Failed Cancer Treatments? Exploring the Evidence - Dr Robert Yoho

Cancer is many diseases, and cures are elusive. Slowgrowing tumors rarely require treatment because most never cause problems and may go away on their own. Fastgrowing tumors are discovered too late to do anything. Only cancers of intermediate growth rate, a minority, have the potential for worthwhile intervention. For most tumors, a modest life extension is the best we can do. Exceptions include metastatic melanoma, renal cell cancer, a few lymphomas, leukemias, and testicular cancers. Chemotherapy may extend life or sometimes cure these. Small numbers prop up the bulk of the other treatments, and careful analysis shows that the expenses and toxicities may not be worth it. Judging what is reasonable in this problematic field among these relatively weak remedies is challenging. 

Communicating the facts honestly and ethically with patients may be harder. Simultaneously, the physician must manage the emotions surrounding decline and death. This work requires a special person, and most doctors are not strong enough to do it. Dying patients reach for anything. People with cancer are tremendously vulnerable and have an overwhelming need to trust caregivers. They continue to believe in their doctors, almost regardless of the circumstances. 

Oncologists always have new, toxic, and expensive drugs. They may have seen a few patients survive long term using some medication that rarely works and makes everyone sick. They have read studies that showed (maybe) two months’ average increased survival with certain drugs. They can usually tell the patient that there is a costly chemo that might help, and it is covered by Medicare or insurance. It is a demanding job, and the oncologists have a terrific financial conflict of interest that makes it harder. They retail chemotherapy infusions for about a 20 percent markup. Inside the specialty, they call this “buy and bill.” By 2013, 65 to 70 percent of oncologists' income was drug charges. Their pay doubled from 1995 to 2004, when it was $335,000, and then it went up again to $445,000 by 2017.

Drug representatives stay in touch with oncologists and let them know whether they are “making their qu otas.” The companies offer doctors higher percentages for certain drugs if they order more. This is an inducement to raise the doses of drugs, which can be harmful. In one egregious case, medications were promoted in this fashion to treat anemia that also increased the chances of premature death. Their sales were $37 billion between 1996 and 2009. Otis Brawley, in How We Do Harm, said, “[These] drugs were not used to cure disease or make patients feel better. They were used to make money for doctors and pharmaceutical companies at the expense of patients, insurance companies, and taxpayers.”

If two physicians made a deal like this between themselves, prosecutors might throw them in prison. “Fee-splitting” is a similar, perhaps nearly identical crime where a physician kicks back a commission to another doctor for a patient referral. Federal Stark laws applying to Medicare and Medicaid plus many state laws impose criminal penalties for this. (Between lawyers and realtors, however, referral fees are accepted practice.) Regardless of the exact legalities, our primary priority must be our patients, always. These harmful and unethical incentives draw us away from this duty and must be made illegal if they are not already. New chemotherapy medications can be 300 times (not 300 percent) more expensive than old ones. Cancer treatment expenses per patient are often over $100,000 a year. Jerome Kassirer adds: 

One oncologist half-jokingly told me, "Chemo is our cardiac cath, or our arthroscopy," implying that chemo offers a profitable "procedure" for the oncologist [which is] "the dirty little secret of oncology." …Some oncologists… make an income of nearly a million dollars a year by pushing chemotherapy… approximately two-thirds of the income of oncologists in community practice was derived from intravenous or intramuscular drugs… [Quoting Dr. Eisenberg] "the financial conflicts I have identified in our discipline... are so pervasive and insidious that we continually must remind ourselves as to the real purpose of our work.” 

