Fenbendazole: Questions Answered, Things to Know, Useful Tips - Ben Fen
How Safe is Fenbendazole?
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The image is from the 2011 film Bernie with the many bags of Safe-Guard |
How is Fenbendazole Best Administered?
Enhancing the Bioavailability of Fenbendazole with Oleic Acid. Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils. The most readily available, oleic acid-rich, practical substance is olive oil. Most likely due to its role as an emulsifying agent, Liu et al (2018) found that pairing mebendazole with oleic acid (olive oil) greatly enhances the bioavailability of mebendazole. The magnitude of the effect was substantial, 1.6 to 2.8 times greater serum levels of mebendazole were obtained when co-administering mebendazole with various oils compared to controls. Olive oil was the most effective mebendazole booster. As should be expected, the increased serum levels of mebendazole translated into more effective parasite killing effects in the animals models used as well.Administration of Fenbendazole
The practical application of interactions of fenbendazole with the substances mentioned above are straight forward. To maximize the likelihood of ingested fenbendazole getting into the blood stream to kill distant cancer cells, helping absorption is wise. Whether you choose to take fenben with a fatty meal, mixed in a tablespoon of olive oil or both, these actions should deliver more bang for your buck with respect to more of the fenbendazole surviving digestive degradation to deliver more cancer killing punch.UPDATE: A chemist recently wrote in suggesting that fenbendazole taken with a teaspoon or so of butter would have optimal absorption characteristics…”take it with a small amount of saturated or monounsaturated fat — something with a carbon chain above 14, to optimize absorption. Butter is an ideal choice.” She estimated that approximately 85% of the ingested fenbendazole would survive first-pass metabolism* en route to the target cells.
Taking fenbendazole is one thing, making sure it is actually absorbed can be a matter of life or death.
Absorption Issues with Fenbendazole
There was recently an instance of a person with small cell lung cancer (SCLC) who had eradicated 90%+ of his tumors with fenbendazole but then he started to feel pain and diagnostic testing showed the tumors returning. We probed and found that, rather than his wife administering the fenben in yogurt as she did initially, when he started to feel better he self-administered his fenben by mixing it into his morning coffee. His wife was asked to run her finger along the inside of his coffee mug. Fenbendazole residue was coating the mug. He immediately switched to liquid fenben and within a week the pain subsided, and in 6 weeks all the lung tumors were gone. This just happened over the past few months (detailed Case Report to come).Test/Re-Test, Within-Subject Demonstration that Fenbendazole Eradicates Cancer
Embedded in the discussion of absorption issues above is an important observation regarding fenbendazole and cancer. This particular person with SCLC had his cancer mostly eradicated by fenbendazole (imaging verification) only to have it return (imaging verification) despite continuing to take fenbendazole. At first blush it seemed that fenbendazole was not working. As mentioned above, it was discovered that there was an administration issue preventing fenbendazole from being ingested and once that issue was resolved his pain subsided and that was accompanied by his cancer resolving.This situation is best described as a happy accident or, scientifically, as an experiment-in-nature. It would obviously be unethical to ask someone with cancer to purposely stop taking fenbendazole “to see what happens”. But that is what happened here by accident. Fenbendazole eradicated almost all of his SCLC, then there was an administration issue with fenbendazole and the SCLC returned. Once the issue was identified and resolved, fenbendazole eradicated the cancer again.
A within-subjects experimental design is among the most powerful in determining whether the agent of interest is really responsible for the observed effect. In essence, in this case of SCLC initially due to the actions of fenbendazole, the cancer was disappearing, then without fenbendazole the cancer returned, and then again under fenbendazole the cancer was eliminated. All in the same person. It is most likely that fenbendazole’s presence or absence is the critical factor in whether this cancer was present or absent.
