The Medical Advisor

Abstract In 2022, approximately 20 million new cancer cases and 9.7 million cancer deaths occurred worldwide. By 2050, new cases are projected to double, driven by population growth, aging, and increased exposure to risk factors. Up to 40% of cancers may be preventable by addressing lifestyle and environmental risk factors. Numerous nutraceuticals and repurposed drugs exhibit chemoprophylactic properties. Epigallocatechin gallate (EGCG), a polyphenol in green tea, appears to be the most effective agent against multiple cancers, followed by curcumin, a . polyphenol derived from turmeric (Curcuma longa), vitamin D, and omega-3 fatty acids. Using artificial intelligence and leveraging synergistic effects among these compounds, we developed the ROOT 3, ROOT 4, ROOT 5, ROOT 6, and ROOT 9 chemoprophylactic protocols. The mechanistic activity of each nutraceutical is described, along with the estimated risk reduction for the most common types of cancer. These protocols may offer a low-risk an...

In March 2025, Dr. Paul E. Marik and Dr. Justus Hope announced an  all-supplement daily cocktail  that reduced cancer risk by some 60%. We improved on this with Metformin, Ivermectin, and Mebendazole to reduce risk to the 70 to 80% range. In this article, Dr. Paul E. Marik and Dr. Justus Hope are announcing a series of significant revisions made over the past few days—with the invaluable support of AI. Update: ROOT Protocols: Preventing Cancer - Dr Paul Marik and Dr Justus Hope (Journal of Independent Medicine, Nov 2025) What would have taken months to research and refine was accomplished in just days. And time is critical, as the world faces an unprecedented surge in cancer cases. This information needs to reach people now. We’ll start from the beginning, sharing the results of our initial 3-supplement AI-driven search that established our baseline for cancer risk reduction. From there, we’ll walk you through the evolution of the protocol—culminating in what we no...