Ivermectin vs Mebendazole for Cancer: What is the Difference?
Contents
- Introduction
- What is Ivermectin?
- The Role of Ivermectin in Cancer Symptoms
- What is Mebendazole?
- Do Ivermectin and Mebendazole help against cancer? (video by oncologist)
- New & Improved Joe Tippens Protocol
- Conclusion
Introduction
Is ivermectin and mebendazole the same thing?
Ivermectin and mebendazole are two anti-parasitic drugs that have gained
attention in recent years as alternative forms of treatment for cancer. We’ve
broken down the essential things you need to know about these medications for
cancer in humans.
This article aims to explore the key differences between Mebendazole and
Ivermectin, examining their mechanisms of action, approved uses, and current
research surrounding their efficacy in various medical contexts. By
understanding these differences, readers can gain a clearer perspective on
the unique characteristics of each drug and their potential roles in human
health.
Mebendazole seem the perfect pairing with Ivermectin as an off label
combination against cancer; recent research shows this combination attacks
the mitochondrial stem cell connection. (source)
"The promise shown by ivermectin and quercetin in their potential anti-prion activities and their modulation of tauopathy offers an interesting avenue for further exploration," he wrote.
What Is Ivermectin?
Ivermectin is an anti-parasite drug used to treat various parasite
infections in humans, but it can also be used to treat other health
conditions like river blindness, onchocerciasis, intestinal
strongyloidiasis, and onchocerciasis.
Ivermectin is often recognized – 2nd to penicillin – for having the
greatest impact on human health. And its discovery won the Nobel Prize
in 2015. Ivermectin has an increasing list of indications due to
its antiviral and anti-inflammatory properties, and is included on
the WHO’s Model List of Essential Medicines.
Several studies reported antiviral effects of ivermectin on RNA viruses such
as dengue, Zika, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine
encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A,
Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency
virus type 1, and COVID 19 virus.
The Role of Ivermectin in Cancer Symptoms
Several clinical trials have been done to prove the effectiveness of Ivermectin against cancer cells with low enough dosages to be non-toxic to the normal cells. Research suggests that Ivermectin suppresses the growth and spread of cancer cells and promotes cancer cell death. Ivermectin proved successful against cancer cells when combined with chemotherapy or other targeted drugs and shows brilliant effectiveness against conventional chemotherapy drug-resistant cancer cells.
Ivermectin also shows efficacy for colorectal antitumor properties. Colorectal cancer still doesn’t have an effective treatment, but Ivermectin has been shown to possess anti-virus, anti-inflammatory, and antitumor properties. Another study shows that after treatment with Ivermectin for breast cancer, the proliferation of multiple breast cancer cell lines was significantly reduced.Ivermectin Effectiveness
- Ivermectin and breast cancer: Ivermectin has been found to turn cold breast tumors hot. Cold tumors mean there are little to no infiltrating T-cells. However, Ivermectin treatment led to robust T-cell infiltration, which turned the tumors into hot ones. This suggests that Ivermectin could synergize with proteins like the PD-1, which help the immune system by acting as a brake on T-cells. This will increase immunity and help the body eradicate cancer.
- Ivermectin and digestive system cancer: Clinical studies show that dose-dependant Ivermectin inhibits the proliferation of glioblastoma cells in humans and induced apoptosis. Ivermectin has the potential to resist tumor angiogenesis and tumor metastasis.
- Ivermectin and lung cancer: Ivermectin significantly inhibits the production of lung cancer cells by inhibiting the YAP1 activity. Ivermectin can also reduce the metastasis of lung cancer cells by impeding EMT.
- Ivermectin and melanoma: Melanoma cells were treated with Ivermectin and showed the potential to effectively inhibit melanoma activity.
- Ivermectin and ovarian cancer: Ivermectin has the potential to block a cell cycle and induce cell apoptosis in ovarian cancer. The combination of Ivermectin and paclitaxel has a synergized effect on ovarian cancer. A combined treatment of these two almost completely inhibited tumor growth in vivo.
- Ivermectin and colon cancer: Ivermectin has been shown to have anti-virus, anti-inflammatory, and anti-tumor properties when it comes to colorectal cancer.
Ivermectin and Fenbendazole for Cancer
Ivermectin and fenbendazole are not the same; they are different medications. Ivermectin is primarily used to treat parasitic infections in both humans and animals, while fenbendazole is an anthelmintic drug mainly used in veterinary medicine to eliminate gastrointestinal parasites, but both have shown potential anticancer properties.
