Mebendazole Patent for Cancer Treatment by Johns Hopkins University Uncovered!

Fenbendazole is part of a larger group of drugs known as benzimidazole*, which are anti-parasitic drugs. Another benzimidazole is mebendazole, which can be prescribed to humans with certain gut infections, including threadworms, whipworms, hookworms, and roundworms.

*The class of drugs known as benzimidazoles includes fenbendazole, mebendazole, albendazole and flubendazole. 

Mebendazole (MBZ; 5-benzoyl-1H-benzimidazol-2-ylcarbamate) first described in 1968, was initially recognized as a broad-spectrum anti-parasitic and deworming agent and was applied to humans in 1971 (JAMA 1971).

Fast forward two decades, and the focus on anthelmintics shifted towards their potential anticancer properties, primarily due to their interactions with microtubules (Cancers 2019).

A 2022 study published in Breast Cancer Research found that mebendazole—a safe, widely available, and low-cost drug with decades of proven safety and efficacy—can prevent and eliminate triple-negative breast cancer. The study also showed that mebendazole helps prevent metastasis by reducing the formation of cancer stem cells in distant tissues.

A 2021 study from Johns Hopkins University, concluded that mebendazole should be investigated further as a component of adjuvant therapy to slow progression and prevent metastasis, and well as for primary prevention in the highest risk patients. (Oncotarget 2021)

Anecdotal evidence from two case reports (refractory metastatic colon cancer, metastatic adrenocortical carcinoma) has further supported the possibility of MBZ being repurposed as an anticancer drug by documenting its success in managing metastatic patients.

Mebendazole Patent for Cancer - Johns Hopkins University

Dr William Makis posted this on X.com in November 2025:

On Sep.7, 2021, Johns Hopkins University in Baltimore, MD secured a patent for MEBENDAZOLE for this use: 

1. Repurposed for Glioblastoma Therapy

(as an oral drug mebendazole polymorph C is a superior form, and it reaches the brain and brain tumors in effective concentrations)

2. May also be used for therapy of other cancers, as well as a chemo-preventative agent.

The title of the patent: "Mebendazole Polymorph for Treatment and Prevention of Tumors".

I will let that sink in. This is what I have been working with for the past 2 years.

Source: https://x.com/MakisMedicine/status/1990571427083530585