Fenbendazole for Cancer: 2023 Review

What Is Fenbendazole?

Fenbendazole (also called Fenben) is a broad spectrum anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the tapeworm genus Taenia (but not effective against Dipylidium caninum, a common dog tapeworm), pinworms, aelurostrongylus, paragonimiasis, strongyles, and strongyloides that can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits, most reptiles, freshwater shrimp tanks as planaria and hydra treatments, as well as seals.

Common brand names include Pancur, Panacur C and Safe-Guard.

However, it is also being used by humans in a cancer treatment method known as the Joe Tippens Protocol.

Is fenbendazole a cancer cure scam? 

One study suggests that fenbendazole has “been safely utilized as an anti-parasitic for various different animal species and could be repurposed for treating human malignancies.” Other benzimidazoles, including albendazole, parbendazole, mebendazole and flubendazole have already been shown to have promising results in humans

Another study states that the “repurposing of veterinary drugs showing promising results for human use can result in considerable time and cost reduction required to develop new drugs.”

Related: Fenbendazole and Cancer - at least 12 Anti-Cancer mechanisms of action

Is Joe Tippens, My Cancer Story Rocks, and Fenbendazole Fame Still Alive?

One of the contributors from CancerDefeated.com met Joe in person and interviewed him in April 2022. Here’s what she discovered…

Joe’s scan was completely clear in early 2017. His scan in Feb. 2022 still shows no evidence of disease.

Since cancer is notorious for recurrences, Joe continues to follow his regimen for prevention… and plans to for the rest of his life. However, he recently revamped the rest of his entire cancer treatment protocol.

Joe has scaled back to three days a week on the FenBen, now that he’s been cancer-free for five years. He recommends staying on the seven-day fenbendazole protocol till you’re cancer-free for at least three years.

Based on his extensive research, he’s added things to his protocol. including Frankincense and berberine. All products are in a much more bioavailable form, too. He notes that getting absorption of nutrients into the bloodstream is a bigger problem than most people realize. His new protocol helps address this problem.

Joe spent much of 2021 collaborating with scientists and M.D.’s in the pharmaceutical and nutraceutical space, to develop processes that dramatically improve nutrient delivery into the bloodstream at previously unheard-of levels.

Here’s the three-pronged approach he uses in 2022 (R):

1: Support healthy cell division. Joe consumes cryogenically extracted CEM™ Hemp. Getting the terpenes and cannabinoids from full-spectrum hemp is critical to gaining its best benefits. The product is now cryo-extracted to preserve these substances. It also includes Frankincense and a Nano MCT oil.

2: Support healthy cell life cycles and clearance of dead cells with curcumin. Curcumin was always part of Joe’s protocol. He previously used the most bioavailable curcumin product he could find. He cringes when he relates how much he was depending on a nutrient that’s so extremely challenging to absorb, while fighting a deadly disease. The new product he uses is light years ahead in terms of absorption – at least six times better – thanks to new technology.

3. Support optimal cellular glucose metabolism with berberine. Berberine is known for its effects on insulin resistance and the normalization of blood glucose levels. Since cancer cells use glucose to grow and spread, berberine helps starve those cancer cells. (Incidentally, he also recommends you strip sugar from your diet, but admits he’s poor at practicing what he preaches.)

All three of these nutritional products are available through a company called Ultra Botanica in their Onco-Adjunct line. Joe made it very clear that he makes no money from recommending any of these products, nor does he own any stock or other interest in the company. He simply thinks their products are the best now available for his protocol and he’s been recommending them since late in 2021.

Q&A Session with Joe Tippens (January 18, 2023)


Is Fenbendazole Safe For Humans With Cancer?

While little research has been done on the effects of fenbendazole and human consumption, studies have shown that the medication is typically tolerated well by humans, and thus far, has not reported any major side effects. While we can’t state that fenbendazole is safe for humans, the research appears promising.

According to a 2018 study, Fenbendazole (methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl) carbamate) is a broad-spectrum benzimidazole anthelminthic approved for use in numerous animal species. Repurposing of veterinary drugs showing promising results for human use can result in considerable time and cost reduction required to develop new drugs. Fenbendazole is known to have a high safety margin and most species tolerate it very well. It has very low degree of toxicity and high degree of safety in experimental animals.

