, right lung, stomach, liver, bladder, pancreas and tail bone. Like the scientist from Merck Animal Hospital, Joe was told he only had three months to live. In 2017, after hearing the story of the scientist who treated her cancer with a canine drug, Joe decided he was going to do the same. However, in addition to taking the fenbendazole, Joe added his own ingredients to the regimen (curcumin, CBD oil, and vitamin E), thus creating the Joe Tippens Cancer Protocol.
Disclaimer: We in no way endorse the Joe Tippens Cancer Protocol as a cure for cancer, and as always, you should consult your physician before starting any new medications or treatment plans.
Joe Tippens founded the protocol after he was told a story about a scientist at Merck Animal Health that had been performing cancer research on mice. The research included injecting different types of cancers into different mice body parts. The scientists discovered, through trial and error, a product in their canine product line, fenbendazole, that was batting 1.000 in killing these different cancers in the mice. The scientist was later diagnosed with stage 4 brain cancer and was given a grim prognosis of only three months to live. She decided to try the fenbendazole, and after six weeks, showed a clean scan.
Joe Tippens had been initially diagnosed with small cell lung cancer. The cancer later spread to his neck, right lung, stomach, liver, bladder, pancreas and tail bone. Like the scientist from Merck Animal Hospital, Joe was told he only had three months to live. In 2017, after hearing the story of the scientist who treated her cancer with a canine drug, Joe decided he was going to do the same. However, in addition to taking the fenbendazole, Joe added his own ingredients to the regimen (curcumin, CBD oil, and vitamin E), thus creating the Joe Tippens Cancer Protocol.
Disclaimer: We in no way endorse the Joe Tippens Cancer Protocol as a cure for cancer, and as always, you should consult your physician before starting any new medications or treatment plans.
What Is Fenbendazole?
Common brand names include Pancur, Panacur C and Safe-Guard.
However, it is also being used by humans in a cancer treatment method known as the Joe Tippens Protocol.
Is fenbendazole a cancer cure scam? One study suggests that fenbendazole has “been safely utilized as an anti-parasitic for various different animal species and could be repurposed for treating human malignancies.” Other benzimidazoles, including albendazole, parbendazole, mebendazole and flubendazole have already been shown to have promising results in humans.
Another study states that the “repurposing of veterinary drugs showing promising results for human use can result in considerable time and cost reduction required to develop new drugs.”
Why cancer patients use Fenbendazole
Developing new drugs requires a lot of time, effort, and money, and generating a promising drug can take years. Fenbendazole is already an established drug showing promising results for human use with a very low level of toxicity. It has been shown to stabilize WT p53, provide moderate microtubule disruption, interfere with cancer cells’ glucose metabolism, and target cell cycle arrest. These factors have led to a decrease in cancer cells both in laboratory environments as well as in live subjects with minimal side effects and toxicity. In addition, Fenbendazole has been shown to kill cancerous cells and promote regression in cancer patients with large B-cell lymphoma that had metastasized, as well as other metastatic malignancies, bladder cancer, renal cell carcinoma, and more.Panacur-C for Cancer
* Please take note that the Panacur C on Amazon is available in three sizes (1 gram, 2 grams and 4 grams) of single dose packets.
Fenbendazole side effects in humans
Although safety data exists for various animals, the safety and tolerability of Fenbendazole in humans for sustained periods of time have not been thoroughly studied yet. Nevertheless, many patients have decided not to wait for the lengthy bureaucratic process of scientific data to be published; they are following the protocol at their own risk. Most of these people report taking Fenbendazole without any side effects.
According to a study available from the European Medicine Agency, doses up to 500 mg per person did not result in serious adverse effects. Moreover, single doses of up to 2,000 mg per person were reported to cause no serious adverse effects over the course of ten days.
According to the product description on Amazon, fenbendazole is "Safe for all Dogs 6 weeks and older, including pregnant Dogs".
Based on toxicology studies, benzimidazoles such as Fenbendazole, Mebendazole or Albendazole seem to be safe drugs.
However, a drug without any side-effects does not exist. Scientific data reports do not reveal significant adverse reactions from taking fenbendazole. Despite the fact, there are anecdotal reports of potential toxicity:Up to 5 % of people can experience stomach discomfort or diarrhea when taking large quantities of fenbendazole with no breaks.
People with severe liver or kidney failure have lower medication excretion rates, therefore, fenbendazole can accumulate and cause unexpected side-effects. Doses should be divided accordingly in this situation.
