Fenbendazole and Ivermectin for Multiple Sclerosis, Rheumatoid Arthritis and Osteoarthritis (2025)
Introduction
Fenbendazole, a medication traditionally used as an anti-parasitic in veterinary medicine, is gaining unexpected attention for its potential benefits in treating chronic inflammatory and autoimmune conditions such as Multiple Sclerosis (MS), Rheumatoid Arthritis, and Osteoarthritis. While research on its use in humans remains limited and largely under the radar, emerging animal studies and personal testimonials suggest that fenbendazole—and, in some cases, ivermectin—may offer significant relief for patients struggling with these debilitating diseases. This post explores the scientific background, shares compelling case reports, and highlights the growing interest in repurposing these medications for conditions far beyond their original scope.Fenbendazole for Multiple Sclerosis
Is there any research on the utility of the anti-parasitic Fenbendazole in Multiple Sclerosis? Yes, but it's very well hidden, and you've likely never heard of it. I'll be honest, I hadn't either. There is a 2010 paper by Australian Researchers led by A A Ramp: "Strain-related effects of fenbendazole treatment on murine experimental autoimmune encephalomyelitis".
Dr William Makis
posted
on X/Twitter:
Is there any research on the utility of the anti-parasitic Fenbendazole in Multiple Sclerosis?
Yes, but it's very well hidden, and you've likely never heard of it. I'll be honest, I hadn't either.
There is a 2010 paper by Australian Researchers led by A A Ramp: "Strain-related effects of fenbendazole treatment on murine experimental autoimmune encephalomyelitis".
What is murine experimental autoimmune encephalomyelitis? Animal model of Multiple Sclerosis!
"FBZ is delivered orally by premixing into rodent chow at a rate of 150 mg/kg of diet. This assumes an average daily food intake of 8 mg/kg body weight, sufficient to ensure a therapeutic dose".
Rodent chow. Sounds delicious.
FENBENDAZOLE decreased # of sick mice from 99% to 38.6% in one MS disease model (NOD/LtJ) FENBENDAZOLE decreased # of sick mice from 99% to 62.5% in another MS disease model (C57BL/6J)
These are absolutely wild results and completely unknown to the world. Have a look at the attached tables (below).
For any Multiple Sclerosis patient, I would start a trial of Fenbendazole at either 444mg or 888mg daily depending on the weight. The adverse events at these doses are minimal vs the potential benefit!
Had a nice lady just diagnosed with Multiple Sclerosis (MS), tried a week of Ivermectin to see how it works & pretty much made everything feel worse. Today, she tried 444mg of fenben for the first time, no ivermectin, and she instantly could move her hands again and ankles. If you have MS and haven't tried FenBen, might be a good time.
Read More:
Multiple Sclerosis series.
Ivermectin and Fenbendazole for Rhematoid Arthritis
Case 2 - 2025: 80-year-old woman post breast cancer lumpectomy with Rheumatoid Arthritis was on maintenance Ivermectin
Dr. William Makis shared on X (Twitter) in May 2025:
80 year old patient with breast cancer had a lumpectomy.
From the patient:
"I started taking Ivermectin 12mg daily about 2 months ago because I had breast cancer lumpectomy and wanted to try to avoid another cancer incident"
"The side effects from the ivermectin have been unexpected and welcomed"
"My RA (Rheumatoid Arthritis) is calmed down, my knees are no longer painful (I was told I needed both replacements)"
"I was diagnosed with Crohn's disease...the problems I have experienced since that time are related to the surgeries I had...best of all my bowels have slowed down and I do not experience the constant diarrhea or near dehydration"
"At almost 80 years old, I am getting back to gardening, housekeeping and cooking".
They’re angry in the 2nd and 3rd pics without taking these fantastic medicines!
Arthritis hurts. Ivermectin and Fenben WORKS.
Dr Makis shared and quoted (post - 2025):
Ivermectin and Fenbendazole Testimonial - 72 year old ER Physician with Osteoarthritis
Dr Makis shared on X (Twitter) in March 2025 in another post:
IVERMECTIN and FENBEDAZOLE Testimonial - 72 year old ER Physician
with Osteoarthritis reports back after 3 weeks:
Osteoarthritis...would you have thought of Ivermectin or
Fenbendazole? I hadn't, to be honest...
72 year old ER Physician who took Ivermectin 12mg and Fenbendazole
222mg for 3 weeks:
“Pain basically gone” “Morning stiffness greatly improved” “Real
improvement immediately began with the addition of Fenbendazole”
This one surprised me a bit.
"So grateful for your post on X. I've been at my wits end to try to
stop the osteoarthritis progression"
There seems to be an anti-inflammatory effect to Fenbendazole I didn’t
account for!
Ivermectin Testimonial - 40s year old man from France successfully treated Autoimmune Inflammatory Gastritis with Metaplasia with Ivermectin
Dr Makis shared on X (Twitter) in May 2025:IVERMECTIN Testimonial - 40s year old man from France successfully treated Autoimmune Inflammatory Gastritis with Metaplasia with only Ivermectin!! World's first.
Every day, patients come to me with Ivermectin success stories but it's not always CANCER. I have a 40s year old patient from France, his father is being treated for Prostate Cancer.
However, I have been helping him with auto-immune conditions.
Here is what he wrote to me:
Here is what he wrote to me:
"I began a course of Ivermectin at 0.25mg/day"
"rapid and significant improvement...suggests a clear effectiveness of treatment with inflammation now back to normal level".
He did testing for his autoimmune disease - a fecal calprotectin test which measures inflammation in the
gastrointestinal tract.
His level was 246ug/g (very high) (normal < 50ug/g)
- after 1 week of ivermectin: 119 ug/g
- after 4 weeks of Ivermectin: 35 ug/g
His bowel inflammation markers went from "severe" to "normal" after 4 weeks of Ivermectin!! High levels are also seen in Inflammatory Bowel Disease (Crohn's Disease, Ulcerative Colitis" and Colon Cancer.
"I sincerely thank you for pointing me in this direction".
Conclusion
In conclusion, the testimonials and emerging research highlighted in these posts underscore the growing interest in repurposing fenbendazole and similar medications for autoimmune and inflammatory conditions such as Multiple Sclerosis, Rheumatoid Arthritis, and Osteoarthritis. While the stories of individual improvement are compelling, it is important to approach these alternative therapies with caution and consult with healthcare professionals before considering their use. Continued research and clinical trials are essential to fully understand the safety, efficacy, and long-term effects of fenbendazole and ivermectin in human health. As the scientific community explores new possibilities, these patient experiences may pave the way for future breakthroughs in the management of chronic diseases.
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