10 Best Probiotic Supplements of 2026: Price and Reviews
Probiotics are living microorganisms that offer lots of health benefits if
consumed in sufficient amounts, such as balancing the “good” bacteria in your
digestive system, strengthening immune system, and lowering the risk and
severity of diarrhoea. Many studies also linked probiotics with improvement in
mental health conditions such as anxiety, depression, and stress.
The global gut health is predicted to grow by around 8% annually at least to the end of the decade. There are a number of factors combining to drive growth in the gut and digestive health market. One is that consumers are increasingly aware of the importance of gut health and comfort, and that they can, to some extent, manage that themselves through food choices and supplements. This is linked to the fact that global populations are ageing, and more and more people are living with chronic gastric disorders. At the same time, scientists are gaining better understanding of both the importance of the gut (microbiome) on human health and how we can influence it.
“The one important thing to remember is that you take them,” Dr.
Cresci states. “Whatever works best so you don’t forget. You’ll
get the most benefits if you do it daily.”
Best Probiotics for Women
Best Probiotics for Men
Inflammation and dysbiosis the most studied conditions for probiotics in
recent years
– new probiotics database (ProBioQuest)
The global gut health is predicted to grow by around 8% annually at least to the end of the decade. There are a number of factors combining to drive growth in the gut and digestive health market. One is that consumers are increasingly aware of the importance of gut health and comfort, and that they can, to some extent, manage that themselves through food choices and supplements. This is linked to the fact that global populations are ageing, and more and more people are living with chronic gastric disorders. At the same time, scientists are gaining better understanding of both the importance of the gut (microbiome) on human health and how we can influence it.
Probiotics can be found in fermented foods such as yogurt and high-fiber
vegetables. However, it is still possible that you aren’t getting enough
probiotics from your diet, therefore a probiotics supplement is a good
solution for a better result.
Where can I buy probiotic supplements? Here are the Best Probiotic
Supplements of 2022, along with their outstanding performance and honest
customers’ reviews.
Physician's CHOICE Probiotic formulation is made with prebiotics and probiotics based on clinical research without unnecessary binders, soy, gluten, milk, egg, wheat, peanuts, shellfish, or preservatives. They provide you exactly what's on the label with 10 probiotic strains, 60 Billion Cfu, and an organic prebiotic blend. Moreover, in order to ensure the stability of their products, they designed a Patented Shelf-Stable bottle.
Their probiotic daily blend, combined with an organic prebiotic fiber blend, helps to support the stomach's digestive environment and supports the natural stomach balance. Excellent for digestive health and intestinal health, as well as occasional gas relief, bloating relief, constipation, digestive health, and intestinal health. Last but not least, regarding their safety, this probiotic is 3rd-party tested for purity and potency.
An increased level of the Akkermansia muciniphila strain in the gut results in a stronger intestinal wall, which is important for keeping your digestive system in good shape. This unique strain is called a keystone strain for gut health as it restores, protects, and strengthens the digestive lining. Take 1 capsule daily to help fuel and boost your gut microbiome and eliminate digestive problems. A well-balanced gut microbiome helps with overall health. Higher amounts of Akkermansia muciniphila mean your gut is healthier, so take a probiotic that contains this beneficial bacteria.
"The beneficial oxygen-intolerant bacteria Akkermansia muciniphila is essential for a healthy microbiome, but many people have few to none at all. When selecting Akkermansia supplements, choose those that utilize advanced, timed-release capsules or microencapsulation technology. These methods keep the bacteria dormant and protected until they reach your colon, typically within two to four hours after ingestion, ensuring that a higher number of live bacteria survive the journey through your digestive system." - Dr Joseph Mercola.
- Once Daily Probiotics for Women: A probiotic supplement for
women with 50 Billion CFUs plus clinically proven ingredients to help
promote digestion, immune support and feminine health. Organic
prebiotics and 6 probiotic strains with D-Mannose & ProCran, a
science backed cranberry extract that provides powerful antioxidants.
50 mg of ProCran is equivalent to 2,500 mg of cranberries without the
sugar and calories.
