10 Best Nicotinamide MonoNucleotide Supplements Review 2023

By Dr. Frank Yap, MD -

NMN stands for Nicotinamide MonoNucleotide, a molecule naturally occurring in all life forms. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered a key component to increase NAD+ levels in cells.

NMN is a precursor to NAD+, or nicotinamide adenine dinucleotide, meaning it becomes NAD+ through a series of chemical transformations. NAD+ is a critical found in every cell of your body, but levels of NAD+ naturally fall with age, making it — and NMN, as a result — crucial.

However, NMN is like a large bed that movers are trying to get through a door: It doesn’t enter the cell easily. One way for NMN to enter the cell is for it to chemically transform into another molecule (called nicotinamide riboside, or NR) before it can enter the cell. NR has earned a name for itself as a highly efficient precursor to NAD+ and can enter the cell as is. NMN, meanwhile, sometimes becomes NR before entering the cell, where it chemically transforms back to NMN and then ultimately becomes NAD+.

We've learned that NR leads to NAD+ and that it also has its own pathway that bypasses various steps other NAD+ precursors have to take. In early 2019, though, new research revealed NMN might only have to become NR for certain cell types, as NMN can enter cells in the small intestine of mice. It’s unclear whether or how this will translate to humans, if at all, but it’s teed up NMN as the newer kid on the block, making many wonder: How does it stack up against NR?

NR vs NMN Molecule

Pitting NR and NMN against each other is, for now, somewhat of a moot point because the two molecules have never been studied side by side in humans. The biggest, and most obvious, difference between NMN and NR is size. NMN is simply larger than NR, meaning it often needs to be broken down to fit into the cell. NR (Nicotinamide Riboside), when compared to other NAD+ precursors (like nicotinic acid or nicotinamide) reigns supreme in efficiency.

But give NMN a new door, one it can fit through, and it’s a whole new game. This is where cellular transporters come into play. Transporters are proteins that are doors on the cell; they allow molecules to enter the cell without needing to chemically transform.

Research from Shin-ichiro Imai, M.D., Ph.D., a professor of developmental biology at Washington University in St. Louis, identified a transporter that allows NMN to get into the cell without converting to NR. The catch? The transporter is only on cells located in the gut of mice and only works in the presence of sodium ions. NR, however, has been shown to enter cells in the liver, muscle, and brain tissue of mouse models. To date there is not yet evidence that these mouse studies can be extrapolated to humans. But again, the two have never been matched up against each other in a way that can truly identify one as superior to the other.

As research grows, it is likely to become clearer that NMN and NR may have differing benefits depending on the part of the body and their use. Where NMN transporters are found, they could make one more preferable over the other. NMN has also been found to improve insulin activity and production which could help to accelerate metabolisms and make the body more glucose tolerant.

Related: David Sinclair supplements

What Does NMN Supplement Do?

In numerous studies, supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more. Here, we look at the science behind NMN, its stability, possible pharmacokinetics, transport, function, and ability to induce biosynthesis of NAD+.15 Supplementing NMN may be an effective nutraceutical anti-aging intervention, with beneficial effects on a wide array of physiological functions.

Update and Alert: Starting March 13th, 2023, Amazon stated it would require further documentation from all nicotinamide mononucleotide (NMN) suppliers if they wanted to continue selling their product on the site. They must show proof that they have been approved by the U.S. Food and Drug Administration (FDA) for over-the-counter sales. If you regularly take NMN supplements, it may be a good idea to consider stocking up on an extra one or two bottles.

What Foods Contain NMN?

NMN can be found naturally in broccoli, cabbage, cucumber, edamame and avocado.

Best NMN Supplements 2023

Although there are many Nicotinamide MonoNucleotide supplement customer reviews on many online sites, we have sifted and curated some of the helpful ones below. Not all NMN supplements are created equal. Check out below the best NMN supplements available online.