A Paper that Apparently Found No Anti-Cancer Effect of Fenbendazole
On occasion we will receive a notice from a reader regarding one particular study that is out there that found no anti-cancer effects from mebendazole. This paper by Mansoori, S., Fryknäs, M., Alvfors, C., Loskog, A., Larsson, R., & Nygren, P. (2021). A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer.This study should have never been published because of the errors in the design of the study, the low number of subjects and the glaring alternative explanation of the failure to find an effect of the drug: the subjects could not absorb the drug as evidenced by the fact that therapeutic serum levels were not reached in most subjects. But it is published and we should be aware of it.
Does Fenbendazole Cause Liver Damage?
Some have expressed concern that fenbendazole has been linked to liver injury. There is a report documenting the effect of fenbendazole on liver function as measured by the enzymes aspartate transaminase (AST) and alanine aminotransferase (ALT). A search using Google of “fenbendazole and cancer” returns this case report as the first result: Teppei Yamaguchi, Junichi Shimizu, Yuko Oya, Yoshitsugu Horio, Toyoaki Hida. Drug-Induced Liver Injury in a Patient with Nonsmall Cell Lung Cancer after the Self-Administration of Fenbendazole Based on Social Media Information. Case Rep Oncol 1 September 2021; 14 (2): 886–891. https://doi.org/10.1159/000516276Elevated liver enzymes may actually be a good sign for a cancer patient taking fenbendazole. Those liver enzyme (AST, ALT) values may spike for one or two months as the liver is stressed by the influx of dead cancer cells as it filters and processes the cellular debris from those dead cancer cells. AST and ALT increasing is a sign of hepatic stress (work), not necessarily disease, in the context of fenbendazole use. These liver enzymes usually normalize after the cancer is eradicated by fenbendazole.
FYI, liver enzymes will also fluctuate with other noncancerous sicknesses/recoveries as dead cellular debris enters the bloodstream and is processed by the liver for removal. This is part of a normal physiological process. Temporary liver enzyme fluctuation should be expected to occur as a matter of course when using fenbendazole as fenbendazole kills the cancer cells.
Interpreting Cancer Diagnostic Tests in Context of Fenbendazole
Another issue is the interpretation of metabolic bone scans (PET studies) after eradicating cancer that spread to bone. Oncologists may interpret the hot spots in the bones that show up in the PET scans, the lytic lesions (the holes left in the bones where the cancer was) as indicative of metabolic activity consistent with cancer, when in actuality the activity is related to bone remineralization/remodeling/regrowth in the previously cancer-filled holes. Because the concept of a ‘cure’ such as fenbendazole is foreign to mainstream oncology they may not factor in the possibility of a cure into their thinking. The upshot is that misdiagnoses may be made and potentially harmful overtreatment could be prescribed.Therefore, it is important for those taking fenbendazole to be aware that post-cancer eradication lytic lesions in bone, that present as hyper-metabolic “hot spots” in PET scans, may not be evidence of the cancer reappearing but rather indicative of healing bone growth in the holes that were previously occupied by the cancer. Those self-treating with fenbendazole should take an active role in understanding how the testing works that is determining whether they have cancer or not, and if treatments, whether they be traditional or non-traditional, are moving the needle in the correct direction.
Fenbendazole for Cancer Prevention
On the one hand there are the risks associated with taking medicine you don't need. And on the other is taking medicine that will prevent something like cancer. The conceptual issue with prevention is the logical issue of proving a negative. That is, if you never get cancer after taking fenben it is impossible to determine that fenben caused you not to get cancer.Regarding a protocol. Some healthy people, with no concerning risk factors do the following: once every 3 months we take 222 mg fenbendazole along with a tablespoon of olive oil for 3 consecutive days. A reasonable preventative protocol could be developed that took into account risk factors and weighed the aggressiveness of fenbendazole administration based on those risk factors. Because the safety profile is so great and the cost of fenbendazole is so low, and the cost of developing cancer is catastrophic, it may be wise to consider some sort of preventative program.
