Which Repurposed Drugs Are Effective in Treating Cancer?
> Mebendazole: Originally used to treat parasites, this drug has shown promise in treating brain tumors and other cancers. A wide variety of cancers, including NSCLC (non small cell lung cancer), adrenocortical, colorectal, chemo-resistant melanoma, glioblastoma multiforme, colon, leukemia, osteosarcoma/soft tissue sarcoma, acute myeloid sarcoma, breast (ER+ invasive ductal), kidney, and ovarian carcinoma, have been shown to be responsive to benzimidazoles, including MBZ (Guerini 2019, Meco 2023). First-in-the-World Ivermectin, Mebendazole and Fenbendazole Protocol in Cancer has been peer-reviewed and published on Sep.19, 2024 in the Journal of Orthomolecular Medicine. Co-authors include Dr Paul Marik and Dr William Makis: Targeting the Mitochondrial-Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol.
> Ivermectin: In a 2021 review paper, the related mechanisms by which ivermectin inhibited the development of different cancers and promoted programmed cell death were discussed. Also reviewed was the prospects for the clinical application of ivermectin as an anticancer drug for cancer therapy. In another study, published in Nature (2021), Ivermectin stimulates T-cells to invade and destroy tumors and synergizes with immune checkpoint blockade for treatment of breast cancer.> Statins: Drugs that lower cholesterol, which may also help in preventing or treating some types of cancer. Statins lower circulating blood lipids including low-density lipoprotein (LDL) cholesterol through the competitive inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR), an enzyme that facilitates the conversion of HMG-CoA to mevalonic acid, which is a crucial step in cholesterol biosynthesis. By inhibiting this process, statins not only reduce cholesterol production but also impact by-products essential for cancer cell growth, thereby demonstrating their potential as anticancer agents (source). Of the statins, simvastatin is particularly interesting due to its anticancer applications, which have been observed in various cancer types and are largely mediated through activation of mutant P53.
> Propranolol: A drug for high blood pressure that has shown effectiveness in treating certain cancers, like angiosarcoma.
> Thalidomide: Originally a sedative, it was repurposed and approved in 1998 to treat multiple myeloma, a type of cancer.
> Arsenic Trioxide: Once used as a poison, it was repurposed and approved in 2000 to treat a type of leukemia (a blood cancer).
These drugs have been repurposed to help treat or prevent cancer. While some are already approved for this use, others are still being studied. Their effectiveness can vary depending on the type of cancer and the individual patient.Sources:
https://www.onedaymd.com/2023/06/top-10-metabolic-interventions-to.html
Ivermectin Cancer Success Stories: Case Series (2025)
Fenbendazole Cancer Success Stories and Treatment Testimonials: Case Series.
https://healnavigator.com/ask-our-experts/which-repurposed-drugs-are-effective-in-treating-cancer/
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