7 Best Probiotics for Mental Health 2023

A probiotic is live micro-organisms, usually found in foods such as yogurt, kefir, and fermented vegetables. It is also available as dietary supplements. Probiotics are thought to help regulate digestion, immunity, and mental health. They are often referred to as "good bacteria" because they help to balance the levels of beneficial and harmful bacteria in the gut.

The Connection Between Brain and Gut

The gut and the brain are linked through the gut-brain axis, a two-way communication system between the digestive system and the nervous system. This connection is largely mediated by the vagus nerve, hormones, and neurotransmitters. The gut-brain axis helps to regulate digestive processes, mood, stress response, and other cognitive functions. Additionally, the bacteria in the gut microbiome can affect how the gut and the brain communicate.

Watch: The Brain-Gut Connection: Anxiety & Stress Coming from Missing Gut Bacteria – Dr.Berg

How Do Probiotics Help Mental Health?

Probiotics have an impact on mental health by supporting a balanced microbiota in the gut. They are essential for proper digestion and nutrient absorption. According to several studies, certain mental health disorders like anxiety, depression, and schizophrenia may be related to the gut microbiome's composition. It has also been shown to reduce stress and improve mood, which can also contribute to improved mental health.

Probiotics Can Help Anxiety and Depression

A recent study performed in the general population, Lactobacillus helveticus R0052 and Bifidobacterium longum R0175, taken daily in combination for 30 days, decreased over time the global score of the hospital anxiety and depression scale (HADs) and the global severity index (GSI) of the Hopkins symptoms checklist, due to the decrease of the sub-scores of the “somatization”, “depression” and “anger-hostility” spheres. 

The results suggest that in the general population, this formulation is beneficial in reducing anxiety and stress response, as well as improving mood in moderately stressed human subjects.

In addition to those two strains, lactobacillus rhamnosus can also be useful for the prevention or treatment of symptoms of depression and anxiety postpartum. According to one study, women who received Lactobacillus rhamnosus had significantly lower depression and anxiety scores in the postpartum period.

Probiotic Benefits for Autism

Research has determined that a large percentage of individuals with autism spectrum disorder (ASD) suffer from gastrointestinal symptoms, and a growing number of studies point at a correlation between the two. 

Probiotics appear to be an important dietary component and a potentially side effect free therapy that can be proposed to treat GIS and ASD symptoms, by correcting the dysbiosis. Moreover, probiotic may also help to reduce inflammation, and reinforce depleted immunity.

Probiotics Offer a Potential Treatment Strategy for Schizophrenia

Due to the adverse effects of antipsychotic drugs and higher levels of stress as a result of their condition, people with schizophrenia may have poor digestion. Therefore, probiotic supplementation may provide a helpful strategy to prevent some of their gastrointestinal symptoms. Probiotic supplementation is considered safe and well-tolerated in patients with schizophrenia.

Best Probiotics for Mental Health

1. Garden of Life Dr. Formulated Probiotics Mood+


- Doctor Formulated Probiotics for Emotional Well Being and Relaxation
Mood Probiotic provides 50 Billion CFU and 16 Probiotic Strains including Clinically Studied probiotics, plus 350 mg of Organic Ashwagandha and Alaskan Blueberry for stress management

- Digestion Support Backed by Science
Emerging science shows a link between gut and brain health; this supplement for mood includes L. helveticus ROO52 and B. longum RO175—Clinically shown to support mood and relaxation—plus Lactobacillus acidophilus

- Stress Management and Prebiotics for Women and Men
Our prebiotic supplement with Organic Acacia and Potato prebiotic fiber to help feed good bacteria in the gut, plus a blend of Ashwagandha and Blueberries for stress management—in just 2 capsules a day

- Probiotic Potency Guaranteed Through Expiration
We begin with high levels of probiotics to ensure viability, even if the product is warm for a few days during shipment—especially during summer or in warmer climates; Shelf stable, no need to refrigerate!

- Third Party Certified Non GMO and Gluten Free
Proudly manufactured following current good manufacturing practices (cGMPs) and Third-Party certified, so you don't have to settle for less than Non-GMO Project Verified and NSF Certified Gluten Free

4.6 out of 5 - more than 6,100 global ratings

Garden of Life Dr. Formulated Probiotics Mood+ Reviews
I've struggled with depression for decades and take medication for it. However, I still didn't feel HAPPY, I always felt stressed or just non-energetic. my doctor wanted me to take a probiotic, and I started with the pink bottle and felt it helped my digestion a lot. I found this when it was time to reorder and within a week I could feel the change. My energy was up a good 25% and my outlook on life was much less cloudy. I haven't felt this good in years. I can't recommend this product enough!

