Flavonoid-Rich Foods, Dementia Risk, and Interactions With Genetic Risk, Hypertension, and Depression (JAMA 2024)
Key Points Question What is the association of a flavonoid-rich diet with dementia risk among UK adults? Findings In this cohort study of 121 986 UK Biobank participants, those with the highest adherence to a flavonoid-rich diet, specifically intakes of tea, red wine, and berries, had a lower risk of dementia. Reductions were more pronounced in participants with a high genetic risk, hypertension, and depressive symptoms. Meaning These findings suggest that increasing daily consumption of flavonoid-rich foods may lower dementia risk, especially in populations at high risk. Abstract Importance A composite score of flavonoid-rich foods (flavodiet) may provide a clear public health message regarding the range of foods with the potential to lower dementia risk. Objective To examine associations of flavodiet score and intakes of flavonoid subclasses with dementia risk according to genetic risk and presence of depression and hype...