Wholesome Wellness Raw Probiotic contains 100 Billion Cfu & 34 Strains per serving or 3 Trillion Cfu per bottle. This probiotic is made with genuine prebiotics, digestive enzymes, and probiotics based on clinical testing. Their formulation is free from binders, soy, gluten, milk, egg, wheat, peanuts, shellfish, additives, and preservatives.
The capsules are designed with Timed Release Technology in order to work effectively. How? This technology ensures that their raw probiotics stay safe, secure, and alive as they travel to your intestines, while some other probiotics are released before they reach the intestines which makes them ineffective.
Regarding their quality, this probiotic is GMP Certified. They guarantee their high-quality supplements will actually work to support the free stomach digestive environment biotics condition and supports the natural stomach balance. Moreover, their raw probiotics are shelf-stable and no refrigeration is required.
1. Physician's CHOICE Probiotics 60 Billion CFU - Probiotics and Prebiotics for Gut Health
Rating: 4.5/5 - More than 120,000 ratings
#1 Amazon's Best Seller in the Probiotics Category
• 30 Veggie Capsules
• 60 Billion CFUs per serving.
• Made with 10 probiotic strains & Non-GMO ingredients
• Patented Shelf-Stable bottle
• Made with 10 probiotic strains & Non-GMO ingredients
• Patented Shelf-Stable bottle
Physician's CHOICE Probiotic formulation is made with prebiotics and probiotics based on clinical research without unnecessary binders, soy, gluten, milk, egg, wheat, peanuts, shellfish, or preservatives. They provide you exactly what's on the label with 10 probiotic strains, 60 Billion Cfu, and an organic prebiotic blend. Moreover, in order to ensure the stability of their products, they designed a Patented Shelf-Stable bottle.
Their probiotic daily blend, combined with an organic prebiotic fiber blend, helps to support the stomach's digestive environment and supports the natural stomach balance. Excellent for digestive health and intestinal health, as well as occasional gas relief, bloating relief, constipation, digestive health, and intestinal health. Last but not least, regarding their safety, this probiotic is 3rd-party tested for purity and potency.
2. Pendulum Akkermansia Probiotic with Prebiotic Fiber
Rating: 4.2/5 - More than 900 ratings
- Next generation probiotic
- Unique delivery system, including chicory inulin and a plant-based, acid resistant, delayed release capsule, so that the strain gets through the stomach acid and nurtures a thriving microbiome.
Pendulum Akkermansia contains 100 million AFU of a patented strain of
Akkermansia muciniphila. It is a novel probiotic strain that naturally
occurs in the layer of the large intestines and works by protecting
and enhancing the gut lining. Studies show that the Akkermansia strain
makes up approximately 4% of the intestinal bacteria in healthy
people, making it essential for a healthy gut microbiome. Akkermansia
increases the levels of these good bacteria in your gut.
An increased level of the Akkermansia muciniphila strain in the gut results in a stronger intestinal wall, which is important for keeping your digestive system in good shape. This unique strain is called a keystone strain for gut health as it restores, protects, and strengthens the digestive lining. Take 1 capsule daily to help fuel and boost your gut microbiome and eliminate digestive problems. A well-balanced gut microbiome helps with overall health. Higher amounts of Akkermansia muciniphila mean your gut is healthier, so take a probiotic that contains this beneficial bacteria.
"The beneficial oxygen-intolerant bacteria Akkermansia muciniphila is essential for a healthy microbiome, but many people have few to none at all. When selecting Akkermansia supplements, choose those that utilize advanced, timed-release capsules or microencapsulation technology. These methods keep the bacteria dormant and protected until they reach your colon, typically within two to four hours after ingestion, ensuring that a higher number of live bacteria survive the journey through your digestive system." - Dr Joseph Mercola.
