Ivermectin: Prophylaxis & Early Outpatient Treatment Protocol for COVID-19 | 2022
Source: covid-nma.com |
Ivermectin and COVID-19 Updates:
May 19, 2021 - A study by Juan Chamie, Jennifer Hibberd of the University of Toronto and David Scheim of the US Public Health Service, shows the sharp rise, fall and resurgence in excess deaths (among the over 60 year-old cohort) in Peru as the virus waxed, waned and waxed again.
May 16, 2021: Do the NIH and WHO COVID treatment recommendations need to be fixed? By Steve Kirsch. Published on TrialSiteNews.
Great article on where we stand on the COVID-19 treatment front debate - COVID19Crusher
May 03, 2021 - Joint Statement on Widespread Use of Ivermectin in India for Prevention and Early Treatment by U.K. Evidence-Based Medicine Consultancy Ltd (E-BMC Ltd) and U.S. FLCCC (Front Line Critical Care Alliance).
Apr 26, 2021: The new FLCCC outpatient protocol (I-MASK+) with the addition of fluvoxamine and nasal/oral "sanitation". Fluvoxamine 50 mg twice daily for 10–14 days. Add to ivermectin if: 1) minimal response after 2 days of ivermectin; 2) in regions with more aggressive variants; 3) treatment started on or after day 5 of symptoms or in pulmonary phase; or 4) numerous co-morbidities/risk factors. Avoid if patient is already on an SSRI (Selective Serotonin Reuptake Inhibitor).
Apr 26, 2021: The new FLCCC hospital treatment protocol (MATH+) with the notable additions of Fluvoxamine and anti-androgen therapy (Dutasteride/Finasteride).
This international collaboration — comprised of physicians, like lead author Peter McCullough, MD, courageously treating patients despite the prevalence of “therapeutic nihilism” among government agencies like the NIH and FDA — outlines the urgency of, “prompt early initiation of sequenced multidrug therapy (SMDT) … to stem the tide of hospitalizations and death.”
The authors wrote:
The early stage of viral replication provides a therapeutic window of tremendous opportunity to potentially reduce the risk of more severe sequelae in high risk patients. Precious time is squandered with a ‘wait and see’ approach … resulting in unnecessary hospitalization, morbidity, and death. … In newly diagnosed, high-risk, symptomatic patients with COVID-19, SMDT has a reasonable chance of therapeutic gain with an acceptable benefit-to-risk profile.
Related Ivermectin and COVID-19 Scientific Publications:
- Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19 by Kory et al. accepted and published on American Journal of Therapeutics.
- A multi-centre randomised controlled study in Egypt (Elgazzar, Research Square) reported that the death rate was significantly lower in Ivermectin treated patients group (severe patients) vs non-Ivermectin group (2% vs 20%). 1,300 patients were included in this randomized controlled trial.
- This randomized controlled trial out of Iran (Hashim, pre-print) used Ivermectin and Doxycycline in mild, moderate, and severe hospitalized COVID-19 patients. No patients in the mild and moderate COVID-19 category died and 18% of the severe patients perished taking this medication combo. In the control group, no mild-moderate patients died, but 27% of the severe COVID patients died. The patients who also got Ivermectin had a shorter recovery.
- A randomized, double-blind, placebo-controlled, multicenter, phase 2 clinical trial at five hospitals (Iran) and 180 patients with mild to severe disease (Niaee, ResearchSquare, Nov 2020). Ivermectin as an adjunct reduced the rate of mortality, the duration of low oxygen saturation, and the duration of hospitalization.
- The ICON study in US, published in Chest, Oct 2020 reported that Ivermectin treatment was associated with lower death rate vs Control (13.3% vs 24.5%) during treatment of COVID-19, especially in patients with severe pulmonary involvement.
- A double-blinded randomised controlled study in Bangladesh (Mahmud et al) reported that the death rate was 0% (0/183) in the Ivermectin arm vs 1.67% (3/180) in the control arm in mild to moderate COVID-19 patients.
- The IDEA (Ivermectin, Dexamethasone, Enoxaparin and Aspirin) study from Argentina reported 1 death out of 167 patients studied. The patient that died was a severe COVID-19 patient that required ventilator support.