— ON THE TAKE: HOW MEDICINE'S COMPLICITY WITH BIG BUSINESS CAN ENDANGER YOUR HEALTH (2004)

Gleevac, for example, is effective for some leukemias but costs nearly $9,000 for ninety 100 mg tablets. In 2014, we spent $92 billion on US cancer therapies, but in 2020, costs are projected to be $173 billion. Some treatments are hundreds of thousands of dollars a year for each person. Even patients who are near death get them. They experience the grim side effects for no benefit. Only a scant few of the expensive, toxic cancer therapies improve lifespan. Once tumor spread has occurred, most chemotherapy barely helps. Drs. Graeme Morgan and his colleagues did an exhaustive literature search that was published in Clinical Oncology in 2004. They found that chemotherapy added only 2.1% to the 5-year survival for US adults treated for cancer. Nortin Hadler wrote in 2011 that survival has been extended only a few months for the most common tumors: 

• Lung cancers (except small cell): 2-6 months after several chemotherapies. 
• Breast cancers: drugs have not improved survival time. Early diagnosis has increased the number of cases, but death rates have changed little. 
• Colon cancers: from 9 to 22 months for the newest drugs. 
• Prostate cancers: 2 months.

He said this was a “dirty little secret” that oncologists withhold from the public. There are new drugs every year, and many do not even improve the quality of life. These opinions are dated, but Vinay Prasad, MD, evaluated the cancer drugs that were approved in 2016-2017. He wrote that they did not extend survival at all. He also studied oncology drugs that the FDA approved between 2008 and 2012. Thirty-six of the 54 were approved using surrogate endpoints and had no known effect on survival. Four years later, only five of them had been shown to help anyone live even a day longer.

Prasad’s conclusion was that post-marketing studies should be required. The American Society of Clinical Oncology knows all of this. Their 2014 goal for chemotherapy life extension was only 2.5 months. The 72 cancer therapies approved from 2002 to 2014 resulted in an average of only 2.1 more months of life than the older drugs. Only one in five from 2014 to 2016 worked even that well. Otis Brawley, MD agrees. He wrote: “I’m starting to hear more and more that we are better than I think we really are. We’re starting to believe our own bullshit.” He said specialties that make money on diseases should not be deciding what is reasonable for testing or therapy. For example, radiologists should not be on panels deciding about the use of mammograms, and urologists should not determine radical prostatectomy standards. As obvious as this sounds, it is a radical idea for doctors.

Cancer ads make exaggerated claims about treatments that barely work. Although many of these therapies do not help people live longer, TV commercials typically promise “a chance for longer life.” Dr. Prasad reviewed contemporary news stories for words like miracle, breakthrough, game-changer, and cure. Fifty percent of the time, they were used to describe drugs not approved by the FDA, and 14 percent of the time, they were talking about drugs that had only been tried in mice. Timothy Turnham, former director of the Melanoma Research Foundation, an advocacy group, said, “there is a disconnect between what researchers think is statistically significant and what is significant for patients. Patients hear ‘progress,’ and they think that means they’re going to be cured.” He was referring to chemotherapy approved for surrogate outcomes—a reduction of tumor size or some other result not affecting longevity.

Ad spending for cancer treatments has doubled in the five years ending in 2018. The total spent by cancer centers was $54 million in 2005 and $173 million by 2014. One group, Cancer Treatment Centers of America, did 60% of all the US cancer marketing that year. Another strategy is to frighten the public by telling them cancers are increasing. Most times, however, the fatality rate, which is the best measure of any cancer’s actual occurrence, has been unchanged for decades. 

One explanation could be that we are curing more cancers and saving more lives, but this is impossible—most of our treatments are ineffective or barely effective. These diseases are being discovered earlier and earlier by aggressive screening, which accounts for the increase in numbers. We promote anxiety, and we sell drugs. Most of the newly discovered tumors would go nowhere, even without treatment. In South Korea, ultrasonic screening diagnosed 15,000 people with thyroid cancer, resulting in thousands of radical thyroidectomies, all of which required lifelong thyroid hormone replacement. The surgery caused vocal cord damage in two percent.

However, mortality rates were rock-stable. This is proof that this early diagnosis had no benefit and harmed some (2).

