How to Detox Spike Protein After COVID (2025)

The spike protein is naturally found in SARS-CoV-2, no matter the variant. In its native form in SARS-CoV-2, the spike protein is responsible for the pathologies of the viral infection.

In its wild form it’s known to open the blood-brain barrier, cause cell damage (cytotoxicity) and, as Dr. Robert Malone, the inventor of the mRNA and DNA vaccine core platform technology, said in a commentary on News Voice, “is active in manipulating the biology of the cells that coat the inside of your blood vessels — vascular endothelial cells, in part through its interaction with ACE2, which controls contraction in the blood vessels, blood pressure and other things.”

It’s also been revealed that the spike protein on its own is enough to cause inflammation and damage to the vascular system, even independent of a virus. (R) 

Base Spike Detox

According to Dr Peter McCullough (in a Twitter post):

Base Spike Detox is what I am currently using in my practice for those who have had COVID-19 multiple times, one or more of the COVID-19 vaccines, or both and believe persistent SARS-CoV-2 Spike protein could be causing problems in their body. 

CLICK HERE FOR THE COMPLETE PAPER > Published on November 21, 2023 in Cureus (PubMed - November 2023)

I have arrived, based on the emerging scientific literature and my clinical observation, that three OTC products are essential as a triple base combination:

1. Nattokinase 2000 FU (100 mg) twice a day
2. Bromelain 500 mg once a day
3. Nano/Liposomal Curcumin 500 mg twice a day

Additional products can be added, including NAC, IVM (Ivermectin), HCQ (Hydroxychloroquine), fluvoxamine, low-dose naltrexone, and blood thinners, depending on the clinical evaluation and the syndrome. The therapeutic objective is to start treatment and allow the body to clear Spike and its fragments with the natural reticuloendothelial system. I believe this triple combination is the best approach.

Patients can get a big head start if they self-initiate Base Spike Detox as they get organized for appointments. I have found three months is a minimum duration, and some require more than a year. Don’t expect instant results, be patient. 

Important safety warnings include bleeding for those on blood thinners or who have bleeding disorders (e.g., hemophilia), soy allergy, allergies to any component of the combination, and gastrointestinal intolerance. Women of childbearing potential without contraception, pregnant, breastfeeding, and children should not take this combination unless directed by a doctor.

COVID-19 Vaccine Myocarditis Research Wins Award

We’re thrilled to announce that Dr Peter McCullough, won first place on Preprints.org for a study he co-authored on vaccine-induced myocarditis.

Preprints.org is a vital platform for the early dissemination of scholarly research before standard peer review and publication in scientific journals. By allowing research findings to be shared early with the scientific community, Preprints.org facilitates scientific communication and collaboration, enabling researchers to receive feedback and engage with the broader scientific community.

Autopsy Proven Fatal COVID-19 Vaccine-Induced Myocarditis claimed the top spot in the 'Medicine and Pharmacology' category, specifically focusing on cardiac and cardiovascular systems. This research paper delves into a critical issue surrounding COVID-19 vaccination — the potential risk of myocarditis, particularly in cases where it leads to fatal outcomes.

Nattokinase and Spike Protein

Tanikawa et al. examined the effect of nattokinase on the spike protein of SARS-CoV-2. In the first experiment, they demonstrated that spike was degraded in a time and dose-dependent manner in a cell lysate preparation that could be analogous to a vaccine recipient. The second experiment demonstrated that nattokinase degraded the spike protein in SARS-CoV-2 infected cells. This was reproduced in a similar study done by Oba and colleagues in 2021.

Tanikawa T, Kiba Y, Yu J, Hsu K, Chen S, Ishii A, Yokogawa T, Suzuki R, Inoue Y, Kitamura M. Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2. Molecules. 2022 Aug 24;27(17):5405. doi: 10.3390/molecules27175405. PMID: 36080170; PMCID: PMC9458005.

Nattokinase is dosed in fibrinolytic units (FU) per gram and can vary according to purity. Kurosawa and colleagues have shown in humans that after a single oral dose of 2000 FU D-dimer concentrations at six, and eight hours, and blood fibrin/fibrinogen degradation products at four hours after administration elevated significantly (p < 0.05, respectively).

Thus an empiric starting dose could be 2000 FU twice a day. Full pharmacokinetic and pharmacodynamic studies have not been completed, but several years of market use as an over-the-counter supplement suggests nattokinase is safe with the main caveat being excessive bleeding and cautions with concurrent antiplatelet and anticoagulant drugs.

Editor's Note: We are aware of a fact-check article by AFP titled "Experts rubbish Covid vaccine 'detoxification' supplement". In my humble opinion, the title may come across as excessively confident and strongly worded.

The article makes a claim that 'There is no evidence that nattokinase dissolves the spike protein of SARS-CoV-2 in the human body,' while also citing evidence from the Tanikawa study. It's important to acknowledge that the Tanikawa study is a small lab study, which is a common starting point in the research process before moving on to larger studies.