- The pre-AndroCoV trial from Brazil reported that early detection of COVID-19 followed by a pharmaceutical approach with different drug combinations (Azithromycin, Hydroxychloroquine, Nitazonide, Ivermectin) yielded irrefutable differences compared to non-treated controls in terms of clinical outcomes, ethically disallowing placebo-control randomized clinical trials in the early stage of COVID-19 due to the marked improvements.
- A retrospective study out of Bangladesh (Khan, Archivos de Bronconeumologia 2020). This retrospective study enrolled a total of 325 from April to June 2020. 248 adult COVID-19 patients were looked at in two groups, 115 received ivermectin plus standard care (SC), while 133 received only standard care (SC). This study showed that Ivermectin was efficient at rapidly clearing SARS-CoV-2 from nasal swabs (median 4 days). This was much shorter than in the COVID-19 patients receiving only SC (15 days) or receiving a combination of three antiviral drugs (7–12 days). In addition, fewer Ivermectin patients developed respiratory distress leading to ICU admission. In fact, with Ivermectin, there was a quick hospital discharge (median 9 days) in 114 out of 115 patients; the one remaining patient had been admitted with advanced disease.
Ivermectin Contraindications
Asthma: Patients with a history of severe asthma should receive ivermectin
with caution. Occasionally, systemic ivermectin has been reported to worsen
bronchial asthma.
Hepatic disease: Although not extensively
studied, due to its extensive hepatic metabolism, ivermectin should be
administered with caution in patients with significant hepatic disease.
Human
immunodeficiency virus (HIV) infection, immunosuppression: In patients with
immunosuppression (including those with human immunodeficiency virus (HIV)
infection) treated for intestinal strongyloidiasis, repeated ivermectin
courses may be necessary. Adequate and well-controlled clinical studies have
not been conducted in such patients to determine the optimal dosing regimen.
Several treatments (i.e., at 2 week intervals) may be required and a cure may
not be achievable. Control of extra-intestinal strongyloidiasis in these
patients is difficult, however, suppressive therapy (i.e., once per month) may
be helpful.
Pregnancy: Data with oral ivermectin use during
pregnancy are insufficient to inform a drug-associated risk. Systemic exposure
from topical use of ivermectin is much lower than from oral use. Four
published epidemiology studies evaluated the outcomes of a total of 744 women
exposed to oral ivermectin in various stages of pregnancy. In the largest
study, 397 women in the second trimester of pregnancy were treated open-label
with single doses of ivermectin or ivermectin plus albendazole; there was no
observed difference in pregnancy outcomes between treated and untreated
populations. However, these studies cannot definitely establish or exclude the
absence of drug-associated risk during pregnancy, because either the timing of
the administration during gestation was not accurately ascertained or the
administration only occurred during the second trimester. In animal
embyrofetal development studies of oral ivermectin given during organogenesis,
adverse developmental outcomes, including cleft palate, exencephaly, wavy
ribs, and clubbed forepaws, occurred at or near doses that were maternally
toxic. Pre-implantation loss and abortion were also noted.
Breast-feeding:
After oral administration, ivermectin is excreted in human breast milk in low
concentrations. Excretion in human breast milk after topical administration
has not been evaluated. According to the manufacturer, treatment with oral
ivermectin in mothers who are breast-feeding should only be undertaken when
the risk of delayed treatment to the mother outweighs the possible risk to the
newborn. Previous American Academy of Pediatrics (AAP) recommendations
considered oral ivermectin to be usually compatible with breast-feeding. The
amount of ivermectin present in human milk after topical application has not
been studied; however, systemic exposure from topical ivermectin use is much
lower than from oral use. According to the manufacturer, discontinue nursing
or discontinue the topical cream, taking into account the importance of the
drug to the mother. Women who are breast-feeding while using topical
ivermectin should avoid accidental transfer of ivermectin to the breast area
where it might be directly ingested while nursing.
Children,
infants: The topical administration of ivermectin to infants and children
should be under the direct supervision of an adult to prevent ingestion of the
lotion.
