Ivermectin and Fenbendazole for Liver and Bile Duct Cancer: A Case Series of 9 Patients (July 2026 Update)

Introduction

When facing aggressive malignancies like liver cancer and cholangiocarcinoma (bile duct cancer), the traditional oncological toolkit can sometimes feel frustratingly limited. However, a growing wave of interest is focusing on drug repurposing—the practice of using well-established, existing medications for entirely new therapeutic targets.

This compilation highlights an emerging series of 9 patient case reports exploring the off-label use of antiparasitic agents, specifically ivermectin, fenbendazole, and mebendazole. While these compounds are traditionally known for clearing parasites, preclinical research suggests they may also strike at the heart of cancer cells by disrupting microtubules (the structural scaffolding cells need to divide) and blocking major cellular growth pathways like Wnt/β-catenin.

Divided into 4 liver cancer cases and 5 bile duct cancer cases, these real-world updates—headlined by clinical accounts shared by figures like Dr. William Makis—document striking instances of tumor shrinkage, center-out cell death (necrosis), and unexpectedly manageable chemotherapy sessions. While these anecdotes are preliminary and should not replace standard oncology protocols, they offer a compelling look into how integrative strategies might play a supportive role in modern cancer care.

Note: The case reports below provide detailed, practical information on fenbendazole, ivermectin, and cancer that both patients and clinicians may find useful and actionable.

They are categorized by:

• liver cancer (4 cases)
• bile duct cancer (cholangiocarcinoma) (5 cases)

Ivermectin and Mebendazole for Liver and Bile Duct Cancer: Case Presentations

11.1 Liver Cancer Success Stories: Fenbendazole (4 cases)

Case No. 4: 73 year old Massachusetts man with 2 liver cancers and liver transplant candidate

In a May 2026 post on X, Dr. William Makis wrote:

73 year old Massachusetts man with 2 liver cancers and liver transplant candidate reports after 10 months of IVERMECTIN & MEBENDAZOLE: tumors shrinking & will get his Liver Transplant! Patient with 2 liver cancers and on list for LIVER TRANSPLANT does so well on Ivermectin and Mebendazole, that he's getting his LIVER TRANSPLANT now in a few weeks! 73 year old Massachusetts man with 2 liver cancers (Cholangioca and HCC) In April 2025 he started: Ivermectin 1mg/kg/day Mebendazole 1000mg/day Results after 10 months: HCC Shrinking (Segment 4A/8) Cholangiocarcinoma (Segment 4) no longer seen He will get his liver transplant this month! Remember all those incompetent doctors who said Ivermectin and Mebendazole hurts the liver? If you've ever heard your doctor say that, fire your doctor immediately, because if they were willing to lie to you about this, they will lie to you about anything. This is a game changer for Liver Cancer patients who are looking at improving their chances of getting a LIVER TRANSPLANT.

Case No. 3: 44 year old Australian Man with Hepatocellular Carcinoma (HCC)

Dr. William Makis shared on X (Twitter) in July 2025:

Ivermectin and Mebendazole Testimonial - 44 year old Australian Man with Hepatocellular Carcinoma (HCC) reports success after 3 months A success story all the way from Australia! I'm actually helping many cancer patients in Communist Australia, where it's much harder to get Ivermectin and Fenbendazole but where there's a will... 44 year old Australian Man with Hepatocellular Carcinoma (HCC) Late Feb 2025 we started:

• Ivermectin 1mg/kg/day
• Mebendazole 1000mg/day
• Melatonin 300mg/day

Results after 3 months: Tumor markers decreased by 25% Liver lesion decreased from 37mm to 30mm = 46% tumor volume shrinkage CT: "Significant decreased volume and extent of enhancement of the hepatic lesions from prior" From patient: "Looks like I am going in the right direction. Thanks a lot for your help"

HCC is extremely difficult to treat and Oncologists have no answer for it.

Case No. 2: September, 2021

I was given less than two years to live in 2020 when I was diagnosed with stage 4 (metastatic) HCC (HepatoCellular Carcinoma) liver cancer. I received radiation directly onto the tumors and went for immunotherapy which did not bring any improvement to my state I was in. My wife and family did research and came across the fenbendazole protocol. I had nothing left to lose, so I decided to give it a try.

Case No. 1: September, 2021

In 2021 the doctor discovered a tumor growth at the end part of my colon. The test results declared a colon tumor with some small lesions on my liver back then. This was a lot to take in considering the thought of having to go through surgery and a colostomy. I have been a super active person for almost all of my life, taking my vitamins on a daily basis as I start my day – I never thought that something like this could ever happen to me.

