Methylene Blue to Fight Aging and COVID-19 (2025)
What is methylene blue? All about the anti-aging stuff biohackers love as RFK Jr. is spotted with blue liquid
Longevity enthusiasts are buzzing after reports surfaced that Robert F. Kennedy Jr. may be a fan of methylene blue.
President Donald Trump’s pick to lead the Department of Health and Human Services was recently filmed adding mysterious blue droplets to his glass mid-flight. Though he wasn’t seen drinking it, the clip — shared on X by the account American AF — quickly went viral, racking up over 20.4 million views.
Naturally, internet sleuths are on the case. Kennedy hasn’t confirmed what the liquid was, but many are speculating that it’s methylene blue, which one user called “one of the best-kept secrets in biohacking.”
What is methylene blue?
Methylene blue, considered the first fully synthetic drug used in medicine, was originally developed as a textile dye. Its potential medical benefits began to catch the eye of researchers in the 1890s, particularly as a malaria treatment.Today, the substance — which can be injected or consumed orally — is approved for treating methemoglobinemia, a rare condition where blood loses its ability to carry oxygen throughout the body.
What are the potential benefits?
In recent years, celebrities, wellness influencers and biohackers have touted methylene blue for several off-label uses, claiming it can boost energy levels and metabolism, enhance cognitive function and combat aging — though evidence remains limited.
Early research suggests that methylene blue may have antioxidant properties that help reduce toxic proteins in the brain, potentially aiding in the prevention of neurodegenerative diseases like Alzheimer’s and Parkinson’s.
Some studies also indicate that the drug may help delay skin aging by stimulating the production of collagen and elastin, reducing cellular damage and promoting wound healing.
However, experts caution that more research is needed to determine if it is both safe and effective for these purposes.
Which biohacking influencers are on the bandwagon?
Methylene blue has gained significant traction in the biohacking community, with popular influencers such as Gary Brecka, Pavel Stuchlik and Dave Asprey promoting its potential benefits online.
In response to the video of Kennedy, Brecka suggested on X that methylene blue can help improve “mitochondrial function,” boost cognitive performance and memory, enhance oxygen delivery to tissues and protect the brain from oxidative stress.
“When used correctly, it’s a game-changer for mental clarity and longevity!” he wrote.
Tim Gray, a UK-based biohacker, told The Post he’s been using methylene blue on and off for three years — especially when he’s “wanted an extra boost in brain power.”
“I find that it helps in my mental clarity,” he said, by assisting the body in utilizing oxygen better.
He said he loves it most when he’s on a flight — so it makes perfect sense to him that RFK Jr. may have used it during air travel.
“I take some on the plane, just because when I’ve measured air quality and carbon dioxide levels in the air in planes, it’s horrendous. So you want to be able to utilize your oxygen better. Methylene blue helps you do that.”
Gray also reports feeling a boost when he exercises.
“I find that when I use it before I’m swimming, I can swim significantly further underwater before I use up all my energy store, my oxygen store,” he said. “For me, it was night or day difference.”
Does it really turn your tongue blue — and can it be used to clean fish tanks?
Social media users who dabble in methylene blue love to show off their blue tongues — and Gray says the effect lasts for four or five hours.
“It stains a lot of things as well, such as clothes, almost as bad as using turmeric,” he added.
He also noted that while it wasn’t made for this purpose, people have found success using it to clean fish tanks.
“The aquarium companies actually use it for fish tanks because it kills the mold off and cleans the water very efficiently,” he said. “And it does this by, I believe, breaking down any pathogenic cell wall and donating an electron. So basically restoring electrical balance, which is why it’s so fantastic at helping with energy production and mental clarity.
“This really is something special.”
What are the potential downsides?
While early research points to some benefits outside its approved uses, many doctors have raised concerns about the risks of using methylene blue, especially without medical supervision.
Canadian physician Dr. Jon cautioned his TikTok followers against taking the drug, warning it can cause potentially deadly complications for people who also take antidepressants.
The Cleveland Clinic lists common side effects of methylene blue, including blue urine, nausea, vomiting, skin discoloration, dizziness and headaches. Some studies also suggest that taking it in large doses may increase the risk of cancer.
As with any supplement, experts strongly recommend consulting with your doctor before trying methylene blue, particularly if you’re on other medications, have kidney issues or a glucose-6-phosphate dehydrogenase deficiency*. Pregnant or breastfeeding women should also be cautious.
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