Best Probiotic Strain for Anxiety 2022

A probiotic is live micro-organisms, usually found in foods such as yogurt, kefir, and fermented vegetables. It is also available as dietary supplements. Probiotics are thought to help regulate digestion, immunity, and mental health. They are often referred to as "good bacteria" because they help to balance the levels of beneficial and harmful bacteria in the gut. 

Connection Between Probiotics and Mental Health

Lactobacillus Helveticus R0052 and Bifidobacterium Longum R0175 for Anxiety

A recent study performed in the general population, Lactobacillus helveticus R0052 and Bifidobacterium longum R0175, taken daily in combination for 30 days, decreased over time the global score of the hospital anxiety and depression scale (HADs) and the global severity index (GSI) of the Hopkins symptoms checklist, due to the decrease of the sub-scores of the “somatization”, “depression” and “anger-hostility” spheres. 

The results suggest that in the general population, this formulation is beneficial in reducing anxiety and stress response, as well as improving mood in moderately stressed human subjects.

Lactobacillus Rhamnosus for Anxiety

A study suggests that intervention with Lactobacillus rhamnosus and Lactobacillus paracase can alleviate in mice the behavioural and neurological changes induced by chronic stress.

Moreover, lactobacillus rhamnosus may be useful for the prevention or treatment of symptoms of depression and anxiety postpartum. According to one study, women who received Lactobacillus rhamnosus had significantly lower depression and anxiety scores in the postpartum period.

Best Probiotic Strain for Anxiety

1. InnovixLabs Mood Probiotic, 60 Capsules, Lactobacillus helveticus Rosell-52ND & Bifidobacterium longum Rosell-175

- Innovation in Probiotic Science
InnovixLabs’ Mood Probiotic is a supplement containing a select group of probiotic bacteria that have been studied for their effect on mood and brain function. These bacteria are sometimes called ‘psychobiotics.’*

- Clinically Studied for Mood Health 
New research reveals a connection between gut health and mood. InnovixLabs’ Mood Probiotic is formulated with 2 unique clinically studied strains: Lactobacillus helveticus Rosell-52ND and Bifidobacterium longum Rosell-175.*

- Tested for Purity, Potency, and Freshness
InnovixLabs’ probiotic supplements are cultivated and encapsulated in Canada. They are tested and packaged in the USA. All batches are tested and verified by in-house and third-party labs for your peace of mind. Manufactured in a cGMP certified facility for safety and reliability.

- Made Without
Mood Probiotic is made without eggs, corn, fish, shellfish, tree nuts, peanuts, wheat/gluten, sugar, GMOs, yeast, Chinese ingredients, and artificial colors or flavors. It may contain trace amounts of soy/milk used in the fermentation process.

4.4 out of 5 - more than 1,050 global ratings

InnovixLabs Mood Probiotic Reviews
I’ve never written a review for anything before but this probiotic has changed my life so much that I had to review it! I’ve been on and off antidepressants my entire life. I decided to add this in a last ditch effort to help my seasonal “extra” depression and anxiety. It’s been 1 week and I notice a significant difference in my mood and anxiety. My motivation is back again and I look forward to my day. I cannot tell you how long it has been since I’ve felt that way.

2. Lifted Naturals Mood Boosting Probiotics Supplement

- Targeted "Feel Good" Strains
This formula features the TOP performing bacterial strains to help with mood. It also offers digestive, immune support.

- 9 Nourishing Strains 
In addition to B. Infantis and B. Longum, we included seven more strains (9 various strains total) to ensure healthy digestion, immunity and mood support

- Shelf Stable
(No refrigeration required.) No worries if you need to travel! Just throw a bottle of our probiotics in your bag and you'll be good to go!

4.3 out of 5 - more than 2,050 global ratings

There was a period of 3 years where I had no anxiolytic whatsoever and I had to find my own way of coping. This one I found when I looked under anti-anxiety supplements on Amazon. It took about a month of taking one a day and it decreased my anxiety by about forty percent. I kid you not. It made such a difference that I have continued taking it for the last 3 years, even though I now have the medication I need. I don't know much about probiotics, but I know they help regulate your digestive system as well. It was a lifesaver for me, so why not continue taking it. 

I tell everyone who has anxiety on social media to try it. I'm so glad I found this wonderful product. Yes it's expensive, but I reserve my money to buy this because it's worth every penny. Be patient though, it takes a month or so and you'll start feeling it's effects.

3. Life Extension Florassist Mood

- Stress Less with This Specialty Probiotic 
This proprietary blend of probiotic strains Lactobacillus helveticus Rosell-52 and Bifidobacterium longum Rosell-175 has been linked to a improved stress response—plus, the gastrointestinal support you’d expect from a probiotic.

- Gut Feelings Should Be Good Feelings
Believe it or not, digestive health is tied to your mood. This blend of probiotics and clinically studied saffron extract supports a balanced mood and brain health.

- Banish the Butterflies from Your Stomach
Sometimes, worries can unsettle your stomach. FLORASSIST Mood relieves minor digestive discomfort that can accompany everyday stress.

- Ingredients Matter
Sourced using only the finest raw ingredients with the purity and potency your body deserves; This product is certified non-GMO and gluten-free; Manufactured in the USA and a Certificate of Analysis is available

Helped with my nervous/stress stomach and the saffron definitely helps with my hormone induced depression and anxiety. Helps me to sleep. Highly recommend. Cheaper than CBD with less side effects.