If you were to compare our case series for fenbendazole vs ivermectin, you will realize that fenbendazole has relatively more clinical
evidence as compared to ivermectin. That does not mean that
fenbendazole is better than ivermectin for cancer as there is no
direct head to head comparative clinical study to prove that.
However, when taken together, ivermectin and fenbendazole could
deliver a one-two punch to cancer. When combined with other
anti-cancer nutrients such as vitamins D and C, quercetin and
curcumin, the effects are even more pronounced.
Preclinical studies show that both ivermectin and fenbendazole exhibit cytotoxic effects against cancer cells. The two drugs also inhibit the growth and spread of cancerous tumors.
"The mechanisms underlying these effects appear to involve disruption of critical cellular processes, leading to cancer cell death," wrote Sid Belzberg in a paper cited by one of 2nd Smartest Guy in the World's readers.
Both ivermectin and fenbendazole are off-patent drugs, meaning their original intended use as licensed has expired and they have become generics. This allows for many different generic drug manufacturers, including a slew of them across India, to produce them cheaply and abundantly.
United States regulators make it hard to access them without a prescription – unless you purchase the versions available for pets – but they are out there. And when combined with other anti-cancer vitamins and minerals they show incredible promise in cancer prevention and mitigation.
You will be hard-pressed to find much helpful information about these two drugs in the mainstream, though. Because they are off-patent, ivermectin and fenbendazole bring in minimal profits, which means pharmaceutical companies are not interested in promoting them or touting their benefits.
Belzberg makes the case for ivermectin and fenbendazole to be compounded with other complementary substances to create a synergistic anti-cancer concoction that is safe and effective for widespread use.
"Despite these challenges, the repurposing of these compounds carries potential advantages that justify further exploration," Belzberg wrote. "Since the safety and pharmacokinetic profiles of these substances are well-known, their development as anticancer agents could be faster and less expensive than for new drugs."
"Furthermore, the successful repurposing of these compounds could provide a cost-effective way to expand anticancer treatments, possibly improving patient outcomes while reducing healthcare costs."
Another paper by Belzberg suggests that taking ivermectin with quercetin can synergistically fight prion diseases, also known as transmissible spongiform encephalopathies, or TSEs.
TSEs represent a group of fatal neurodegenerative diseases characterized by the misfolding of the prion protein, or PrP.
Preclinical studies show that both ivermectin and fenbendazole exhibit cytotoxic effects against cancer cells. The two drugs also inhibit the growth and spread of cancerous tumors.
"The mechanisms underlying these effects appear to involve disruption of critical cellular processes, leading to cancer cell death," wrote Sid Belzberg in a paper cited by one of 2nd Smartest Guy in the World's readers.
Both ivermectin and fenbendazole are off-patent drugs, meaning their original intended use as licensed has expired and they have become generics. This allows for many different generic drug manufacturers, including a slew of them across India, to produce them cheaply and abundantly.
United States regulators make it hard to access them without a prescription – unless you purchase the versions available for pets – but they are out there. And when combined with other anti-cancer vitamins and minerals they show incredible promise in cancer prevention and mitigation.
You will be hard-pressed to find much helpful information about these two drugs in the mainstream, though. Because they are off-patent, ivermectin and fenbendazole bring in minimal profits, which means pharmaceutical companies are not interested in promoting them or touting their benefits.
Belzberg makes the case for ivermectin and fenbendazole to be compounded with other complementary substances to create a synergistic anti-cancer concoction that is safe and effective for widespread use.
"Despite these challenges, the repurposing of these compounds carries potential advantages that justify further exploration," Belzberg wrote. "Since the safety and pharmacokinetic profiles of these substances are well-known, their development as anticancer agents could be faster and less expensive than for new drugs."
"Furthermore, the successful repurposing of these compounds could provide a cost-effective way to expand anticancer treatments, possibly improving patient outcomes while reducing healthcare costs."
Another paper by Belzberg suggests that taking ivermectin with quercetin can synergistically fight prion diseases, also known as transmissible spongiform encephalopathies, or TSEs.
TSEs represent a group of fatal neurodegenerative diseases characterized by the misfolding of the prion protein, or PrP.
"The promise shown by ivermectin and quercetin in their potential anti-prion activities and their modulation of tauopathy offers an interesting avenue for further exploration," he wrote.
What is Mebendazole?
Fenbendazole, mebendazole and albendazole are part of a larger
group of drugs known as benzimidazole*, which are anthelmintic
drugs (i.e., drugs that kill parasitic worms). Mebendazole is another benzimidazole, which can be prescribed to humans
with certain gut infections, including threadworms, whipworms,
hookworms, and roundworms.