Time-Course and Half-Life of Fenbendazole (Mebendazole)
Knowing how long a drug is active in the body is useful for a number of reasons, the most important of which is to help guide dosing. In a study measuring the disposition and time-course of mebendazole in the blood of healthy human volunteers, Conti et al., (2009) found that a single 1000 mg dose had an average half-life of 7.4 hours. According to Drugs.com, the half-life of a 500 mg dose of mebendazole varies between 3-6 hours.Using Conti et al.’s (2009) value of a 7.4 hr half-life in human subjects suggests that if multiple doses per day are used that spreading them out by 7 or so hours might be a reasonable strategy to maintain therapeutic blood levels of fenbendazole.Covid-19 Shots and Boosters, Cancer and Fenbendazole
The recent phenomenon called “turbo Cancer” appears to be linked to covid shots and boosters. There are many other Substacks that present convincing evidence linking covid mRNA shots and boosters to the appearance of sudden, very aggressive, often fatal cancers in a variety of subgroups, most troubling in the 25-54 age group. These cancers, along with mRNA shot-induced cardiovascular injuries are reflected in the much higher death rates in most age groups since the pre-Covid-shot era in 2020. These deaths are also reflected in the greatly increased payouts of life insurance companies compared to the pre-Covid mRNA shot time-period (the increased deaths have nothing to do with the covid virus).This Substack was actually spawned by one of those turbo Cancer cases. Several of the Case Reports that are presented here are related to covid mRNA shots. Many of the cancer in the Case Reports that are in progress were caused by the mRNA shots according to the person making the report.
So far, in the roughly one year time period that this Substack has been around, the only instances that we’re aware that fenbendazole was not effective (absent failure to take it) was when covid shots or boosters were administered after self-treatment began (and was showing positive results). Those instances described involved three separate cases of pancreatic, esophageal and renal cancer.
If fenbendazole is kryptonite to the cancer cell, it appears that mRNA covid shots are kryptonite to fenbendazole’s effectiveness. Don’t know what the mechanism might be through which these shots interfere with the actions of fenbendazole. Most likely it is not a direct effect of the mRNA shots on the microtubule or glucose utilization action of fenbendazole on the cancer cell but more likely a generalized immune system exhaustion effect, p53 tumor suppression gene disruption or undiagnosed cardiovascular injury, blood clot, or stroke caused by the mRNA shots that masqueraded as a cancer death. Just theories.If you are self-treating cancer with fenbendazole, avoiding future covid shots and boosters, as if your life depended on it, is something to consider.
Is Fenbendazole Safe for Pregnant or Nursing Mothers?
One warning for the veterinary use of fenbendazole is during pregnancy. Don’t administer to pregnant or nursing animals.Recall that fenbendazole eradicated cancer stem cells in experimental preparations. According to Guerini et al (2019) “its (fenbendazole/mebendazole) wide range activity could also affect stemness-associated factors shared between CSCs and normal stem cells.” To the extent that normal and malignant stem cells share common mechanisms that may similarly be disrupted by fenbendazole, caution should be exercised when considering the use of fenbendazole during a period of heightened stem cell activity as would be present in pregnancy.
Are There Any Interactions of Fenbendazole with Other Substances and/or Drugs?
Cimetidine: Searching for drug interactions for mebendazole, the human form of fenbendazole, returns a few potentially minor interactions. One interaction noted is with cimetidine “Cimetidine may decrease the hepatic metabolism of mebendazole. Serum levels of mebendazole may be increased. Since plasma levels of mebendazole vary greatly among patients receiving this drug, the clinical significance of this interaction is not well established.”What is cimetidine? Cimetidine, sold under the brand name Tagamet, among others, is an H2 histamine receptor antagonist (blocker) that inhibits stomach acid production. It is mainly used in the treatment of heartburn and peptic ulcers.So a heartburn drug may decrease the metabolism of fenbendazole/mebendazole by presumably disrupting stomach acids which has the net effect of increasing the blood levels of the fenbendazole/mebendazole.
