10 Best Melatonin Gummies for Adults: Reviews 2022 and COVID-19
For many, getting a good night’s sleep has not been an easy feat during the pandemic. If you’re looking for an effective sleep, non-habit-forming sleep aid, elevating your nighttime routine with the best melatonin gummies will help you catch up on some sleep.
Best Melatonin Gummies for Adults 2022
1. Vitafusion Extra Strength Melatonin Gummies 5mg
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These tart and tasty blackberry-flavored gummies melt in your mouth. Each gummy contains chamomile, lemon balm, and L-theanine, an amino acid that promotes calm and relaxation.
These gummies carry the NSF seal.
3. Vicks ZzzQuil PURE Zzzs Gummies - Melatonin Gummies for Anxiety
Vicks Melatonin Gummies for Sleep Price: $29.99
Each blackberry-vanilla-flavored serving contains 6 mg of melatonin per dose, which is 2 gummies. The formula also contains ashwagandha, an herb used in traditional Ayurvedic medicine to reduce stress and anxiety, and valerian root, which promotes sleep.
Be aware that these substances may pose some risks. For instance, they may interfere with medication. People who are pregnant shouldn’t take valerian.
4. Nordic Naturals Zero Sugar Melatonin Gummies - Sugar Free Melatonin Gummies
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5. MegaFood Melatonin Berry Good Sleep Gummies
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Melatonin Significantly Lowers COVID-19 Mortality
As of January2022, there are 12 published clinical studies of melatonin for treatment and prevention in COVID-19 and the results are promising even when it's given as a late treatment.
On the last day of 2021, Melatonin Research published a research commentary discussing an October 2021 study by Hasan et. al., which found melatonin significantly lowered mortality when given to severely infected COVID patients. According to the authors:
“In a single-center, open-label, randomized clinical trial, it was observed that melatonin treatment lowered the mortality rate by 93% in severely-infected COVID-19 patients compared with the control group.
This is seemingly the first report to show such a huge mortality reduction in severe COVID-19 infected individuals with a simple treatment. If this observation is confirmed by more rigorous clinical trials, melatonin could become an important weapon to combat this pandemic.”
The commentators point out that, at less than $5 per course of treatment, melatonin is a cost-effective addition to any treatment plan. For comparison, Regeneron monoclonal antibodies cost about $2,100 per dose and remdesivir is $3,100 per treatment. Melatonin also has no serious side effects, so it can be universally used.In the standard care only group, 13 of the 76 patients died (17.1%), compared to just one of the 82 patients (1.2%) who received melatonin in addition to everything else. That’s a reduction in mortality of 93%.
The Hasan trial included 158 hospitalized COVID patients between the ages of 18 and 80. All had confirmed severe SARS-CoV-2 infection.
Eighty-two of the patients were enrolled in the melatonin arm and received 10 milligrams (mg) of melatonin half an hour before bedtime for 14 days, in addition to standard therapeutic care, which included oxygen intubation, remdesivir, levofloxacin (an antibiotic for protection against secondary bacterial infections), dexamethasone (an anti-inflammatory) and enoxaparin (an anticoagulant).
In the standard care only group, 13 of the 76 patients died (17.1%), compared to just one of the 82 patients (1.2%) who received melatonin in addition to everything else. That’s a reduction in mortality of 93%, which is quite remarkable. Three mechanisms of action responsible for this success appears to be a combination of its antioxidant, anti-inflammatory and immunoregulatory activities.
During the second week of infection, a time when severely infected patients can take a drastic turn for the worse, the melatonin group fared much better than the standard care only group, with only two patients developing sepsis, compared to eight in the standard care only group.
The Hasan trial also supports findings from a clinical case series published in 2020, where patients diagnosed with COVID-19 pneumonia received 36 mg to 72 mg of melatonin intravenously per day, in four divided doses, as an adjunct therapy to standard of care.
All of the patients given melatonin improved within four to five days, and all survived. On average, those given melatonin were discharged from the hospital after 7.3 days, compared to 13 days for those who did not get melatonin.
Melatonin Is an Integral Part of Front Line Critical Care Alliance Protocol
Dr. Paul Marik, a critical care doctor known for his life-saving vitamin C sepsis protocol, published a paper in the Journal of Thoracic Disease in February 2020 giving the scientific rationale for using melatonin to help regulate the oxidative imbalance and mitochondrial dysfunction that are commonly found in sepsis.
This was followed by a paper published in the Frontiers in Medicine in May 2020, in which he and a team of scientists presented a therapeutic algorithm for melatonin in the treatment of COVID-19 specifically. “Melatonin's multiple actions as an anti-inflammatory, antioxidant and antiviral (against other viruses) make it a reasonable choice for use,” they wrote.
Based on its known mechanisms of action, the FLCCC has included melatonin in its early treatment and hospital treatment protocols from the start. You can download the latest protocols on the FLCCC’s website.
As a supportive therapy, the FLCCC recommends taking 6 mg before bed if you’re treating early or mild symptomatic COVID-19. The hospital treatment protocol calls for anywhere from 6 mg to 12 mg of melatonin at night, until discharge.
For patients treating long-haul COVID-19 syndrome (LHCS), they recommend taking between 2 mg and 12 mg nightly. Begin with a low dose and work your way up as tolerated. If your sleep is disturbed, lower your dose. (Low doses of melatonin will help make you sleepy, while higher doses can trigger sleeplessness.)
General Guidance for SupplementationThere is no federal RDA nor any formal advice on supplement dose ranges. Too much can cause daytime sleepiness. Whatever dose you take — we recommend starting low, at 1 mg or less — be sure to take melatonin at night, before bed. Rising melatonin levels is the reason you feel sleepy in the evening, so it’s ill advised to take it in the morning or during the day, when your natural level is (and should be) low.
While the doses suggested when used against COVID are significantly higher than what you’d normally take to improve your sleep, there does not appear to be any danger to these doses. Research has found no adverse effects for dosages ranging from 20 mg up to 100 mg.
These dose ranges are up to 100 times more than what a typical conservative dose of 0.5 mg, but it is encouraging that no adverse effects were observed at these high doses. It would still be prudent however to only use doses this high for limited times when you might need them.
Melatonin is also best taken sublingually, either in the form of a spray or sublingual tablet. Sublingually, it can enter your blood stream directly and doesn’t have to go through the digestive tract. As a result, its effect will be felt more rapidly.