Ineffective or barely effective cancer treatments are costing us a fortune. In 2014, US spending on oncology was $88 billion, and patients spent another $4 billion. Other estimates are closer to $100 billion now. The newest medications, often offering only a few months of progression-free survival, and not extending life at all, cost an average of $171,000 a year (2016). Some are $100,000 a dose. As I published this book, the prices were still higher. They seem to reflect an attitude of “grab what you can.” The industry mantra is that the newest is best, problems are a thing of the past, and that we must trust modern therapies. However, physician experience with many decades of new drugs debunks this. It takes years and thousands of patients before a medication can be deemed reliable. The most likely outcome with any novel treatment is failure or newly found toxicity. 

For example, the FDA approved a novel chemotherapy, the heavily hyped chimeric antigen receptor T-cell therapy. This uses genetically modified T white blood cells to kill cancer. The first drug in this class was approved in 2017, so long-term patient survival is unclear. It is mainly used for blood cancers, it sometimes has neurological side effects, and it may only work once. Then the tumors recur. One estimate of the costs, including hospitalizations, is $1.5 million per patient. Chemotherapy causes fatalities and dementia. For example, Avastin may produce a few months of survival advantage, or possibly the surrogate outcome of a few more months of disease-free survival. Unfortunately, when combined with certain other chemotherapy agents, it may make breast cancer patients die sooner. The FDA carelessly allowed it to be marketed for breast cancer in 2008, but three years later, followup studies showed heart attacks, bleeding episodes, and high blood pressure. The agency took the rare step of recalling it. Even if patients survive, post-chemotherapy mental impairment or “chemo brain” affects 30 percent of everyone treated. This can include memory loss, visual changes, and even brain shrinkage. Tamoxifen, the anti-estrogen drug used for breast cancer, also causes mental impairment. Estrogen is a vital support for many human systems. Women need it to function at their best, and it is important for men also.

The Skin Cancer Charade

I tried to become a dermatologist once. These specialists stay cleverly in their own world, avoid dealing with serious problems, and make a lot of money without losing sleep. It seemed like a masterful concept. I was an annoying young man, but through family connections and somehow conjuring a fragile veneer of charm, I got accepted into one of their most selective training programs. I thought this feat qualified me for the dermatologic lifestyle and wanted to spend my weekends hiking the Appalachian Trail. My mentors, however, thought I should spend 70 hours a week learning skin disease. After a year, they exposed me as a poseur and kicked me out. I viewed it as a personal failure, but the whole time, I smelled something fishy. I was too close to see clearly and I had plenty of problems, so I could not put my finger on it. Like the dermatologists who were unsuccessfully trying to train me, I did not know the history.

The modern era for skin doctors started in the 1980s when the American Academy of Dermatology hatched a plan to contrive an epidemic of dangerous skin cancers. A Madison Avenue public relations firm charged them two million dollars to come up with the idea. The proposal was for them to disease monger themselves from pimple poppers into fierce cancer fighters. After this, they evangelized about patients coming to their offices to get a complete skin examination. This would supposedly prevent a plague of skin cancers. 

The USPSTF later exposed this idea as worthless and said the screening frenzy was cultivating lucrative skin surgery rather than preventing cancer. One ploy involved proclaiming the skin bumps they call actinic keratoses or AKs precancerous (dermatologists love names and acronyms). Many seniors have dozens, if not hundreds of these. Since then, armies of skin doctors have been billing Medicare for treating millions of AKs with liquid nitrogen devices resembling tiny blow-torches. Studies show that over half of all these bumps disappear on their own. Only one percent change to skin cancer after a year and four percent after four years, and these are virtually all slow-growing and easily treatable.

At about the same time, to handle this pandemic, dermatologists dreamed up the most expensive skin procedure ever seen, “Mohs” surgery. Many of these specialists bill Medicare hundreds of thousands of dollars a year for this alone. I have an acquaintance who does ten of these cases every Friday and gets paid about $15,000 each. Patients spend up to a full day sitting around an accredited surgicenter operating room while dermatologists remove slices of their tumor bit by bit. They examine each morsel under the microscope as it comes off. A bill is submitted for each cut. There is another for processing each bit into a slide, and yet another for each look into the microscope. This goes on until they have removed all diseased tissue. After this, the area is “reconstructed.” This involves a lot of sewing, sometimes in areas as small as a dime. Insurance pays more if this is performed on a separate day, so the patient often gets sent home with a hole in their face. Sometimes the patients get referred to plastic surgeons, who may use surgical center charges and other tricks to make even more money. In return, the plastics try to dig up skin cancer cases to send to dermatologists for Mohs treatment. These get bounced back to them for reconstruction.

