Lumbrokinase vs Nattokinase vs Serrapeptase: What's the Difference?

Lumbrokinase, nattokinase, and serrapeptase are all enzymes that have been studied for their potential health benefits. They are all considered as proteolytic enzymes. Proteolytic enzymes have a variety of roles in the body, from helping to digest food to taking part in the immune response.

What is Lumbrokinase?

Lumbrokinase (LK) is an enzyme derived from earthworms is thought to aid in blood clot prevention, inflammation reduction, and circulation problems. 

Lumbrokinase for Blood Clots

Thrombolytic agents typically used to dissolve clots are urokinase (u-PA), streptokinase, and tissue plasminogen activator (t-PA). These drugs, however, are not specific for fibrin and have adverse and dangerous side effects including severe bleeding and heavy blood loss which may result in death. In contrast, LK is very specific to fibrin as a substrate and it does not cause excessive bleeding. It can dissolve the fibrin itself or convert plasminogen to plasmin by inducing endogenous t-PA activity to dissolve fibrin clots (Source)

Interestingly, for more than ten years, clinical trials have also used lumbrokinase as an oral supplement to support and maintain healthy cardiovascular function as well as to treat cardiovascular diseases.

According to some studies, post-ischemic treatment with lumbrokinase attenuates myocardial I-R injury through the activation of Sirt1 signaling, and thus enhances autophagic flux and reduces I-R-induced oxidative damage, inflammation and apoptosis.

As of January 2023, a simple PubMed keyword search of "lumbrokinase" generated 87 results, with papers dating as far back as 1991. However, performing the same keyword search in one of the largest Chinese digital periodicals database ( generated over 650 publications! 

What is Nattokinase?

Nattokinase (NK) is an enzyme derived from a traditional Japanese food called natto, and it is thought to help lower cholesterol, reduce inflammation, and improve circulation. 

Nattokinase for Blood Clots

Nattokinase dissolves blood clots by directly hydrolyzing fibrin and plasmin substrate. It converts endogenous prourokinase to urokinase (uPA). It also degrades plasminogen activator inhibitor (PAI-1) and increases the level of tissue plasminogen activator (t-PA). (Source)

Furthermore, a study has also suggests that daily NK supplementation is an effective way to manage the progression of atherosclerosis and potentially may be a better alternative to statins which are commonly used to reduce atherosclerosis and further to prevent cardiovascular attack and stroke in patients.

Tanikawa et al. (2022) examined the effect of nattokinase on the COVID-19 spike protein. In the first experiment, they demonstrated that spike was degraded in a time and dose-dependent manner in a cell lysate preparation that could be similar to a vaccine recipient. The second experiment demonstrated that nattokinase degraded the spike protein in SARS-CoV-2 infected cells. This was reproduced in a similar study done by Oba and colleagues in 2021.

Related: Holy Grail of COVID-19 Spike Protein Detoxification

What is Serrapeptase?

Serrapeptase is an enzyme derived from silkworms and is thought to lessen pain, thin the blood, and reduce inflammation. Although more research is required to pinpoint their precise effects, all three enzymes may have potential health advantages.

Serrapeptase for Blood Clots
Serratiopeptidase is known to dissolve blood clots and artherosclerotic plaques by breaking down fibrin and other dead or damaged tissue. It can also remove deposits of fatty substances, cholesterol, and cellular waste inside the arteries. The fibrinolytic property of serratiopeptidase may also help with the problems of thick blood, risk of stroke, and thrombophlebitis. (Source)

Lumbrokinase vs Nattokinase vs Serrapeptase

Lumberkinase is good for angina, diabetes, heart disease, lyme disease, stroke prevention, DVT prevention. Lumberkinase can promotes both fibrolysis and fibronogenesis so it can both break down or build up fibrin, depending on the body’s needs. 

In a study comparing lumbrokinase to Serrapeptidase, aka serrapeptase, and nattokinase on a milligram to milligram basis, researchers found that lumbrokinase is about 300 times (1/294) stronger than serrapeptase and 30 times (1/36) times stronger than nattokinase. (R)

Nattokinase is good for atherosclerosis (add magnesium), vascular health, stroke prevention, clot prevention. Interestingly, Nattokinasi is also contain high amounts of vitamin K2. K2 helps to pull the calcium where it shouldn’t be and into the bone where it should be. Low amount of K2 cause calcium to build up in the arteries.

