FLCCC I-MASK+ Protocol for COVID-19 (2023)

FLCCC (Front Line COVID-19 Critical Care) I-MASK+ Protocol

I-MASK+ Prevention & Early Outpatient Treatment Protocol for COVID-19 was designed for use as a prevention and in early outpatient treatment, for those who test positive for COVID-19. Component nutrients include vitamin D, C, melatonin, quercetin and zinc.

All the component medicines are FDA-approved (except ivermectin), inexpensive, readily available and have been used for decades with well-established safety profiles.

Please take note that I-MASK+ protocols are now:


As rates of infection with influenza and RSV rose in fall/winter 2022, FLCCC adapted the I-PREVENT protocol to include prevention against these viruses. The interventions recommended are likely to reduce the risk and severity of infection with COVID-19, influenza, and RSV infections as well as the common cold. It should be noted that the medications included in the I-PREVENT protocol are inexpensive, safe, and widely available. This protocol includes a section for pre-exposure (long-term) as well as a post-exposure (acute, short-term).

The I-PREVENT protocol has been updated several times. Please refer to their latest version: I-PREVENT protocol.



Please refer to the latest FLCCC's I-CARE protocol (constantly updated).

Ordinary Vitamin D3 Does not work in Acute Illness

According to this webinar (below) by Dr Pierre Kory and Dr. Keith Berkowitz:

Video time from 11:30 - 12:30: 

Vitamin D3 (ordinary form) does not work in acute illness. It doesn't become active for at least a week... Vitamin D3 is for prevention and you should continue to take it if your levels are below 50 ng/ml...

There is only one form of vitamin D that will have an acute impact and that is calcifediol (vitamin D3 analog). 

About FLCCC Alliance

The Front Line COVID-19 Critical Care (FLCCC) Alliance was initially formed as a working group under “emergency” conditions of the early COVID-19 pandemic in response to multiple early reports of COVID patients with an inexplicably high need for prolonged mechanical ventilation and an excessive mortality associated with the prevailing “supportive care only” recommendations disseminated by the majority of national and international health care organizations.

As a group of highly published leaders in critical care with expertise in therapies directed at severe infections, in particular “HAT” therapy first developed by Dr. Paul Marik for the treatment of bacterial sepsis, and along with published high patient survival rates from our centers, we were contacted by equally concerned and motivated colleagues from other specialties.

With the increasing publications in addition to our rapidly accumulating personal clinical experiences and investigations into the pathophysiology of COVID-19 patients, we formulated the MATH+ Hospital Treatment Protocol in March 2020. On August 5, 2020, FLCCC published our findings in the rationale paper Scientific Review of COVID-19 and MATH+.

In October 2020, the FLCCC Alliance identified, based on a review of the recent and rapidly emerging clinical trials evidence, that ivermectin, an anti-parasitic medicine, has highly potent real-world, anti-viral, and anti-inflammatory properties against SARS-CoV-2 and COVID-19. This conclusion is based not only from multiple in-vitro and animal models, but from numerous clinical trials from centers and countries around the world showing repeated, consistent, large magnitude improvements in clinical outcomes when ivermectin is used not only as a prophylactic agent but also in mild, moderate, and even severe disease states. Further, data from large “natural experiments” that appear to have occurred when various regional health ministries and governmental authorities within South American countries initiated “ivermectin distribution” campaigns which then led to temporally associated decreases in case counts and case fatality rates.

Other Potential Treatments

For other potential treatments for COVID-19, check out c19early.com (constantly updated).

Other FLCCC Protocols

Conclusion and Key Takeaway

If you are an average layperson, you will likely find this protocol overwhelming. This is a guide and may need to be personalized according to your unique situation. Always see or talk to your doctor before taking these drugs, supplements and over the counter products.

Be aware that most of the 'treatment' doses for supplements are above the recommended dietary allowance (RDA) and therefore such doses should not be maintained on a long term basis.

This guide may not be the answer to everything but it could be everything to you or your loved ones.
    • Please do not consider these protocols as personal medical advice, but as a recommendation for use by professional providers. Consult with your doctor, share the information on this website and discuss with her/him.
    • We are fans and affiliates of FLCCC. We do not represent FLCCC. Any opinions are our own.
    • Always see or talk to your doctor before taking these drugs, supplements and over the counter products. Be aware that most of the 'treatment' dosages are above the recommended dietary allowance (RDA) and therefore such dosages should not be maintained on a long term basis. 
    • Our aim here isn't to replace your doctors' advice. It is intended as a sharing of knowledge and information. Do take note that supplements are not 100% protective or curative against COVID-19.
    • The I-MASK+ protocol is a bridge to vaccines and a safety net for those who cannot or have not been vaccinated; or are vaccinated and have concerns regarding declining protection against emerging variants. Vaccines have shown efficacy in preventing the most severe outcomes of COVID-19 and are an important part of a multi-modal strategy that must also include early treatment. The decision to get a vaccine should be made in consultation with your health care provider. 
    • You still need to follow the advice given by CDC, WHO and your local authority in terms of local guidelines such as mask wearing, social distancing, vaccination and avoiding crowds. It's better to combine multiple strategies in order to defend yourself against this virus.
    • According to US NIH: "...Guidelines should not be considered mandates. The choice of what to do or not to do for an individual patient is ultimately decided by the patient and their provider."

    Z-Stack Supplement

    In an effort to make it easier for patients, Dr Zelenko has developed an oral supplement that contains all four key ingredients (which was based on his Nobel Prize-nominated Zelenko Protocol): Quercetin, vitamin D3, C and zinc. It’s referred to as 'Z-Stack Supplement.
    Studies have shown that treatment needs to be started 'early'. Don't wait until it's too late to start treatment – keep a bottle on hand for peace of mind. 

    The Z-Stack Vitamins are Kosher certified, GMP certified and made in the USA.

    The cost of the Z-STACK vitamin cocktail is $55 per bottle for a one month supply.

    Where to buy Z-Stack: Z-stack is available on Dr Zelenko's website. Here is the link: Z Stack Supplement.

    Note: To get 5% OFF, please use this coupon code: drfrancis


    1. I'm so encouraged by the stand more doctors are taking to prevent and treat COVID-19 the way they swore an oath to do, instead of insisting that only a vaccine can end the pandemic and prevent deaths. It's baffling to me why all doctors are not on board demanding the NIH, WHO and CDC end their irrational, non-health-oriented approach to COVID-19 protocols. It seems they are controlled by the pharmaceutical industry. I hope even more doctors will wake up and let their own knowledge and experience and desire to heal guide them. I hope a huge contingent of healthcare practitioners will march on Washington and demand changes in those organizations. Thank you all who prescribe known safe medications for prevention and treatment for standing up to them so fewer people die going forward.

    2. Why are you promoting masks and social distancing? In your press conference, Frontline dr.s compared throwing sand at a chain link fence to wearing masks. Also some of those brands have fillers that are not beneficial, do not state tested by 3rd party for contaminates, nor non gmo, like most corn and soy....rice. Why haven't you come together to sue the CDC, FDA, hospitals, nih, government... any one? In some states they're masking our kids, mandating vaccines, not allowing us to choose. Frontline Dr.s... We need you to start suing. Also , please consider adding NAC to some of the natural protocols... consider what steroids may do to some and some herbals, like elderberry contribute to cytokine storm of its own.

    3. A resounding THANK YOU!!!
      The medical industry in the US is acting negligent at least in suppressing your information.

    4. What is safe for high fevers 103 plus for 14 year old


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