Note: Most people hear “Mohs,” and think it's an acronym. It isn't. Mohs surgery (technically, “Mohs Micrographic Surgery”) is named after Frederic E. Mohs.

At first, dermatologists did Mohs only for selected patients using careful criteria. Some areas of the body are critical for function and appearance, and their preservation can be essential. For example, this procedure produces excellent results for skin cancers of the nose and corners of the eyes. Other tumors have an octopus-like spread with indistinct borders. Here, Mohs is used to remove just the tumor with as little normal tissue as possible. These issues have all been worked out by dermatologists and published in their journals. The older methods involved scratching, burning, or cutting away skin cancers. The holes were often left to heal without stitches, and we would then follow the patient for recurrence. With the use of a greasy antibiotic ointment a few times a day, normal healing regenerates the skin within a few weeks. The results are typically reasonable, even on the face.

Although this is adequate for the vast majority of skin cancers, dermatologists now perform Mohs indiscriminately. Robert Stern, a Harvard dermatologist, said, “The decision to utilize [Mohs] is likely to reflect the economic advantage to the provider rather than a substantial clinical advantage for the patient.” He reported wide variations in usage by the practice and region and estimated that the costs of Mohs surgery in the US were $2 billion in 2012. A panel charged with developing reimbursement criteria produced vague guidelines that are used to justify almost anything. The experts who were making money made the rule—that they could do nearly anything they wanted. Mohs is primarily used to remove basal cell or squamous cell skin cancers, which rarely leapfrog to other areas of the body. It is not appropriate for melanomas, which surgeons remove along with a sizable chunk of surrounding tissue to prevent these metastases. Mohs primary advantage is that it reduces the chances of having to perform a second procedure for local recurrence. It also allows the surgeon to leave as much healthy tissue as possible.

The older, much less expensive method is to have the patient return a few months after cutting the skin cancer out to be sure there was no regrowth. This follow-up check takes only a few moments if no further work is necessary. Subsequent removal procedures are usually easy. Mohs surgeries are medically minor procedures that require only local anesthesia. But the fees are often higher than those for complex, lengthy, and hazardous general surgeries. Dermatologists spend money on lobbyists, who do their job defending exorbitant reimbursement for skin procedures. Melanoma is the only skin cancer that routinely metastasizes and kills people. The dermatologists almost universally refer these cases to plastic surgeons for removal and then to oncologists for chemotherapy. Few skin doctors want to get involved with a fatal disease.

But when the dermatologists became cancer slayers, they began crying about the exploding numbers of melanomas along with the other skin tumors. As a result, they discovered so many that they made the claim that melanomas were increasing faster than any other cancer. This epidemic now seems to be on the point of slaughtering anyone who dares to walk outside in sunlight. Left unsaid was that small, early tumors require only a simple procedure rather than an overpriced, supposedly complicated plastic surgery. Treating low-grade (thin) melanomas in seniors does not prolong their lives, either. However, once discovered, since progression into a fatal disease is unpredictable, they are cut off. Because of all this, far more melanomas are being identified, but the total deaths are not increasing. Like thyroid and kidney cancer, the disease-specific mortality for melanoma has not gone up one iota. All the extra procedures to chase them, however, cost us time, pain, money, and anxiety.

People over 85 years old get twenty percent of all Mohs surgery. Many are performed in the last year of life, and even in the last weeks before death. Demented people in nursing homes get frozen, biopsied, and operated on. These procedures hurt. The skin doctors even got approval for a code to bill insurance for pimple-popping or “acne surgery.” During my training, when I reached a certain stage, they slapped the specially designed pimple extractor into my hand. I felt like a general surgery resident who was finally being given the scalpel to do my first appendectomy (4).