Serrapeptase is good for healthy anti-inflammatory response. It induces fibrolynic anti inflammatory and anti-edemic activity to tissues. This helps desire dissolve scar tissue inflammation like uterine fibroids, blocked fallopian tubes. They are superior for anti inflammatory effects because they have ability to dissolve the fibrous and or scar tissue due to inflammation. 

If you want to take these enzyme, best to take with an empty stomach. The dose varies depending on your condition. Best to consult your doctor for deciding the right dose and whether you need these supplement.

Important Safety Information: Do not take while using blood thinners or if you are pregnant or nursing.

Best Lumbrokinase Supplements

1. Doctor's Best Lumbrokinase

- Doctor’s Best Lumbrokinase
Is a highly active enzyme that may be used to support healthy cardiovascular function. Helps to maintain healthier blood and lower blood viscosity.

- Unique Enzymes
Lumbrokinase consists of a group of highly stable fibrinolytic enzymes, that have been studied and utilized extensively in China for many years. Lumbrokinase is a group of fibrinolytic enzymes originally derived from the earthworm Lumbricus rubellus.

- Clinical Studies 
A study reinforces the effect of lumbrokinase on blood circulation and showed a decrease in blood viscosity significantly. By reducing fibrinogen resulted in fibrinolysis, a breakdown of blood clots.

- Optimal Absorption
Each vegetarian capsule contains pure lumbrokinase designed for optimal absorption in the intestinal tract. The enzyme activity is measured in units: Lumbrokinase 20mg is equal to 360,000 units of enzyme activity.

Ratings: 4.6 out of 5 - more than 500 global ratings

The brand is good. Must have if you have clots and of course always talk to a good Natural Pathic doctor if you are on other meds. Worked wonders on my DVT.

2. Dr. Mercola Lumbrokinase Enzymes

Each Bottle of Lumbrokinase Enzymes Contains 30 Servings. Following Dr. Mercola’s belief in providing the best quality products, this product is Gluten Free and Soy Free

Lumbrokinase Enzymes are a blend of fibrinolytic enzymes that assist your body in clearing away fibrin, clots and biofilms. Our Lumbrokinase Enzymes provides a full 40 mg of lumbrokinase enzyme in every capsule. Plus, we’ve added 4 mg of Protease to enhance lumbrokinase’s actions further down in your GI tract

I was having a few health concerns, when a friend recommended this product. I feel strongly this product has helped me feel better. With the current unpredictability of the times, i have been under tremendous stress. This product helped my heart and thinned my blood. Allowing my blood to function better.

Best Nattokinase Supplements

1. Horbaach Nattokinase Supplement 4,000 FU

- Innovative Support
Delivers 200 mg of Nattokinase per serving in convenient quick-release capsules

- Expertly Crafted
Our professional formula is backed by our commitment to purity and potency

- Horbaach Manufacturers
Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!

- Naturally Free Of
Gluten, Wheat, Milk, Lactose, Artificial Flavor, Preservatives & Non-GMO

4.6 out of 5 - more than 1,100 global ratings

Thank you to the other people that left reviews. I decided to give it a try and after a little more than a week I have more feeling in my legs. I am able to exercise more and being diabetic the feeling in my legs had dissipated. I now have feeling in my calves and feet and this product is the reason. Thank God for another great natural remedy!

2. Doctor's Best Nattokinase 2,000 FU

- Doctor’s Best Nattokinase 
Nattokinase is an enzyme derived from natto, a traditional fermented soy food popular in Japan. During the natto production process, non-GMO soybeans are boiled and fermented with friendly Bacillus subtilis bacteria producing nattokinase. It contains pure nattokinase enzyme with Vitamin K2 removed. Nattokinase has been shown to support a healthy circulatory system by helping to maintain normal fibrinogen levels in blood.*

- Nattokinase for a Healthier Heart Health 
Clinical and non-clinical studies have shown that Nattokinase can support heart and circulatory health by helping to maintain normal blood flow.

