8 Best Formula for Reflux and Lactose Intolerance 2022

Acid reflux and lactose intolerance are some common problems in infants. Acid reflux is what happens when stomach contents and acid flow back up into the throat, where as lactose intolerance happens when infant is unable to digest the lactose found in milk and dairy products. Symptoms of lactose intolerance in infants can include bloating, gas, abdominal pain, and diarrhea.

The best formula for reflux and lactose intolerance is a hypoallergenic formula. This formula contains protein that has been hydrolyzed into very small proteins, making them easier for a baby’s body to digest.

There are two main types of hypoallergenic formula available, including: 
  • Extensively Hydrolyzed Formula (EHF): EHF is made from proteins that have been extensively broken down, making them easier to digest. This formula breaks down the milk proteins into even smaller pieces than partially hydrolyzed formula.
  • Amino Acid-Based Formula (AAF): AAF is the most hypoallergenic of the formulas available. This formula has been broken down so extensively that only amino acids remain. Because amino acids are the building blocks of proteins, the baby receives all of the nutrients included in standard formula without having to break down the protein internally.

Best Formula for Reflux and Lactose Intolerance

A. Extensively Hydrolyzed Formula (EHF)

1. Enfamil Nutramigen Infant Formula, Hypoallergenic and Lactose Free Formula with Enflora LGG

- Helps to Ease Colic
Delivers clinically proven relief when managing colic due to cow’s milk allergy for a happier, better-rested baby & mom

- Fast Relief Now
As early as the first feeding, with 90% of infants improving within 48 hours

- Includes LGG
The most extensively studied probiotic for allergy management and supporting the digestive health of your baby

- Brain Support
Nutramigen is a gentle, lactose free baby formula that has important nutrients found in breast milk such as omega-3 DHA, ARA, and choline that provide brain support

- Immune Support
Helps support baby's immune system to return to consuming traditional milk protein formula without an allergic response

4.7 out of 5 - more than 9,750 global ratings

We tried several formulas and everything made our daughter throw up. We don't know for certain that she has a lactose allergy but once she started taking this she no longer needed her acid reflux meds and rarely throws up. Worth every single penny. Definitely lives up to the "liquid gold" reputation.

2. Gerber Good Start Baby Formula Powder, Extensive HA, Hypoallergenic, Stage 1

Gerber Good Start Baby Formula Powder, Extensive HA, Hypoallergenic, Stage 1

- Hypoallergenic Nutrition
This hypoallergenic formula is designed for babies with cow’s milk protein allergies (CMPA). If your baby is suspected to have or is diagnosed with CMPA, your baby’s doctor might recommend changing from a routine formula to a hypoallergenic extensively hydrolyzed infant formula

- For Cow's Milk Protein Allergy
Cow’s milk protein allergy is the most common allergy among infants. This formula features 100 percent high-quality whey protein, broken down into tiny pieces and is designed to be well-tolerated

- Give Your Baby a Good Start
Your baby’s nutritional needs evolve over time. That's why we created the Gerber Good Start line. Made to comfort your baby's tummy and available in a range of products

- Gerber Goodness
Our foods start with whole ingredients like real fruits, veggies and grains to help nourish your baby right from the start, from infant formula to baby food to snacks and toddler food

- Wholesome Options
Introduce your infant or toddler to fruits, veggies and other wholesome ingredients with Gerber infant formulas and breastfeeding supplements, cereals, puree pouches and tubs, snacks and more

4.3 out of 5 - more than 750 global ratings

Our baby was having trouble gaining weight and controlling acid reflux. This was the only formula that he didn’t have issues with. Thankful we found it when we did and glad he was able to put on weight after switching to this.

