FENBENDAZOLE and CANCER - at least 12 Anti-Cancer Mechanisms of Action by Dr William Makis (2024)

By Dr. Frank Yap, MD -
The main goal with these article is to provide as much clear information as possible for someone dealing with cancer or mRNA Induced Turbo Cancer. This article deals with the basis and practical approach to using Fenbendazole, Mebendazole and Ivermectin.

Fenbendazole Literature and Papers:

  • 2024 Apr, Rodrigues et al - Repurposing mebendazole against triple-negative breast cancer CNS metastasis

  • 2024 Feb, Eid et al - Investigating the Promising Anticancer Activity of Cetuximab and Fenbendazole Combination as Dual CBS and VEGFR-2 Inhibitors and Endowed with Apoptotic Potential

  • 2024 Feb, Park et al - The microtubule cytoskeleton: A validated target for the development of 2-Aryl-1H-benzo[d]imidazole derivatives as potential anticancer agents

  • 2024 Jan, Matsuo et al - Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes

  • 2023, Dec, Iragavarapu-Charyulu et al - A novel treatment to enhance survival for end stage triple negative breast cancer using repurposed veterinary anthelmintics combined with gut‑supporting/immune enhancing molecules

  • 2023 Nov, Aliabadi et al - In vitro and in vivo anticancer activity of mebendazole in colon cancer: a promising drug repositioning

  • 2023 Nov, Jung et al - Fenbendazole Exhibits Differential Anticancer Effects In Vitro and In Vivo in Models of Mouse Lymphoma

  • 2023 Sep, Garg et al - Network pharmacology and molecular docking study-based approach to explore mechanism of benzimidazole-based anthelmintics for the treatment of lung cancer

  • 2023 Jun, Mukherjee et al - Ketogenic diet as a metabolic vehicle for enhancing the therapeutic efficacy of mebendazole and devimistat in preclinical pediatric glioma

  • 2023 Feb, Lee et al - Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine

  • 2023 Jun - Movahedi et al - Repurposing anti-parasite benzimidazole drugs as selective anti-cancer chemotherapeutics
  • 2023 Apr - Chi-Son Chang et al - Anti-cancer effect of fenbendazole-incorporated PLGA nanoparticles in ovarian cancer
  • 2023 Mar - Semkova et al - Redox-mediated Anticancer Activity of Anti-parasitic Drug Fenbendazole in Triple-negative Breast Cancer Cells
  • 2023 Mar - Haebeen Jung et al - Differential cytotoxic effects of fenbendazole on mouse lymphoma EL-4 cells and spleen cells
  • 2022 Sep - Deokbae Park et al - Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells
  • 2022 Jan - Li-wen Ren et al - Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle
  • 2020 Aug - Deok-Soo Son et al - The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs
  • 2020 Jun - Yong Han et al - Involvement of reactive oxygen species in the anti-cancer activity of fenbendazole, a benzimidazole anthelmintic (leukemia)
  • 2018 Aug - Dogra et al - Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways.

DR WILLIAM MAKIS'S REVIEW ON MOST RECENT RESEARCH:

Image Source: (2023 Feb, Lee et al) - Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine

There is still some research being done on Fenbendazole & Cancer, but researchers are focusing more on other related compounds in the “Benzimidazole family”, namely Mebendazole, but also Albendazole, Parbendazole. Why?

COST:

Fenbendazole is cheap. If big pharma is going to make money (especially in cancer treatment), they need an expensive compound and Fenbendazole isn’t it.

Fenbendazole is not FDA approved. It’s dirt cheap.

Mebendazole is FDA approved. It’s expensive.

Albendazole is FDA approved. It’s very expensive.

Dr.Thomas Seyfried talks about the cost of Mebendazole

PRACTICAL APPROACH TO USING FENBENDAZOLE IN CANCER TREATMENT (Disclaimer: the following is not medical advice)

In “Fenbendazole and Cancer Part 1”, I covered all the mechanisms of action that Fenbendazole has shown against cancer in many in vitro and in vivo studies.

The 10 new studies published in 2023-2024 only confirm what we already know from previous studies. Fenbendazole, Mebendazole, Albendazole are highly effective against many cancers.