4. Lifted Naturals Probiotics Mood Super Strains Probiotic

L. rhamnosus (GG), B. longum, B. bifidum, B. lactis, B. breve, B. infantis

Just probiotics. No prebiotics. No fillers. Targeted super strains designed to help with mood, featuring L. Rhamnosus GG*

- D-lactate free & histamine free. 
- 30 billion CFU with key strains for mood and digestion make it a probiotic offering digestive, immune, and mood support*
- high quality and shelf stable.
- no refrigeration required!*

4.3 out of 5 - more than 500 global ratings

Hands down the best probiotic for anxiety, depression, and D-Lactate free bacteria strains! They are great for inflammation in the body without a histamine response, as well as people who suffer from ADHD or Autism! These are the same strains found in Custom Probiotics blend, but for a fraction of the price ($28 vs $105). My wife and I find that we are now completely regular as well. Highly recommend!

5. Inessa Advanced Daily Biotic, Probiotics Lactobacillus Rhamnosus (LGG)

- Gut, Digestive, and Autoimmune Support
Our Vegan Daily Biotic supplement leverages the most studied strain, Lactobacillus rhamnosus (LGG) you need to support improvement in gut, digestive and immune support. Taking just 1 capsule a day brings you the support you need for everyday general health and wellbeing.

- Evidence Based Dose
Inessa’s Advanced Daily Biotic provides 10 billion live bacteria in each vegan delayed-release capsule, which aligns with the optimal daily dose of Lactobacillus rhamnosus (LGG). This powerful strain is more important than using multiple strains at a higher dose like those inferior ”padded” powder strains like other probiotics out there.

- Delayed Release Technology
Lactobacillus rhamnosus (LGG) delivery is improved with delayed-release capsules as stomach acid can destroy bacteria and reduce their ability to reach the digestive system alive. Although Lactobacillus rhamnosus (LGG) has good acid resistance, our Daily Biotic’s delayed-release capsule technology improves survival of the bacteria, and delivers them alive to the gut to offer maximum benefit and result in a lower dose requirement.

- Guaranteed to Arrive Alive 
We pride ourselves in the use of the highest-quality ingredients in our Advanced Daily Biotic. Every Inessa Formulation is prepared in cGMP laboratories, then meticulously inspected by the strictest 3rd party laboratories in the world, ensuring it’s the most powerful, pure, potent, safe, and effective womens and mens probiotic.

4.4 out of 5 - more than 1,000 global ratings

I can honestly say that since I’ve started taking this probiotic, I feel normal the first time in 20 years. I am getting my life back. I don’t even know what to do with the free time I’m no longer spending dealing with my flare ups, but you better believe I’m going to do some fun things!

I have used other brands of lactobacillus rhamnosus in the past without the same positive effects as this one, and I believe it was because most come in much lower doses. This 10 billion CFU seems to do the trick! I actually take 2/day. Once in morning, once at night.

6. Supersmart Lactobacillus Rhamnosus GG

- What is it?
Lactobacillus Rhamnosus supplement is a probiotic strain that provides 10 Billion of Micro-Organisms (Cfu) a Day. Contains LifeinU Lactobacillus rhamnosus GG (10 billion micro-organisms), Inulin | Other ingredients : Acacia gum, rice bran.

- Benefits
It supports both healthy intestinal & vaginal flora as well as promoting digestive confort. This supplement is recommended for restoring balance to gut flora.

Take 2 DrCaps (Gastro Resistant Capsule) Daily

Good quality product. Digestion and mood feel good due to this product. Would highly recommend!

7. Life Extension Bifido GI Balance - Probiotics Bifidobacterium Longum BB536

- The Friendly Bacteria
Bifidobacterium longum BB536 is a kind of bacteria, but don’t worry: it’s the good kind! It lives in your digestive system and helps your body do everything from break down the foods you eat to mount a healthy immune response!

- Digestive Health
Bifidobacterium occur naturally in your digestive system. These digestive helpers break down the food you eat and maintain a healthy ratio between the good bacteria in your digestive tract and the unwanted ones. Many factors of everyday life, including getting older, can cause those populations to decline — that’s why a high-quality supplement is key.

- Immune Health
This supplement delivers Bifidobacterium longum BB536, a special strain of bifidobacterium that has been studied for its ability to encourage a healthy immune response—including support against seasonal immune challenges.

- Ingredients Matter
Sourced using only the finest raw ingredients with the purity and potency your body deserves. This product is certified non-GMO and gluten-free. Manufactured in the USA and a Certificate of Analysis is available for every product we produce.

4.4 out of 5 - more than 300 global ratings

Well the introduction of this strain to my gut must have caused a significant shift in the balance of bugs in my belly because I’ve experienced some significant changes since taking it. I originally sought out this strain because I read a study indicating that it could help reduce anxiety. I’ve felt a significant reduction of anxiety and increase of confidence since I started taking it.


a. Understanding Anxiety Disorder

b. Signs You Need Probiotics

  • Digestive irregularity
  • Your metabolism is a bit slow
  • You’ve taken an antibiotic, even if it was a long time ago. Antibiotic can kill both bad and good bacteria, as the result, you may need probiotic to balance your gut bacteria.
  • You’ve got some skin issues like eczema, psoriasis, and itchy rashes
Above all, these symptoms are not always linked to a lack of probiotics. Best to talk with your doctor for a diagnosis.

c. How Do You Know if Probiotics Are Working?

When you take a high-quality probiotic supplement, you may feel a variety of benefits in your body, from better digestion and energy to a better mood and clearer skin. Improved digestion is frequently the first and most noticeable change people will notice.

The probiotic bacteria help to restore your gut flora, which can enhance things like bowel movement frequency and regularity while also reducing bloating and gas.

d. Connection Between Probiotics and Antibiotics

There are already good and bad bacteria live in your body. The good bacteria help keep you healthy, by boosting your immune system and preventing illness.

Bad bacteria, on the other hand, can get in and cause illness. Antibiotics can kill bad bacteria, but they usually kill a lot of healthy bacteria as well. This is where probiotics can help, by balancing your gut bacteria.



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