Ivermectin and Mebendazole for Cancer: The Game-Changing Combo You Need to Know About (2025)
Mel Gibson lit up The Joe Rogan Experience with an explosive claim: Ivermectin and fenbendazole might be a secret weapon against cancer. Mel Gibson told Rogan about three close friends with stage 4 cancer who turned their lives around after using these anti-parasitic drugs.
“All three of them don’t have cancer now — at all,” Gibson declared.
Not surprisingly, this sent shockwaves across the internet.
Suddenly, ivermectin — demonized during COVID — was back in the spotlight. But this time, not just as a parasite killer. Scientists are already looking into ivermectin’s potential to shrink tumors. And fenbendazole? It’s showing promise in laboratory studies against aggressive cancer cells.
Here’s where it gets interesting: Fenbendazole is an animal drug. But mebendazole, its FDA-approved counterpart for humans, is available NOW.
Laboratory studies indicate that mebendazole enters the brain and brain tumors at concentrations that may be effective for a combination of anti-cancer mechanisms. (source)
In a clinical trial for brain cancers in children (https://clinicaltrials.gov/study/NCT01837862), mebendazole doses will be escalated from the initial dose level of 50 mg/kg/day divided twice daily, to a second dose level of 100 mg/kg/day divided twice daily, to the final dose level of 200 mg/kg/day divided twice daily.
In another clinical trial "To Study the Effects of Addition of Mebendazole to Lenvatinib in Cirrhotics With Advanced Hepatocellular Carcinoma", mebendazole will be given at dose of 100 mg orally twice a day (BD) daily.
"All Mebendazole cancer trials were severely underdosed in my opinion. Probably intentionally."
Although studies are limited, researchers have found mebendazole to have anti-cancer properties like fenbendazole. It stops worms from absorbing glucose, which they need to grow. Researchers have found that it can also prevent cancer cells from absorbing glucose, keeping them from expanding.
While most of the pre-clinical research uses mebendazole, probably because it is the FDA-approved-for-humans form of fenbendazole, virtually most of the self-treating clinical reports involve the use of fenbendazole.
If a patient has elevated liver enzymes, liver damage, liver metastasis, or liver diseases, it is important to work with a health professional who is familiar with the use of Fenbendazole or mebendazole and can advise whether it can be used and/or monitor lab values. A typical dose of 250mg of Fenbendazole usually does not cause side effects, but vigilance is key due to the lack of extensive studies on its effects in humans.
“All three of them don’t have cancer now — at all,” Gibson declared.
Not surprisingly, this sent shockwaves across the internet.
Suddenly, ivermectin — demonized during COVID — was back in the spotlight. But this time, not just as a parasite killer. Scientists are already looking into ivermectin’s potential to shrink tumors. And fenbendazole? It’s showing promise in laboratory studies against aggressive cancer cells.
Here’s where it gets interesting: Fenbendazole is an animal drug. But mebendazole, its FDA-approved counterpart for humans, is available NOW.
Is ivermectin and mebendazole the same thing?
Ivermectin and mebendazole are two anti-parasitic drugs that have gained attention in recent years as alternative forms of treatment for cancer. We’ve broken down the essential things you need to know about these medications for cancer in humans.
This article aims to explore the key differences between Mebendazole and Ivermectin, examining their mechanisms of action, approved uses, and current research surrounding their efficacy in various medical contexts. By understanding these differences, readers can gain a clearer perspective on the unique characteristics of each drug and their potential roles in human health.
Mebendazole seem the perfect pairing with Ivermectin as an off label combination against cancer; recent research shows this combination attacks the mitochondrial stem cell connection. (source)
What Is Ivermectin?
Ivermectin is an anti-parasite drug used to treat various parasite infections in humans, but it can also be used to treat other health conditions like river blindness, onchocerciasis, intestinal strongyloidiasis, and onchocerciasis.
Ivermectin is often recognized – 2nd to penicillin – for having the greatest impact on human health. And its discovery won the Nobel Prize in 2015. Ivermectin has an increasing list of indications due to its antiviral and anti-inflammatory properties, and is included on the WHO’s Model List of Essential Medicines.
