The Medical Advisor

A recent viral post by William Makis sparked widespread discussion in the cancer and repurposed-drug community after a Florida physician in his 70s reportedly experienced his first completely polyp-free colonoscopy in 25 years while taking ivermectin and mebendazole for Stage 3 prostate cancer. The story quickly gained traction because it touched on a growing scientific topic: the role of PAK1 signaling in colon polyps, colorectal cancer, and abnormal cellular growth. While the case is anecdotal and does not prove causation, the underlying biology is more interesting than many critics realize. Research over the past 15 years has linked PAK1 (p21-activated kinase 1) to colorectal adenomas, Wnt/β-catenin signaling, cancer cell proliferation, and tumor progression. Multiple preclinical studies have also shown that ivermectin can inhibit PAK1 activity. Could this help explain the unexpected colonoscopy result? Here’s what the science actually says. What Happened in the Viral Colonoscopy S...