When used in large quantities for a long period of time without breaks, fenbendazole can cause an asymptomatic liver enzyme increase due to the fact of the substance being mainly metabolized in the liver. This is reversible with the help of a couple week pause from the medication.
The protocol was designed to keep the liver in optimal health, therefore the schedule of weekly 3 days on, 4 days off was previously suggested. However, more and more people are using fenbendazole on a daily basis without problems.
We would still recommend taking at least 1 day off per week to avoid overstressing the liver if the medication is to be used for prolonged periods of time (like months or years).
To keep the liver health optimal, we advise you to take 250 mg capsules of Milk Thistle or 150 mg of Silymarin daily as a supportive supplement for keeping it in great shape.
References:
- Lacey, E. (1979). Mode of action of benzimidazoles
- Blanchard, P., & Villard, J. (2008). Toxicological profile of benzimidazole derivatives: Fenbendazole and mebendazole
- Morris, G. M., & Keppler, D. (2019). The role of anthelmintic drugs in the treatment of cancer
- Lacey, E., & Morrell, A. (2013). Benzimidazoles in cancer therapy: repurposing anthelmintics for oncology
Side Effects of Fenbendazole Reported:
Most people have NO side effects. The main complaints of the small group of people who did experience side effects were:* Mild diarrhea
* Mild stomach discomfort
* Elevated liver enzymes
Who May Be At Greater Risk of Side Effects?:
- People who use Fenbendazole in high doses.
- Use of medications and supplements that use the same pathways for metabolism as Fenbendazole
- Those taking treatments/medications that increase liver enzymes
- One research suggests that those who are weak from chemotherapy may experience more side effects than those not receiving conventional cancer treatment, particularly in elevated liver enzymes.
Does fenbendazole cause liver damage?
Although fenbendazole is generally well tolerated, there have been reports of elevated liver enzymes from the use of Fenbendazole, as well as the similar human medications mebendazole and albendazole.Therefore, patients should get a blood panel that includes the liver enzymes of AST, ALT, Alkaline Phosphatase, before taking Fenbendazole.
Liver enzymes may be elevated from cancer treatments, alcohol use, certain medications, and cancer itself.
Elevated liver enzymes indicate a liver that is stressed and inflamed, and adding to its burden with Fenbendazole would not be recommended.
There is a report documenting the effect of fenbendazole on liver function as measured by the enzymes aspartate transaminase (AST) and alanine aminotransferase (ALT). A search using Google of “fenbendazole and cancer” returns this case report as the first result: Teppei Yamaguchi, Junichi Shimizu, Yuko Oya, Yoshitsugu Horio, Toyoaki Hida. Drug-Induced Liver Injury in a Patient with Nonsmall Cell Lung Cancer after the Self-Administration of Fenbendazole Based on Social Media Information. Case Rep Oncol 1 September 2021; 14 (2): 886–891. https://doi.org/10.1159/000516276
Elevated liver enzymes may actually be a good sign for a cancer patient taking fenbendazole. Those liver enzyme (AST, ALT) values may spike for one or two months as the liver is stressed by the influx of dead cancer cells as it filters and processes the cellular debris from those dead cancer cells. AST and ALT increasing is a sign of hepatic stress (work), not necessarily disease, in the context of fenbendazole use. These liver enzymes usually normalize after the cancer is eradicated by fenbendazole.
FYI, liver enzymes will also fluctuate with other non-cancerous sicknesses/recoveries as dead cellular debris enters the bloodstream and is processed by the liver for removal. This is part of a normal physiological process. Temporary liver enzyme fluctuation should be expected to occur as a matter of course when using fenbendazole as fenbendazole kills the cancer cells.
If a patient has elevated liver enzymes, liver damage, liver metastasis, or liver diseases, it is important to work with a health professional who is familiar with the use of Fenbendazole and can advise whether it can be used and/or monitor lab values. A typical dose of 250mg of Fenbendazole usually does not cause side effects, but vigilance is key due to the lack of extensive studies on its effects in humans.
Generally, for those with normal lab values, after one month of Fenbendazole treatment, patients should get a comprehensive metabolic panel (CMP). This standard blood test will check the liver and kidney function to assure that the patient is tolerating Fenbendazole without any concerning impacts on the vital organs.
