6 Best Melatonin Supplements and Reviews 2022

According to the Centers for Disease Control and Prevention (CDC), about 1 in 3 Americans don’t get enough sleep. Others may experience poor sleep or insomnia. But melatonin, a widely available supplement, may help with several sleep issues. Research from 2014 reported that it shows promise in the treatment of insomnia among healthy adults. Some people also use it for jet lag, delayed sleep-wake phase disorder (DSWPD), and anxiety before or after surgery.

Melatonin is a hormone produced by the pineal gland in the brain, mainly during the night, that helps regulate circadian rhythms [Source]. Its levels decrease with aging. Most melatonin supplementation studies have evaluated its ability to control sleep and wake cycles, promote sleep, and reduce jet lag.

Assisting sleep and rest is already an immune system-supporting benefit, but melatonin has more to offer. It is a powerful antioxidant that supports your immune health, brain, eyes, digestion, and more. It may even be helpful when it comes to COVID-19.

While it is most well-known as a natural sleep regulator, it also has many other important functions. For example, melatonin is a potent antioxidant (Antioxidants, 2020) with the rare ability to enter your mitochondria, where it helps “prevent mitochondrial impairment, energy failure and apoptosis of mitochondria damaged by oxidation.” It also helps recharge glutathione and glutathione deficiency has been linked to COVID-19 severity.

The potential utility of melatonin in treating COVID patients has not gone unnoticed, with a PubMed search combining melatonin and COVID producing more than 50 citations.

Check out the evidence tracker on melatonin and COVID-19 from c19melatonin.com (constantly updated).

Laboratory and animal studies suggest that melatonin enhances immune response by increasing the proliferation and maturation of natural killer cells, T and B lymphocytes, granulocytes and monocytes . Melatonin also appears to have anti-inflammatory and antioxidant effects [Source]. However, whether these properties have a clinically significant effect on immunity in humans is not clear.

Safety: If you take a melatonin supplement, be careful: Too much can cause daytime sleepiness. There is no federal RDA nor any formal advice on supplement dose ranges. Based on an on-going Spanish study, a 2 mg daily dose protocol is being investigated for prevention of COVID-19. Do take note that the dosage for 'prevention' and 'treatment' is different, For prevention or maintenance, a lower dosage is normally recommended whereas a 'treatment' or 'therapeutic' dosage is normally higher.

Typical doses of 1–10 mg/day melatonin appear to be safe for short-term use (Source). Reported side effects, which are usually minor, include dizziness, headache, nausea, upset stomach, rash, and sleepiness. However, some reports have linked high blood levels of melatonin with delayed puberty and hypogonadism.

Studies have not evaluated melatonin supplementation during pregnancy and breastfeeding, but some research suggests that these supplements might inhibit ovarian function (Source). Therefore, some experts recommend that women who are pregnant or breastfeeding avoid taking melatonin.

In this article we will explore which melatonin is best for adults.

Best Melatonin Supplements for Adults 2022

1. Natrol Melatonin Fast Dissolve Tablets

Natrol Melatonin fast dissolve tablets are available in 3 different doses:
  1. Natrol Melatonin 3 mg (4.7/5 overall rating, more than 10,000 reviews)
  2. Natrol Melatonin 5 mg (4.7/5 overall rating, more than 30,000 reviews)
  3. Natrol Melatonin 10 mg (4.6/5 overall rating, more than 30,000 reviews)

Natrol Melatonin received the highest rating on overall consumer satisfaction within the melatonin supplement market segment based on ConsumerLab's Top-rated Vitamin and Supplement Brands and Merchants for 2022 survey.

Natrol Melatonin can help establish normal sleep patterns to give you a more restful, relaxing sleep.

It is recommended that you start with the lowest dose, taken 20 - 30 minutes before bedtime. If you're still having trouble falling asleep, you might wish to increase your dose i.e. from 3 mg to 5 mg. However, if you're experiencing dizziness or grogginess the next morning, it is recommended that you decrease the dose.

Despite repeated emphasis upon the distinction between dose and dosage, the two terms continue to baffle many writers. A dose refers to a specified amount of medication taken at one time. By contrast, the dosage is the prescribed administration of a specific amount, number, and frequency of doses over a specific period of time.

2. Vitafusion Extra Strength Melatonin Gummies


Dosage : 5mg (2 gummies)

Vitafusion Melatonin Gummies for Adults Price: $11.49

Comprised of five milligrams of melatonin, Vitafusion’s Extra Strength Melatonin Gummies offer a stronger sleep aid to those who have difficulty falling asleep on their own. A fan-favorite jet lag solution, this top-rated melatonin gummy also helps improve your quality of sleep so you can wake up feeling refreshed and well-rested.

Ratings : 4.7 / 5 - more than 35,000 Ratings on Amazon

These are a life saver for good sound sleep and waking up rested. I take them right as I go to bed and doze right off peacefully. I normally can'r shut my mind off and get anxiety when trying to sleep some nights. my mom recommended these and they work like a charm. Good healthy sleep aids!