Onchodermatitis: Patients with hyperreactive
onchodermatitis (i.e., sowda) may be more likely than others to experience
severe edema and worsening of onchodermatitis after ivermectin use.
NIH Recommendation on the Use of Ivermectin for the treatment of COVID-19
NIH Summary Description of the Evidence Base
Ivermectin Dosage in Humans for COVID-19 - FLCCC Protocol
PREVENTION PROTOCOL
- Gargle mouthwash: 2 x daily – gargle (do not swallow) antiseptic mouthwash with cetylpyridinium chloride (e.g. Scope mouthwash™, Crest mouthwash, Colgate mouthwash) or povidone/iodine 1 % solution as alternative (e.g. Betadine® Antiseptic Sore Throat Gargle™).
- lvermectin
- Chronic Prevention: 0.2 mg/kg per dose (take with or after a meal) — twice a week for as long as disease risk is elevated in your community (Ref)
- Post COVID-19 Exposure Prevention: 0.4 mg/kg per dose (take with or after a meal) — one dose today, repeat after 48 hours.
- Vitamin D3: 1000–3000 IU/day. (Amazon) (iHerb)
- Vitamin C: 500 - 1,000 mg BID (twice daily) (Amazon) (iHerb)
- Quercetin: 250 mg daily. (Amazon) (iHerb)
- Zinc: 30 - 40 mg/day (elemental zinc). Zinc lozenges are preferred. (Amazon) (iHerb)
- Melatonin: 6 mg before bedtime (causes drowsiness). (Amazon)
- Nigella Sativa 40mg/kg daily (black seed)
- High risk Individuals: > 60 years with co-morbidities (hypertension, diabetes, chronic lung disease, chronic kidney disease), obesity, long term care facilities, etc.
- Post COVID-19 exposure: To use if a household member is COVID-19 positive, or you have prolonged exposure to a COVID-19 positive patient without wearing a mask.
- Precautionary Note: Ivermectin has a number of potentially serious drug-drug interactions. Please check for potential drug interaction at Ivermectin Drug Interactions - Drugs.com. The most important drug interactions occur with cyclosporin, tacrolimus, anti-retroviral drugs, and certain anti-fungal drugs.
- Due to the possible drug interaction between quercetin and ivermectin (may increase ivermectin levels), these drugs should not be taken simultaneously (i.e. should be staggered morning and night).
- Ivermectin is also lipophilic and therefore, bioavailability is maximised on a full stomach; or best to be taken with meal.
- Vitamin D3 RDA (Recommended Daily Allowance) is 800–1000 IU/day. The safe upper-dose daily limit is likely < 4000 IU/day. Vitamin D deficiency has been associated with an increased risk of acquiring COVID-19 and from dying from the disease. Vitamin D supplementation may therefore prove to be an effective and cheap intervention to lessen the impact of this disease, particularly in vulnerable populations, i.e. the elderly and obese.
- When Is the Best Time to Take Vitamin D? Morning or Night? It is possible that increasing vitamin D levels during the day may act, in part, as a signal that suppresses melatonin generation (source). Therefore, it's better to take vitamin D (with meal) during the day and melatonin to be taken just before bedtime.
- It is likely that vitamin C and quercetin have synergistic prophylactic benefit. Quercetin should be used with caution in patients with hypothyroidism and TSH levels should be monitored.
- Please consult with a qualified doctor and only use human ivermectin. Ivermectin for animals contain excipients (binding and storage compounds such as polyethylene glycol (PEG)) that are known to cause liver failure in high doses.
EARLY TREATMENT PROTOCOL
1. First line agents (use any or all medicines; listed in order of priority/importance)
- Ivermectin: 0.4–0.6 mg/kg per dose (take with or after meals) — one dose daily, take for 5 days or until recovered. (Find a Doctor). Use upper dose range if: 1) in regions with more aggressive variants; 2) treatment started on or after day 5 of symptoms or in pulmonary phase; or 3) multiple comorbidities/risk factors. (Ref)
- and/or Nitazoxanide: 500 mg 2 x daily for 5 days after meals. Combine with ivermectin (preferred) or substitute if ivermectin is not available. (Nitazoxanide is often unavailable or high-priced in the USA) (Ref).
