12 Best Quercetin Zinc Immune Support Supplements 2021

What Is Quercetin?

Quercetin is an antioxidant that belongs to a class of water-soluble plant substances called flavonoids, which are present in certain fruits and vegetables. According to an article in Current Research in Nutrition and Food Science, the bioavailability of quercetin absorbed by your body varies, depending on the source where you get it, as well as your individual body’s metabolism of it. Sugar and dietary fat and fiber also affect it.

While the best way to get quercetin is through your diet, it also is available in supplement form, as pills or capsules. Sometimes, quercetin in supplement form is packaged with bromelain, an enzyme found in pineapples, because both have anti-inflammatory properties (Quercetin & Bromelain for inflammation). Most dietary supplements contain a chemical compound, aglycone, which is the free form of quercetin.

When looking for and using quercetin supplements, it’s important to maintain a nutritious, balanced diet with fiber and healthy fats in it, as research shows that accumulation of quercetin in the body is dependent on “factors such as glucose moieties, solubility, human factor, vitamin C status and food matrix.”

Specifically, research also says that quercetin supplementation is best achieved when consumed with a fat-enriched diet.




There are foods high in quercetin that you can add to your diet. Arguably, red onions are some of the most potent sources of quercetin; one study found that absorption of onion-derived quercetin was 52% compared to only 24% in supplement form. In fact, onions can give you three times the amount of quercetin than you’d get from apples. Other food sources that are high in quercetin include:
  • Organically grown apples, grapes and tomatoes
  • Dark cherries and dark berries like blueberries, blackberries and bilberries (eaten in moderation)
  • Cocoa, unsweetened
  • Hot green chili peppers
  • Lingonberries

Benefits of Quercetin

Quercetin has been linked to the following health benefits:
  • Possessing anti-inflammatory, antioxidant properties that can help combat certain diseases. One study found that 500 mg of quercetin a day could improve symptoms of rheumatoid arthritis.
  • Helping prevent cancer cell growth from breast, colon, prostate, endometrial and lung.
  • Counteracting allergic reactions and helping with immune responses.
  • Helping to prevent osteoporosis
  • Addressing cognitive decline, including Alzheimer’s and dementia.
  • Assisting in control of blood pressure. A study in 2002 found that quercetin can have vasodilator effects.
  • Potentially helping to lower blood sugar levels. One study found that dosages of 500 mg per day “significantly reduced” fasting glucose levels.

Quercetin and Vitamin C for COVID-19?

There is evidence that vitamin C and quercetin co-administration exerts a synergistic antiviral action due to overlapping antiviral and immuno-modulatory properties and the capacity of ascorbate to recycle quercetin, increasing its efficacy.

For prevention, the Front Line COVID-19 Critical Care Working Group (FLCCC) I-MASK+ protocol recommends (updated April 26, 2021):
  • Vitamin D3: 1000–3000 IU/day. Note RDA (Recommended Daily Allowance) is 800–1000 IU/day. The safe upper-dose daily limit is likely < 4000 IU/day. Vitamin D deficiency has been associated with an increased risk of acquiring COVID-19 and from dying from the disease. Vitamin D supplementation may therefore prove to be an effective and cheap intervention to lessen the impact of this disease, particularly in vulnerable populations, i.e. the elderly and obese. (Amazon)
  • Vitamin C: 500 - 1,000 mg BID (twice daily) 
  • Quercetin: 250 mg daily. It is likely that vitamin C and quercetin have synergistic prophylactic benefit. Quercetin should be used with caution in patients with hypothyroidism and TSH levels should be monitored. (Amazon)
  • Melatonin: 6 mg before bedtime (causes drowsiness). (Amazon)
  • Zinc: 30 - 40 mg/day (elemental zinc). Zinc lozenges are preferred. (Amazon)
  • Ivermectin prophylaxis dosage:
    • prevention for high-risk individuals: 0.2 mg/kg per dose (take with or after meals) — one dose today, repeat after 48 hours, then one dose weekly. 
    • Post COVID-19 exposure prevention: 0.2 mg/kg per dose (take with or after meals)  — one dose today, repeat after 48 hours.
High risk Individuals: > 60 years with co-morbidities (hypertension, diabetes, chronic lung disease, chronic kidney disease), obesity, long term care facilities, etc.