3. Best Probiotic for Women Weight Loss - Physician's Choice Probiotics for Women
Ratings: 4.5 out of 5 – more than 48,000 global ratings
Amazon Best Sellers Rank: #1 in Prebiotic Nutritional Supplements
Amazon Best Sellers Rank: #2 in Probiotic Nutritional Supplements
Amazon Best Sellers Rank: #2 in Probiotic Nutritional Supplements
4. NewRhythm Probiotics 50 Billion CFU 20 Strains - Probiotics Without Sugar
Rating: 4.6/5 - More than 30,000 ratings
Amazon Best Sellers Rank: #9 in Probiotic Nutritional Supplements
• 60 Vegetarian Capsules
• 50 Billion CFUs per serving.
• Made with Non-GMO ingredients
• Fridge-free
• Made with Non-GMO ingredients
• Fridge-free
NewRhythm Probiotic contains 50 Billion Living Organisms per
serving. Their formulation is made with 100% natural ingredients,
verified non-GMO, and free from gluten, sugar, soy, yeast, egg,
magnesium stearate, artificial ingredients, preservatives.
Featuring Targeted Release Technology to help probiotics survive
stomach acids and reach your intestinal tract.
This potent and pure probiotic can help support healthy digestion
and balanced intestinal ecology. Moreover, good news for
travelers! Their product is shelf-stable and they do not require
refrigeration. Regarding their quality, NewRhythm Probiotc
obtained Good Manufacturing Practices (GMP) certification,
which represents the highest level of technology, quality purity,
and consistency.
5. Wholesome Wellness Raw Probiotic 100 Billion CFU - Probiotics and Digestive Enzymes
Rating: 4.5/5 - More than 18,000 ratings
• 30 Vegetable Capsules
• 100 Billion CFU, 34 Strains
• No refrigeration required
• Non-GMO ingredients
Wholesome Wellness Raw Probiotic contains 100 Billion Cfu & 34 Strains per serving or 3 Trillion Cfu per bottle. This probiotic is made with genuine prebiotics, digestive enzymes, and probiotics based on clinical testing. Their formulation is free from binders, soy, gluten, milk, egg, wheat, peanuts, shellfish, additives, and preservatives.
The capsules are designed with Timed Release Technology in order to work effectively. How? This technology ensures that their raw probiotics stay safe, secure, and alive as they travel to your intestines, while some other probiotics are released before they reach the intestines which makes them ineffective.
Regarding their quality, this probiotic is GMP Certified. They guarantee their high-quality supplements will actually work to support the free stomach digestive environment biotics condition and supports the natural stomach balance. Moreover, their raw probiotics are shelf-stable and no refrigeration is required.
6. Florastor Daily Probiotic Supplement for Women and Men
Ratings : 4.8 out of 5 - More than 6,000 global ratings
Amazon Best Sellers Rank: #7 in Probiotic Nutritional Supplements
Proven to Support Digestive Health, Saccharomyces Boulardii CNCM
I-745 (100 Capsules)
Daily Probiotic Supplement
Each capsule contains 250mg of our unique probiotic strain, which
is larger and stronger than many other probiotics and provides
increased intestinal coverage and protection
Digestive and Immune Support
Florastor helps increase the natural flora in your digestive tract
and supports overall health by strengthening your digestive
balance and supporting a healthy immune system
Healthy Lifestyle
Made with ingredients found in nature that are vegetarian,
gluten-free, and appropriate for lactose intolerance, Florastor
probiotics complement your healthy and active lifestyle
No Refrigeration Required
Our capsules and powder sachets do not require refrigeration and
have a 3-year shelf life. You can swallow capsules whole or mix
the powder into your favorite food or beverage
About a week ago, I came home from work absolutely defeated and
at the end of my rope. I had only eaten 2 eggs the whole day and
I felt completely swollen and looked 6 months pregnant. The last
doctor I went to had briefly mentioned probiotics and I had a
bottle of Florastor sitting in my medicine cabinet that I never
tried. I took 2 pills in the evening and shortly after felt a
slight burn in my stomach. I went to sleep that night and the
next morning woke up with no bloat. Later in the morning, I had
the best bowel movement I’ve had in 1.5 yrs (sorry tmi) and
since then I have been feeling great! I take 2 pills in the
morning on an empty stomach & 2 pills before dinner in the
evening. I feel like the old me! No more bloat, no more GI issues,
digestion is exactly how it was before I got sick and I’ve even
lost a few pounds! I don’t feel swollen or defeated anymore. I
feel like me again! Thank you Florastor, you saved my life!!!
