8 Best Pain Relief Cream 2022

Chronic joint pain affects almost one-quarter of people worldwide. Common joints affected include the knees, hands, elbows, shoulders, back and elsewhere. In most cases, this is caused by the most common type of arthritis, osteoarthritis.

Topical painkillers are products that you apply onto your skin to provide relief for joint and muscle aches. They also help with burns and hemorrhoids. 

What Is The Main Cause of Joint Pain?

The most common causes of chronic pain in joints are: Osteoarthritis, a common type of arthritis, happens over time when the cartilage, the protective cushion in between the bones, wears away. The joints become painful and stiff. Osteoarthritis develops slowly and usually occurs during middle age.

How Can I Stop Joint Pain?

- Stay at a healthy weight. Extra pounds put pressure on weight-bearing joints like hips and knees. Each pound you gain adds nearly four pounds of stress on your knees and puts six times the pressure on your hips.

- Control your blood sugar. High blood sugar can stiffen the tissue that supports your joints and make them more sensitive to stress.

- Exercise. Just 30 minutes of exercise five times a week helps joints stay limber and strengthens the muscles that support your knees and hips. Focus on low-impact exercises like walking, cycling or swimming.

- Stretch. Gentle stretching can improve your range of motion and keep your joints limber. Try to work in simple stretches into every day.

- Avoid injury. An injured joint is more likely to develop arthritis than one that was never injured. Wear protective gear when playing sports and always lift with your knees and hips, not your back. 

- Quit smoking. Smoking puts stress on tissues that protect your joints and can lead to arthritis pain. Learn how Blue Cross can help you quit.

- Eat fish twice a week. Eat fish high in Omega-3s, like salmon, trout and mackerel. Omega-3s have many health benefits and may reduce inflammation.

- Get routine preventive care. Your doctor may be able to suggest lifestyle changes that can help reduce your risk or slow the progress of arthritis.

Best Topical Pain Relief Products 2022

1. Penetrex Joint and Muscle Therapy Cream - Best Muscle and Joint Relief Cream

- Penetrex Pain Relief Cream
- Intensive Concentrate for Relief & Recovery 
- Whole-Body Formula with Arnica, Vitamin B6 & MSM (DMSO2) 
- Penetrex is recommended for use on its own & is safe to use in conjunction with complementary therapies such as Heating Pads, Ice Packs, Back Massagers, Knee Braces and Supplements.
- Relief & Recovery for Joints & Muscles on your Back, Neck, Knee, Hand, Foot, and more. 
- Contains unique ingredients including Arnica, Glucosamine, MSM (DMSO2), Choline, Boswellia Serrata (Frankincense) & Vitamin B6 deep into the tissue to soothe affected areas.
- Vanishing scent / non-greasy / non-sticky / non-staining / paraben-free 
- Vegan and Cruelty-free (never tested on animals).

4.3 out of 5 - 70,458 global ratings

 If I wake up with a sore back or neck, I rub this in and it instantly diminishes the pain at least 75 percent. I rubbed it into my hands and wrists and it helped my carpel tunnel at least 40- 50 percent. 

Buy on Amazon

2. Neosporin Pain Relief Dual Action Cream - Best Burn Cream for Pain Relief

Neosporin + Pain Relief Cream provides dual antibiotic infection protection and soothes painful minor cuts, scrapes, and burns. Using first aid antibiotics neomycin and polymyxin B and pain reliever pramoxine hydrochloride, this cream from the number-one doctor-recommended brand not only helps fight infection for 24 hours, but also soothes and reduces pain with maximum-strength relief.

- Helps prevent infection and provides pain relief
- Neomycin and polymyxin B for 24-hour infection protection
- Pramoxine hydrochloride for pain relief

4.9 out of 5 - 10,974 global ratings

Neosporin is the best antibiotic cream on the market for over the counter use!. I have used other antibiotic creams but the way Neosporin heals your cuts, scrapes, burns on your skin while healing with NO scars or marks is remarkable. I now make sure I stay stocked with Neosporin, keeping a tube of it in my car, purse and desk at work. This is an amazing product and you can even use it as a concealer to heal chapped ,wind blistered, sun burns, allergic reactions and many others to lips, hands, feet, arms etc.. I truly recommend this product for every 1st aid kit, home use, camping or other outings just in case the unknown scrape or cut appears!