*The class of drugs known as benzimidazoles includes
fenbendazole, mebendazole, albendazole and
flubendazole.
Mebendazole (MBZ; 5-benzoyl-1H-benzimidazol-2-ylcarbamate) first
described in 1968, was initially recognized as a broad-spectrum
anthelmintic agent and was applied to humans in 1971 (JAMA 1971).
Fast forward two decades, and the focus on anthelmintics shifted
towards their potential anticancer properties, primarily due to
their interactions with microtubules (Cancers 2019).
A 2021 study from Johns Hopkins University, concluded that mebendazole should be investigated further as a
component of adjuvant therapy to slow progression and prevent
metastasis, and well as for primary prevention in the highest risk
patients. (Oncotarget 2021)
According to, Gregory Riggins, M.D., Ph.D., professor of neurosurgery and oncology at the Johns Hopkins
University School of Medicine:
“We are advocating for use of mebendazole as a therapy for those
diagnosed before metastasis to see if we can slow or prevent
pancreatic cancer,” Riggins says. “For those with more advanced
cancers, it could be an alternative to certain surgeries. Mebendazole
may have utility as a therapy after initial treatment to prevent tumor
recurrence in the 15% to 20% of pancreatic adenocarcinoma patients who
undergo surgery. It may also increase the durability of response to
standard chemotherapy in the remaining 80% to 85% of patients with
advanced disease.”
Anecdotal evidence from two case reports (refractory metastatic colon cancer, metastatic adrenocortical carcinoma) has further supported the possibility of MBZ being repurposed as
an anticancer drug by documenting its success in managing metastatic
patients.
Fenbendazole, mebendazole and albendazole are part of a larger
group of drugs known as benzimidazole*, which are anthelmintic
drugs (i.e., drugs that kill parasitic worms). Mebendazole is another benzimidazole, which can be prescribed to humans
with certain gut infections, including threadworms, whipworms,
hookworms, and roundworms.
*The class of drugs known as benzimidazoles includes
fenbendazole, mebendazole, albendazole and
flubendazole.
Mebendazole (MBZ; 5-benzoyl-1H-benzimidazol-2-ylcarbamate) first
described in 1968, was initially recognized as a broad-spectrum
anthelmintic agent and was applied to humans in 1971 (JAMA 1971).
Fast forward two decades, and the focus on anthelmintics shifted
towards their potential anticancer properties, primarily due to
their interactions with microtubules (Cancers 2019).
“We are advocating for use of mebendazole as a therapy for those diagnosed before metastasis to see if we can slow or prevent pancreatic cancer,” Riggins says. “For those with more advanced cancers, it could be an alternative to certain surgeries. Mebendazole may have utility as a therapy after initial treatment to prevent tumor recurrence in the 15% to 20% of pancreatic adenocarcinoma patients who undergo surgery. It may also increase the durability of response to standard chemotherapy in the remaining 80% to 85% of patients with advanced disease.”
Anecdotal evidence from two case reports (refractory metastatic colon cancer, metastatic adrenocortical carcinoma) has further supported the possibility of MBZ being repurposed as
an anticancer drug by documenting its success in managing metastatic
patients.
Mebendazole dosage for cancer treatment
The recommended dosage for mebendazole typically involves taking 100
mg of mebendazole twice daily (Endocr Pract 2011). The patient was receiving mebendazole as a sole treatment for
19 months, his disease remained stable. He did not experience any
clinically significant adverse effects, and his quality of life was
satisfactory.
As with any unconventional treatment approach, it’s crucial to
consult with a healthcare provider before starting the experimental
protocol to ensure safety and discuss potential interactions with
existing medications or health conditions.
According to Dr William Makis (X.com):
Do Ivermectin and Mebendazole help against cancer? - Dr. Igor Atabekov (oncologist)
Fenbendazole vs. Mebendazole
Fenbendazole and mebendazole are similar in that they both eliminate
parasitic worms, but there is a difference. Mebendazole is approved for
human consumption by the FDA, while fenbendazole is only approved for
veterinary use and has not been approved for human use.
Mebendazole is the form that is approved for human use while fenbendazole
is approved for veterinary use. The main difference is the cost.
Mebendazole is expensive ~$450 per pill (two pills of mebendazole cost
just $4 in the UK.), while fenbendazole is inexpensive ~48 cents per 222
mg free powder dose (Williams, 2019). Albendazole is the form used to
treat intestinal parasites in India and these cost 2 cents per pill.