After I made peace with what was happening inside my body, I gathered myself and started seeking for the best possible advice/guidance out there on any alternative approach other than putting my body through all this stress. I managed to start a protocol on: 1mg FECO, RSO oil which I used on the daily, and supplements at night along with some juicing which includes soursop & green tea, 20000mg Vit D, 5000mg Vit C & Vit K, 800mg grape seed extract, 2100mg ashwagandha, 1950mg curcumin with ginger & black pepper, sea cucumber extract, and 2000mg Fenbendazole on a daily basis (½ in the morning; ½ at before bed).

I never told my doctors about this and continued with treatment alongside the use of this protocol. A few months has passed since I started this journey and I received my results again later that year, showing no presence of any tumor. It completely vanished into thin air! After only four chemo treatments the doctor could not comprehend how the cancer just managed to disappear like that, and so quickly too – considering the time period for chemo to work to be proven to take much longer before it actually starts working.

See Bile Duct Cancer (Cholangiocarcinoma) below.

11.2. Bile Duct Cancer (Cholangiocarcinoma) (5 cases)

Case 5: 77 year old UK woman with Cholangiocarcinoma

Dr. William Makis posted on X.com in June 2026:

IVERMECTIN, FENBENDAZOLE and MEBENDAZOLE Testimonial - 77 year old UK woman with Cholangiocarcinoma reports after 8 months: tumors shrinking, doing better than others on chemo... STORY: 77 year old UK woman with Cholangiocarcinoma. In July 2025 she started: Ivermectin 1mg/kg/day Mebendazole 1000mg/day Chemo Results after 8 months: tumors shrinking: “cancer has shrunk” “mum’s overall health has improved, she is no longer on painkillers” “Mum started chemo…she has noticed she seems to have fewer side effects compared to other patients” Patients on Ivermectin & Mebendazole usually have significantly less side effects when taking chemo or radiation therapy, due to reduced inflammation and enhanced cancer cell killing. Ivermectin's anti-inflammatory effects are well documented in the published literature.

Case 4: 75 year old FLORIDA man with 14 cm Intrahepatic Cholangiocarcinoma

Dr. William Makis posted on X.com in January 2026:

IVERMECTIN and MEBENDAZOLE Testimonial - 75 year old FLORIDA man with Intrahepatic Cholangiocarcinoma reports after 3 months: 14cm tumor necrotic inside!

A positive "Florida man" story for a change! 75 year old Florida man with Cholangiocarcinoma On August 13, 2025 he started: Ivermectin 105mg/day Mebendazole 1000mg/day From the patient: "Dr.Makis, my Oncologist is very pleased with my response to chemo and immunotherapy treatments....she is amazed at how well I am tolerating the treatments and is not aware I am using your protocol of Ivermectin, Mebendazole, etc..." "I'm glad you got to help us here in Florida with your recent visit" PET Nov.24, 2025: "large infiltrative mass involving majority of the right hepatic lobe...on today's exam this does demonstrate central regions of photopenia compatible with necrotic change." Key POINTS: 1. Ivermectin and Mebendazole significantly reduce chemo side effects!! 2. TUMOR NECROSIS - I have seen this happen several times, so I am raising it as an important thing to keep an eye on. Large tumors, especially Cholangiocarcinomas, will first die in the center when responding to Ivermectin and Mebendazole (and usually chemo). During this time, the tumor size itself may not change, but inside the tumor, usually in the center, the tumor liquifies as it is dying. This is described as “necrosis”, or hypodense on CT, or “photopenia” on PET/CT (as there is no cancer metabolism going on in dead tumor tissue so it doesn’t light up on PET scan) The tumor size eventually starts to decrease but it takes several months for the body to remove a significant amount of dead cells from inside the tumor to make that obvious on CT.

Case 3: 85 year old Toronto, Ontario man with Cholangiocarcinoma (Klatskin Tumor)

Dr. William Makis shared on X.com in December 2025:

IVERMECTIN, FENBENDAZOLE, CBD Oil Testimonial - 85 year old Toronto, Ontario man with Cholangiocarcinoma (Klatskin Tumor) reports after 4 months - goes from progressing to Complete Remission!

Trigger Warning! This post may cause seizures in some because there is no chemo and no mainstream Oncology Treatment. You have been WARNED!!

STORY: 85 year old Toronto, Ontario man with Early Stage Cholangiocarcinoma, 2.8cm tumor involving common hepatic and common bile ducts. From June 21, 2025 to Oct.15, 2025 (4 months) he took:

• Ivermectin 64mg/day, then 48mg/day
• Fenbendazole 500mg/day
• CBD Oil 100mg/day

Results after 4 months: Complete Remission!! KEY POINTS: No chemo, no radiation, no immunotherapy. Yes, he had radiation 5 months before starting the Ivermectin Protocol (in Jan.2025) but May 2025 CT showed his tumor was still growing after the radiation therapy!! The bile duct tumor grew to 2.8cm from 2.3cm after radiation therapy. An 85 year old man can take Ivermectin and Fenbendazole safely with no side effects. This really puts into perspective when I hear from 40 year olds who are afraid to take either, because their Oncologist told them it could be “dangerous”. These were mild doses of Ivermectin and Fenbendazole. Some tumors respond incredibly well to Ivermectin, Fenbendazole, Mebendazole, even at mild doses. Cholangiocarcinomas are in this category. This was truly the simplest possible solution and the patient is now in remission. I often present Stage 4 cases but remember, this is an early stage case, and shows you what is possible if you start Ivermectin and Fenbendazole at a much earlier stage.