3. Bengay Lidocaine 4% Topical Analgesic Cream, 3oz - Best Muscle Pain Relief Cream

lidocaine pain relief cream

- Lidocaine Topical for Back Pain
- Pain Relief Cream with Lidocaine

This pain reliever cream works to desensitize aggravated nerves with the numbing relief of maximum strength 4% lidocaine HCl as an active ingredient. It is formulated with a light tropical jasmine scent that is both soothing and pleasant and a non-greasy formula that doesn't leave any residue behind

Benefits of Bengay
Localized treatment - allows you to concentrate treatment only on affected area
Speed of effect - ingredients do not have to travel through the bloodstream and are absorbed directly into affected area
Lightly scented lidocaine cream has a soothing and pleasant scent

- Works to desensitize aggravated nerves with effective, numbing relief. 
- Formulated with 4% lidocaine HCI as an active ingredient
- The topical analgesic cream also helps relieve pain. 
- 3-ounces of Bengay Pain Relieving Lidocaine Cream for maximum strength pain relief in a fresh tropical jasmine scent
- Great for back, neck, shoulder, knee, elbow, hand & wrist pain, as well as backaches, joint pain and arthritis
- For use, apply the topical lidocaine cream to the affected area no more than 3-4 times a day for effective, numbing relief

4.5 out of 5 - 8,791 global ratings

Amazing scent, smells like a jasmine perfume, and super effective!!!!!!! I have ankylosing spondylitis , psoriatic arthritis, and fibromyalgia! Super helpful for the muscle / joint pain, and for my nerve pain it reduces the swelling.

4. Preparation H Hemorrhoidal Cream - Best Hemorrhoid Cream for Pain Relief

- Includes one 1.8 Ounce tube of Preparation H Multi-Symptom Hemorrhoid Pain Relief cream
- The only over the counter hemorrhoid treatment cream with maximum strength pramoxine for multi-symptom relief
- The proprietary blend of Glycerin, Phenylephrine HCl, Pramoxine HCl and White Petrolatum provides maximum relief of uncomfortable hemorrhoid symptoms.
- Proprietary hemorrhoid cream blend with vitamin E, panthenol and soothing aloe
- Provides rapid hemorrhoid relief from pain, burning, itching and discomfort
- Preparation H cream rapidly relieves external hemorrhoid symptoms
- Hemorrhoid treatment formula shrinks swollen hemorrhoidal tissue
- Use with Preparation H Medicated Wipes to cool, soothe and cleanse before you treat for better hemorrhoid relief

4.6 out of 5 - 7,779 global ratings

This is literally not a pain in the butt. Cleared them things up fast. Stopped the severe itching in public when you needed it most.

5. Voltaren Arthritis Pain Gel - Diclofenac Sodium Topical Gel for Knee Pain

The Voltaren emulgel formula, which combines a cream and a gel, penetrates deep through the skin to deliver powerful arthritis pain relief. When applied to the skin it creates a cooling and moisturizing effect.

Voltaren provides targeted pain relief in the areas you need it most. All you have to do is rub Voltaren directly to the site of pain. Voltaren Arthritis Pain Gel can be applied to your hands, wrists, elbows, feet, ankles, and knees.

Voltaren relieves arthritis pain, improves mobility and reduces stiffness to provide prescription strength arthritis joint pain relief.

- Voltaren Topical for Back Pain
- Topical Arthritis Pain Relief
- Contains One 3.5 oz/100 g tube and one 0.71 oz/20 g sample tube 
- Non-greasy Voltaren Emulgel combines the properties of an arthritis pain relief cream and a gel to target pain
- Diclofenac sodium topical gel penetrates deep to attack arthritis pain directly at the site, treating pain rather than just masking it
- Apply on up to two joints at the same time for hand pain, wrist pain, elbow pain, ankle pain, foot pain or knee pain relief

4.4 out of 5 - 7,188 global ratings

So I did not expect much... I put some on my elbow which had moderate pain. Then I applied to my right foot at the ball of the big toe where it attaches to the foot. I have had trouble walking on it for about a year. This hurt a lot. To my amazement I had about a 90 % percent reduction in pain in about 30 min! 600 mg of Ibuprofen would barley knock the edge off. I will buy again.

6. Topricin Pain Relief Cream 8oz - Best Pain Relief Cream for Joint Pain

Topricin is moisturizing, non-irritating, odorless and non-staining. It supports the body's natural processes that work to Heal the Cells Causing the Pain. Topricin has 22-years of history in the medical community and is used by hundreds of thousands all over the world.

Topricin contains 11-natural biomedicines delivering reliable pain relief, improving quality-of-life, and providing a strong adjunct to professional care with no side effects and won’t interfere with other medications

The safest alternative for people who cannot tolerate prescription and non-prescription OTC oral pain medication. It stimulates and supports your body's desire to ""Heal the Cells that are Causing the Pain"". Topricin is safe effective and ideal treatment for the entire family and for all skin types.