While most of the pre-clinical research uses mebendazole, probably because it is the FDA-approved-for-humans form of fenbendazole, virtually most of the self-treating clinical reports involve the use of fenbendazole.
While fenbendazole for human cancer has gained more popularity with some
interesting fenbendazole cancer success stories, some research suggests mebendazole might be more effective for
treating different types of tumors. For example, research studies have
shown that mebendazole could be more effective for brain, prostate, and
ovarian cancers.
Clinical Trials
There are more than 10 studies for mebendazole for cancer in ClinicalTrials.gov.
As of now, there are limited clinical trials exploring the use of
fenbendazole in humans. Research is primarily in preclinical stages.
However, the Fenbendazole Cancer Protocol gained rapid interest over
the past years following some fenbendazole advanced cancer success stories.
Safety
Although fenbendazole and mebendazole are generally well tolerated,
there have been reports of elevated liver enzymes from the use of
Fenbendazole, as well as the similar human medications mebendazole and
albendazole.
If a patient has elevated liver enzymes, liver damage, liver metastasis, or liver diseases, it is important to work with a health professional who is familiar with the use of Fenbendazole or mebendazole and can advise whether it can be used and/or monitor lab values. A typical dose of 250mg of Fenbendazole usually does not cause side effects, but vigilance is key due to the lack of extensive studies on its effects in humans.
Fenbendazole vs Mebendazole in Pancreatic Cancer, Colon Cancer and Paragangliomas
According to a 2021 Italian Study:
“Intriguingly, the repurposing of non-antitumor drugs to be exploited in
cancer therapy represents a valuable and an alternative strategy, since
candidate agents have well documented pharmacokinetic and pharmacodynamic
features, together with good safety profiles, which may speed up their
approval and implementation in the clinics”
In this study, we explored the effects of a large series of
benzimidazole-based anthelmintics on the viability of different tumor cell
lines derived from paraganglioma, pancreatic and colorectal cancer.
Flubendazole, parbendazole, oxibendazole, mebendazole, albendazole and
fenbendazole showed the most consistent antiproliferative effects.
“Notably, for the two derivatives fenbendazole and mebendazole, target
prediction analysis pointed out a few cancer-related molecular targets
having very high probability scores, thus suggesting polypharmacological
profiles of these drugs.”
According to Dr William Makis, a Canadian oncologist:
VERDICT: Fenbendazole has superior cancer killing at higher doses for pancreatic cancer, colorectal cancer and paragangliomas (compared to Mebendazole and Albendazole).
Fenbendazole vs Mebendazole in Pancreatic Cancer
FENBENDAZOLE vs MEBENDAZOLE in Pancreatic Cancer - which is better? Obscure Italian study gives the answer in the battle of the anti-parasitics It's the question everyone is asking.
According to Dr William Makis:
Repurposed anti-parasitics are now being used successfully to treat Stage
4 Cancers and Turbo Cancers. The most popular repurposed anti-parasitics
are: Ivermectin, Fenbendazole and Mebendazole! I have developed High Dose
Protocols to use these successfully, in situations where conventional
Oncology has utterly failed. So which is better? Fenbendazole? Or its
sister compound, FDA approved and much more expensive Mebendazole? An
Italian team tested them head to head and got a surprising answer. Their
published results are very difficult to find.
|
| Florio et al. Cancers 2019 |
Mebendazole vs Fenbendazole in treatment of Glioblastoma Brain Cancer
According to this 2011 study from Oxford:
There is a need to broaden the available treatments for GBM by
introducing new therapeutic agents. One possible means to expedite
initiation of GBM clinical trials is to examine previously established
drugs with known track records of safety in humans, regardless of their
intended use...
We accidentally found that fenbendazole, a benzimidazole, reduced brain
tumor engraftment in nude mice after the mouse colony was treated for
pinworms. Fenbendazole was previously reported to interfere with one
lymphoma model in 2008, after we had already noted problems with
fenbendazole disrupting brain tumor engraftment"
We pursued this finding by evaluating whether the 2 most widely used
human approved benzimidazoles showed efficacy against glioblastoma
models...Subsequent in vitro and in vivo experiments with benzimidazoles
identified mebendazole as the more promising drug for Glioblastoma
therapy...
Mebendazole disrupted microtubule formation in GBM cells...We showed that
mebendazole significantly extended mean survival up to 63% in mouse glioma
models...Our findings indicate that mebendazole is a possible novel
anti-brain tumor therapeutic that could be further tested in clinical
trials.