There is one article I want to highlight though because it has an extremely important concept:

  • (2023 Jun, Mukherjee et al) - Ketogenic diet as a metabolic vehicle for enhancing the therapeutic efficacy of mebendazole and devimistat in preclinical pediatric glioma

  • “This study investigated the influence of nutritional ketosis on the therapeutic action of mebendazole (MBZ) and devimistat (CPI-613) against the highly invasive VM-M3 glioblastoma cells in juvenile syngeneic p20-p25 mice”

  • “maximum therapeutic benefit of mebendazole and CPI-613 on tumour invasion and mouse survival occurred only when the drugs were administered together with a ketogenic diet (KD)

KETOGENIC DIET IS CRUCIAL IN CANCER!!!

Since my previous Fenbendazole article, I‘ve had 1000s of questions sent to me. Not about mechanisms of action against Cancer. But about practical use - how to use Fenbendazole or Mebendazole to treat Stage 4 Cancers, what formulations, what doses?

The goal of this article (Part 2) is to answer many of those questions to the best of my ability.

EXPERIMENTAL CANCER PROTOCOLS:

I propose the following thought experiment & hypothetical “Experimental Protocols” for Turbo Cancer Treatment:

  • You can look at fenbendazole.org for suggested dosing and dose calculator

  • Dr.Tom Rogers, Founder of “Performance Medicine” has similar protocols.

  • For anyone COVID-19 mRNA Vaccinated diagnosed with cancer (Turbo Cancer), I’d probably be looking at starting at 444 mg a day.

  • For particularly aggressive Turbo Cancers or bad cases, I’d even consider pushing towards 888 mg/day (444 mg twice a day) or 1000 mg/day.

  • Highest dosing I’ve seen is 30-50mg/kg/day for 5 days, based on the “Merck Manual”, however very few claim to have taken this dose.

  • Fenbendazole can elevate liver function tests, so it would be a good idea to have a family doctor monitor those

WHAT ABOUT MEBENDAZOLE?

  • Here are the references for this dosing schedule:

  • For Maximum dose of 4g/day being safe, that’s from a Phase 2 Clinical Trial for Gastrointestinal Cancer: (2021 Mansoori et al)

  • (2021 Chai et al) - summarizes the various studies that have looked at Mebendazole in Cancer and the doses used.

  • So far, several studies in the literature have used 200mg/day with some success, however given that it is safe to go up to 4g/day, when we’re dealing with aggressive mRNA Induced Turbo Cancers, 200mg/day is probably not sufficient.

  • Why Mebendazole over Albendazole (2021 Chai et al):

    • “However, because of the toxicity of albendazole, for example, neutropenia due to myelosuppression, if high doses are used for a prolonged time, mebendazole is currently more popularly used than albendazole in anti-cancer clinical trials.”

Fenbendazole vs. Mebendazole

Fenbendazole and Mebendazole are similar in that they both eliminate parasitic worms, but there is a difference. Mebendazole is approved for human consumption by the FDA, while fenbendazole is only approved for veterinary use and has not been approved for human use.

Although studies are limited, researchers have found mebendazole to have anti-cancer properties like fenbendazole. It stops worms from absorbing glucose, which they need to grow. Researchers have found that it can also prevent cancer cells from absorbing glucose, keeping them from expanding.

While fenbendazole for human cancer has gained more popularity with some interesting fenbendazole cancer success stories, some research suggests mebendazole might be more effective for treating different types of tumors. For example, research studies have shown that mebendazole could be more effective for brain, prostate, and ovarian cancers. 

Dr. Tom Rogers MD (Performance Medicine - Knoxville, TN) Suggests Several Protocols utilizing Fenbendazole which are interesting:

ACTIVE CANCER TREATMENT – For active cancer, take one capsule of Fenbendazole (444 mg) daily. Some people recommend you take one day off a week. Note: I think I would just take Sundays off. Again, you’re not supposed to develop a tolerance to this, but taking a little break is probably a good idea. To improve the protocol , take CBD oil (25mg) 1-2 drops every night before sleep. To strengthen the protocol take Curcumin (600mg) twice a day with food. To support the liver, take Milk Thistle (250mg) twice a day with food. Note: Fenbendazole should be taken with or after a meal to improve absorption.

COMPLEMENTARY CANCER TREATMENT – Take one capsule of Fenbendazole (222mg) every day, once a day after a fatty meal; Curcumin (600mg) one capsule, two times a day after breakfast and lunch; CBD oil (25mg) 1-2 drops under the tongue every day before sleep.  