Another study also discussed the potential side effects of using fenbendazole in humans. “Based on limited human data it appears that doses up to 500 mg per person did not result in adverse effects,” the study states. “Moreover, single doses up to 2,000 mg per person were reported to cause no adverse effects.”

A medical specialist’s YouTube video on how cancer patients should take fenbendazole, has caused controversyDefying the warning from the Korean Medical Association and the Ministry of Food and Drug Safety against the use of the dog dewormer for unexpected side effects, radiology oncologist Dr Kim Ja-young claimed on her YouTube channel that it was safe to take fenbendazole. 

Kim uploaded the video clip titled “Is dog dewormer safe for human?” on YouTube on Oct. 7, 2019, after fenbendazole became a hot topic among cancer patients and physicians. The YouTube video has currently been taken down.

She cited four reasons why fenbendazole was safe for people.

According to Dr Kim (Korea BioMedical Review):

Fenbendazole has been proven to be safe for 40 years, and the human absorption rate of the drug is very low at 20 percent, making it difficult to show toxicity. Besides, the agent is toxic to lower organisms such as parasites, and less toxic to higher organisms such as humans and mammals, she said. Even if a patient takes fenbendazole for three consecutive days, rest for four days will release most of the drug ingredient, Kim claimed.

“Fenbendazole is a dog dewormer, while humans take mebendazole or albendazole. Their basic action is the same. The drug (fenbendazole) was developed in the early 1970s and has been proven to be safe for 40 years,” Kim said in the video.

If a patient takes 2,000 mg liquid fenbendazole at once, it has no acute side effects, and patients can purchase the human deworming drugs mebendazole and albendazole at a pharmacy, Kim said, emphasizing that they were all safe for humans.

“Regardless of whether the drug has an anticancer effect or not, it is a safe medicine,” she said.

Kim explained how to take the dog dewormer in detail. For a patient with rapidly progressing and multiple metastatic cancer, she recommended taking fenbendazole 222mg four times a day for three weeks, taking 222mg for once or twice a day after the third week, and giving a break for four days.

It was safe to use the high dose of fenbendazole because patients in the past took high doses of mebendazole, up to 2,000-3,000 mg for more than three weeks, when parasites were found in the brain, Kim went on to say.

She also detailed the amount of fenbendazole to take and the medication schedule for those who benefited from taking the drug.

To increase the absorption rate, patients should take the drug immediately after meals or take the deworming pill with 60-100cc olive oil so that bile can be secreted.


Fenbendazole For Cancer In Humans

This study revealed when testing cancer cell lines against the off-label drug, “the group supplemented with both vitamins and fenbendazole exhibited significant inhibition of tumor growth.” 

Another study suggested, “it caused mitochondrial translocation of p53 and effectively inhibited glucose uptake, expression of GLUT transporters as well as hexokinase (HK II) – a key glycolytic enzyme that most cancer cells thrive on.” 

While I’ve discovered positive studies, there are others that show no benefits of Fenbendazole, so we must take a balanced approach.

Fenbendazole Joe Tippens Protocol Dosages


The Fenbendazole Joe Tippens protocol has been last updated on October 28, 2021.

According to Joe Tippens:

I have a significant announcement to make. Several months ago, I was introduced to a researcher who collaborates with other PHD’s, MD’s and researchers globally in the pharma and nutraceutical space.

They have developed some patented technologies that they apply to specific classes of plant extracts and botanicals that dramatically enhance delivery of those ingredients into the bloodstream at exponential levels.

Over the months we have met together, and I have performed extensive due diligence on what they can offer. We’ve discussed a 3-pathway approach and philosophy for cellular support through supplementation that I believe will complement fenbendazole greatly.

The Joe Tippens protocol involving fenbendazole is not solely centered around fenbendazole, as it incorporates three other significant components (below) known as Onco Adjunct Pathway 1, Onco Adjunct Pathway 2, and Onco Adjunct Pathway 3.
  1. Fenbendazole
  2. Onco Adjunct Pathway 1
  3. Onco Adjunct Pathway 2
  4. Onco Adjunct Pathway 3

1. Fenbendazole: One Packet a Day

Fenbendazole which has 222mg of Fenbendazole per gram: one packet of powder per day for seven days a week. It can be mixed with food such as yogurt or simply taken by itself.

It is advised to purchase Panacur C or Safeguard brands only, as both are regulated and have been consistent in third-party lab results.

Note if you are using liquid – most liquids are 100 mg/ml. You would take 2.2 ml of the liquid.
 