Urology is the 5th Most Corrupt Medical Specialty

My friend John’s father is 80. Although he had no symptoms, he went to a urologist, who checked his “prostate-specific antigen” (PSA). It was high, so the doctor tried to enroll him in a medical treatment cascade, starting with a biopsy and probably ending with a painful, deforming radical prostatectomy surgery that would be unlikely to extend his life. The most common cause of an elevated PSA is a prostate infection, but John’s dad was never offered antibiotics.

Urology’s approach to this disease has undergone an embarrassing outing. The specialty traditionally recommends that the surgeon draw blood for prostate-specific antigen (PSA). The urologists also insert a finger into the patient's rectum to feel for prostate lumps.

If the blood test is high, or the surgeon feels nodules, they stick a large needle repeatedly through the rectum into the prostate to get tissue samples. If the biopsy shows cancer, urologists recommend perilous surgeries or other alarming therapies. This system has been discredited because it never improved survival rates for early disease.

The cancer is present but inactive in most men over 50. Only about twelve percent of men will be diagnosed with prostate cancer during their lives, and their five-year relative survival rate for this cancer after it is diagnosed (the percent with the disease who are alive compared to matched controls) is 97.8 percent. Ignoring it in the early stages produces the same results as treatment but without horrific surgical complications. The commonly performed operation, a radical prostatectomy, causes death in 1/200. Compromised or ruined sexuality and uncontrollable urination requiring diapers are common, often for the rest of a man’s life.

Some patients already have metastatic cancer before surgery. In these cases, it kills the patient even though he has suffered through the grisly procedure and recovery.

The PSA test is unreliable. It goes up with any prostate gland irritation due to factors such as infection or even bicycle riding. Antibiotics or anti-inflammatories are the treatments, not surgery. The vast majority of these tumors grow so slowly that death occurs from something else before the disease becomes an issue. PSA is little help in identifying aggressive cancers that would be fatal.

Here is a little math: The USPSTF (US Preventive Services Task Force) did a large-scale analysis of the research literature. They concluded that for every 1,000 men ages 55 to 69 who had their PSA checked every one to four years for a decade, it would save one man from prostate cancer. The number needed to test is 1000, over 10,000 patient-years, and who knows how many tests, possibly 50,000.

Even if you believe these small numbers are meaningful, the cost-benefit ratio is terrible. False-positive PSAs lead to biopsies, which have complications just like the true positives. Men with biopsies that show cancer get surgery or other treatments. The harms resulting from these interventions include erectile dysfunction, urinary incontinence, serious cardiovascular events, deep vein thrombosis, pulmonary embolism, and occasionally death. Checking PSA in asymptomatic men produces no improvement in survival.

The American Veterans Administration “PIVOT” trial compared surgery versus observation for localized prostate cancer over 13 years. There was no statistically or clinically significant difference in all-cause (absolute survival) or disease-specific mortality (relative survival). Prostate removal surgery is a net harm.

A Scandinavian study looked at 695 men with prostate cancer. They were divided into two groups. One had radical prostatectomy surgery, the other “watchful waiting.” With the surgery, the men were half as likely to die of the cancer (relative death rate). Their overall death rates from all causes (absolute deaths) at five and ten years were identical to those who did not have the surgery. Other researchers support these results.

By 2013, urologists partially responded to the heckling from the rest of the medical community. Their new guidelines recommended “individualizing” this test using “shared decision-making” between physicians and patients aged 55 to 69. This is misguided. Otis Brawley, head of the American Cancer Society until 2018, told the story of an unfortunate patient who was victimized by this system in his book How We Do Harm (2012):

Ralph entered the prostate cancer meat grinder after he had his PSA drawn in a shopping mall at a free cancer screening event. It was 4.3. He had twelve painful biopsies. Two of them showed moderate-grade cancer in about fifteen (15) percent of each specimen. Ralph read everything he could. He decided on robotic surgery because the advertising said it was “advanced.” It left him impotent and incontinent, and he required diapers for the rest of his life. His PSA several months later was .9. It would have been zero if the surgeon had entirely removed his prostate. He became obsessed with the idea that he still had cancer. So he went to a radiation oncologist who obligingly treated him with “proton beam therapy.” When he began seeing blood in his stools later, his surgeons found a fistula. This connects his urethra (urine tube) and his bowel. It was confirmed when he began passing bowel gas from his penis. The surgeons treated him by sewing his colon to the front of his abdomen with a “colostomy,” which required him to change a bag containing his stool several times a day. They also created a similar passage from his bladder to his belly, a urostomy. He still had both when he died of a severe urinary infection a few years later. He was 72.