2. Lifted Naturals Mood Boosting Probiotics Supplement

- Targeted "Feel Good" Strains
This formula features the TOP performing bacterial strains to help with mood. It also offers digestive, immune support.

- 9 Nourishing Strains 
In addition to B. Infantis and B. Longum, we included seven more strains (9 various strains total) to ensure healthy digestion, immunity and mood support

- Shelf Stable
(No refrigeration required.) No worries if you need to travel! Just throw a bottle of our probiotics in your bag and you'll be good to go!

4.3 out of 5 - more than 2,050 global ratings

I can't believe how much of my life I have wasted from gastrointestinal discomfort throughout most of the morning after taking supplements, vitamins, and medications (mostly since I had my gall bladder removed 8 years ago). Now I add one of these pills into my morning regimen and not only is the discomfort gone, so is most of my anxiety. 

My general mood throughout the day has even improved far beyond what any anti-depressant medication has ever done for me, and I've tried them all. It never occurred to me that gut health is directly connected to mental health as no doctor has ever mentioned this to me, probably because psychiatrists know nothing about gastroenterology and vice versa.

3. InnovixLabs Mood Probiotic, 60 Capsules, Lactobacillus helveticus Rosell-52ND & Bifidobacterium longum Rosell-175

- Innovation in Probiotic Science
InnovixLabs’ Mood Probiotic is a supplement containing a select group of probiotic bacteria that have been studied for their effect on mood and brain function. These bacteria are sometimes called ‘psychobiotics.’*

- Clinically Studied for Mood Health 
New research reveals a connection between gut health and mood. InnovixLabs’ Mood Probiotic is formulated with 2 unique clinically studied strains: Lactobacillus helveticus Rosell-52ND and Bifidobacterium longum Rosell-175.*

- Tested for Purity, Potency, and Freshness
InnovixLabs’ probiotic supplements are cultivated and encapsulated in Canada. They are tested and packaged in the USA. All batches are tested and verified by in-house and third-party labs for your peace of mind. Manufactured in a cGMP certified facility for safety and reliability.

- Made Without
Mood Probiotic is made without eggs, corn, fish, shellfish, tree nuts, peanuts, wheat/gluten, sugar, GMOs, yeast, Chinese ingredients, and artificial colors or flavors. It may contain trace amounts of soy/milk used in the fermentation process.

4.4 out of 5 - more than 1,050 global ratings

InnovixLabs Mood Probiotic Reviews
Very easy to swallow with no after taste. I definitely feel better when I’m consistent with taking these. They help my gut and my mood. So many people don’t realize the direct connection between your gut health and mental health, a good probiotic is essential but add in the extra mood support along with the probiotic and you golden. It’s not a miracle cure for debilitating depression but it’s a great supplement to help with your overall mental healthy and getting you where you need to be.

4. Klaire Labs Target gb-X Gut Brain Axis - Mood Probiotic Powder

A specialty shelf-stable probiotic formulation targeted to provide robust gut-brain axis support*. Clinically demonstrated to support positive mood.*

- 5 billion CFU (9-strain) blend in 30 single-serving sachets
- no refrigeration required. Protected by PROBIOACT Technology for optimal efficacy and shelf-stability*
- hypoallergenic* and non-GMO
- free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, and soybeans. 
- no artificial additives, colors, flavorings, preservatives, sugar, or salicylates are used.

I get periodic depression and anxiety... My doctor recommended this, and it works wonders. I think for most people it doesn’t work as fast, but I can feel myself “spiraling”, and becoming anxious, depressed, etc. and this seems to stop it in its tracks! The sick feeling I feel in stomach from anxiety goes away and my brain is able to function on tasks ahead instead of thinking upsetting thoughts about the future / pasts! I highly recommend!

5. OMNi BiOTiC Stress Release

- Gut-Brain Axis Support
Imbalances in the gut microbiome can result in damage to the gut barrier, exaggerated inflammatory response, and decreased neurotransmitter production. Our formulation is designed to help rebalance the gut, strengthen the gut-brain axis, and provide effective psychobiotic stress management.