Click here to buy Fenbendazole (Safe-guard) on Amazon

Best Fenbendazole For Humans

Merck and Safeguard are well established companies whose products have been safety tested in animals and used by veterinarians for many years.

1.1. Safe-Guard Dewormer for Cancer


Buy on Amazon

How To Use Fenbendazole for Cancer

It can be taken as a single dose in the morning, with or without food. 

It may be best to place the powdered substance directly in your mouth and chase it down with a flavored drink such as cranberry juice as it does not dissolve well in any liquids. You could also try to mix it into a smoothie, greens drink, or something else. 

Fenbendazole for Cancer Dosage

One box of three packets will last a week on the beginning dose since you take one packet per day for three straight days and then take FOUR DAYS OFF. Example: Take the Fenbendazole only on Monday, Tuesday, and Wednesday each week. 

Those with later-stage cancers may choose to take 2-3 packets per day and take no days off!

Do not follow the weight-dependent dosing (for dogs) that is given on the back of the packaging!
 
1.2. Panacur-C for Cancer

Buy on Amazon

How To Use Panacur C for Cancer

It can be taken as a single dose in the morning, with or without food. 

It may be best to place the powdered substance directly in your mouth and chase it down with a flavored drink such as cranberry juice as it does not dissolve well in any liquids. You could also try to mix it into a smoothie, greens drink, or something else. 

Panacur C for Cancer Dosage

One box of three packets will last a week on the beginning dose since you take one packet per day for three straight days and then take FOUR DAYS OFF. Example: Take the Fenbendazole only on Monday, Tuesday, and Wednesday each week. 

Those with later-stage cancers may choose to take 2-3 packets per day and take no days off!

Do not follow the weight-dependent dosing (for dogs) that is given on the back of the packaging! 


While little research has been done on the effects of fenbendazole and human consumption, studies have shown that the medication is typically tolerated well by humans, and thus far, has not reported any major side effects. While we can’t state that fenbendazole is safe for humans, the research appears promising.

Fenbendazole is a benzimidazole used to treat cancer as part of the Joe Tippens Protocol
According to a 2018 study, Fenbendazole (methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl) carbamate) is a broad-spectrum benzimidazole anthelminthic approved for use in numerous animal species. Repurposing of veterinary drugs showing promising results for human use can result in considerable time and cost reduction required to develop new drugs. Fenbendazole is known to have a high safety margin and most species tolerate it very well. It has very low degree of toxicity and high degree of safety in experimental animals.

Another study also discussed the potential side effects of using fenbendazole in humans. “Based on limited human data it appears that doses up to 500 mg per person did not result in adverse effects,” the study states. “Moreover, single doses up to 2,000 mg per person were reported to cause no adverse effects.”

2. Onco Adjunct Pathway 1: CBD, Frankincense and Nano C60 Carrier

Pathway 1: CBD Tincture: CBD has always been part of his protocol, but the new product will incorporate some important changes. 

As we have learned more about the potential benefits of hemp extracts we have discovered that the species of hemp, the methods of its extraction, the ratios of acidic forms of cannabinoids to non-acidic forms of cannabinoids all play a critical role in how well Hemp extracts can have on cancer outcomes.

In my research of Hemp extracts – Onco Adjunct Pathway 1 – product hits all of the important qualities for a hemp extract. First the product is cryoextracted, this preserves the terpenes and the non-decarboxylated cannabinoids. 

Second, this product uses a proprietary strain of cannabinoid that has actually been tested on cancer cell lines. 

And Third, they supplement the CBGa cannabinoid to standardize it up to 7mg per dose, something that I believe could be significant. 

Finally, they add in two other important ingredients, the first being Frankincense, an iconic material dating back to the biblical times and recently the topic of a ton of cancer research. The company’s work on Frankincense focused on a collaboration with Dr HK Lin, the iconic researcher who studied Frankincense as a supplement for cancer for more than a decade. Together they developed an approach that uses specific fractions of Frankincense that are the most beneficial, according to his research.
 
Finally, a Nano molecule carrier, C60 has evidence to show that it could help significantly with low dose chemotherapy, reducing the toxicity of chemo to healthy cells and increasing the toxicity to unhealthy cells.

The Onco Adjunct Pathway 1 is a unique combination of Cryo Extracted Hemp, with Middle Eastern frankincense essential oils and the Nano C60 carrier, all in one tincture.