Post COVID-19 exposure: To use if a household member is COVID-19 positive, or you have prolonged exposure to a COVID-19 positive patient without wearing a mask.

Precautionary Note: Ivermectin has a number of potentially serious drug-drug interactions. Please check for potential drug interaction at Ivermectin Drug Interactions - Drugs.com. The most important drug interactions occur with cyclosporin, tacrolimus, anti-retroviral drugs, and certain anti-fungal drugs. 

Due to the possible drug interaction between quercetin and ivermectin (may increase ivermectin levels), these drugs should not be taken simultaneously (i.e. should be staggered morning and night). 

Ivermectin is also lipophilic and therefore, bioavailability is maximised on a full stomach; or best to be taken with meal.

Related: List of Doctors that will prescribe Ivermectin

For early outpatient protocol (COVID-19 positive), the Front Line COVID-19 Critical Care Working Group, FLCCC I-MASK+ protocol recommends (updated Apr 26, 2021):
  • Vitamin D3 — 4000 IU/day. (Amazon)
  • Vitamin C: 500 - 1,000 mg BID (twice daily) (Amazon)
  • Quercetin: 250 mg twice a day. (Amazon)
  • Melatonin: 10 mg before bedtime (causes drowsiness). (Amazon)
  • Zinc: 100 mg/day. Zinc lozenges are preferred. (Amazon)
  • Ivermectin: 0.2–0.4 mg/kg per dose (take with or after meals) — one dose daily, take for 5 days or until recovered. (Find a Doctor). Use upper dose range if:  1) in regions with more aggressive variants; 2) treatment started on or after day 5 of symptoms or in pulmonary phase; or 3) multiple comorbidities/risk factors.
  • Fluvoxamine: 50 mg twice daily for 10–14 days. Add to ivermectin if: 1) minimal response after 2 days of ivermectin; 2) in regions with more aggressive variants; 3) treatment started on or after day 5 of symptoms or in pulmonary phase; or 4) numerous co-morbidities/risk factors. Avoid if patient is already on an SSRI (selective serotonin reuptake inhibitor).
  • Nasopharyngeal Sanitation: Steamed essential oil inhalation 3 times a day (i.e. vapo-rub) and/or chlorhexidine/benzydamine mouthwash gargles and Betadine nasal spray 2–3 times a day.
  • Aspirin: 325 mg/day unless contraindicated.
  • Pulse Oximeter: FLCCC also recommend monitoring your oxygen saturation with a pulse oximeter and to go to the hospital if you get below 94%.
Optional (Editor's Note): Curcumin: 500 mg twice a day (Ref) (Amazon)

The medical evidence to support each drug and nutrient can be found under “Medical Evidence” on the FLCCC’s website.

Quercetin, Zinc and Vitamin C - Dr Zelenko's Protocol for COVID-19

According to Dr. Zelenko, the best over the counter substitute or natural alternative to hydroxychloroquine is quercetin. 

When hydroxychloroquine is not available, Dr. Zelenko recommends the following OTC (over-the-counter) treatment in the early stages of COVID-19 and quercetin as a natural alternative to hydroxychloroquine. He recommends this treatment immediately after you have symptoms.
  • Zinc 50mg 1 time a day for 7 days (PubMed) (Amazon)
  • Quercetin 500mg 2 times a day for 7 days (PubMed) (Amazon
  • Vitamin C 1000mg 1 time a day for 7 days (Amazon)
  • Vitamin D3 5000 IU 1 time a day for 7 days (Amazon)
As a prevention treatment, Dr. Zelenko recommends the OTC (over-the-counter) alternatives to hydroxychloroquine. His prophylaxis protocol for COVID-19 is the following:

What is Zinc?