- Promote Positive Mood
Support your gut flora and digestion during times of occasional stress to help increase emotional balance and improve memory and cognition. With individual packaging and a shelf stable, no refrigeration required formula, we make it easy to release stress wherever you may be.

- Studied & Proven 
During controlled clinical trials, OMNi-BiOTiC STRESS Release was found to improve decision making and attention, reduce signs of depressed mood, while strengthening gut-barrier function and improving IBS symptom severity.

Like many people I have had my share of stress in the last year and was hoping to improve my nutritional habits in 2021. Stress Release seemed a good bet. Now 3 weeks later, I feel less anxious. I’m also sleeping better and more regular. I have tried probiotics before with little noticeable difference. This one is special. It works!

6. Life Extension Florassist Mood

- Stress Less with This Specialty Probiotic 
This proprietary blend of probiotic strains Lactobacillus helveticus Rosell-52 and Bifidobacterium longum Rosell-175 has been linked to a improved stress response—plus, the gastrointestinal support you’d expect from a probiotic.

- Gut Feelings Should Be Good Feelings
Believe it or not, digestive health is tied to your mood. This blend of probiotics and clinically studied saffron extract supports a balanced mood and brain health.

- Banish the Butterflies from Your Stomach
Sometimes, worries can unsettle your stomach. FLORASSIST Mood relieves minor digestive discomfort that can accompany everyday stress.

- Ingredients Matter
Sourced using only the finest raw ingredients with the purity and potency your body deserves; This product is certified non-GMO and gluten-free; Manufactured in the USA and a Certificate of Analysis is available

Thought I would give this a try. Wasn't expecting much, but was pleasantly surprised that it actually works for lifting depression quite well.

7. Hyperbiotics Gut-Brain Balance, Mood 


- 6 Targeted Probiotic Strains
Specifically chosen for the benefits they provide to both cognitive and overall health, including supporting mood, memory, focus, immune function, digestion, and regularity. With a patented delivery method, the probiotic organisms in this formula are released over an 8-10 hour period so they bypass your stomach acids and reach deep into your intestinal tract alive (where they are needed most) so you can experience the benefits that probiotics have to offer.*

- An Easy Regimen and Convenient
This probiotic formula also contains prebiotics for additional support. Prebiotics are to probiotics what fertilizer is to a garden. There is also 0 refrigeration necessary. With the patented LiveBac manufacturing process, we offer a guaranteed, extended shelf life.*

- Formulated For Your Needs
Probiotics combined with excellent ingredients such as Suntheanine (L-theanine) to support a calm and positive emotional state. Gut-Brain Balance also contains 100 mg of FOS to help probiotics colonize and take up residence within your intestinal tract, so they can give you the support you need to stay focused.*

- Tested for Safety, Purity & Potency*
This formula is vegetarian, non-GMO, and free of dairy, gluten, and yeast. There is also no soy, sugar, iron, nuts, artificial flavors, artificial colors, or preservatives. Our ingredients are carefully selected and follow good manufacturing (GMP) practices for optimal purity and safety.*

Hyperbiotics Gut-Brain Balance Reviews
I’ve had stomach problems for a long
Time and hyperbiotics are the only probiotics that help. This was my first time trying GBX-focus and it has helped my stomach stay calm. I’m hoping it helps with my anxiety as well. Highly recommend.


a. Signs You Need Probiotics

  • Digestive irregularity
  • Your metabolism is a bit slow
  • You’ve taken an antibiotic, even if it was a long time ago. Antibiotic can kill both bad and good bacteria, as the result, you may need probiotic to balance your gut bacteria.
  • You’ve got some skin issues like eczema, psoriasis, and itchy rashes
Above all, these symptoms are not always linked to a lack of probiotics. Best to talk with your doctor for a diagnosis.

b. How Do You Know if Probiotics Are Working?

When you take a high-quality probiotic supplement, you may feel a variety of benefits in your body, from better digestion and energy to a better mood and clearer skin. Improved digestion is frequently the first and most noticeable change people will notice.

The probiotic bacteria help to restore your gut flora, which can enhance things like bowel movement frequency and regularity while also reducing bloating and gas.

c. Connection Between Probiotics and Antibiotics

There are already good and bad bacteria live in your body. The good bacteria help keep you healthy, by boosting your immune system and preventing illness.

Bad bacteria, on the other hand, can get in and cause illness. Antibiotics can kill bad bacteria, but they usually kill a lot of healthy bacteria as well. This is where probiotics can help, by balancing your gut bacteria.



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