The Medical Advisor

Executive Overview Few environmental health controversies have generated as much scientific, legal, and public debate as the relationship between Roundup (a glyphosate-based herbicide) and Non-Hodgkin lymphoma (NHL) . In 2015, the International Agency for Research on Cancer (IARC) classified glyphosate as “probably carcinogenic to humans.” Regulatory agencies such as the United States Environmental Protection Agency (EPA) and the European Food Safety Authority (EFSA) reached different conclusions. Meanwhile, juries awarded billions in damages against Monsanto , now owned by Bayer . This report evaluates: The epidemiologic data Regulatory risk assessments Mechanistic toxicology Litigation outcomes Absolute vs relative risk Occupational vs consumer exposure Systems-level environmental carcinogenesis All major claims below are linked to primary or authoritative sources. 1. What Is Glyphosate and Why Is It So Widely Used? Glyphosate is the active ingredient in Roundup. Introduced in 197...

In recent years, researchers have discovered glyphosate, the active ingredient in Roundup and other common weed killer formulations, may affect your body's ability to produce fully functioning proteins, inhibit the shikimate pathway (found in gut bacteria) and interfere with the function of cytochrome P450 enzymes (required for activation of vitamin D and the creation of nitric oxide and cholesterol sulfate). However, the risks and safety concerns of glyphosate have received very little detailed attention and media coverage. Glyphosate also chelates important minerals; disrupts sulfate synthesis and transport; interferes with the synthesis of aromatic amino acids (shikimate pathway) and methionine, resulting in folate and neurotransmitter shortages; disrupts your microbiome by acting as an antibiotic; impairs methylation pathways; and inhibits pituitary release of thyroid stimulating hormone, which can lead to hypothyroidism. (1,2) Note:  70 to 80% of your immune system resi...