- Antiviral mouthwash: Gargle 3 x daily (do not swallow; must contain chlorhexidine, povidone-iodine, or cetylpyridinium chloride). (e.g. Scope mouthwash™, Crest mouthwash, Colgate mouthwash, Betadine® Antiseptic Sore Throat Gargle)
- Iodine Nasal Spray: Use 1 % povidone iodine commercial product as per instructions 2–3 x daily. If 1 %-product not available, must first dilute the more widely available 10 %-solution and apply 4–5 drops to each nose every 4 hours. (No more than 5 days in pregnancy)
- Aspirin: 325 mg/day unless contraindicated. (Amazon)
- Vitamin D3: 5,000 IU daily. Preferred forms if available: Calcitriol (Rocaltrol) 0.5 mcg on day 1, then 0.25 mcg daily for 7 days – or Calcifediol 0.5 mg on day 1, then 0.2 mg on days 3 + 7, then 0.2 mg weekly until recovered.
- Melatonin: 10 mg before bedtime (causes drowsiness). (Amazon)
- Vitamin C: 500 - 1,000 mg BID (twice daily) (Amazon) (iHerb)
- Quercetin: 250 mg twice a day. (Amazon) (iHerb)
- Zinc: 100 mg/day. Zinc lozenges are preferred. (Amazon) (iHerb)
- Optional: Betadine nasal spray applied 3 times a day (Ref) (Amazon)
- Optional: Xlear Nasal Spray with Xylitol: use twice a day (Ref) (Amazon)
- Optional: Azithromycin 250 mg twice a day. (Ref) (Find a Doctor).
- Optional: Bromhexine 8 mg three times a day (Ref) (Lazada Malaysia*)
2. Second line agents (listed in order of priority /importance)
- Spironolactone 100 mg 2 x daily for ten days
- Dutasteride 2 mg on day 1, followed by 1 mg daily for 10 days. If dutasteride is not available, use finasteride 10 mg daily for 10 days.
Consider fluoxetine (Prozac) 30mg daily for 10 days as an alternative (it is often better tolerated).
Avoid if patient is already on an SSRI.
- Combining fluvoxamine and melatonin may significantly increase the blood levels and effects of melatonin (Drugs.com). You can check for other potential drug interactions with fluvoxamine at Fluvoxamine Drug Interactions - Drugs.com.
- Some individuals who are prescribed fluvoxamine experience acute anxiety which needs to be carefully monitored for and treated by the prescribing clinician to prevent rare escalation to suicidal or violent behavior.
3. Third line agent
Ivermectin Dosage Chart for Humans by body weight for prophylaxis and treatment of COVID-19 |
Ivermectin Dosage in Humans for COVID-19 - AAPS Protocol
- Ivermectin 0.2 - 0.6 mg/kg [6-36 mg] single oral dose given daily or every other day for 2-3 doses.
Where can you find a doctor who will prescribe ivermectin?
1. Ask your doctor to prescribe it.2. Try contacting PushHealth.com for a prescription
3. The FLCCC Alliance has a network of “Doctors who prescribe Ivermectin” who use the i-MASK and MATH+ protocols, and who may prescribe ivermectin and/or other useful medications for Covid-19.
4. America’s Frontline Doctors (aflds.com) also has a network of physicians who may be reached by telemedicine for an evaluation and possible prescription.
5. Text2MD favors the i-MASK protocol and will often prescribe ivermectin for their telemedicine patients.
6. EXSTNC.com – pronounced “existence”; they have a list of doctors and what drugs they typically prescribe for Covid-19, including many ivermectin-friendly doctors.
7. The Complete Guide To Health has a directory of doctors who may give ivermectin to their Covid-19 patients.
8. Here is a video from Dr. Mobeen Syed discussing different ways to find a doctor who will prescribe ivermectin for Covid-19.
9. use GoodRx to find low cost pharmacies to fill your prescription
10. This website “ivermectin24h” offers ivermectin but it takes about 4 weeks to arrive in the mail.
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