Zinc is a powerful immune nutrient known for its benefits for providing immune health support and inflammation reduction as well as for improving cold and respiratory symptoms, wound healing, acne reduction, and lowering the risk of age-related diseases. Research on atherosclerosis and diabetes mellitus suggests that zinc deficiency may contribute to low-grade systemic inflammation.

Even more popular at the moment is the role of zinc and the potential benefits against COVID-19. This is probably one of the reasons that's driving the demand on zinc related products. In a ConsumerLab survey of 9,647 people who use dietary supplements shows that the supplements which experienced the greatest growth in popularity in 2020 were those being promoted to prevent or treat infection with SARS-CoV-2, the coronavirus that causes COVID-19. Zinc supplements achieved the highest growth with 13.5% points.

Does zinc help treat COVID 19? In order to answer that question, there are many zinc studies underway and you can review the status of these trials on clinicaltrials.gov. As of March 2021, there are 20 studies that have been launched to investigate the benefits of Zinc against COVID-19.

Are all zinc supplements the same? The zinc supplements in this review are all manufactured by reputable companies that follow Good Manufacturing Processes (GMP), use high quality ingredients, and test for purity and quality.

Here are the best zinc supplements to help you meet your nutritional needs. As everyone has their own set of criteria, the best option for you might be different from another person.

Best Zinc Supplement 2021

1. NOW Foods Zinc Glycinate Softgels - Best Chelated Zinc

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Price: From $11.49

Amazon Reviews: 4.7 out of 5. More than 600 customer reviews.

Zinc Dosage : 30mg

Chelated zinc is a type of zinc supplement that uses a chelating agent to help your body absorb zinc more easily.

While there are several chelated zinc supplements on the market, one of the best options is NOW Foods’ Zinc Glycinate softgels. Each softgel contains 30 mg of zinc glycinate — a form of zinc that human and animal studies suggest may be better absorbed than other types of zinc. (Trusted SourceTrusted Source).

All NOW Foods supplements are certified by Underwriters Laboratories and follow GMP to ensure the quality and accuracy of their products. Additionally, these supplements tend to be more affordable than many other high quality brands.

I take this in combination with Vitamin A to help with cystic acne, and have noticed a drastic improvement in both my acne and my overall complexion. I have noticed little to no side effects since taking Now Foods Zinc Glycerinate 30mg Soft-gels over a year ago.


2. Pure Micronutrients Pure Zinc Chelate




Price: From $20.00

Amazon Reviews: 4.7 out of 5. More than 4,000 customer reviews on Amazon.com.

Zinc Dosage : 25mg

FAST RELIEF / PEAK IMMUNE SUPPORT – Our advanced zinc chelate supplements deliver zinc in the form of Bisglycinate, a clinically proven highly absorbable form that's faster acting. Pure Zinc further acts to neutralize free radicals, enhances the body's inflammatory response, and increases energy levels, the foundations for a strong healthy immune system. 

FEEL ENERGETIC, ENJOY CLEAR SKIN, SUPPORT REPRODUCTIVE HEALTH - Specifically designed to restore optimal zinc levels critical for energy production, healthy immune function and growth / repair within the body. Zinc is an essential mineral for cell function and healthy tissue development, in particular, DNA synthesis and cell division, promoting a healthy reproductive system, skin (eg: acne), hair & eyes and great for avoiding common illness.

GENTLE, NO UPSET STOMACH - Pure Zinc contains a very gentle form of Zinc that breaks down in the small intestine, greatly reducing the incidence of digestive discomfort, nausea and/or diarrhoea or constipation. Perfect for women, men, elderly, women during pregnancy & teenagers who are prone to stomach irritability following vitamin supplementation. Pure Zinc is easily digested with or without food.

NATURAL, PURE & TRUSTED – Pure Zinc is the perfect natural alternative to pharmaceutical medicines. Contains only pure ingredients; gmo free, no fillers, preservatives or other non-active ingredients - so you can reap the benefits, nurture & protect your body, without any of the Nasties. Kosher & Halal friendly. #1 Pharmaceutical Grade, USA MADE, Third Party Tested with a 100% Lifetime Satisfaction Guarantee.