Several studies reported antiviral effects of ivermectin on RNA viruses such as dengue, Zika, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency virus type 1, and COVID 19 virus.
Ivermectin Effectiveness
- Ivermectin and breast cancer: Ivermectin has been found to turn cold breast tumors hot. Cold tumors mean there are little to no infiltrating T-cells. However, Ivermectin treatment led to robust T-cell infiltration, which turned the tumors into hot ones. This suggests that Ivermectin could synergize with proteins like the PD-1, which help the immune system by acting as a brake on T-cells. This will increase immunity and help the body eradicate cancer.
- Ivermectin and digestive system cancer: Clinical studies show that dose-dependant Ivermectin inhibits the proliferation of glioblastoma cells in humans and induced apoptosis. Ivermectin has the potential to resist tumor angiogenesis and tumor metastasis.
- Ivermectin and lung cancer: Ivermectin significantly inhibits the production of lung cancer cells by inhibiting the YAP1 activity. Ivermectin can also reduce the metastasis of lung cancer cells by impeding EMT.
- Ivermectin and melanoma: Melanoma cells were treated with Ivermectin and showed the potential to effectively inhibit melanoma activity.
- Ivermectin and ovarian cancer: Ivermectin has the potential to block a cell cycle and induce cell apoptosis in ovarian cancer. The combination of Ivermectin and paclitaxel has a synergized effect on ovarian cancer. A combined treatment of these two almost completely inhibited tumor growth in vivo.
- Ivermectin and colon cancer: Ivermectin has been shown to have anti-virus, anti-inflammatory, and anti-tumor properties when it comes to colorectal cancer.
What is Mebendazole?
Fenbendazole, mebendazole and albendazole are part of a larger group of drugs known as benzimidazole*, which are anthelmintic drugs (i.e., drugs that kill parasitic worms). Mebendazole is another benzimidazole, which can be prescribed to humans with certain gut infections, including threadworms, whipworms, hookworms, and roundworms.
*The class of drugs known as benzimidazoles includes fenbendazole, mebendazole, albendazole and flubendazole.
Mebendazole (MBZ; 5-benzoyl-1H-benzimidazol-2-ylcarbamate) first described in 1968, was initially recognized as a broad-spectrum anthelmintic agent and was applied to humans in 1971 (JAMA 1971).
Fast forward two decades, and the focus on anthelmintics shifted towards their potential anticancer properties, primarily due to their interactions with microtubules (Cancers 2019).
A 2021 study from Johns Hopkins University, concluded that mebendazole should be investigated further as a component of adjuvant therapy to slow progression and prevent metastasis, and well as for primary prevention in the highest risk patients. (Oncotarget 2021)
According to, Gregory Riggins, M.D., Ph.D., professor of neurosurgery and oncology at the Johns Hopkins University School of Medicine:
“We are advocating for use of mebendazole as a therapy for those diagnosed before metastasis to see if we can slow or prevent pancreatic cancer,” Riggins says. “For those with more advanced cancers, it could be an alternative to certain surgeries. Mebendazole may have utility as a therapy after initial treatment to prevent tumor recurrence in the 15% to 20% of pancreatic adenocarcinoma patients who undergo surgery. It may also increase the durability of response to standard chemotherapy in the remaining 80% to 85% of patients with advanced disease.”
Anecdotal evidence from two case reports (refractory metastatic colon cancer, metastatic adrenocortical carcinoma) has further supported the possibility of MBZ being repurposed as an anticancer drug by documenting its success in managing metastatic patients.
Fenbendazole, mebendazole and albendazole are part of a larger group of drugs known as benzimidazole*, which are anthelmintic drugs (i.e., drugs that kill parasitic worms). Mebendazole is another benzimidazole, which can be prescribed to humans with certain gut infections, including threadworms, whipworms, hookworms, and roundworms.
*The class of drugs known as benzimidazoles includes fenbendazole, mebendazole, albendazole and flubendazole.
Mebendazole (MBZ; 5-benzoyl-1H-benzimidazol-2-ylcarbamate) first described in 1968, was initially recognized as a broad-spectrum anthelmintic agent and was applied to humans in 1971 (JAMA 1971).