1. Codeage Liposomal NMN + Resveratrol + Quercetin + TMG Supplement


Buy on iHerb (over 800 reviews)

Click to Enlarge

About this item
  • Liposomal delivery matrix: NAD precursor blend offering NMN nicotinamide mononucleotide + resveratrol, betaine, riboflavin, vitamin B12, and quercetin all-in-one through a liposomal phospholipid complex.
  • NMN Stabilized Form + Resveratrol: Codeage NMN nicotinamide mononucleotide performance supplement comes in powder-filled capsules for both women and men. This nicotinamide mononucleotide stable blend has been paired with trans-resveratrol, a polyphenol extracted from the root of Japanese knotweed, also know as Polygonum cuspidatum.
  • NAD Supplement Precursor & Betaine: This NAD precursor athletic fitness formulation delivers 85 mg of betaine anhydrous in each serving. Also called trimethyglycine (TMG), betaine usually consists of an amino acid derived from plants and sugar beets. NAD has been researched for its role on stem cells, telomere, and cellular energy.
  • Riboflavin & Vitamin B12 with Quercetin: Codeage Liposomal NMN formula also combines two of the vitamin B complex essential vitamins as well as quercetin. This formula provides Vitamin B2 as riboflavin-5-phosphate and vitamin B12 as methylcobalamine. These essential vitamins to support the metabolism have been blended with quercetin dihydrate from Japanese sophora flowers.
  • Manufactured in the USA: Codeage NMN & resveratrol vitality blend is non-GMO and manufactured in the USA in a cGMP certified facility. This liposomal nicotinamide with riboflavin supplement doesn't contain any fillers, hormones, or artificial ingredients. Third-party tested.
  • Liposomal delivery matrix: NAD precursor blend offering NMN nicotinamide mononucleotide + resveratrol, betaine, riboflavin, vitamin B12, and quercetin all-in-one through a liposomal phospholipid complex.
  • Suggested use: Take 3 capsules daily with 8 ounces of water or your favorite beverage. May be taken with or without food.
  • iHerb Best Seller Product Rank: #2 in Nicotinamide Mononucleotide (NMN) category;
    #2 in NAD+ category.
  • Over 800 customer reviews, most of them 5-stars on iHerb.com.
Important safety note: Resveratrol is not suitable for people undergoing blood-thinning medication.

2. ProHealth Longevity NMN Pro 500


Buy on iHerb (capsules) (over 300 reviews)

Also available as: 
- One of the few NMN products from the ChromaDex NMN Supplement Test Report (Oct 2021) that passed the test (contained at least 88% of the NMN label claim).
- ProHealth Uthever NMN is CLINICALLY PROVEN TO BOOST NAD+ LEVELS IN HUMANS. In a peer reviewed, double blind placebo controlled clinical study NAD+ decline was reversed by an average of 12 years. That's 38% more NAD+ in 60 days. Higher NAD+ levels are associated with more energy, feeling younger, less genetic damage, heart health, and SIRTUIN activation- longevity genes that are key for living better longer. Also, study participants’ quality-of-life test scores improved by 6.5%.
- ProHealth is the most trusted longevity supplement brand on the market, celebrating 34 YEARS with a BBB A+ RATING. Other brands may be cheaper, but do you trust that they actual contain any NMN?
- PUREST, HIGHEST QUALITY, PHARMACEUTICAL GRADE NMN IN THE WORLD. Every batch is 3rd party tested in a US lab to be at least 99.5% pure, and independent lab tests prove that our NMN products contain at least the number of grams of NMN per serving listed on the label. All 3rd party lab Certificates of Analysis are publicly posted. Our NMN is always manufactured in a FDA registered, GMP certified facility in the USA.
- ProHealth Uthever NMN is proven safe for human consumption in a clinical study. And our unique NMN capsules dissolve after passing unharmed through the stomach so the potency is preserved when it is delivered to the section of the intestine with the highest absorption rates- maximizing bioavailability.
- SHELF STABLE FOR TWO YEARS, and at OVER 200 DEGREES. Lab tests prove that ProHealth's Uthever NMN can be safely stored at ambient room temperature for up to two years with no loss in quality or potency. No refrigeration required.
- Over 500 customer reviews, most of them 5-stars on iHerb.com.