- Topricin Pain Relief Cream
- Fast acting pain relieving cream

• Headaches, Joint, Muscle, Nerve Pain
• Post-Surgical Pain
• Carpal Tunnel Syndrome (CTS)
• Injury of Hand, Wrist and Fingers
• Joint Pain: (neck, shoulders, back, wrist, hand, knee and fingers)
• Neck & Shoulder Pain/Bursitis
• Lower Back Pain / Sciatica
• Sports / Trauma Injuries / Impact Injuries
• Dislocations and any other trauma injuries of the joints and muscles
• Ankle Sprain & Heel Spurs
• Muscle Spasm/Night Leg Cramps
• Tennis/Golfers Elbow/Tendonitis
• Scar Tissue Management

• 11-natural Homeopathic Biomedicines
• Safe, Effective And Gentle
• Will Not Interfere With Any Medication
• Effective For Pain Associated With A Wide Range Of Ailments
• Ideal For The Entire Family: Elderly, Children
• Guaranteed To Work Or Your Money Back
• Made In The USA

- Generously apply 3 to 4 times daily or more if needed, 3 inches on and around affected area.
- Massage in until absorbed.
- Use before and after sports workouts and competitions.
- Apply immediately for acute trauma.
- Seek immediate medical attention if pain or swelling is severe.
- Reapply before bedtime and in the morning for Best Results.
- For external use only Do not apply in eyes. Use only as directed.

4.4 out of 5 - 4,770 global ratings
I have neuropathy in my feet/legs and find that using this cream at night before bedtime really helps things calm down so I can sleep. I recommend this to others who are looking for a cream to use for similar reasons.

7. MaxRelief Arnica Montana Pain Cream - Best Topical Pain Relief for Arthritis 

arthritis pain relief cream

- Anti Inflammatory Cream for Arthritis
- For Sufferers of Knee, Joint & Outback Muscle Pain. Reduce Arthritis & Joint Inflammation. 
- Plantar Fasciitis & Fibromyalgia Relief + Emu Oil 3.5 oz

Apply MaxRelief anywhere you experience Pain, Discomfort, Tingling, or Numbness including your Back, Neck, Knee, Hand, Wrist or Foot. Excellent for Sciatic pain. MaxRelief works on its own or with complementary therapies such as Heating Pads, Ice Packs, Arthritis Gloves, Back Pain Massagers, Tennis Elbow Straps, Carpal Tunnel Braces, Fibromyalgia Supplements, Neuropathy Socks, Sciatica Cushions, Tendonitis Supports, Bursitis Braces, etc.

Sufferers all over the world have now discovered our unique formulation. Arnica montana (a mountain flower) has been used for centuries as a natural pain reliever, and today, it’s one of the most popular natural medicines in the world. MaxRelief is 23% Arnica – 3 times that of other leading products. Maximum Strength, compared to Arnica Gel at 7%

We are the ONLY pain relief cream to include the tremendous pain relief benefits of Arnica, Eucalyptus, & Emu Oil in one incredible product. Support for Wrist and Lower Back pain. Arnica is trusted by professional athletes to soothe sore muscles, by prominent cosmetic surgeons to relieve post-procedure pain, and by savvy moms to treat playground bumps and bruises.

Reduces arthritis pain, tingling and joint inflammation while increasing capillary circulation. Just rub it in.

Arnica for Inflammation. Emu Oil for Cell Regeneration, Rosemary for Improved Blood Flow. 

- Vanishing Scent 
- Made in the USA 
- Non-Greasy / Non-Staining 
- Paraben-Free 

4.3 out of 5 - 2,522 global ratings

MaxRelief Arnica is absolutely amazing! Not only does it provide extremely fast pain relief in a matter of minutes but it doesn't just provide a 'bandaid' of temporary relief and instead the anti-inflammatory aspect of the compound helps to decrease inflammation to the area of pain and promote healing.

8.  Sciaticream Nerve Pain Relief Cream - Best Topical Pain Relief for Sciatica

- Best Topical Pain Relief for Nerve Pain

Sciaticream Sciatica Nerve Pain Relieving Cream
The Sciatic nerve is the longest nerve in your body so even small twists or injury can lead to frustrating pain. Additionally, when a disk herniates, it might put pressure on the nerves around it. This can cause a lot of pain when that happens to be the sciatic nerve.

Here is where Vita Sciences Sciaticream can help you. As experts of neuropathy & nerve pain-relieving products, we formulated a natural formula that is scientifically targeted to relieve sciatica nerve pain while deeply soothing your skin.

Our sciatica nerve pain-relieving cream:
- prevents burning, tingling, numbness
- calms & gives quick relief from sciatica nerve pain
- uses natural ingredients and is quick to absorb

- Contains Arnica, B1, B5, B6, MSM. Soothing Aloe and Coconut Oil Base Fast Treatment for Sciatic Pain 
- Reduce Burning, Tingling, Numbness. 
- Airless dispenser provides metered dose.
- Odor Free
- Contains high doses of Vitamin B12 and Vitamin E. 
- Contains Vitamin B1, B5, & B6, MSM, Cetyl Myristoleate, Capsaicin and Andrographis extract that all work to lessen symptoms and support nerve health. and comfort
- Moisturizers and antioxidants allow this powerful cream to easily absorb into the skin.