Nevertheless, we agree that nattokinase is not a miracle drug, and further research is necessary. It's worth noting that there are more than 200 studies related to nattokinase published on PubMed.

Moreover, it's essential to recognize that there are multiple approaches to managing COVID-19. We encourage you to consult with your trusted healthcare provider to thoroughly discuss and assess the potential benefits and risks of various possible treatments.

Ivermectin and Spike Protein

Former NIH researcher David Scheim, PhD, early in the pandemic proposed that SARS-CoV-2 Spike protein was acting like a grappling hook pulling together circulating red blood cells (RBCs) into long chains and clumps in a process called hemagglutination (HA). 

This explained why the red blood cells could not carry oxygen normally and was congruent with the finding of micro blood clots in the lungs. Boschi et al have provided additional support for this mechanism (source). By reversing the clumping of red blood cells, ivermectin enabled the patient’s proper respiratory function to return.

According to the authors:

“Ivermectin blocked HemAgglutination when added to RBCs prior to spike protein and reversed HA when added afterwards.”

In another spectacular publication, Stone et al, describes the prompt improvement of oxygenation in patients with ivermectin (source).

The published oxygenation curves from multiple studies clearly show this physiological effect of ivermectin occurs so rapidly, it must be explained by a direct anti-Spike protein effect of ivermectin. An anonymous video of a critically ill man demonstrates the very effect that Scheim, Stone, Hazan, and Babalola have described in the Figure above. So for the next critically ill patient with COVID-19, if the opportunity presents itself, push for the administration of ivermectin. This is the only published therapy for COVID-19 that improves oxygen saturation while the patient mounts a recovery. As in this man, it may be the critical factor for a turnaround and a chance to walk out of the hospital.

COVID spike protein vs Vaccine spike protein

According to Google AI Overview:

The spike protein produced by a COVID-19 mRNA vaccine is designed to mimic the spike protein found on the surface of the SARS-CoV-2 virus, the virus that causes COVID-19. While the proteins are nearly identical in their structure, the mRNA vaccine-induced spike protein is handled differently by the body. Specifically, vaccine-induced spike proteins are more likely to be stuck on the cell's outer membrane and are less likely to have escape mechanisms. This difference in how the proteins are handled leads to a reduced risk of toxicity compared to the spike proteins produced during viral infections. (source)

A toxic possibility

It’s important to understand that 320 peer-reviewed scientific studies demonstrate that the Spike protein is highly pathogenic on its own and causes damage to all organ systems while persisting in the body for years. Thus, it can be reasonably assumed that clearing the body of this potent toxin is a key step toward addressing post-vaccination syndromes and long-COVID.

Contact with the spike protein appears to damage endothelial cells, which line every blood vessel in our body, including hundreds of billions in our lungs. If spike proteins are toxic, wouldn't a vaccine that causes our cells to make them be toxic, too?

Could the mRNA vaccines directed at SARS-CoV-2 trigger a deluge of that protein into the bloodstream, where it could wreak havoc with heavily vascularized organs such as the heart, intestine and, of course, lungs?

Conversations with several Stanford Medicine experts suggest there may be less to this concern than meets the eye. Here's one reason: For virtually every spike-protein molecule induced by vaccination, the cell that made it becomes its jail cell.

"The spike proteins made by SARS-CoV-2-infected cells and the spike proteins cells produce in response to the vaccine are nearly, although not exactly, identical," Davis said. 

COVID spike protein

Inside a SARS-CoV-2-infected cell, the COVID virus commandeers the cell's protein-making machinery and forces it to make myriad copies of the invader's own proteins and genetic material. Once made, the vast majority of newborn spike proteins are incorporated into new viral particles that have evolved ingenious ways of escaping from the cell that made them. Those particles are free to invade the cell next door or spill into the circulatory system and points beyond.

Some of those virally originating spike protein molecules miss their exit bus and wind up getting stuck on the cell's outer membrane. That's how the immune system learns to attack SARS-CoV-2-infected cells directly as well as to start pumping out antibodies that put the little pathogens out of business before they can get into more cells, Davis said.

Spike protein molecules induced by mRNA vaccines have a different fate.

The COVID-19 vaccine's cargo is a bunch of mRNA strands that, once safely inside a cell, direct the production of a whole lot of a single substance: the spike protein. Once produced inside a vaccine-recipient cell, it has no escape accomplices (the other components of the viral structure) to latch onto, because the cell isn't making them. So, it has no dependable passage out of the cell. Instead, Davis told me, the vast majority of vaccine-induced spike proteins float or are carried, either intact or sawed into snippets by enzymes inside the cell, to the cell's outer membrane. There they get stuck, right where the immune system can most easily spot them and mount a coordinated response.

  

"An intact vaccine-generated spike protein molecule, by virtue of its transmembrane domain, almost invariably sticks to the cell that makes it," agreed vaccinologist and biochemistry professor Peter Kim, PhD. 