Fenbendazole is an anti-parasitic drug that increases p53 tumor suppressor
levels and blocks glucose utilization by cancer cells. When Joe Tippens got
a tip on how to treat his Stage 4 Small Cell Lung Cancer, this was the study
that his friend told him about, which helped him cure his Stage 4 Cancer.
(source)
We have described two papers (mentioned above) that tested Fenbendazole head
to head with Mebendazole.
Although the two anti-parasitics are very similar in efficacy at higher
doses, Mebendazole has superior brain cancer cell killing at lower loses
compared to Fenbendazole. So for Glioblastoma, it’s Mebendazole if you can
get it. Otherwise, you can't go wrong with Fenbendazole. It's still almost
as good. (source)
Mebendazole vs Fenbendazole in Osteosarcoma
According to a Master's Degree Thesis by Joanna Schmit (2013):
"The high morbidity and mortality of osteosarcoma despite standard
therapy warrants the need to investigate new treatment options"
“Benzimidazole (BZ) drugs are used routinely as effective anti-parasitics
in both human and veterinary medicine. Their safety is well-established
and side effects are minimal”
"Our findings demonstrate that the clinically used veterinary BZs
(Albendazole ABZ, Fenbendazole FBZ, and Mebendazole MBZ) possess
anti-neoplastic activity in an Osteosarcoma cell line."
"In addition to direct effects on tubulin polymerization, cell cycle,
proliferation, and cytotoxicity, BZs demonstrate indirect activity through
modulation of a key pro-angiogenic cytokine."
"Overall Mebendazole shows superior inhibition of proliferation,
apoptosis, and inhibition of VEGF secretion. When it comes to
OSTEOSARCOMA, Mebendazole is preferred over Fenbendazole. Where the
difference was most noticeable, was in inhibiting VEGF secretion - which
doesn't allow the cancer to establish new blood vessels to grow."
New & Improved Joe Tippens Protocol
The holy grail turbo cancer treatment may just be the
synergistic combination therapy of Fenbendazole AND
Ivermectin as follows:
Please note that this protocol now includes the vital
Vitamin D addition, with the one day off for the fenbendazole administration. This protocol represents the most
comprehensive and cutting edge repurposed drug and vitamin
treatment approach to date.
-
Fenbendazole (300mg, 6 days a week) or in the case of severe turbo cancers up to 1 gram.
-
Ivermectin (24mg, 7 days a week) or in the case of severe turbo cancers up to 1mg/kg/day (Find a Doctor)
-
Bio-Available Curcumin (600mg per day, 2 pills per day 7 days a week).
-
Vitamin D (62.5 mcg [2500 IU] seven days a week).
-
Adopting a healthy lifestyle is essential during this protocol. This includes eliminating sugar from the diet (BMJ 2023), consuming a nutritious, whole-food diet rich in fresh fruits and vegetables, avoiding ultra-processed foods (BMJ 2024), and minimizing stress.
Conclusion
Ultimately, the choice between Ivermectin and
Fenbendazole should be based on the patient’s individual
health profile, and the most current clinical
guidelines. When taken together, ivermectin and fenbendazole
could deliver a one-two punch to cancer. When combined with
other anti-cancer nutrients such as quercetin, vitamins C
and D, and curcumin, the effects are even more pronounced.
Ivermectin vs Fenbendazole for Cancer
Repurposed Drugs for Cancer: What You Need to Know
Disclaimers:
- Please do not consider this guide as personal medical advice, but as a recommendation for use by professional providers. Consult with your doctor and discuss with her/him.
- As we do not have information about you, our aim here isn't to replace your doctors' advice. It is intended as a sharing of knowledge and information. Do take note that most treatments are not 100% protective or curative against cancer. It's a continuous struggle between the immune system and the cancer cells. Cancer treatments are meant to assist the immune system in this battle.
- Cancer treatment should be part of a multi-modal approach in order to provide the best possible outcome. Diet and lifestyle changes are meant to run alongside conventional treatment. They are complementary, not alternative.
Fenbendazole: One Packet a Day
Fenbendazole 222 mg (1 gm of Panacur™) per day every
day. It can be mixed with food such as yogurt or simply
taken by itself.
It is advised to purchase Panacur C (powder) brand only, as Panacur is
regulated and has been consistent in third-party lab
results.
* Please take note that the Panacur C on Amazon is
available in three sizes (1 gram, 2 grams and 4 grams)
of single dose packets.
Do not follow the weight-dependent dosing (for dogs) that is
given on the back of the packaging!
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