UTHEVER's CO-BRANDING PARTNERS

3. Life Extension NAD+ Cell Regenerator and Resveratrol Elite

Buy on iHerb (over 1,100 reviews)
  • NAD+ Cell Regenerator™ and Resveratrol Elite™ is Life Extension's Best in Class formula for energy support. It combines 300 mg of NIAGEN® nicotinamide riboside with an ultra-bioavailable trans-resveratrol (as well as bioavailability-enhanced forms of the phytonutrients quercetin and fisetin) to fight general fatigue and promote longevity with every dose.
  • NIAGEN® nicotinamide riboside increases your levels of NAD+, an enzyme critical to healthy cellular energy production. Resveratrol promotes a variety of health and longevity mechanisms; quercetin supports heart and immune health; and fisetin encourages your body to clear senescent cells. This formula combines highly bioavailable forms of all four of these nutrients, creating an unrivaled supplement for energy, vitality and defense against cellular aging.
  • iHerb Best Seller Product Rank: #1 in Fisetin category; #2 in Nicotinamide Riboside category.
  • Over 1,100 customer reviews, most of them 5-stars on iHerb.com.


4. TRU Niagen NAD+ Booster Supplement



TRU Niagen NAD+ Supplement comes in 3 sizes:

Amazon Best Sellers: #1 in Vitamin B3 (Niacin) Supplements.

- Technically, Nicotinamide Riboside is not the same molecule as NMN but they are both NAD precursors and are categorised under Vitamin B3 (Niacin) supplements by Amazon.com. Since, TruNiagen is the #1 best seller, we have decided to feature them as part of the best 10 list.
- ChromaDex markets TruNiagen, which is based on its branded Niagen ingredient, which is a form of nicotinamide riboside (NR), the form of nicotinamide that actively crosses into the cell to participate in the NAD+ pathway. 
- Reduces the cellular effects of aging by elevating NAD+, a key coenzyme your body uses for healthy cellular metabolism.
- Nicotinamide Riboside for Energy, Metabolism, Vitality, Muscle Health, Healthy Aging, Cellular Repair 
- Unlike NMN, the key ingredient Niagen was successfully notified two times as an NDI (New Dietary Ingredient) and reviewed as GRAS (Generally Recognized As Safe) under the United States notification programs.
- There are many cheaper alternative sources to buy NMN today, but are you getting what you paid for? If the price for NMN is too good to be true, it probably is not NMN.
 
"While this is not a scientific review I have been taking Niagen in one form or another non stop for several years. I have been gradually increasing my doses with what I can only describe as a profound effect. Without a doubt I feel younger than 46. I also think I look younger than most people my age. I certainly don't feel my age and have a ton of energy every single day. I also try to eat plenty of vegetables with lots of non meat proteins along with limited meat consumption. I am not a health nut but basically try to stay away excess sugars and processed foods whenever I can. I also do a hard bike ride once or twice a week. I think this also helps the entire aging process some." - Amazon

Tru Niagen vs Elysium Basis

Over 75% of registered ongoing or completed nicotinamide riboside trials use Niagen®. Here are six of their studies, just to name a few.
  1. A phase 3 randomized controlled study published in Advanced Science in 2021 (Read More)
  2. A study published in the American Journal of Clinical Nutrition in 2020 (Read More)
  3. A clinical study published in Scientific Reports in 2019 (Read More)
  4. A study published in Cell Reports in 2019 (Read More)
  5. A study published in the American Journal of Clinical Nutrition in 2018 (Read More)
  6. A study published in Nature Communications in 2018 (Read More)

5. Nutricost Niacinamide


Amazon Best Sellers: #2 in Vitamin B3 (Niacin) Supplements.

Ratings: 4.6 out of 5 - more than 9,000 global ratings

Do not get confused with Nutricost Niacin. This is the form that may cause 'Niacin Flush'. Niacinamide is the 'non-flush' form.