7. Garden of Life Probiotics for Men and Adults - Best Probiotics with Lactobacillus
Rating: 4.7/5 - More than 6,000 ratings
This unique formula is created exclusively for men, with a high
potency count of beneficial probiotics made from diverse strains,
including Lactobacilli and Bifidobacteria, that are resistant to
stomach acid and bile, to support colon health and support immune
digestive system health. Each capsule has a powerful 50 billion CFU
tailored to support men’s daily gastrointestinal health.
No refrigeration needed—suitable for travel use! Their supplement is also shelf-stable to ensure your probiotics arrive alive and stay alive. Moreover, their ingredients are verified non-GMO, dairy-free, certified gluten-free by NSF, soy-free, and vegetarian.
"Your stomach’s low pH can destroy most of the good bacteria in
probiotics before they get to your distal gut,” says digestive
disease researcher and registered dietitian Gail Cresci, PhD, RD,
LD. (clevelandclinic.org)
• 30 Vegetarian Capsules
• Specially designed for Men
• No refrigeration required
• Non-GMO ingredients
No refrigeration needed—suitable for travel use! Their supplement is also shelf-stable to ensure your probiotics arrive alive and stay alive. Moreover, their ingredients are verified non-GMO, dairy-free, certified gluten-free by NSF, soy-free, and vegetarian.
8. Garden of Life Whole Food Probiotic Supplement - Best Probiotics Without Soy
Ratings : 4.8 out of 5 - more than 2,000 global ratings
- Primal Defense Ultra Ultimate for Digestive and Gut Health
- 216 Vegetarian Capsules
DIGESTION SUPPORT
Primal Defense 15 billion CFU probiotic supplement contains
Lactobaccilus acidophilus, Bifidobacteria, and other strains
to maximize the benefits of a healthy diet, boost nutrient
absorption, relieve constipation and support digestive health.
SOIL BASED PROBIOTICS
The only shelf stable probiotic powder formula containing a
unique whole food blend with Homeostatic Soil Organisms (HSO)
IMMUNE SUPPORT
This dietary supplement has 15 billion CFU and 13 hardy
beneficial strains for immune system health. Supports normal
digestion of dairy products. Soy free.
COLON HEALTH SUPPORT
These probiotics for constipation promote regular, healthy and
comfortable bowel movements.
VEGETARIAN PROBIOTIC
Whole food, gluten free, vegetarian probiotics supplement for
a balanced, health internal environment.
This comes from a trusted brand and I'm using quiet a lot
of products from this brand.
I can kuch for this probiotic and I must say extremely
effective.
9. Lifted Naturals Mood Boosting Probiotic - Best Probiotics for Mood and Anxiety
Ratings: 4.3 out of 5 - more than 1,800 global ratings
Mood Boosting Probiotic is our original MOOD formulated
probiotic featuring 9 feel-good strains of probiotic bacteria
+ prebiotic GOS; all designed to help with mood health,
digestive health, and immune health.
Recent studies have proven that adding beneficial bacteria to
the gut can reduce stress in the body and promote feelings of
wellbeing. We've included the best bacterial strains to help
with mood and aid the body's stress response.
- 30 Billion CFU
- Mood Boosting Supplement w/ prebiotics & probiotics for
Women and Men
- 60 Days Supply
- Supports Digestive Health
- Shelf Stable Probiotic Supplement
- Vegan, Non-GMO
TARGETED "FEEL GOOD" STRAINS - This formula features the TOP
performing bacterial strains to help with mood.
30 BILLION CFU with the BEST probiotic strains for MOOD and
DIGESTION make it a HIGH POTENCY probiotic... offering
digestive, immune, and mood support. 60 Capsules per bottle --
a TWO MONTH supply!