Review 
My nutrition coach insisted I find a zinc supplement to add to my health regimen. I usually avoid supplements, therefore this is the only one in my arsenal. I take it every morning and feel confident in its benefits. I survived the flu season without a single sniffle or sneeze (hope it's fair to give this product some credit for that). I have paired this product with a healthier diet throughout the last few months and have noticed a great improvement in my energy and well being. 


3. Albion Minerals Smarter Vitamins Zinc Glycinate 



Price: From $16.00

Amazon Reviews: 4.6 out of 5. More than 1,500 customer reviews on Amazon.com.

Zinc Dosage : 15mg
- 15mg Zinc Glycinate from Albion® 
- Boosted with 5 Extra Essential Trace Minerals to Support Metabolism, DNA and Enhanced Supplement 
- 90 Plant-Based Vegan Capsules

- Enhanced Multi-Mineral Zinc Supplement with Selenium, Manganese, Boron, Chromium, Selenium, Molybdenum For Next Level Trace Mineral Boost In Health. 
- MicroMinerals Supports Cellular Energy Production, Hormones, Neurotransmitters, Metabolism and DNA.
- 6 Essential Trace Minerals Complex 
- 1 Plant Based Capsule Pill Supports you with a Multi Mineral Supplement In Chelate, Glycine, Bisglycinate + Glycinate Absorable forms. 
- No Citrate or Oxide Forms
- Made in the USA without Fillers, Magnesium Stearate, Dioxides, Silica, Maltodextrin, Carrageenan, Soy, Milk, Egg, Corn, Tree Nuts, Artificial Colors, or Preservatives.

I'm sleeping better, my joints feel better, I feel better overall. I don't know if it's random or the supplement but I don't want to stop using it. Plus my dr said my boron levels were low so this is a great way to bring them up and that can help my nails and hair as well.


4. NutriGold Zinc Gold - Best Organic


Price: $18.38

Zinc Dosage : 15mg

If you’re looking for an organic zinc supplement, NutriGold’s Zinc Gold is one of the best options out there.

Each capsule contains 15 mg of whole-foods-based zinc that’s derived from an organic sprouted blend, which the supplement claims may be gentler on your stomach. Additionally, NutritGold’s supplements are certified organic by SCS Global Services, an official partner of the United States Department of Agriculture (USDA) that sets sustainability, quality, and organic standards. Each product is also third-party tested, as well as non-GMO and vegan certified.

Adults should take 1 capsule daily, or as directed by your healthcare provider.


5. Nature's Bounty Zinc 50mg Caplets



Price: From $5.21 

Amazon Reviews: 4.8 out of 5. More than 50,000 customer reviews on Amazon.com.

Zinc Dosage : 50mg

This product is the #1 best seller under the zinc mineral supplements on Amazon Best Sellers and has more than 50,000 customer reviews on Amazon.
One vegetarian-friendly caplet a day contributes to carbohydrate, protein, fat and energy metabolism, and helps promote wellness in key areas of reproductive health for men. Plays a key role in the synthesis of testosterone.



6. SM Nutrition - Chelated Zinc Glycinate



Price: From $19.00

Amazon Reviews: 4.8 out of 5. More than 250 customer reviews on Amazon.com.

Zinc Dosage : 30mg

- Zinc Glycinate Chelate 
- 30 mg Supplement (120 Capsules) 
- TRAACS Chelated Bisglycinate Zinc, Vitamin B6 & BioPerine 
- Zinc Supplements for Immune Support, Acne & Metabolism

OPTIMAL ZINC BIOAVAILABILITY: Chelated Zinc Glycinate by SMNutrition uses the patented TRAACS delivery system to bind this essential mineral to amino acids for thorough absorption. Each serving contains net 30mg of elemental Zinc, with BioPerine and Vitamin B-6 added to make this the most absorbable Zinc available.

IMMUNE SUPPORT: Studies indicate that Zinc is critical for supporting overall immune function.

