Betadine Cold Defense Nasal Spray Review 2022


Carragelose™, a natural ingredient derived from a type of red seaweed.

Carragelose™ is proven to help eliminate multiple types of cold and flu viruses such as H1N1 and rhinoviruses - common causes of respiratory infections.

TM: CARRAGELOSE™ is a Trademark of Marinomed Biotech AG used under license by Mundipharma Laboratories GmbH.

Iota-carrageenan nasal spray

How Carragelose™ Works To Eliminate Cold & Flu Viruses

  1. Forms a protective layer on the surface of the nasal lining.
  2. Binds/traps the viruses, hindering their spread and multiplication
  3. Viruses are eliminated naturally through the nasal mucus


1. Blow your nose gently.

2. Remove the protection cap, shake the bottle and pump the spray a few times until a fine mist comes out.
3. Sit up with your head tilted slightly forward and to breathe out slowly.
4. Close one nostril and gently insert the nozzle into the other
5. Gently squeeze the pump as you breathe in. 1 spray into each nostril 3 times a day.
6. Repeat steps 1 to 6 for the other nostril.
7. Use 1 spray for each nostril, three times per day.

Carragelose nasal spray side effects

The lack of toxicity and pharmacological activity of the Iota Carrageenan nasal spray with its high safety profile means that this treatment may be suitable for use in children as well as adults. [Source]

About Carragelose®

Carragelose® is a sulfated polymer from red seaweed and is a unique, broadly active anti-viral compound. It is known as a gentle yet effective and safe prevention and treatment against respiratory infections. Several clinical and preclinical studies have shown that Carragelose® forms a layer on the mucosa wrapping entering viruses, thereby inactivating them, and preventing them from infecting cells. Increasing clinical evidence indicates that Carragelose® can also inactivate SARS-CoV-2.[MedRxiv],[Marinomed

Marinomed is holder of the IP rights and has licensed Carragelose® for marketing in Europe, parts of Asia, Canada, and Australia. For a full list of Marinomed’s portfolio of Carragelose® containing nasal sprays and oral products, please visit a list of scientific publications on Carragelose®, please visit

Frequently Asked Questions

1. Can BETADINE® COLD DEFENSE NASAL SPRAY be used for both treatment and prevention of common cold?

BETADINE® COLD DEFENSE NASAL SPRAY is an innovative treatment for early intervention and treatment of common cold and flu-like illness.

2. Does BETADINE® COLD DEFENSE NASAL SPRAY relieve common cold symptoms?

BETADINE® COLD DEFENSE works by an antiviral effect. It traps and eliminates viruses, thereby have effects on symptom relief. Our studies have looked at total symptoms and we have demonstrated that BETADINE® COLD DEFENSE will reduce the total symptoms such as runny nose, nasal congestion, sore throat, etc. when given as an early intervention for treatment of common cold and flu-like illness.

3. How long should BETADINE® COLD DEFENSE NASAL SPRAY be used? Is it well tolerated?

The recommendation is for up to 7 days.

The clinical trials have shown that BETADINE® COLD DEFENSE has a high tolerability, no nasal irritation, smell or taste.82,83,88 One of the key things is that the iota carrageenan in the spray is not absorbed by the body. It really is working physical means not by medicinal means. It is a medical device.

4. Is carrageenan contained in BETADINE® COLD DEFENSE NASAL SPRAY safe?

Carrageenan is commonly found in food products and is generally recognized as safe. You have to remember there are three different types of carrageenan: iota, kappa and lambda. The BETADINE® COLD DEFENSE spray only contains one type of carrageenan, which is the iota carrageenan, and the iota carrageenan is generally well tolerated.

5. Can we use BETADINE® COLD DEFENSE NASAL SPRAY with Saline Nasal Sprays?

You can continue to use the saline spray to remove crusting and wash the nose. But you should always use the BETADINE® COLD DEFENSE after the saline spray, otherwise you are going to wash out the Cold Defense and reduce its efficacy. Always seek the advice of your physician with any questions you may have.

6. What is the concentration of iota-carrageenan contained in BETADINE® COLD DEFENSE NASAL SPRAY for kids and for adults?

The concentration of BETADINE® Cold Defense for adult and paediatric is 1.2 mg/ml.86 Whilst the concentration is the same for both adults and kids, the spray mechanism is designed to deliver a smaller volume for kids noses.

7. What is the recommended dosage of BETADINE® COLD DEFENSE NASAL SPRAY?

The spray comes in two formulations: the adult spray and the kid spray. The adult spray is 1 spray into each nostril 3 times per day. For the kid spray, which delivers a smaller dose, 2-3 sprays into each nostril, 3 times a day.

8. What is the duration of the antiviral effect of BETADINE® COLD DEFENSE NASAL SPRAY after usage?

The antiviral effect in vivo, in human beings, the duration has not been measured, but we do know that when BETADINE® COLD DEFENSE is administered 3 times per days. It is effective in reducing severity of symptoms.



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