- Technically, Niacinamide is not the same molecule as NMN but they are both NAD precursors and are categorised under Vitamin B3 (Niacin) supplements by Amazon.com. Since, Niacinamide is the #2 best seller under this category, we have decided to feature them as part of the best 10 list.
- Niacinamide is a popular form of Vitamin B3, but without the often uncomfortable feeling known as "Niacin Flush". Vitamin B3 is most often found in meats like tuna and beef. However, in order to get a similar amount of Vitamin B3, you would have to eat large amounts of tuna and beef or other sources containing Vitamin B3.
- 240 Capsules of Niacinamide Per bottle / 1 Capsule per serving
- 500mg of Vitamin B3 (Niacinamide) Per Capsule
- No "Niacin Flush"
- Non-GMO, Gluten Free, Soy Free, and Made in a GMP Compliant, FDA Registered Facility

Nutricost Niacinamide Review
After a recent news article about this being a favorite supplement in Australia for sun damage protection, I asked my dermatologist about it. She said it might help prevent me getting as many 'barnacles' as she calls them. You know, those nasty, old-age, sun-damage, crunchy brown or white patches all over your body. (I have many). I'm still on my first bottle but after about two weeks the most amazing thing happened. I happened to scratch an area near one of my barnacles and it just flaked off in my hand. Since then, many more have succumbed. Not all; just some. But I'm happy. Even one less of those ugly bumps is an improvement.

6. Nuchido TIME+ Nicotinamide, EGCG, Vitamin C, Alpha Lipoic Acid, Zinc

Buy Now

At Nuchido Laboratories science is at the core of everything they do. This is why they conducted a clinical trial on their next generation NAD+ boosting supplement, Nuchido TIME+.

In this trial, they measured levels of NAMPT. This is the key enzyme which powers NAD+ production and recycling (the Salvage Pathway) in youthful cells.

Unfortunately, levels of this enzyme decline as we get older and this is one of the main causes of NAD+ decline.

Nuchido TIME+ is the only product clinically proven to restore NAMPT and fix the root causes of NAD+ decline.

Precursor supplements such as NR or NMN fail to fix the Salvage Pathway and therefore, fail to address the root causes of NAD+ decline.

This is why precursor supplements can cause further cellular dysfunction such as methyl donor depletion and inadvertently driving inflammation.

Where to buy Nuchido TIME+: Nuchido TIME+ is available on Nuchido's website. Here is the link: Nuchido TIME+

Note: To get 20% discount on your first purchase, please use this coupon code: ONEDAYMD20

7. Wonderfeel® Youngr™ NMN

Buy Now

This is not your average NAD supplement. Youngr™ NMN is a patented solution to aging. Formulated with emergent antioxidants and sirtuin activation, it uses a multi-targeted approach to defend and slow down biological aging at the cellular level.

It’s an investment in your cells that pays off across your entire body by increasing energy levels, restoring skin elasticity, while optimizing organ health, and cognition. You can enjoy faster recovery from rigorous activity or even from late nights by improved sleep quality.

Ingredients

60 Capsules per Bottle. Each capsule contains:
  • 450 mg Nicotinamide Mononucleotide
  • 2 mg Ergothioneine
  • 50 mg Trans Resveratrol
  • 40 mg Olea25® (25% hydroxytyrosol)
  • 10 mcg Vitamin D3 (Cholecalciferol)
Does not contain soy, gluten, dairy or fish. Non-GMO, vegan friendly, does not contain preservatives. Rice hull powder added for stabilization. Capsule shells are made from vegetable cellulose and are 100% vegan.

8. Peak Performance NMN + Resveratrol

peak performance nmn resveratrol

Buy on Amazon (Not available)