Manufacturers of Fenbendazole: Does the Brand Matter?
We get asked constantly whether there is a difference in effectiveness between the brands. We have not done any analyses on any of the products. However, we can report that all of the products listed above have been identified as instrumental in eradicating various cancers in the various Case Reports presented here. As such that evidence would seem to argue that all the brands are equivalent in function.However, we specifically don’t recommend, endorse or ding any brand because all that matters is that it works. And so far, they all appear to work. Use whatever you’re comfortable with, we have no evidence that the brand used matters.
Hurry Up…and Wait is an Opportunity to Self-Treat
In the last few months there was a 40 yr old man, named Brian, diagnosed with bladder cancer. He noticed some diffuse pain, reddish urine, went in to the doctor and he received a definitive diagnosis of early stage bladder cancer using serum, radiographic and biopsy techniques. Brian’s first radiation session was scheduled about a month later. His wife knew about fenbendazole, he took it (222 mg per day), his urine cleared up and he felt better.
They were convinced that the cancer was gone so they asked for followup diagnostics. After some back and forth, they received updated testing.
The cancer was gone.
At the follow up visit the couple reported to the doctor that they used fenbendazole to eradicate the cancer. The doctor’s response was “No, that can’t be it, we must have misdiagnosed you in the first place.”
Let that response sink in for a minute. The doctor’s response was to deny that Brian ever had cancer. But didn’t Brian show up to get irradiated for a bladder tumor that they had verified the type and location of through corroborating methods? So either Brian was going to receive treatment for a cancer he didn’t have or the initial tests that he had to determine the type and location of his cancer were fraudulent. Either option is not good.
There is a lot to unpack in that report but three of the most important points are these.
- If given the opportunity to self-treat before any traditional treatments are scheduled it may be wise to use that time period productively like Brian did. Many of the Case Reports here use fenbendazole along with traditional treatments. Brian avoided all traditional treatments by taking advantage of the opportunity to self-treat by virtue of the lag in scheduled appointments commonplace in today’s medicine.
- The assertion that the initial diagnosis of cancer was incorrect is stunning. This is not the first time this Substack has heard that response from an oncologist. One method to discredit fenbendazole may be to discredit the initial diagnosis. This would seem to be a drastic example of falling on your own sword in an effort to not admit the truth.
- Just about everyone here will know of the Joe Tippens story. The thumbnail sketch is he had terminal metastatic small cell lung cancer, exhausted all traditional treatments and was given up for dead. A veterinarian friend of his told him about fenben, which he started to take. Coincident with that Joe was enrolled in a clinical trial, along with 1099 others, to test the effects of an experimental drug on SCLC. Of the 1100 people in the study, one survived, that was Joe Tippens. Joe was the only one taking fenben and the rest is history. The relevance of this for the present discussion surrounds the rewriting of history. In a recent Epoch Times article on parasites and health, in a discussion of how parasitic infestation can mimic various illnesses, the author indicated that parasitic infection can be misdiagnosed as cancer citing Joe Tippens’ SCLC case. The implication is that because fenbendazole is an antiparasitic that Joe must have been misdiagnosed, did not have SCLC - despite being diagnosed, treated and enrolled in a Clinical Trial for SCLC.
Crackle, Sizzle and Burn
Another person self-treating for cancer reported a sensation of mild burning/irritation in both deltoid (shoulder) muscles that coincided with the locations of covid mRNA injections after taking fenbendazole.
Whether these sensations are related to the main effects of fenbendazole (cancer eradication) or more in line with what might be better characterized as side effects remains to be determined. All are very interesting, and as time passes hopefully we’ll get more reports like these from attentive readers that will help us understand what fenbendazole is doing.