CANCER RELAPSE PREVENTION – Taking Fenbendazole for active cancer and cancer relapse prevention, take one capsule (222 mg) three times a week, once a day after a fatty meal.In addition, take Curcumin (600mg) one capsule/two times a day after breakfast and lunch, Milk Thistle, and CBD Oil (25mg) 1-2 drops under the tongue everyday before going to sleep. Note: Have your doctor follow and check liver and kidney function tests. It’s easy, cheap, and you can get this at any doctor’s office.

CANCER PREVENTION (prophylactic) – Those that have had genetic tests and know they’re really prone to getting cancer can take Fenbendazole prophylactically. Take one capsule (222 mg) 3 times a week, once a day after a fatty meal. Then no Fenbendazole for four days. Repeat for 10 weeks and then take 10 weeks off; Curcumin (600 mg) one capsule two times a day after breakfast and lunch; CBD oil (25mg) 1-2 drops under the tongue every day before sleep. Continue that regimen indefinitely.

Fenbendazole has at least 12 proven anti-cancer mechanisms in vitro and in vivo:

  1. disrupts microtubule polymerization (major mechanism)
  2. induces cell cycle (G2/M) arrest
  3. blocks glucose transport and impairs glucose utilization by cancer cells (major)
  4. increases p53 tumor suppressor levels (major)
  5. inhibits cancer cell viability (mTOR)
  6. inhibits cancer cell migration and invasion (EMT pathway)
  7. induces apoptosis
  8. induces autophagy
  9. induces pyroptosis and necrosis
  10. induces differentiation and senescence
  11. inhibits tumor angiogenesis
  12. reduces colony formation and inhibits stem-ness in cancer cells
  13. inhibits drug resistance and sensitizes cells to conventional chemo as well as radiation therapy 
A very similar drug in the same family as Fenbendazole is FDA approved: Mebendazole, and it is in several Clinical Trials right now for brain cancers and colon cancers.

So why are there no Fenbendazole Clinical Trials for Cancer?

The answer seems rather obvious: it’s very cheap, it’s safe, and it seems to be very effective.
Fenbendazole is not going to make anyone rich, and in cancer treatments, that is a non-starter.

What about COVID-19 mRNA Vaccine Induced Turbo Cancers?

Fenbendazole shows in vitro and/or in vivo activity against these cancers: 
  • breast cancer (including triple negative breast cancer - which is seen in COVID-19 mRNA Vaccinated individuals with Turbo Cancer)
  • lymphomas (these are the most common COVID-19 mRNA Vaccine Turbo Cancers and there is more evidence for Fenbendazole with Lymphomas than with Ivermectin)
  • leukemias (most aggressive COVID-19 mRNA Vaccine Turbo Cancers)
  • glioblastomas and gliomas (extremely aggressive COVID-19 mRNA Vaccine Turbo Cancers)
  • lung cancer (NSCLC) (strong signal for COVID-19 mRNA Vaccine Turbo Cancers)
  • hepatocellular carcinoma (signal for COVID-19 mRNA Vaccine Turbo Cancers)
  • rhabdomyosarcomas (possible signal for COVID-19 mRNA Vaccine Turbo Cancers, sarcomas in general are on the rise)
  • ovarian cancers
  • urothelial cancers

CONCLUSION

Fenbendazole is NOT approved for human use by Food and Drug Administration (FDA) and European Medicines Agency (EMA). It is available as a veterinary medication.

Fenbendazole is part of a larger group of drugs known as benzimidazoles, which are anthelmintic drugs (i.e., drugs that kill parasitic worms). Another benzimidazole is mebendazole, which can be prescribed to humans with certain parasitic infections.

Mebendazole (Vermox) is FDA approved for human use, but it’s significantly more expensive.

Hypothetical - if I was diagnosed with mRNA Induced Turbo Cancer, as a 40s year old male, I’d be strongly looking at taking a combination of Ivermectin (1mg/kg/day) and Fenbendazole (444mg/day). This decision would be made based on dozens of peer-reviewed papers that have been published, previous and ongoing Clinical Trials, etc.

Everyone’s situation is different, however, it is important to arm yourself with medical knowledge that cancer doctors (Oncologists) will simply not give you, because they either don’t know it, or they won’t risk their careers to save you.

New & Improved Joe Tippens Protocol

The holy grail turbo cancer cure may just be the synergistic combination therapy of Fenbendazole AND Ivermectin as follows:


Adapted from: https://makismd.substack.com/p/fenbendazole-and-cancer-part-2-treating

Joe Rogan Talks Fenbendazole and Cancer


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