- Not all NMN supplements are created equal! Many supplements come with just NMN, which by itself is less effective to produce higher levels of NAD which the body needs to prevent cellular degeneration as we age. Peak Performance combines NMN with Resveratrol. Resveratrol works synergistically with NMN as it acts as an accelerator to produce better results in DNA repair.
- Published in Pharmacology Research and Perspectives, Jiang and colleagues from Macau University of Science and Technology in China demonstrated that combining NMN with resveratrol increases NAD+ levels in heart and skeletal muscle of mice significantly more than NMN alone.
- Anti Aging = NMN + Resveratrol! Our cells use NAD+ to produce energy and to activate proteins that repair damaged DNA. Scientists believe that the decline of NAD+ as we age results in many health-related problems. To sustain healthy levels of NAD+ we can supplement this with its precursor, nicotinamide mononucleotide (NMN) . When combined with Resveratrol this supplement becomes even more powerful. Great for cellular + DNA repair, muscle endurance and strength, vascular health and blood flow.
- What's in your supplement? - Many supplements on the market use standard formulas that may contain cheap fillers and sometimes questionable ingredients. All of our ingredients are carefully chosen and 3rd party tested for purity.
- Vegan & Allergy Free - Free Of Soy, Milk, Egg, Shellfish, Corn, Wheat & Peanuts. Contains NO Gluten or Preservatives. Manufactured Under The Highest Quality GMP Regulations and USA Standards.

9. Thorne Research ResveraCel (Best Nicotinamide Riboside with Resveratrol and Quercetin Phytosome)


Amazon Best Sellers: #3 in Resveratrol Nutritional Supplements.

- Each capsule contains Nicotinamide Riboside (NR) ingredient, in addition to Resveratrol, Quercetin Phytosome, and Betaine. 
- The ingredients in this product are complexed with Time-Sorb, a time-release matrix.
- Supports healthy aging and helps regulate metabolism.
- Resveratrol and quercetin increase the activity of sirtuins.
- Betaine provides important methylation factors.
- Flavors, colors, preservatives, and sweeteners derived from natural sources. 
- No gluten, Genetically Modified Organisms (known as GMOs), artificial preservatives, stearates, wheat, rye, barley, eggs, or nuts. This product does not contain dairy, soy, corn, yeast, sugar, or magnesium stearate.
- No unnecessary binders, coatings, disintegrants, fillers, or lubricants (including magnesium stearate) that could impair absorption.
- Adheres to the FDA’s current Good Manufacturing Practices (cGMPs) and has the highest number of NSF Certified for Sport products which tests for more than 200 banned substances for elite athletic competitions.

Review - My husband and I are in our 60s and have been taking these capsules for a few weeks. We both started with 2 capsules daily and experienced an increase in energy and in focus. We also both had trouble remaining asleep at night and had strange dreams. We have decreased our consumption of the capsules to one per day and have had a resolution to the sleep problems. We both continue to enjoy an increase in energy and in focus. We have reordered this Thorne product and are very satisfied with the results. It would be best to start with one capsule per day and work up from there until you find your own correct dosage.

10. Tru Niagen Immune Support Supplement (Nicotinamide Riboside with Vitamin D, C, Zinc and Curcumin)

Buy on Amazon

ChromaDex Corp. (NASDAQ:CDXC) announced the company’s latest product innovation with the U.S. launch of Tru Niagen® Immune in April 2022, a first-of-its-kind combination of ChromaDex’s proprietary NAD-boosting ingredient Niagen® (patented nicotinamide riboside or NR), high-quality and proven immune-boosting nutrients (vitamins C, D, and zinc) for the optimal maintenance of aging cells, and Theracurmin® (a superior form of curcumin). NAD+ is important to the healthy function of immune cells and is depleted by up to 80% when the body is under immune stress. Born from consumer insights, this new innovation was created to fulfill a customer need for an immune product. Tru Niagen Immune is now available online in the United States.

Ratings: 4.4 out of 5 - more than 150 reviews

Buyer Beware

In late February 2022, a shocking third-party investigation uncovered thousands of fake supplements sold on Amazon. Many of these included NMN. A few of the dozens of brands include:
  • Komprocha
  • NMN Max
  • NMN Plus
  • Energecko
  • Vitablossom
  • Mistacy
  • ChriBubble
  • Glorifikation 
Many of which are the “best sellers” in their respective categories.

Fake NMN Supplements Scam
Source
You can see the references and lab CoA data for yourself here.