The urologists, or at least the males, do not seem to understand the PSA math. Eighty percent of them and half the internal medicine specialists continue to test their own PSAs. Patients have little chance of understanding this if most physicians do not.

Like other diseases with expensive treatments, the prostate cancer industry has nonprofit “advocacy” associations growing in a dense thicket all around it. These universally promote PSA screening, which starts the cascade of billions of dollars in medical services. One organization, Us TOO, is 90 percent funded by the pharmaceutical and device companies that profit from this prostate circus. Zero, formerly the National Prostate Cancer Coalition, has funding from Amgen, AstraZeneca, Aventis, Cytogen, Merck, Pharmacia, and Pfizer.

Kimberly-Clark, the maker of Depends incontinence diapers, is another donor. Prostate cancer surgery sells a lot of adult diapers for them, and in 2021, they are advertising on TV using images of rough-looking senior men in diapers. Zero and the others claim to be independent, unbiased grassroots groups not beholden to any company.

Shared decision-making is an abdication of responsibility. We are losing trust in advisers who cannot advise. Fewer and fewer will shoulder responsibility in this age of lawsuits. Other People’s Money, a book about finance, explains the issue: “A good lawyer manages our problem; a bad lawyer responds to every issue by asking us what we want to do. When ill, we look for a recommended course of action, not a detailed description of our ailments and a list of references to relevant medical texts. The demand for transparency in finance is a symptom of the breakdown of trust.”

I recommend men pretend they do not have a prostate unless they get symptoms. (Disclaimer: I am not a prostate specialist. There may be advantages to these treatments that I did not find. Prostate cancer therapy has common themes with the rest of medicine, however. It is complex, and there are conflicts of interest. The treatment studies have large numbers, slight differences, and outsize claims.)

Many men cannot wrap their heads around the idea that they should not allow urologists to mess with their prostate. If you still do not get it and you think that there is merit in identifying prostate cancer at an early stage, consider magnetic resonance imaging (MRI) and, if necessary, laser treatment by a radiologist. These are currently the least invasive tests and therapies. If the MRI shows a tumor is likely, an imaging specialist can put a guided sampling needle into the suspicious area(s). This results in a diagnosis rate of 90 percent after only one or two sticks.

Contrast this with the usual dozen “random” biopsies that discover only about half of the cancers. You are left sore and in limbo, anticipating a new round of biopsies a year later. Or, if you received a cancer diagnosis, you have to start considering radiation or horrifying, ineffective surgery on your most private parts.

However, with MRI guidance, a laser can accurately burn tiny cancer spots. You do not get complications from surgery or radiation. Only a few centers in the USA offer this expensive but safe and accurate method. These include Desert Medical Imaging (now Halo Diagnostics) in Palm Springs, CA, and affiliates nationwide. They also offer a noninvasive treatment for benign prostatic hypertrophy using this same technology.

Since radical prostatectomy for prostate cancer is a multi-billion-dollar surgical industry, these radiologists receive a brutal reception at urological surgery meetings and are not allowed to speak. However, the standard approaches are outdated and deforming, require years of care, and have horrible outcomes.

Note: all of these therapies are doubtful because the radiologists, like the surgeons, primarily treat low-grade prostate cancer, which rarely kills anyone. Since I can do without needles stuck in my tender places, I refuse to check my PSA ever again unless I have symptoms.

Prostate cancer that has spread or metastasized outside the gland is a different issue. For more than 50 years, synthetic estrogen has been used effectively and inexpensively to treat this, and some doctors still use it. Bio-identical estradiol is available now and should be used instead of the older horse estrogen compounds. For many patients, this suppresses the tumor, and they feel fine. The PSA should be checked at intervals to make sure.