WIDE-RANGING BENEFITS: Supplementing with a Zinc vitamin may support: skin health, hormone balance, heart health, digestive health, liver health, and much more

I've been taking zinc for many years for a medical condition...this product is awesome and seems more bioavailable than other brands I've tried. It is CLEAN...and as someone with celiac I am grateful!


7. Sandhus Zinc Quercetin 120 Vegetarian Capsules


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Price: $11.39

Amazon Best Sellers: #4 Best Seller in zinc mineral supplements. 4.8 out of 5 overall rating with more than 6,000 customer reviews.
  • Supports immune system health
  • 60 servings per bottle
  • Supports cardiovascular health

Best Quercetin Supplements 2021

8. Now Foods Quercetin with Bromelain (Now Quercetin with Bromelain Amazon)


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Price: From $30.00

Amazon Reviews: 4.8 out of 5. More than 1,900 customer reviews on Amazon.com.

Quercetin Dosage : 400mg

A two-pack of top notch bromelain-enhanced quercetin from a giant in the health supplement industry. Reliable quality from a trustworthy brand.

Each capsule contains 400 mg of quercetin and 82.5 mg of bromelain. Do take note that their suggested usage is 2 capsules twice daily. Meaning the total daily dosage of quercetin will be 1,600 mg daily.

Daily value (DV) for quercetin not established.

Now Foods Quercetin supplements contain Bromelain, as some evidence suggests they boost absorption.

For prevention of COVID-19, the FLCCC recommends 250 mg daily for prevention and the Zelenko protocol recommends 500 mg daily for prevention. If you wish to stick to the dosage which is within the range of the FLCCC - Zelenko protocols; that would be 250 mg to 500 mg daily i.e. 1 capsule of Now Foods Quercetin per day.

BestReviews.com: Not suitable for those with pineapple allergies.

Our Take: If you are looking for best value and are taking it on a long term basis, this would be your choice.

So as someone who suffers from constant sinus issues , I decided to try it. I’ve only taken 3 doses and I’m super happy I got it . For the first time I don’t feel like there is something in my nose (which my ENT says it’s inflammation I’m feeling ). I’ve had ballon sinuplasty , endoscopic sinus surgery ,do sinus nasal rinses, had allergy testing (no allergies at all ) and use Flonase daily & still felt ‘something ‘ in my nose and often feel sinus pressure.
Well 3 days later I can finally breath without feeling anything in my nose !!!!


9. Thorne Research Quercenase  



Price: From $45.00

Amazon Reviews: 4.8 out of 5. More than 100 customer reviews on Amazon.com.

Quercetin Dosage : 250mg

Quercenase is a combination of quercetin phytosome and bromelain. Quercetin phytosome is a new food-grade lecithin-based formulation of quercetin, was developed to overcome the low bioavailability hurdle of quercetin. Phytosome complexes are created by a patented process that binds a botanical extract to a phospholipid (phosphatidylcholine), which are key components of every cell membrane.

Each capsule contains 250 mg of quercetin phytosome and 100 mg of bromelain.

BestReviews.com: Pricier than many similar products on the market

Our Take: If you are looking to buy from a reputable brand, this would be your choice.

I have histamine intolerance and had spent many years taking prescription and OTC drugs. I wanted to get away from drugs and my functional medicine doctor recommended d-hist. It worked on my allergies but I would get migraines if I took it too often. I think it was the nettles. Anyway, I also didn't like that they used magnesium stearate. I bought this and it works just as well as my Claritin did. I get relief from runny nose and sneezing as well as itchy skin. I will sometimes add some extra bromelain but I am very happy. Thorne products are often more expensive but they use better ingredients and omit questionable ingredients that make production cheaper

10. Amazing Formulas - Quercetin 500 Mg



Price: From $12.00

Amazon Best Sellers: #1 Best Seller in Flavonoid Vitamin Supplements. 4.7 out of 5 overall rating with more than 15,000 customer reviews.