References
Bai, R. Y., Staedtke, V., Aprhys, C. M., Gallia, G. L., & Riggins, G. J. (2011). Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. Neuro-oncology, 13(9), 974–982. https://doi.org/10.1093/neuonc/nor077Chauca Strand, G., Johansson, N., Jakobsson, N. et al. Cancer Drugs Reimbursed with Limited Evidence on Overall Survival and Quality of Life: Do Follow-Up Studies Confirm Patient Benefits? Clinical Drug Investigation (2023). https://doi.org/10.1007/s40261-023-01285-4
Corti, N., Heck, A., Rentsch, K., Zingg, W., Jetter, A., Stieger, B., & Pauli-Magnus, C. (2009). Effect of ritonavir on the pharmacokinetics of the benzimidazoles albendazole and mebendazole: an interaction study in healthy volunteers. European journal of clinical pharmacology, 65(10), 999–1006. https://doi.org/10.1007/s00228-009-0683-y
Guerini AE, Triggiani L, Maddalo M, Bonù ML, Frassine F, Baiguini A, Alghisi A, Tomasini D, Borghetti P, Pasinetti N, et al. Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature. Cancers. 2019; 11(9):1284. https://doi.org/10.3390/cancers11091284
Liu, C. S., Zhang, H. B., Jiang, B., Yao, J. M., Tao, Y., Xue, J., & Wen, A. D. (2012). Enhanced bioavailability and cysticidal effect of three mebendazole-oil preparations in mice infected with secondary cysts of Echinococcus granulosus. Parasitology research, 111(3), 1205–1211. https://doi.org/10.1007/s00436-012-2954-2
Milner, C. (2023) Parasites: An overlooked and underestimated health threat. Epoch Times, September 9, 2023.
Fenbendazole vs. Mebendazole vs. Albendazole vs. Flubendazole
FYI, to illustrate how Americans are screwed by Big Pharma, two pills of mebendazole cost just $4 in the UK, 27 cents per 100 mg pill in India and $555 per 100 mg pill in the US.
While most of the pre-clinical research uses mebendazole, probably because it is the FDA-approved-for-humans form of fenbendazole, virtually all of the self-treating clinical reports involve the use of fenbendazole. Because the preclinical cancer studies use mebendazole (ironically the human form of fenbendazole) and humans self-treat their cancers with fenbendazole (the animal form of mebendazole) it is very reasonable to assume that mebendazole and fenbendazole are functional equivalents with respect to cancer. It would be helpful if future pre-clinical and clinical investigations simply used fenbendazole as a practical matter. For the purposes of this Substack, fenbendazole, mebendazole and albendazole are used interchangably.
Where to buy fenbendazole for humans
In our experience and the experiences of those that write in, it appears that the three readily available brands of fenbendazole (Panacur-C, FenBen Labs, Happy Healing Labs) are equally effective. Panacur-C can be obtained locally in pet stores, while they all can be obtained from Amazon.Disclaimer:
Statements on this website have not been evaluated by the Food and Drug Administration. The contents of this website is for educational and informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis or treatment. This website does not provide any kind of health or medical advice of any kind. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The case reports presented reflect the real-life experiences and opinions of other readers or users of the website. The experiences of those readers or users are personal to those particular readers/users and may not necessarily be representative of all readers/users. We do not claim, and you should not assume, that all other readers/users will have the same experiences. Do you own research, consult with relevant medical professionals before attempting to self-treat for any condition.
About the Author:
Retired University scientist who happened across fenbendazole when a loved one developed terminal cancer.
Source: https://fenbendazole.substack.com/p/fenbendazole-questions-answered-things
Fenbendazole Joe Tippens Protocol FAQs
Can fenbendazole be taken in tablet, liquid or powder?
Fenbendazole is available in powder (Panacur). There may be other formulations available, but those are the primary products that patients are using.
Since fenbendazole is a veterinary medicine, and is not licensed for human use and there is no specific human safety data available. The similar human forms of this class of medications, mebendazole and albendazole, have been used for parasitic infections for many years and have a good safety record. Fenbendazole has been reported to have a very low degree of toxicity and a high degree of safety in animal experiments. Do not follow the weight-dependent dosing (for dogs) that is given on the back of the packaging! According to the product description on Amazon, fenbendazole is "Safe for all Dogs 6 weeks and older, including pregnant Dogs".