Case 2: 48 year old TEXAS woman with Stage 4 Cholangiocarcinoma

Dr. William Makis shared on X.com in December 2025:

IVERMECTIN and FENBENDAZOLE Testimonial - 48 year old TEXAS woman with Stage 4 Cholangiocarcinoma. "She lasted in Palliative Care Unit twice as long as anyone expected"

Sometimes you get a beautiful story from Hospice... You will have to read the whole story but here is a highlight: "I did want you to know though...it was the only thing she took (secretly) while in the hospital for her last month." "She was in multi organ failure... but her kidney doctor kept saying, "I've never seen this before, but your kidneys seem to be improving in function. I have no idea why."  But we knew why. (I have another cousin with stage 4 breast cancer who is also using IVM & FBZ and her kidneys were weeks away from dialysis and now are normal function. All she takes is IVM & FBZ).  "Anyway... XXXXX lasted in the Palliative Care Unit at XXXX twice as long as anyone expected. She took IVM & FBZ consistently her last three weeks in hospital and that gave her a little more time with family and friends." "THANK YOU. Your research and constant perseverance makes a BIG difference... People are researching and pursuing alternative protocols for their health because of you. And they have HOPE!"

Case 1: 53 year old Stage 4 Cholangiocarcinoma Cancer patient with 15 cm tumor

Dr William Makis shared on X/Twitter (December 2024 update):

IVERMECTIN and FENBENDAZOLE Testimonial - 53 year old Stage 4 Cholangiocarcinoma Cancer patient with 15cm tumor declared "Cancer Free" after reaching out to me 14 months ago!! This is a very special story. 53 year old Canadian Cancer patient diagnosed with Stage 4 Cholangiocarcinoma, metastatic to liver in March 2023. Multiple lesions, largest 15cm. Patient had chemo and reached out to me in October 2023. "I was taken off the bag of immunotherapy because the tumour didn't shrink" "Second oncologist...was worse than the oncologist I have now...told me my supposed mortality chart and to watch for "the end" because I'd be lucky to make it to summer (2024)"

"I'm terrified...I'm losing hope" I replied on Nov.3, 2023: "Don't lose hope..

• Ivermectin is 1mg/kg/ or 2mg/kg daily
• Fenbendazole is typically 444mg daily
• Melatonin is 100mg-300mg daily" (see note below)

Life went on...then I get an email in July 2024: "I'm still here thanks to you :)"

We went to work. Oncologists were pressuring to give her more and more chemo.  In November 2023, she had started Fenbendazole 444mg (Panacur) and Melatonin 100mg

In August 2024 we added 150mg of Ivermectin or 2.5m/kg/day, and CBD-THC Oil. You heard that right. Ivermectin 2.5mg/kg/day. And then... December 12, 2024: "Cancer Free".

Note: "Melatonin induces apoptosis in cholangiocarcinoma cell lines by activating the reactive oxygen species-mediated mitochondrial pathway" (source)

Related: 

• Adjuvant Chemoradiation and Immunotherapy for Extrahepatic Cholangiocarcinoma and Gallbladder Cancer (2025 JAMA Oncology)
• Ivermectin & Fenbendazole Case Reports - Terminal Bile Duct & Gallbladder Cancer (2024 Dr Justus Hope).

Conclusion

The 9 case histories shared in this update provide a fascinating, ground-level look at the potential of repurposed antiparasitics in challenging oncological scenarios. From significant tumor volume reductions to instances where central necrosis rendered massive lesions inactive, these individual accounts hint at a powerful synergy when off-label protocols are combined with traditional chemotherapy and immunotherapy. Crucially, many patients also reported an enhanced quality of life and fewer debilitating side effects from their standard treatments—a benefit potentially driven by the documented anti-inflammatory properties of these drugs.

However, it is vital to approach these success stories with balanced optimism. Anecdotal case updates and social media testimonials are highly encouraging, but they are not a substitute for rigorous, large-scale clinical trials. Because liver and bile duct cancers are highly complex, anyone considering incorporating ivermectin, fenbendazole, or mebendazole into their protocol should do so transparently and in close consultation with their treating oncology team to ensure safety and prevent unwanted drug interactions.

This case series is part of the 'Ivermectin, Fenbendazole, and Mebendazole Cancer Case Series' (700+ case reports).