3. OLLY Sleep Gummies


Dosage : 3mg (2 gummies)

OLLY Melatonin Gummies for Sleep Price : From $13.99

These tart and tasty blackberry-flavored gummies melt in your mouth. Each gummy contains chamomile, lemon balm, and L-theanine, an amino acid that promotes calm and relaxation.

These gummies carry the NSF seal.

Ratings : 4.5 / 5 - Over 10,000 Ratings on Amazon

I can’t believe how well these worked. Sleeping pills and things to help me sleep haven’t been very helpful in the past. So being skeptical I took 2x the dosage. I ate 4 of the gummies instead of two. I figured it would help me get a much needed nap and instead it might as well have caused me to go into a coma. Lol. I took them around 11:00am and after 5 times of trying to get me up my wife gave up. It’s now 3:00 and we have to go to a dinner at her parents house but I’m not sure if I’ll be able to drive. I don’t know what you guys created but...I’m a huge fan. Knocked me right out!

Dosage : 6mg (2 gummies)

Vicks Melatonin Gummies for Sleep Price: $29.99

#36 on Amazon Best Sellers in Medicinal Sleep Aids category

Each blackberry-vanilla-flavored serving contains 6 mg of melatonin per dose, which is 2 gummies. The formula also contains ashwagandha, an herb used in traditional Ayurvedic medicine to reduce stress and anxiety, and valerian root, which promotes sleep.

Blackberry and vanilla-flavored, these top-rated gummies also contain chamomile, lemon balm, valerian root and lavender.

Be aware that these substances may pose some risks. For instance, they may interfere with medication. People who are pregnant shouldn’t take valerian.

Ratings : 4.5 / 5 - Over 3500 Ratings on Amazon

I take them about half an hour to an hour before I plan on sleeping and oh boy! They do work! When my head hits the pillow I knock out fast! The first few days I woke up with a little brain fog but after the first few uses that went away and I’ve slept better then I have in years. I was surprised at how well they worked! Definitely will order again when I run out! 

5. Nordic Naturals Zero Sugar Melatonin Gummies - Sugar Free Melatonin Gummies


Dosage : 1.5mg (1 Gummy)

Nordic Naturals Melatonin Gummies Price: $16.96

For those looking for a sugar-free alternative, the Nordic Naturals Zero Sugar Melatonin Gummies feature 1.5 milligrams of melatonin and encourage and support a healthy sleep pattern, ensuring that you wake up feeling rested and refreshed following a good night’s sleep. They also provide a rich source of antioxidants, which contain healthy nutrients and help neutralize free radical damage in the body.

Ratings : 4.5 / 5 - Over 500 Ratings on Amazon

I’ve been sleeping surprisingly well since starting these. I don’t take them every night, but typically 3-4 nights per week. I take one or two gummies about an hour before bedtime, and I fall asleep right away when I get into bed. This is a huge improvement from my usual routine of lying awake or tossing and turning for hours.

6. MegaFood Melatonin Berry Good Sleep Gummies


Dosage : 3mg (2 gummies)

Megafood Melatonin Gummies for Adults Price: $11.51

Made with a healthy dose of 3 milligrams of melatonin, MegaFood’s Melatonin Berry Good Sleep Gummies are flavored with organic wild blueberry and tart cherry to give each gummy their signature fruity flavour while helping you stay asleep throughout the night.

Ratings : 4.6 / 5 - 200 ratings on Amazon

This stuff is truly amazing! My 8yo son is currently on chemotherapy treatment for leukemia which has huge impact on his sleeping pattern unfortunately. When his oncologist gave us green light I was excited to try this gummies but I must say I did this with a bit of reluctance. However to my surprise it works wonderfully! We didn’t have such restful sleep in ages! He take one gummy each night and within 30-40 minutes he’s ready to slumber zzzz he wakes up refreshed and not grumpy any more! 

Frequently Asked Questions

Melatonin and COVID-19?
The Frontline COVID-19 Critical Care Alliance (FLCCC) recommends the use of melatonin in their outpatient treatment protocols.

Melatonin is a known cyto-protector and has served in the past to combat several of the comorbidities associated with severe disease, including cardiovascular disease, diabetes and metabolic syndrome. Additionally, melatonin has neuroprotective properties that can potentially reduce the neurological sequelae documented in patients infected with COVID-19.

The potential utility of melatonin in treating COVID patients has not gone unnoticed, with a PubMed search combining melatonin and COVID producing more than 50 citations.

As of October 2021, there are 10 published clinical studies of melatonin for treatment and prevention in COVID-19 and the results are promising even when it's given as a late treatment.

How Much Melatonin Is Safe For Adults?
A safe dose for adults is between 0.5 mg and 5 mg. An adult dose is generally thought to be around 1 and 10mg.

Is it ok to take 30mg of Melatonin?
Doses of Melatonin near the 30mg mark is usually considered to be harmful.

Does Melatonin Help Adults Sleep?
Yes. In fact, Melatonin is commonly known as the "sleep hormone" as an increased level of the chemical allows your body to relax and fall asleep easier.

Does Melatonin Cause Weight Gain?
Melatonin is not associated with weight gain. However, poor sleep is associated with weight gain which may be remedied with Melatonin supplements.

Is Melatonin Good For Anxiety?
Yes, Melatonin has been shown to improve symptoms of anxiety.




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