Some people may wish to stay with the previously recommended Forgotten Trails CBD from Pharmacy Plus at mcadoorandy@gmail.com and they will continue to supply that as well.


3. Onco Adjunct Pathway 2: Curcumin and Quercetin

Curcumin has always been part of Joe Tippens protocol, but even the product that he has previously recommended, Theracurmin HP, simply does not tackle the problem of absorption into the blood stream.

You all know I have recommended Theracurmin for some time as being the best, most highly bioabsorbable Curcumin I had found. What I didn’t know about was Ultra Botanica’s LPS technology UltraCur (UltraCurcumin). Data shows better absorption above Theracurmin by at least 6X and their consumer experience proves this out. Their product by itself is a game changer in curcumin and I would have left it at that except the science behind Quercetin, an equally important polyphenolic compound as Curcumin also using their LPS technology to make it absorb into the body. 

Previously I had been reluctant to recommend Quercetin (also recommended by Jane McClelland and many others) as it had the same problem as Frankincense and Curcumin in absorption into the blood stream. Why take something that simply isn’t being utilized in the bloodstream? UB’s LPS technology solves that problem and they have added the convenience of taking them together with one product.

Specifically, Onco Adjunct Pathway 2 is a combination of 300 mg of Clinical Grade UltraCurcumin, 200 mg of Clinical grade UltraQuercetin and 100 mg of Frankincense powder.There is a lot I could share about the cellular pathways that Curcumin, Quercetin and Frankincense affect, I will leave that to another time.


4. Onco Adjunct Pathway 3: Berberine

None of you have heard me recommend Berberine up to this point, even though many researchers have recommended it. Much like Frankincense, Curcumin and Quercetin, Berberine also is not bio-available into the blood stream Something this company’s LPS technology solves. 

In evaluating the new curcumin and new hemp options I had the opportunity to take a fresh look at Berberine. As most people know, cancer cells are devourers of sugars / glucose in the body. In fact, cancer cells are glucose monsters. 

Jane McClelland and many cancer coaches strongly recommend starving your cancer cells by ketogenic diets, and Care Oncology recommends Metformin in its protocol for the same reason. For those of you that are serious about starving your cancer cells from glucose, adding in Pathway 3 to your regime could help. 

Berberine in its soluble LPS form modifies glucose metabolism in much the same way that Metformin modifies glucose metabolism. The scientists in India proved that Fenbendazole is effective in interrupting cancer cells’ability to metabolise sugars and I believe by adding in UltraBerberine as Onco-Adjunct Pathway 3 you further diminish the ability of cancer cells to devour glucose, weaking them and putting their survival at risk.


Fenbendazole for Cancer FAQs

Can fenbendazole be taken in tablet, liquid or powder?

Fenbendazole is available in tablets (Happy Healing Store), liquid (Safeguard) and powder (Panacur). There may be other formulations available, but those are the primary products that patients are using.

Is it safe for humans to take fenbendazole?

Since fenbendazole is a veterinary medicine, and is not licensed for human use and there is no specific human safety data available. The similar human forms of this class of medications, mebendazole and albendazole, have been used for parasitic infections for many years and have a good safety record. Fenbendazole has been reported to have a very low degree of toxicity and a high degree of safety in animal experiments.

Is fenbendazole toxic for the liver?

Although fenbendazole is generally well tolerated, there have been reports of elevated liver enzymes from the use of fenbendazole, as well as the human medications mebendazole and albendazole. 

I’ve found a Fenbendazole brand which is not made by Merck, is it ok?

There are a variety of opinions on which product is best, but no research exists that compares the effectiveness of various formulations in humans. Merck and Safeguard are well established companies whose products have been safety tested in animals and used by veterinarians for many years. 

Would the fenbendazole protocol work with conventional treatment? - chemotherapy?


Yes, fenbendazole has the potential to synergize with conventional treatments, and possibly enhance treatment response. Some aspects of the protocol, such as vitamin E and curcumin, may interfere with chemotherapy and radiation due to their anti-oxidant properties. 

Some people take it 3 day on 4 off, some 1 gram a day, some 2 or even 4 grams a day. What is the correct dosage?

Joe Tippens, who popularized the use of Fenbendazole for cancer, recommends 222 mg for three consecutive days, then four days off. There are many people who take larger doses, more frequently. Since Fenbendazole is not licensed for the treatment of cancer in humans, there is no correct dose that is supported by research, pharmacists or physicians. The dose you choose to take should be assessed based on your other medications and treatments, your type of cancer, prognosis, organ function and lab values.