Quercetin Dosage : 500mg
  • Quercetin is a flavonoid (plant pigment) naturally found in fruits and vegetables. It is found in many foods, such as red wine, onions, green tea, apples, berries etc. It known for its Anti-oxidant and Anti-Inflammatory Properties. Amazing Nutrition Quercetin 500 Mg is offered in Veggie Capsule to suit most diet preferences
  • Anti-oxidant properties of Qurecetine Supports Healthy Ageing, Cardiovascular Health, and Immune Health. It helps to reduce the damage and irritation caused by free radicals
  • Anti-Inflammatory properties of Quercetin helps to lower the release of histamines, a compound that is released by cells in response to allergic and inflammatory reactions. Subsequently helping to lower pains and discomfort related to Inflammation.
  • All Amazing Nutrition products are manufactured in accordance with Good Manufacturing Practices (GMP), among the highest standards in the world.
As someone with fibromyalgia who wants to minimize the number of prescriptions I take, I am always looking for natural supplements for pain managerment and energy. I did my research and decided to try a Quercetin supplement for inflammation support. I am not disappointed in the least. While it's only been a short time I have been taking it, I feel good! So glad I took the chance!

11. Natural Factors Bioactive Quercetin



Price: From $20.00

Amazon Best Sellers: #25 Best Seller in Flavonoid Vitamin Supplements. 4.8 out of 5 overall rating with more than 290 customer reviews.

Natural Factors Bioactive Quercetin EMIQ claims to have 40 times better absorption than ordinary quercetin. Other quercetin supplements here use bromelain to boost bioavailability, but this supplement uses “EMIQ”, a proprietary formula made from “Enzymatically Modified IsoQuercetin”.

Dosage of quercetin is somewhat low (as compared to other brands) in each capsule. However, Natural Factors claims the quercetin is more bioavailable, which means your body gets a strong dose regardless. Each capsule contains 167 mg of EMIQ and 50 mg of vitamin C. Natural Factors claims their formula will provide year-round protection while supporting a healthy inflammatory response and maintaining good sinus and upper respiratory function.

This literally took away all of my excessive histamine responses within a couple of hours. the second day got even better. If you suffer from allergies or inflammation and would like a natural option, please consider this.

Our Take: Best Quercetin for Bioavailability

12. MoxyVites Quercetin 500mg with Bromelain Supplement

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Price : From $25.00

Reviews : 4.9 out of 5 - 89 global ratings on Amazon

Quercetin Dosage : 500mg

- Bioactive Phytosome Complex
- Pure Organic Whole Food Seasonal Support
- Healthy Inflammatory Response
-120 Caps
- Plant Based
- Made in USA
- Quercetin, Phytosome, Bromelain
- All Natural, Organic, Vegan, Vegetarian, Gluten Free, Non GMO, No Artificial or Synthetic Ingredients
- GMP certified facility, THIRD PARTY TESTED!

- IMPROVED ORAL ABSORPTION BY 20X
> Regular quercetin has poor solubility and low oral absorption. Our technology binds quercetin with a glucose bond & incorporation of phospholipids into standardized extracts improving the absorption and bioavailability by 20X. If you settle for regular quercetin your body may only absorb 20% with minimal to no benefit.

- BIOACTIVE FORM OF QUERCETIN
> Our complex delivery system utilizes phytosome technology in which phytoconstituents react with phospholipids for better and improved bioavailability. Our quercetin is one of the most effective on the market today!

- POWERFUL BENEFITS
> Powerful antioxidant, healthy inflammatory responses, boost the immune system, reduce histamines and skin irritations, supports cardiovascular & cellular health.

Review
This is the best quercetin I found on the market! It was a revelation to me to discover that regular quercetin is difficult for the body to absorb. After doing my research I discovered that quercetin phytosome has much greater absorption and is therefore more effective. I have been taking this for over a month and my allergy symptoms have been reduced tremendously. In addition, this company added specific Whole Foods that contain the highest amount of added quercetin for additional quercetin benefits. Besides allergies I also take this for it’s high anti oxidants and many other health benefits. I love this brand and I will continue to buy their products.

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