- Improve Blood Flow 
Nattokinase vegan formula promotes better circulation and heart health*

- Vegan, Non-GMO Ingredients 
When healthy bacteria called natto bacillus and soybeans are combined the blood-flow friendly, Nattokinase enzyme with 2,000 fu (fibrinolytic units) is formed which helps maintain proper blood flow.*

Ratings: 4.7 out of 5 - more than 2,000 global ratings

I will use this for some time. Following surgery I had a small blood clot in my leg. I was on blood thinners for 6 months. While I am not considered to be genetically predisposed to clots, I am at higher risk. Aspirin and I do not get along well. Nattokinase has been a welcome alternative to daily aspirin without the side effects I get with aspirin like stomach irritation (yes even a little aspirin). I am glad to have found these easy to swallow good potency capsules.

3. Nattovena, Pure Nattokinase, 4,000 FU

- Fibrin cleanse: A powerful nattokinase supplement formulated to cleanse your blood of fibrin to help support circulatory and cardiovascular function.

- All-natural relief: From fatigue, painful joints, arterial blockage, and high blood pressure resulting from an imbalance of fibrin in the blood.

- Nattovena: Provides more than 4,000 fibrinolytic (fibrin-dissolving) units per capsule, is naturally acid-stable, and does not require an enteric coating.

- Nattokinase: Is a fibrinolytic enzyme originally derived from a Japanese fermented soybean food called natto; In nutritional supplements, the nattokinase is extracted and purified in a lab.

- A safe and effective: Way to replace natural enzymes lost through aging while reducing symptoms related to unhealthy levels of fibrin in the blood.

Ratings: 4.7 out of 5 - more than 200 global ratings

Best Serrapeptase Supplements

1. Zazzee Extra Strength Serrapeptase

- Outstanding Value
Our Extra Strength Serrapeptase Capsules contain 120 capsules per bottle, 120,000 SPU per capsule AND come in absorption-enhancing delayed release capsules – an amazing value! Compare this to other leading brands that provide lower dosages, contain less capsules per bottle, and are not in "must-have" delayed release capsules. Our Extra Strength Serrapeptase is a bargain not be found elsewhere!

- Extra Strength - 120,000 SPU Per Capsule 
Each capsule contains an extra strength dosage of 120,000 SPU. This dosage is per capsule, which means that each bottle provides a full 4 month supply!

- Enhanced Absorption With Delayed Release Capsules
Stomach acid destroys these delicate enzymes. To prevent this, our Extra Strength Serrapeptaste comes in delayed release capsules, which enable the enzymes to survive past the stomach acid and pass into the small intestine for maximum absorption.

- Natural, Vegan, & Non-GMO
All ingredients, including the capsule, are 100% vegan. Our Extra Strength Serrapeptase does not contain any sweeteners, artificial flavors, wheat, corn, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients. Enjoy the amazing benefits of our potent Serrapeptase without worrying about what else might be hiding in each capsule!

4.5 out of 5 - more than 400 global ratings

Works great for me. High potency for a low price. Also slow release to work even better. Small size easy to swallow. Great addition with nattozimes for clot busting. Good company, lots of other supplements too.

2. Doctor's Best High Potency Serrapeptase

Serrapeptase is a proteolytic enzyme that comes from the Serratia bacteria species strain E15
- promotes and maintains healthy sinus and airway function and healthy immune response*
- helps dissolve hard particles made of protein that cause unwanted side effects from toxins, scar tissue, blood clots and cysts*

Uses Serrateric, a coating that protects the enzyme from stomach acids until it reaches the intestines and therefore optimizes absorption

Ratings: 4.4 out of 5 - more than 7,400 global ratings

Helped my period right away. I was having big blood clots from endometriosis and after a week of taking my period was like a normal period. A month later I thought it had made my period late but ended up I was pregnant! Would recommend to anyone with endometriosis!


a. How Do You Take Nattokinase/Serrapeptase/Lumbrokinase?

It is recommended to take these proteolytic enzymes on an empty stomach.

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