How long do I need to be on this protocol?

This will be up to you based on your treatment response to the protocol. It is reported that Joe Tippens continues to use the protocol for prevention.

How do I know when it is time to dose up?

This is an individual decision based on treatment response, tolerance, other treatments/medications and lab values. 

Find Integrative Oncologists in USA, Mexico, Europe or Asia

To find integrative oncologists, check out "find integrative oncologists".

LaValley Protocols — The Other Half of Cancer Treatment

Dr. William LaValley is one of the world's most advanced clinical researchers and medical doctor practitioners in the field of integrative cancer treatment. He has broken new ground by creating state-of-the-art databases of tens of thousands of studies covering the molecular biology of cancer and the anticancer benefits of nutritional supplements and repurposed drugs (drugs used off-label).

If you've been diagnosed with cancer, or know someone who has been diagnosed, you may want to consider tackling it from more angles than just one. Chemotherapy and radiation are hardly magic bullets. Overall, they have fairly low success rates for many cancers. 

Also know that LaValley and his team, as well as other integrative medicine doctors, are available to help, regardless of where you live. Oftentimes LaValley will initially be contacted by the patient. He can then contact your chosen oncologist or integrative medicine doctor to establish a collaborative team. If you don't have an integrative medicine doctor, or oncologist, he and his team can also help you find one. Once a collaboration has been set up, LaValley can develop a customized treatment protocol just for you for your integrative medicine physician to consider in your treatment. Remember, it's important to have an integrative team working together to ensure the entire spectrum of care is properly covered. 

You can find more information on his website, www.LaValleyMDProtocols.com. It's a phenomenal resource that both you and your doctor can peruse. To set up a consultation with LaValley, see the "Get Started" tab.

Fenbendazole Publications and References

1) Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways.
https://www.nature.com/articles/s41598-018-30158-6

2) Unexpected Antitumorigenic Effect of Fenbendazole when Combined with Supplementary Vitamins.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687140/

3) Fenbendazole as a Potential Anticancer Drug.
http://ar.iiarjournals.org/content/33/2/355.full

4) The Anthelmintic Drug Mebendazole Induces Mitotic Arrest and Apoptosis by Depolymerizing Tubulin in Non-Small Cell Lung Cancer.
https://mct.aacrjournals.org/content/1/13/1201.long

5) Pilot study of albendazole in patients with advanced malignancy. Effect on serum tumor markers/high incidence of neutropenia.
https://www.ncbi.nlm.nih.gov/pubmed/11474247

6) Antitumor activity of albendazole against the human colorectal cancer cell line HT-29: in vitro and in a xenograft model of peritoneal carcinomatosis.
https://www.ncbi.nlm.nih.gov/pubmed/15565325

7) Benzimidazole as Novel Therapy for Hormone-Refractory Metastatic Prostate Cancer.
https://apps.dtic.mil/dtic/tr/fulltext/u2/a545657.pdf

8) Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells.
https://www.ncbi.nlm.nih.gov/pubmed/18667591

9) Phase I clinical trial to determine maximum tolerated dose of oral albendazole in patients with advanced cancer.
https://link.springer.com/article/10.1007%2Fs00280-009-1157-8

10) Repurposing Drugs in Oncology (ReDO) — mebendazole as an anti-cancer agent.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/

11) Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy.
https://pdfs.semanticscholar.org/2b47/0bf133be75b36c09ebc8b17e70cea85fd9af.pdf

12) Chronic myelogenous leukemia in a great horned owl (Bubo virginianus)
https://www.ncbi.nlm.nih.gov/pubmed/19530405



Notes and Disclaimers: 
  • Please do not consider this guide as personal medical advice, but as a recommendation for use by professional providers. Consult with your doctor and discuss with her/him. 
  • Our aim here isn't to replace your doctors' advice. It is intended as a sharing of knowledge and information. Do take note that most treatments are not 100% protective or curative against cancer. It's a continuous struggle between the immune system and the cancer cells. Cancer treatments are meant to assist the immune system in this battle.
  • Cancer treatment should be part of a multi-modal approach in order to provide the best possible outcome. Diet and lifestyle changes are also meant to run alongside conventional treatment. They are complementary, not alternative. That said, there is no miracle treatment that can cure all cancers.



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