3. Similac Alimentum with 2’-FL HMO Hypoallergenic Infant Formula

- Hypoallergenic Formula
Our formula is suitable for lactose sensitivity and has broken-down protein that is easy to digest for babies with food allergies or colic due to protein sensitivity

- Start Feeling Better Today
Similac Alimentum starts reducing colic symptoms due to protein sensitivity within 24 hours in most infants*

- With an Immune Nourishing Ingredient
First and only hypoallergenic formula with 2’-FL HMO, an immune-nourishing ingredient

- EBT Eligible
Eligible to be purchased with Supplemental Nutrition Assistance Program (SNAP) benefits in select stores; The SNAP name is a service mark of the US Department of Agriculture The USDA does not endorse any goods, services, or enterprises

4.8 out of 5 - more than 4,300 global ratings

I stopped producing milk when my little one hit 4 months and switched to this because of her dairy allergy. She's packed on so much weight and is healthy as can be. Fixed hee reflux too!

4. HiPP HA (Hypoallergenic) Formula Stage 1 from Birth 600g


Hipp HA formula is a hypoallergenic formula that is suitable for babies with milk protein allergies. Milk protein can be an important factor to trigger allergies. The Hypoallergenic (HA) protein diet contains milk which is split in simple molecules. This reduces the risk of allergies. The protein formula used in Hipp is completely hydrolyzed and was proven by studies to prevent allergies.

A low-allergen diet cannot give complete protection but reduces the risk of allergies in infants. The HA formula should stay constant for 4 to 6 months in order to produce best results. A small amount of non-hydrolyzed protein can promote sensitivity and destroy the benefits of the low-allergen diet.

Hipp HA Formula Review
Love this! Easy absorption! No bitter taste. My baby loves it! Highly recommend.

5. Enfamil Pregestimil Infant Formula with DHA & ARA

Enfamil Pregestimil Infant Formula with DHA & ARA

Pregestimil is specially designed for infants who experience fat malabsorption & who may also be sensitive to intact proteins.
  • It contains 55% fat from MCT oil, which is more easily absorbed by babies with some GI problems.
  • Hypoallergenic suitable for someone with lactose intolerance
  • 55% of the fat from MCT oil
  • Designed for infants with fat malabsorption problems
  • Has DHA & ARA—important nutrients also found in breast milk that promote brain & eye development
  • Perfect for plan-ahead feedings
Enfamil Pregestimil Infant Formula Review
When my son was 2 months old he was diagnosed with a severe milk protein allergy. His stomach lining was torn severely causing bloody diapers and lots of pain. We had tried nutramigen and aulimentum and many other kinds with no success. 

Finally after a few days in the hospital his doctor suggested this formula. After a week of using it he was a completely different baby! He started sleeping through the night, smiling, laughing and barely cries. It's been a lifesaver. 

B. Amino Acid-Based Formula (AAF)

6. Enfamil PurAmino Hypoallergenic Infant Formula

- Suitable for Tube Feeding
Puramino is appropriate for both oral and tube feeding

- Why Choose PurAmino
PurAmino is an iron-fortified, hypoallergenic, amino acid-based infant formula for the dietary management of infants with severe cow’s milk protein allergy (CMA). PurAmino can be an infant's sole nutrition source through 6 months of age, and be a major supplemental nutrition source up to 2 years old

- Suitable for Many Dietary Conditions
PurAmino is also suitable for other conditions that may require an elemental diet including - Eosinophilic esophagitis, short bowel syndrome, malabsorption, Protein maldigestion

- Expert Recommended DHA
PurAmino has expert recommended DHA which provides brain-building nutrition

- Hypoallergenic
100% Amino-Acid based, iron-fortified formula, suitable for infants & toddlers with lactose intolerance


4.7 out of 5 - more than 700 global ratings

Enfamil PurAmino Hypoallergenic Infant Formula Reviews
It took a few weeks and adding some Splenda but our baby girl is spitting up a lot less now finally at 7 months. She had bad acid reflux and a serious protein allergy. This formula is not tasty but it's very broken down and good for tummies that have been overworked by allergies or anything else. She will drink it now for the most part without the Splenda.

Our baby girl is now 11 months old. She is still on Pure Amino and I still think it was a life saver. We are struggling with the cost these days, but she is as healthy as any other baby her age these days and we have this formula to thank for it.