Read More: Fenbendazole side effects in humans
Although fenbendazole is generally well tolerated, there have been reports of elevated liver enzymes from the use of fenbendazole, as well as the human medications mebendazole and albendazole.
I’ve found a Fenbendazole brand which is not made by Merck, is it ok?
There are a variety of opinions on which product is best, but no research exists that compares the effectiveness of various formulations in humans. Merck and Safeguard are well established companies whose products have been safety tested in animals and used by veterinarians for many years.
Would the fenbendazole protocol work with conventional treatment? - chemotherapy?
Yes, fenbendazole has the potential to synergize with conventional treatments, and possibly enhance treatment response. Some aspects of the protocol, such as vitamin E and curcumin, may interfere with chemotherapy and radiation due to their anti-oxidant properties.
Some people take it 3 day on 4 off, some 1 gram a day, some 2 or even 4 grams a day. What is the correct dosage?
Joe Tippens, who popularized the use of Fenbendazole for cancer, recommends 222 mg for three consecutive days, then four days off. There are many people who take larger doses, more frequently. Since Fenbendazole is not licensed for the treatment of cancer in humans, there is no correct dose that is supported by research, pharmacists or physicians. The dose you choose to take should be assessed based on your other medications and treatments, your type of cancer, prognosis, organ function and lab values.
How long do I need to be on fenbendazole?
This will be up to you based on your treatment response to the protocol. It is reported that Joe Tippens continues to use the maintenance protocol (below) for prevention of relapse. Monitor cancer markers and liver enzymes. If cancer markers are normal or liver enzymes are high, take a break.
How do I know when it is time to dose up?
This is an individual decision based on treatment response, tolerance, other treatments/medications and lab values.
Fenbendazole dose guide
Protocol (the initial version) – complementary treatment of cancer
- Fenbendazole 222 mg. Consume one capsule 3 days weekly, once time daily after eating a fatty dinner. * Then do not take any for 4 days. Replicate this cycle each week.
- Vitamin E 800 U/I. Consume one capsule or another form once daily after eating without any waiting.
- Bio-Available Curcumin 600 mg. Consume one capsule twice daily after eating breakfast and lunch without waiting.
- CBD oil 25 milligrams. Consume one to two drops (total ~25 milligram) under your tongue daily before bedtime.
Protocol (the altered, stronger version) – complementary cancer treatment
- Fenbendazole 222 milligrams. Consume one capsule daily after eating a fatty dinner without waiting. **
- Vitamin E 800 U/I. Consume one capsule or some other version daily without waiting.
- Bio-Available Curcumin 600 mg. Consume one capsule twice daily after eating breakfast and lunch without waiting.
- CBD oil 25 milligrams. Consume one to two drops (total ~25 milligrams) under your tongue daily before bedtime.
Avoiding cancer relapse – prophylactic procedure (Maintenance protocol)
- Fenbendazole 222 milligrams. Consume one capsule 3x weekly, once daily after eating a fatty dinner. Then don’t take it for 4 days. Replicate this cycle each week.
- Vitamin E 800 U/I. Consume one capsule or some other version daily after eating without stopping.
- Bio-Available Curcumin 600 milligrams. Consume one capsule twice daily after you eat breakfast and lunch without stopping.
- CBD oil 25 milligrams. Consume one to two drops (a total of~25 milligrams) under your tongue daily prior to bedtime.\
- Tumour marker steady checks every few months, routine annual cancer imaging tests. If there’s not any cancer relapse after five years, reduce the test frequency.
Avoiding cancer for somebody who was always free of cancer – prophylactic procedure
- Fenbendazole 222 milligrams. Consume one capsule 3x weekly, once daily after eating a fatty dinner. Then don’t take it for 4 days. Duplicate this for ten weeks. Halt for ten weeks. Then replicate the cycle once more.