Fast forward two decades, and the focus on anthelmintics shifted towards their potential anticancer properties, primarily due to their interactions with microtubules (Cancers 2019).
“We are advocating for use of mebendazole as a therapy for those diagnosed before metastasis to see if we can slow or prevent pancreatic cancer,” Riggins says. “For those with more advanced cancers, it could be an alternative to certain surgeries. Mebendazole may have utility as a therapy after initial treatment to prevent tumor recurrence in the 15% to 20% of pancreatic adenocarcinoma patients who undergo surgery. It may also increase the durability of response to standard chemotherapy in the remaining 80% to 85% of patients with advanced disease.”
Anecdotal evidence from two case reports (refractory metastatic colon cancer, metastatic adrenocortical carcinoma) has further supported the possibility of MBZ being repurposed as an anticancer drug by documenting its success in managing metastatic patients.
Mebendazole dosage for cancer treatment
The recommended dosage for mebendazole typically involves taking 100 mg of mebendazole twice daily (Endocr Pract 2011). The patient was receiving mebendazole as a sole treatment for 19 months, his disease remained stable. He did not experience any clinically significant adverse effects, and his quality of life was satisfactory.
As with any unconventional treatment approach, it’s crucial to consult with a healthcare provider before starting the experimental protocol to ensure safety and discuss potential interactions with existing medications or health conditions.
According to Dr William Makis (X.com):
Do Ivermectin and Mebendazole help against cancer? - Dr. Igor Atabekov (oncologist)
Fenbendazole vs. Mebendazole
Fenbendazole and mebendazole are similar in that they both eliminate parasitic worms, but there is a difference. Mebendazole is approved for human consumption by the FDA, while fenbendazole is only approved for veterinary use and has not been approved for human use.
Mebendazole is the form that is approved for human use while fenbendazole is approved for veterinary use. The main difference is the cost. Mebendazole is expensive ~$450 per pill (two pills of mebendazole cost just $4 in the UK.), while fenbendazole is inexpensive ~48 cents per 222 mg free powder dose (Williams, 2019). Albendazole is the form used to treat intestinal parasites in India and these cost 2 cents per pill.
While most of the pre-clinical research uses mebendazole, probably because it is the FDA-approved-for-humans form of fenbendazole, virtually most of the self-treating clinical reports involve the use of fenbendazole.
While fenbendazole for human cancer has gained more popularity with some interesting fenbendazole cancer success stories, some research suggests mebendazole might be more effective for treating different types of tumors. For example, research studies have shown that mebendazole could be more effective for brain, prostate, and ovarian cancers.
Clinical Trials
There are more than 10 studies for mebendazole for cancer in ClinicalTrials.gov.
As of now, there are limited clinical trials exploring the use of fenbendazole in humans. Research is primarily in preclinical stages. However, the Fenbendazole Cancer Protocol gained rapid interest over the past years following some fenbendazole advanced cancer success stories.
Safety
Although fenbendazole and mebendazole are generally well tolerated, there have been reports of elevated liver enzymes from the use of Fenbendazole, as well as the similar human medications mebendazole and albendazole.
The Dynamic Duo: Ivermectin + Mebendazole
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If you want to fight off parasites, this combo is the gold standard. And we're the only provider offering this powerhouse combination — safely compounded, doctor-prescribed, and ready for human use. Why does this matter? Because these medications work. Ivermectin is a Nobel Prize-winning treatment. Mebendazole has been trusted for decades to eliminate parasites with precision. Together, they form a one-two punch for ridding yourself of infections and optimizing health. Cancer experts like Dr. William Makis are already seeing success using ivermectin and mebendazole with patients. His Substack is loaded with case studies and the results are eye-opening. All this shows the tide is turning. More people are waking up to alternative treatments that work. With a 90-day supply of Ivermectin + Mebendazole, you can take control of your wellness — without waiting for permission from the mainstream medical machine. Read More: This article is part of the Winning the War on Cancer series. Related: Ivermectin vs Fenbendazole for Cancer Repurposed Drugs for Cancer: What You Need to Know Disclaimers:
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