The Medical Advisor

Medically Reviewed by: Dr Frank Yap, MD | Written by:     OneDayMD Editorial Team | Last Updated:  September  2026 Introduction: The Obesity Drug Revolution Is Entering a New Phase Obesity treatment is undergoing a major transformation. Over the past decade, therapies targeting incretin hormones have reshaped clinical practice, but the next five years (2026–2030) are expected to redefine obesity medicine entirely. The field is evolving from single-hormone appetite suppression to multi-hormonal metabolic reprogramming , combining appetite control, energy expenditure, satiety signaling, and body composition regulation. This article provides a structured, evidence-based overview of the most important obesity drugs in development and clinical use, including GLP-1 receptor agonists, dual and triple agonists, amylin analogs, and emerging combination therapies. 1. The Current Standard (2024–2026): GLP-1 and Dual Incretin Therapies The foundation of modern obesity pharmac...

OneDayMD Master Evidence Guide • Updated September 2026 Semaglutide, tirzepatide, oral GLP-1 medicines, retatrutide and the next generation of metabolic therapies have changed the obesity and cardiometabolic treatment landscape. But the phrase “GLP-1 drug” can hide major differences in mechanism, indication, dose, study population and clinical evidence. This master guide organizes the most important clinical trials into an ebook-style reference—from the landmark STEP and SURMOUNT obesity trials to SELECT , FLOW , SUMMIT , ESSENCE , OASIS 4 , ATTAIN-1 , TRIUMPH, SURPASS  and the emerging CagriSema program. 2026 update: The field has moved beyond injections alone. Oral semaglutide (Wegovy tablets) and orforglipron (Foundayo) are now U.S. FDA-approved options for weight management, while higher-dose semaglutide (Wegovy HD) has also ...

Since its approval for human dermatological use, ivermectin has transformed how we manage specific inflammatory and parasitic skin conditions—most notably rosacea and scabies. If you are struggling with persistent facial redness, bumps, or intense itching, understanding how ivermectin works can help you determine if it is the right addition to your skincare regimen. What is Ivermectin and How Does It Work for Skin? Ivermectin is a powerful anti-parasitic and anti-inflammatory medication available in both topical (cream) and oral (pill) forms. In dermatology, it works via a dual-action mechanism: it eliminates microscopic skin parasites while simultaneously calming the pathways that cause swelling, redness, and acne-like lesions. Topical vs. Oral Ivermectin: A Quick Reference Depending on your diagnosis, a dermatologist will prescribe either a localized cream or a systemic oral dose. Here is how they compare: Form Common Brand Names Primary Skin Co...