- Vitamin E 800 U/I. Consume one capsule or some other kind daily after eating without stopping.
- Bio-Available Curcumin 600 milligrams. Consume one capsule twice daily after eating breakfast and lunch without stopping.
- CBD oil 25 milligrams. Consume one to two drops (a total of ~25 milligrams) under your tongue daily prior to bedtime.
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Source: https://www.onedaymd.com/2024/11/fenbendazole-and-cancer-15-minutes-with.html |
New & Improved Joe Tippens Protocol
Fenbendazole (300mg, 6 days a week) or in the case of severe turbo cancers up to 1 gram.
Ivermectin (24mg, 7 days a week) or in the case of severe turbo cancers up to 1mg/kg/day* (Find a Doctor)
Bio-Available Curcumin (600mg per day, 7 days a week).
Vitamin D (62.5 mcg [2500 IU] seven days a week).
Tocotrienol and Tocopherol forms (all 8) of Vitamin E (400-800mg per day, 7 days a week). A product called Gamma E by Life Extension (Amazon).
CBD oil (1-2 droppers full [equal to 167 to 334 mg per day] under the tongue, 7 days a week) CBD-X: The most potent full spectrum organic CBD oil, with 5,000 milligrams of activated cannabinoids and hemp compounds CBD, CBN & CBG per serving.
Removing sugars and processed foods from one’s diet is crucial during this protocol.
The medical industry can't deny fenbendazole and mebendazole are anti-cancer drugs because PubMed tells us they are.
ReplyDelete“The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs”
Abstract
“The development of refractory tumor cells limits therapeutic efficacy in cancer by activating mechanisms that promote cellular proliferation, migration, invasion, metastasis, and survival. Benzimidazole anthelmintics have broad-spectrum action to remove parasites both in human and veterinary medicine. In addition to being antiparasitic agents, benzimidazole anthelmintics are known to exert anticancer activities, such as the disruption of microtubule polymerization, the induction of apoptosis, cell cycle (G2/M) arrest, anti-angiogenesis, and blockage of glucose transport. These antitumorigenic effects even extend to cancer cells resistant to approved therapies and when in combination with conventional therapeutics, enhance anticancer efficacy and hold promise as adjuvants. Above all, these anthelmintics may offer a broad, safe spectrum to treat cancer, as demonstrated by their long history of use as antiparasitic agents. The present review summarizes central literature regarding the anticancer effects of benzimidazole anthelmintics, including albendazole, parbendazole, fenbendazole, mebendazole, oxibendazole, oxfendazole, ricobendazole, and flubendazole in cancer cell lines, animal tumor models, and clinical trials. This review provides valuable information on how to improve the quality of life in patients with cancers by increasing the treatment options and decreasing side effects from conventional therapy.”
Son DS, Lee ES, Adunyah SE. The antitumor potentials of benzimidazole anthelmintics as repurposing drugs. Immune Netw. 2020;20(4):e29.
https://pubmed.ncbi.nlm.nih.gov/32895616/
My husband, Joel Bolen, has stage 4b Adenocarcinoma Colon Cancer. He has a loop ileostomy due to his colon leaking after resection surgery. Joel has been taking 222 mg of fenben, Safeguard by Merck, since diagnosis and surgery in 8/2023.
DeleteHis cancer has grown. It does not appear that Fenben has healed him. But to be fair, he has had trouble absorbing nutrients. After reading this article, he will start taking the fenben with olive oil.
Joel has had 14 rounds of Keytruda. This helped tremendously at first, but the cancer has learned how to work around it. We have just started a new immunotherapy treatment which is Ipilimumab and Nivolumab combination.
Terri Bolen
Please keep us updated! Praying for healing!
DeleteI have spots in my liver diagnosed as leimyosarcoma which is a rare cancer. I haven't seen anything in any of the articles regarding a sarcoma. Would this work on this rare cancer?