Elevated liver enzymes may actually be a good sign for a cancer patient taking fenbendazole. Those liver enzyme (AST, ALT) values may spike for one or two months as the liver is stressed by the influx of dead cancer cells as it filters and processes the cellular debris from those dead cancer cells. AST and ALT increasing is a sign of hepatic stress (work), not necessarily disease, in the context of fenbendazole use. These liver enzymes usually normalize after the cancer is eradicated by fenbendazole.
FYI, liver enzymes will also fluctuate with other non-cancerous sicknesses/recoveries as dead cellular debris enters the bloodstream and is processed by the liver for removal. This is part of a normal physiological process. Temporary liver enzyme fluctuation should be expected to occur as a matter of course when using fenbendazole as fenbendazole kills the cancer cells.
If a patient has elevated liver enzymes, liver damage, liver metastasis, or liver diseases, it is important to work with a health professional who is familiar with the use of Fenbendazole and can advise whether it can be used and/or monitor lab values. A typical dose of 250mg of Fenbendazole usually does not cause side effects, but vigilance is key due to the lack of extensive studies on its effects in humans.
Generally, for those with normal lab values, after one month of Fenbendazole treatment, patients should get a comprehensive metabolic panel (CMP). This standard blood test will check the liver and kidney function to assure that the patient is tolerating Fenbendazole without any concerning impacts on the vital organs.
If you decide to continue using this combination, closely monitor for potential side effects, such as gastrointestinal issues from metoclopramide or liver problems from acetaminophen.
In conclusion, while there is no specific evidence of harmful interactions between metoclopramide, acetaminophen, and fenbendazole, the experimental nature of fenbendazole’s use in humans necessitates caution and vigilant monitoring of the patient’s health. Be sure to regularly check liver enzyme levels to manage any emerging issues effectively.
We would still recommend taking at least 1 day off per week to avoid overstressing the liver if the medication is to be used for prolonged periods of time (like months or years).
To keep the liver health optimal, we advise you to take 250 mg capsules of Milk Thistle or 150 mg of Silymarin daily as a supportive supplement for keeping it in great shape.
Fenbendazole dosage for humans
Protocol (the initial version) – complimentary treatment of cancer
- Fenbendazole 222 mg. Consume one capsule 3 days weekly, once time daily after eating a fatty dinner. * Then do not take any for 4 days. Replicate this cycle each week.
- Vitamin E 800 U/I. Consume one capsule or another form once daily after eating without any waiting.
- Bio-Available Curcumin 600 mg. Consume one capsule twice daily after eating breakfast and lunch without waiting.
- CBD oil 25 milligrams. Consume one to two drops (total ~25 milligram) under your tongue daily before bedtime.
Protocol (the altered, stronger version) – complimentary cancer treatment
- Fenbendazole 222 milligrams. Consume one capsule daily after eating a fatty dinner without waiting. **
- Vitamin E 800 U/I. Consume one capsule or some other version daily without waiting.
- Bio-Available Curcumin 600 mg. Consume one capsule twice daily after eating breakfast and lunch without waiting.
- CBD oil 25 milligrams. Consume one to two drops (total ~25 milligrams) under your tongue daily before bedtime.
Avoiding cancer relapse – prophylactic procedure
- Fenbendazole 222 milligrams. Consume one capsule 3x weekly, once daily after eating a fatty dinner. Then don’t take it for 4 days. Replicate this cycle each week.
- Vitamin E 800 U/I. Consume one capsule or some other version daily after eating without stopping.
- Bio-Available Curcumin 600 milligrams. Consume one capsule twice daily after you eat breakfast and lunch without stopping.
- CBD oil 25 milligrams. Consume one to two drops (a total of~25 milligrams) under your tongue daily prior to bedtime.
- Tumour marker steady checks every few months, routine annual cancer imaging tests. If there’s not any cancer relapse after five years, reduce the test frequency.
Avoiding cancer for somebody who was always free of cancer – prophylactic procedure
- Fenbendazole 222 milligrams. Consume one capsule 3x weekly, once daily after eating a fatty dinner. Then don’t take it for 4 days. Duplicate this for ten weeks. Halt for ten weeks. Then replicate the cycle once more.
- Vitamin E 800 U/I. Consume one capsule or some other kind daily after eating without stopping.
- Bio-Available Curcumin 600 milligrams. Consume one capsule twice daily after eating breakfast and lunch without stopping.
- CBD oil 25 milligrams. Consume one to two drops (a total of ~25 milligrams) under your tongue daily prior to bedtime.
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