Casodex and Lupron are the patented, expensive anti-testosterone drugs that are the current “standard of care” for metastatic prostate cancer treatment. They typically work for about five years, and then the cancer comes back. They cause heart disease, Alzheimer’s, and osteoporosis and make patients feel terrible. Otis Brawley speculates that they produce more deaths than they prevent:

Lupron is one of urology’s many embarrassments.

This is a “chemical castration” medicine, approved in 1985 to treat metastatic prostate cancer. It did not sell well until the company figured out how to pay off the surgeons. They developed a long-acting monthly shot, and urologists could buy it wholesale and retail it in their offices. This was a nasty conflict of interest that made patient care secondary.

The company increased the temptation further by giving the doctors samples. This enticed them to sell the freebies to patients and keep the money, which is illegal. Medicare paid $1200 for one of these shots. Urologists could make several hundred thousand dollars a year on this. Internally, the manufacturer called these doctors their “drug whores.” Lupron treatments accounted for 40 percent of all Medicare payments to some of these practices in the late 1990s.

After a whistleblower lawsuit and years of litigation, federal prosecutors settled this “nationwide conspiracy.” The manufacturer paid $885 million, and no corporate executives were imprisoned. The industry now skirts illegality by paying doctors an administration fee for using Lupron instead of providing free samples.

The worst part of this story is that Lupron is an atrocious drug. Men feel terrible, get hot flashes, and become impotent. Some have weight gain, fatigue, muscle loss, anemia, Alzheimer's disease, and osteoporosis. It also causes strokes, heart attacks, diabetes, and sudden death.

Otis Brawley, former head of the American Cancer Society, says men are dying earlier because of Lupron therapy. This drug and others have decreased prostate cancer deaths by 30 percent since 1990, but all-cause deaths may have increased because the drug is so toxic:

Widespread use of [anti-] hormonal agents is causing men to die of cardiovascular disease and diabetes before they would ordinarily die of prostate cancer. That’s what I suspect is taking place. If urologists stop prescribing these drugs as widely as they used to, we will see deaths from prostate cancer inch up. That could be good news. Some men who would have died earlier with strokes and heart attacks caused by hormonal treatments of their asymptomatic disease would now live long enough to die of their prostate cancer.

How We Do Harm (2012)

My friend Paul had his PSA checked every year. When he was 73, it jumped to 10 (normal is 4.0 ng/mL or less). Even though Paul felt fine, he went off to see the urologists, who obligingly biopsied his prostate. They found a tumor and now use a Lupron shot every few months to “block” his testosterone. Medicare pays them a nice injection fee. Paul feels terrible and will likely die sooner of heart disease because his testosterone levels are low.

Estrogen is a far better treatment. It is cheap, works for many, and has few side effects. Fifty years of experience show it controls metastatic prostate cancer, and although they are not interested in sex, it does not feminize men. Since companies cannot patent substances identical to those in the human body, they do not promote drugs like this. (Occasionally, delivery systems such as the estrogen patch or a supposedly unique drug strength are used to justify patent protection. For these medications, windfall profits can still be made.)

CANCER TREATMENT CONCLUSION 

Honest physicians place their patients’ interests ahead of their own. This is not always happening for cancer treatments. To an outsider like me, much of oncology seems like a toxic, expensive failure. Some of these treatments prey on people during their defenseless time at the end of their lives. But some work, some are cures, and a few are miracles. You have to do your research, make your decisions, take your chances, and stay hopeful. This field may be changing more rapidly than any other, and some of the outrageously expensive new drugs work. Dermatologists self-promote and disease-monger. Most of the diseases they handle are cosmetic or nearly cosmetic. Just like the others, both these specialties cannot resist reaching for all the insurance money stacked around them.

Sources: Excerpts from Chapter 27 and Chapter 28 of the book by Dr Robert Yoho: Butchered by "Healthcare" (Available on Amazon)