Ivermectin vs Mebendazole for Cancer: What is the Difference?
Contents
- Introduction
- What is Ivermectin?
- The Role of Ivermectin in Cancer Symptoms
- What is Mebendazole?
- Do Ivermectin and Mebendazole help against cancer? (video by oncologist)
- New & Improved Joe Tippens Protocol
- Conclusion
Introduction
What Is Ivermectin?
The Role of Ivermectin in Cancer Symptoms
Several clinical trials have been done to prove the effectiveness of Ivermectin against cancer cells with low enough dosages to be non-toxic to the normal cells. Research suggests that Ivermectin suppresses the growth and spread of cancer cells and promotes cancer cell death. Ivermectin proved successful against cancer cells when combined with chemotherapy or other targeted drugs and shows brilliant effectiveness against conventional chemotherapy drug-resistant cancer cells.
Ivermectin also shows efficacy for colorectal antitumor properties. Colorectal cancer still doesn’t have an effective treatment, but Ivermectin has been shown to possess anti-virus, anti-inflammatory, and antitumor properties. Another study shows that after treatment with Ivermectin for breast cancer, the proliferation of multiple breast cancer cell lines was significantly reduced.Ivermectin Effectiveness
- Ivermectin and breast cancer: Ivermectin has been found to turn cold breast tumors hot. Cold tumors mean there are little to no infiltrating T-cells. However, Ivermectin treatment led to robust T-cell infiltration, which turned the tumors into hot ones. This suggests that Ivermectin could synergize with proteins like the PD-1, which help the immune system by acting as a brake on T-cells. This will increase immunity and help the body eradicate cancer.
- Ivermectin and digestive system cancer: Clinical studies show that dose-dependant Ivermectin inhibits the proliferation of glioblastoma cells in humans and induced apoptosis. Ivermectin has the potential to resist tumor angiogenesis and tumor metastasis.
- Ivermectin and lung cancer: Ivermectin significantly inhibits the production of lung cancer cells by inhibiting the YAP1 activity. Ivermectin can also reduce the metastasis of lung cancer cells by impeding EMT.
- Ivermectin and melanoma: Melanoma cells were treated with Ivermectin and showed the potential to effectively inhibit melanoma activity.
- Ivermectin and ovarian cancer: Ivermectin has the potential to block a cell cycle and induce cell apoptosis in ovarian cancer. The combination of Ivermectin and paclitaxel has a synergized effect on ovarian cancer. A combined treatment of these two almost completely inhibited tumor growth in vivo.
- Ivermectin and colon cancer: Ivermectin has been shown to have anti-virus, anti-inflammatory, and anti-tumor properties when it comes to colorectal cancer.
Ivermectin and Fenbendazole for Cancer
Ivermectin and fenbendazole are not the same; they are different medications. Ivermectin is primarily used to treat parasitic infections in both humans and animals, while fenbendazole is an anthelmintic drug mainly used in veterinary medicine to eliminate gastrointestinal parasites, but both have shown potential anticancer properties.Preclinical studies show that both ivermectin and fenbendazole exhibit cytotoxic effects against cancer cells. The two drugs also inhibit the growth and spread of cancerous tumors.
"The mechanisms underlying these effects appear to involve disruption of critical cellular processes, leading to cancer cell death," wrote Sid Belzberg in a paper cited by one of 2nd Smartest Guy in the World's readers.
Both ivermectin and fenbendazole are off-patent drugs, meaning their original intended use as licensed has expired and they have become generics. This allows for many different generic drug manufacturers, including a slew of them across India, to produce them cheaply and abundantly.
United States regulators make it hard to access them without a prescription – unless you purchase the versions available for pets – but they are out there. And when combined with other anti-cancer vitamins and minerals they show incredible promise in cancer prevention and mitigation.
You will be hard-pressed to find much helpful information about these two drugs in the mainstream, though. Because they are off-patent, ivermectin and fenbendazole bring in minimal profits, which means pharmaceutical companies are not interested in promoting them or touting their benefits.
Belzberg makes the case for ivermectin and fenbendazole to be compounded with other complementary substances to create a synergistic anti-cancer concoction that is safe and effective for widespread use.
"Despite these challenges, the repurposing of these compounds carries potential advantages that justify further exploration," Belzberg wrote. "Since the safety and pharmacokinetic profiles of these substances are well-known, their development as anticancer agents could be faster and less expensive than for new drugs."
"Furthermore, the successful repurposing of these compounds could provide a cost-effective way to expand anticancer treatments, possibly improving patient outcomes while reducing healthcare costs."
Another paper by Belzberg suggests that taking ivermectin with quercetin can synergistically fight prion diseases, also known as transmissible spongiform encephalopathies, or TSEs.
TSEs represent a group of fatal neurodegenerative diseases characterized by the misfolding of the prion protein, or PrP.
"The promise shown by ivermectin and quercetin in their potential anti-prion activities and their modulation of tauopathy offers an interesting avenue for further exploration," he wrote.
What is Mebendazole?