According to Prof Peter Kim:

As I wrote in the magazine article, "Spike-proteins generated by the mRNA vaccines for COVID-19 -- while their lack of toxicity may not be absolute (they could in principle still bother neighboring cells, for example) -- are a good bet to be a lot less toxic than the spike proteins produced during the viral infections the vaccines prevent."

Read More: COVID spike protein vs Vaccine spike protein

Scientific Accuracy and Differing Views

According to Nebraska Medicine, "the spike proteins that were generated by COVID-19 vaccines last up to a few weeks." However, updated studies claimed that the vaccine spike protein might last more than a few weeks.

• Spike Protein Persistence (709 Days): The claim that spike protein can be detected for 709 days is directly supported by the Yale study (2025). However, the study emphasizes that this was observed in a subset of PVS patients, not the general population, and the implications of this persistence are unclear.

• The study titled, Altered Circulating Cytokine Profile Among mRNA‐Vaccinated Young Adults: A Year‐Long Follow‐Up Study, was published in the journal Immunity, Inflammation and Disease (April 2025): "this study found that in young adults (mean age = 27.2), mRNA injection likely leads to sustained Spike protein production lasting at least one year—evidenced by persistently elevated levels of multiple proinflammatory cytokines. Elevation of inflammatory markers is likely to play a role in symptomatic long pandemic syndromes."

• A study of 19 stroke victims published in the Journal of Clinical Neuroscience (2025) confirmed that spike protein from mRNA COVID-19 vaccines can remain in the cerebral arteries for up to 17 months. In one case, a 70-year-old woman, had spike protein present 17 months after her last shot and in another, 11 months. None of the cases showed nucleocapsid protein positivity, supporting the absence of active viral infection.

• Another study published in Molecular Systems Biology (2025) revealed that mRNA vaccines induce a highly dynamic and persistent training of innate immune cells enabling a sustained pro-inflammatory immune response. According to Sonia Elijah, "The findings point to a disturbing picture of chronic inflammation with cancer risks (e.g., Roe et al., 2017, on H3K27ac in leukemia) tied to this epigenetic rewiring."

Does Covid vaccine contain spike proteins?

The mRNA COVID-19 vaccines do not contain spike proteins themselves (with a couple of exceptions), but most of them work by teaching your body to make the spike protein, so your immune system can recognize and fight the real virus if it shows up later.

So, only protein subunit vaccines like Novavax actually contain spike proteins directly. The others (mRNA vaccines) just give your body the blueprint to make them.

Key Takeaway

It is important to realize that in the absence of completed large randomized placebo controlled trials, which are easily 5 or more years away in the future, no therapeutic claims can be made. In the meantime we must be perceptive as patients and open-minded as clinicians to come up with reasonable approaches that can be used to help those sick now with post-COVID syndromes.

References:

Halma, M.T.J.; Plothe, C.; Marik, P.; Lawrie, T.A. Strategies for the Management of Spike Protein-Related Pathology. Microorganisms 2023, 11, 1308. https://doi.org/10.3390/microorganisms11051308

Tanikawa T, Kiba Y, Yu J, Hsu K, Chen S, Ishii A, Yokogawa T, Suzuki R, Inoue Y, Kitamura M. Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2. Molecules. 2022 Aug 24;27(17):5405. doi: 10.3390/molecules27175405. PMID: 36080170; PMCID: PMC9458005.

62% Normalization in SpO2 within 24 Hours for severe COVID-19 patients after Ivermectin-Based Combination Treatment.

Peter A. McCullough’s Substack.

Editor's Note:

Why should you trust this article? While we don't ask for blind trust, we do encourage you to trust in your own judgment. Our primary goal is to empower you to conduct thorough research and make informed healthcare decisions in consultation with your trusted medical doctor.

Though there are many spike protein detox treatment protocols out there, we consider and recommend the I-Recover protocol as one of the best.

Given the lack of clinical trials of long-haul COVID-19 syndrome, these recommendations are based on the abnormal changes within the body associated with the COVID-19 disease and post viral illnesses along with the collective experience of FLCCC members.

This protocol has also been used to treat post-vaccine inflammatory syndromes with similar success. As with all FLCCC Alliance protocols, the components, doses, and durations will evolve as more clinical data accumulates. 

Due to the marked overlap between long COVID and post-vaccine syndrome, please refer to the I-RECOVER Post-Vaccine Treatment protocol for detailed treatment strategies.

Disclaimers:

• Statements on this website have not been evaluated by the Food and Drug Administration. The contents of this website is for educational and informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis or treatment.
• Please do not consider this guide as personal medical advice, but as a recommendation for use by professional providers. Consult with your doctor and discuss with her/him. Our aim here isn't to replace your doctors' advice. It is intended as a sharing of knowledge and information. 

The Wellness Company's Base Spike Detox Trio

The spike detox protocol that appeared in the US Medical Literature is now available to you!

This base spike protein detox protocol consists of these three powerful ingredients: Nattokinase, Bromelain, and Tumeric Extract.

Vaccinated or not, prioritizing your well-being has never been more crucial.

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