ReplyDeleteCase 2: IVERMECTIN & FENBENDAZOLE for Stage 4 Spindle Cell Sarcoma
DeleteDr William Makis shared on X/Twitter (November 2024):
https://x.com/MakisMD/status/1862462643891839346
IVERMECTIN & FENBENDAZOLE Testimonial - 70 year old woman with Stage 4 Spindle Cell Sarcoma gets 60% tumor shrinkage & multiple metastases disappear with low dose protocol. 70 year old woman with Stage 4 Spindle Cell Sarcoma originally in the right leg, with lung metastases.
She took the following:
Palliative chemo (was not expected to help and it's all the doctors had left to offer)
222mg Fenbendazole 3 days on / 4 days off (Joe Tippens Protocol)
12mg Ivermectin 3 days on / 4 days off
Unexpected Results: tumor shrinkage by 60% & disappearance of multiple lesions (!!)
Dr William's Take…
Spindle Cell Sarcoma is a cancer that’s notoriously difficult to treat.
The response rate of chemo is on the order of 20% (which means 80% of patients don’t see ANY improvement). The ones who respond see minimal results.
To get tumor shrinkage by 60% and disappearance of multiple lesions is stunning. The chemo was palliative and was not expected to help in this case.
So yes, it wasn't the chemo. Sorry.
And these were VERY LOW doses of Ivermectin & Fenbendazole !!
I tend to suggest higher doses as cancer killing with Ivermectin & Fenbendazole is dose dependent.
Case 1: September, 2023
Condition: Alveolar Rhabdomyosarcoma
"When my 13 year old son was diagnosed, I basically became a cancer researcher!
I discovered a few new very promising treatments that are close to being ready for pediatric use, and I also came across Joe Tippen’s story. I joined a couple of large, international Facebook groups related to the Protocol, which are by far the most positive of all of the cancer-related groups I’m in, and have the most success stories. I connected with a mom in the group whose 2 year old has the same type of cancer as my son, which had spread to his lymph nodes during frontline chemotherapy treatment. She started him on Fenben and his next 2 scans so far have been clear!
I would do anything to help my son beat the odds, and I came to the conclusion that it would be far more dangerous NOT to give him repurposed meds than to give them.
My husband supported my decision, but wanted some medical oversight, which we have received from Heal Navigator.
We noticed an improvement in our son’s energy level and general health after just 2 days of giving him the Fenben! He had zero side effects, besides feeling a lot better.
I hope and pray that is a sign that it’s doing what we need it to! If you’re hesitating about getting started, I would encourage you to go for it!
Protocol components used: Fenbendazole , Curcumin, Milk thistle, Ivermectin, Vitamin D3, Claritin, Melatonin, Propranolol, Niclosamide, Mushroom blend, Omega 3, Papaya Leaf Extract as needed to raise blood counts."
Conventional treatments: Radiation, Chemotherapy
Source: https://www.onedaymd.com/2024/02/fenbendazole-cancer-success-stories.html
I’m seeking advice about my mother, who had breast cancer removed from her right breast seven years ago and had been living normally and healthy since. However, around 10 months ago, she began experiencing pain in her leg, which progressively worsened to the point where she is now unable to walk. Doctors have confirmed that the cancer has spread to her bones and lungs.
ReplyDeleteWe’ve decided not to pursue chemotherapy or radiation, but about a week ago, we started her on fenbendazole (222mg, one pill for 3 days on, 7 days off). After starting the treatment, she began experiencing pain in her right upper abdomen. We’re concerned that it could be liver damage, God forbid, or possibly a result of the medication working and detoxing her system.
She’s also feeling very tired, sad, and has a very low appetite. I’m really worried about continuing the fenbendazole and would greatly appreciate any advice or if anyone has faced a similar situation. Is this response normal, or should we be concerned?
Thank you so much for your help and guidance. God bless you.