Fenbendazole, mebendazole and albendazole are part of a larger
group of drugs known as benzimidazole*, which are anthelmintic
drugs (i.e., drugs that kill parasitic worms). Mebendazole is another benzimidazole, which can be prescribed to humans
with certain gut infections, including threadworms, whipworms,
hookworms, and roundworms.
*The class of drugs known as benzimidazoles includes
fenbendazole, mebendazole, albendazole and
flubendazole.
Mebendazole (MBZ; 5-benzoyl-1H-benzimidazol-2-ylcarbamate) first
described in 1968, was initially recognized as a broad-spectrum
anthelmintic agent and was applied to humans in 1971 (JAMA 1971).
Fast forward two decades, and the focus on anthelmintics shifted
towards their potential anticancer properties, primarily due to
their interactions with microtubules (Cancers 2019).
A 2021 study from Johns Hopkins University, concluded that mebendazole should be investigated further as a
component of adjuvant therapy to slow progression and prevent
metastasis, and well as for primary prevention in the highest risk
patients. (Oncotarget 2021)
According to, Gregory Riggins, M.D., Ph.D., professor of neurosurgery and oncology at the Johns Hopkins
University School of Medicine:
“We are advocating for use of mebendazole as a therapy for those
diagnosed before metastasis to see if we can slow or prevent
pancreatic cancer,” Riggins says. “For those with more advanced
cancers, it could be an alternative to certain surgeries. Mebendazole
may have utility as a therapy after initial treatment to prevent tumor
recurrence in the 15% to 20% of pancreatic adenocarcinoma patients who
undergo surgery. It may also increase the durability of response to
standard chemotherapy in the remaining 80% to 85% of patients with
advanced disease.”
Anecdotal evidence from two case reports (refractory metastatic colon cancer, metastatic adrenocortical carcinoma) has further supported the possibility of MBZ being repurposed as
an anticancer drug by documenting its success in managing metastatic
patients.
“We are advocating for use of mebendazole as a therapy for those diagnosed before metastasis to see if we can slow or prevent pancreatic cancer,” Riggins says. “For those with more advanced cancers, it could be an alternative to certain surgeries. Mebendazole may have utility as a therapy after initial treatment to prevent tumor recurrence in the 15% to 20% of pancreatic adenocarcinoma patients who undergo surgery. It may also increase the durability of response to standard chemotherapy in the remaining 80% to 85% of patients with advanced disease.”
Mebendazole dosage for cancer treatment
Do Ivermectin and Mebendazole help against cancer? - Dr. Igor Atabekov (oncologist)
Fenbendazole vs. Mebendazole
While most of the pre-clinical research uses mebendazole, probably because it is the FDA-approved-for-humans form of fenbendazole, virtually most of the self-treating clinical reports involve the use of fenbendazole.
If a patient has elevated liver enzymes, liver damage, liver metastasis, or liver diseases, it is important to work with a health professional who is familiar with the use of Fenbendazole or mebendazole and can advise whether it can be used and/or monitor lab values. A typical dose of 250mg of Fenbendazole usually does not cause side effects, but vigilance is key due to the lack of extensive studies on its effects in humans.
Fenbendazole vs Mebendazole in Pancreatic Cancer, Colon Cancer and Paragangliomas
VERDICT: Fenbendazole has superior cancer killing at higher doses for pancreatic cancer, colorectal cancer and paragangliomas (compared to Mebendazole and Albendazole).
Fenbendazole vs Mebendazole in Pancreatic Cancer
FENBENDAZOLE vs MEBENDAZOLE in Pancreatic Cancer - which is better? Obscure Italian study gives the answer in the battle of the anti-parasitics It's the question everyone is asking.
![]() |
Florio et al. Cancers 2019 |
Mebendazole vs Fenbendazole in treatment of Glioblastoma Brain Cancer
Mebendazole vs Fenbendazole in Osteosarcoma
New & Improved Joe Tippens Protocol
-
Fenbendazole (300mg, 6 days a week) or in the case of severe turbo cancers up to 1 gram.
-
Ivermectin (24mg, 7 days a week) or in the case of severe turbo cancers up to 1mg/kg/day (Find a Doctor)
-
Bio-Available Curcumin (600mg per day, 2 pills per day 7 days a week).
-
Vitamin D (62.5 mcg [2500 IU] seven days a week).
-
Adopting a healthy lifestyle is essential during this protocol. This includes eliminating sugar from the diet (BMJ 2023), consuming a nutritious, whole-food diet rich in fresh fruits and vegetables, avoiding ultra-processed foods (BMJ 2024), and minimizing stress.
Conclusion
- Please do not consider this guide as personal medical advice, but as a recommendation for use by professional providers. Consult with your doctor and discuss with her/him.
- As we do not have information about you, our aim here isn't to replace your doctors' advice. It is intended as a sharing of knowledge and information. Do take note that most treatments are not 100% protective or curative against cancer. It's a continuous struggle between the immune system and the cancer cells. Cancer treatments are meant to assist the immune system in this battle.
- Cancer treatment should be part of a multi-modal approach in order to provide the best possible outcome. Diet and lifestyle changes are meant to run alongside conventional treatment. They are complementary, not alternative.
Comments
Post a Comment