9 NOURISHING STRAINS. In addition to B. Infantis and B.
Longum, we included seven more strains (9 various strains
total) to ensure healthy digestion, immunity and mood support
I take this product with an SSRI and a mood stabilizer. The
product nothing short of amazing and works better the longer you
take it!!! I'm very in tune with my body and noticed a
difference the first day! It has helped tremendously with both
depression and anxiety.
10. Best Lactobacillus Gasseri probiotic for Weight loss - Physician's Choice Thin 30 Probiotic
Amazon Reviews: 4.1 out of 5 – more than 13,000 global
ratings
Amazon Best Sellers Rank: #17 in Probiotic Nutritional Supplements
- In a clinical study, 100 patients lost an average of over 30 lbs. in 90 days taking 300 mg of stimulant-free Greenselect Phytosome daily with a reduced-calorie diet. Greenselect is a caffeine-free extract from green tea.
- In a clinical study, 100 patients lost an average of over 30 lbs. in 90 days taking 300 mg of stimulant-free Greenselect Phytosome daily with a reduced-calorie diet. Greenselect is a caffeine-free extract from green tea.
Probiotics and Microplastics
Certain beneficial bacteria strains can help clear microplastics from the gut — A 2025 animal study found that two specific strains, Lacticaseibacillus paracasei DT66 and Lactiplantibacillus plantarum DT88, were able to bind to and eliminate tiny polystyrene particles in lab tests. These probiotics work by forming protective biofilms that trap plastic particles, making them easier to flush out.When Should I Take Probiotics for Best Results?
Probiotic supplements have a rough journey through your digestive
system. Once you swallow them, they enter your stomach’s harsh,
acidic environment, which isn’t very probiotic-friendly.
If this happens, the probiotics won’t colonize. They’ll keep
moving through your body until you poop them out. Live strains
like the popular
Lactobacillus
or
Bifidobacteria
struggle with this the most. Dormant strains like Bacillus
bacteria or yeast called
Saccharomyces boulardii
have a greater chance of surviving a trip through the stomach.
To combat this, try taking your probiotics with pH-balancing foods
that are low in acid and high in vital nutrients.
While you can take probiotics with water on an empty stomach, that
doesn’t neutralize your stomach’s acid. But food does — and some
types of food help more than others. (clevelandclinic.org)
Dr. Cresci says combining your supplement with all three
macronutrients
gives probiotics the best chance of colonizing. The macronutrients
are:
- Carbohydrates
- Fat
- Protein
Milk and yogurt
are great choices, as they have all three macronutrients, unless
they’re fat-free. Another plus?
Fermented foods
like
yogurt
contain gut-friendly probiotics that can further boost
colonization efforts.
One important thing to remember — avoid taking probiotics with
acidic foods like:
- Coffee
- Orange juice
- Pineapples
- Tomato juice or sauce
Those foods add extra acid to your stomach, so it’s best to wait
to take your supplement until you’ve had a more pH-neutral
meal.
If you’re an early bird, you may wonder if it’s best to take a probiotic first thing in the morning. Or if you’re more of a night owl, bedtime might work better for you. Does it matter?
Morning is a great time to add a probiotic to your routine, Dr. Cresci says.
“You’re trying to get the probiotic to move from your stomach to your colon to colonize,” she explains. “And your bowels are more active when you’re active. So, taking a probiotic with breakfast is a great way to help them along this journey.”
If breakfast or mornings aren’t your thing, that’s OK. You can take probiotics at any time of day and still get good results.
If you’re an early bird, you may wonder if it’s best to take a probiotic first thing in the morning. Or if you’re more of a night owl, bedtime might work better for you. Does it matter?
Morning is a great time to add a probiotic to your routine, Dr. Cresci says.
“You’re trying to get the probiotic to move from your stomach to your colon to colonize,” she explains. “And your bowels are more active when you’re active. So, taking a probiotic with breakfast is a great way to help them along this journey.”
If breakfast or mornings aren’t your thing, that’s OK. You can take probiotics at any time of day and still get good results.
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