7. Alfamino Infant Amino Acid Based Infant Formula with Iron

- Amino Acid Based Infant Formula 
Alfamino is a hypoallergenic amino acid based infant formula designed for infants with cow's milk protein allergy, multiple food allergies or malabsorptive conditions. Appropriate for conditions of severe malabsorption, Alfamino formulas offer unique compositions with tailored nutrient profiles and highly selective ingredients

- Nutritionally Complete Formula
Alfamino provides essential nutrients that infants need for growth and development and has a unique fat blend containing medium chain triglycerides (MCT) to facilitate fat absorption

- Use Under Medical Supervision
Alfamino Infant Formula is easy to digest and is lactose free and gluten free; For infants 0 to 12 months

- Nutrition Solutions
Nestlé Health Science’s portfolio of nutrition solutions targets health areas, such as pediatric and acute care, surgery, weight management, healthy aging and gastrointestinal health

4.5 out of 5 - more than 350 global ratings

Alfamino Infant Amino Acid Based Infant Formula Reviews
Nothing to dislike here. I was a bit worried at first about purchasing this formula online since there are a lot of scammers out there, but this came through. My youngest was born with an allergy to the protein in my milk, so I ended up having to switch to this special formula. Thank you!

8. Neocate Infant - Hypoallergenic, Amino Acid-Based Baby Formula with DHA/ARA


- Medical Food
Dairy-free, Soy oil free hypoallergenic formula for use under medical supervision

- Hypoallergenic
For the dietary management of cow milk allergy (CMA) and multiple food allergies (MFA)

- With Nucleotides and DHA/ARA
DHA/ARA supports brain and eye development

- Nutritionally Complete for Infants 0-12 Months
Provides key nutrients to support normal growth and development

4.6 out of 5 - more than 800 global ratings

This formula is a life saver for us as our child suffers from severe acid reflux and is allergic to dairy products. Always ships quickly and our child loves it.


a. How Do I Know if My Baby Needs Hypoallergenic Formula?

i. Extreme Irritability
If your baby cries for long periods of time and/or seems unconsolable, it may be a good idea to discuss this with your doctor. He can evaluate your baby further and help diagnose a cow’s milk allergy. In this case, switching to a hypoallergenic baby formula may help your baby’s symptoms.

ii. Family History of Food Allergies
If you or a member of your family has a history of food allergies, your baby is more likely to have one as well. An extensive French study done in 2019 showed a strong genetic link in cow’s milk protein allergies (CMPA).

iii. Constant diarrhea / vomiting

iv. Your baby has acid reflux (GERD)
Acid reflux is what happens when stomach contents and acid flow back up into the throat. This is a common problem in infants, especially those below 3 months old. Hypoallergenic formula may help reduce the symptoms.

v. Eczema
Your baby’s skin is sensitive, which can make it difficult to tell the difference between dry skin and eczema. Eczema is extreme dry skin that is red, inflamed, itchy, and often cracked. Babies with eczema are more likely to develop food allergies and oftentimes will develop skin symptoms before other food allergy symptoms appear. (Source)

vi. Respiratory Issues
If your baby is wheezing or experiencing other respiratory issues, your baby may need immediate medical attention. See a doctor as quickly as possible.

Above all, if you're unsure, best consult a doctor for determining the best formula for your baby.

b. When Will My Baby's Reflux Go Away?

A normal baby with mild acid reflux may spit up after feedings, but usually isn’t irritable. This problem usually stops after 12 months.

c. How can I treat my baby's reflux naturally?

  • Avoid overfeeding. If the baby's stomach is too full, some of the contents might be pushed back out. To reduce overfeeding, feed your baby smaller amounts more frequently.
  • Burp your baby frequently. Extra gas in the stomach causes gas bubbles to escape, which has a tendency to bring the rest of the stomach's contents up as well. Burp after and during meals.
  • Limit active play after meals
  • Hold your baby upright. Pressing on a baby's belly right after feeding may push their stomach contents out. 
  • Consider the formula. Frequent vomiting may serve as one of several signs that it's time to consider alternative formulas with your pediatrician. 
  • Give oatmeal. Only recommended for babies after 6 months old. Babies with reflux may need thicker food to order to swallow safely or reduce reflux. 
  • Avoid tight diapers or clothing



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