3.7 out of 5 - 689 global ratings

Fantastic !!! Got this by accident. It was for someone else but Amazon told me to keep it. I will keep buying it. Two years ago I had a massive infection on my sciatic nerve and I spent two horrible weeks in the hospital while they tried to find the source of the worst pain I ever had. Of course I still have pain and this stuff works. It is also great for nighttime leg cramps


1. What Causes Chronic Knee Pain?

Temporary knee pain is different from chronic knee pain. Many people experience temporary knee pain as a result of an injury or accident. 

Chronic knee pain rarely goes away without treatment, and it isn’t always attributable to one incident. It’s most often the result of several causes or conditions.

Step 1 in dealing with a chronic knee pain is to know the cause or 'diagnosis', a term used by medical doctors. Treatment is step 2. This may appear logical but many people jump into various kind of treatments without even knowing the cause of the knee pain. Thus, wasting their hard-earned money in none effective treatments.

Physical conditions or diseases can cause knee pain. These include:
  • osteoarthritis: pain, inflammation, and joint destruction caused by degeneration and deterioration of the joint
  • tendinitis: pain in the front of the knee that is made worse when climbing, taking stairs, or walking up an incline
  • bursitis: inflammation caused by repeated overuse or injury of the knee
  • chondromalacia patella: damaged cartilage under the knee cap
  • gout: arthritis caused by the buildup of uric acid
  • Baker’s cyst: a buildup of synovial fluid (fluid that lubricates the joint) behind the knee
  • rheumatoid arthritis (RA): a chronic autoimmune inflammatory disorder that causes painful swelling and can eventually cause joint deformity and bone erosion
  • dislocation: dislocation of the kneecap most often the result of trauma
  • meniscus tear: a rupture in one or more of the cartilage in the knee
  • torn ligament: tear in one of the four ligaments in the knee — the most commonly injured ligament is the anterior cruciate ligament (ACL)
  • bone tumors: osteosarcoma (second most prevalent bone cancer), most commonly occurs in the knee
As you can see from the above, there are many causes of knee pain. That's why you need to understand the importance of 'diagnosis' or finding the cause of the knee pain. Knee pain due to gout or rheumatoid arthritis has to be treated differently from knee osteoarthritis. A mis-diagnosis will lead to a mis-treatment.

2. How Can I Get Rid of Inflammation Naturally?

- Anti-Inflammatory Diet

Researchers have identified certain foods that can help control inflammation. Many of them are found in the so-called Mediterranean diet, which emphasizes fish, vegetables and olive oil, among other staples.

There’s a standardized research tool that’s updated regularly that allows anybody to see if they’re eating foods we know cause chronic inflammation. This is called the The Dietary Inflammatory Index or DII. The choices of pro-inflammatory foods were initially based on studies showing that certain foods like trans-fatty acids (unsaturated fats) caused a spike in serum inflammatory markers in people.

- Autoimmune Protocol Diet

The Autoimmune Protocol (AIP) is a diet that aims to reduce inflammation, pain, and other symptoms caused by autoimmune diseases, such as lupus, inflammatory bowel disease (IBD), celiac disease, and rheumatoid arthritis (pubmed).

Many people who have followed the AIP diet report improvements in the way they feel, as well as reductions in common symptoms of autoimmune disorders, such as fatigue and gut or joint pain. Yet, while research on this diet is promising, it’s also limited.

The AIP diet is an elimination diet designed to help reduce inflammation or other symptoms caused by autoimmune disorders.

It’s comprised of two phases designed to help you identify and ultimately avoid the foods that may trigger inflammation and disease-specific symptoms. Research on its efficacy is limited but appears promising.

Due to its limited downsides, people with autoimmune disorders generally have little to lose by giving it a try. However, it’s likely best to seek guidance from a qualified health professional to ensure you continue to meet your nutrient needs throughout all phases of this diet.


Your doctor will likely recommend non-drug treatments if you have joint pain, and these recommendations may include supplements.

However, not all supplements are equally effective, and it’s essential to learn how to safely use them.

Before taking any supplements:
  • check first with your doctor that they are safe for you to use
  • get your supplements from a reputable source
  • follow the instructions provided
Other non-drug treatments can include:
  • trying to follow a healthy, balanced, and nutrient-dense diet
  • if you are over-weight, strive to loss weight 
  • find out the underlying cause of the joint pain. Could be from poor sitting or standing position.
  • physical therapy



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