Chromadex NMN Supplement Test Report: 64% of NMN Supplements Fail Tests

ChromaDex NMN Report (Oct 2021): Supplement manufacturer ChromaDex alleges that testing has revealed that more than half of NMN anti aging supplements being sold on Amazon contained almost none of the bioactive molecule.

ChromaDex markets TruNiagen, which is based on its branded Niagen ingredient, which is a form of nicotinamide riboside (NR), the form of nicotinamide that actively crosses into the cell to participate in the NAD+ pathway. Boosting this pathway, and thus maintaining cellular function at a lively, youthful level, has become a prominent theme in recent anti aging research.

Credit: ChromaDex

* The same distributor (SerumLab S&C International LLC) was listed on the product packaging from 10 of the 22 product brands.

Some researchers have argued that a transporter exists for NMN too, which is something that ChromaDex disputes. It claims that NMN must first be converted into NR in the blood before it can be used by the cells.

In the several years since the NMN transporter discovery was asserted, the NAD+ anti aging field has become crowded with NMN based supplements all seeking a piece of the pie created by ChromaDex and its competitor and one time customer Elysium. (The two companies have been locked in various patent infringement and breach of contract suits for several years.)

Last fall, ChromaDex obtained 22 samples of NMN products being sold on Amazon. Of these, 14 claimed to contain 500 mg of NMN. A further two products claimed 300 mg on the label; five claimed 250 mg and one product claimed 125 mg.

Only one of the 500 mg products came close to meeting label claim. It had 456 mg of NMN. All of the other 13 products in the 500 mg group either came in at below reporting limit (BRL, defined as less than 1% of the stated amount) or, in the case of 3 products, no NMN was detected at all.

Almost all of the rest of the products performed better, having at least 88% of the label claim. A lone 250 mg product was identified as BRL.

In summary, ChromaDex said that 64% of the products tested contained less than 1% of the stated amount of the active ingredient, which should give consumers pause, the company said.

"While this is a limited snapshot of the vast NMN finished product landscape, it does provide a glimpse into the high variability of product quality that is available... According to this study, the majority of the products one might purchase online contain such a small amount of NMN that there would be no clinical benefits achieved from the dose. Another concern with these adulterated products is that the actual contents are not known and could pose a risk to the user," the company said in a statement.

Editor's Note: In February 2022, another third-party investigation uncovered tens of thousands of fake supplements sold on Amazon. Many of these included NMN.

Location: United States

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By Dr. Frank Yap, MD -
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NAC vs NAD vs NR vs NMN ? Due to the small alphabetical differences, these supplements are often mixed up and confused by most consumers. We will cover the essentials and explain about each of these supplements below. NAD NAD is derived from Nicotinamide Riboside (NR). The levels of NAD in our body determine the speed of aging process. In younger cells and tissues, the levels of NAD are higher. As a result, younger people tend to have better physical activity, cognitive function and potential for cell repair and regeneration. As we grow, the levels of NAD in our body start to decline. This is reflected in the form of slowed cognitive response, loss of memory and reduced agility. Research suggests it may be possible to reverse mitochondrial decay with dietary supplements that increase cellular levels of a molecule called NAD (nicotinamide adenine dinucleotide).  NAD is a linchpin of energy metabolism, among other roles, and its diminishing level with age has been implicated in mitochond
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Dr George Fareed and Dr Brian Tyson Early Treatment Protocol (2022)

By Dr. Frank Yap, MD -
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IMPERIAL VALLEY – After more than one year of treating COVID-19 on the Imperial Valley frontlines, which included the months the County was the virus epicenter of California, two doctors — Dr. Brian Tyson and Dr. George Fareed— have added to their effective treatment. The treatment changes are based on latest results by other frontline doctors and what they have observed personally. Dr. George Fareed, Imperial Valley frontline doctor fighting against the COVID-19 pandemic locally, has been fielding phone calls from across the nation helping those afflicted but unable to get early treatment from their medical establishments. Related: Dr Brian Tyson and Dr George Fareed Early Treatment Protocol Results    “I’m really busy, but I’m willing to help anyone,” Fareed said. The doctor reached out to The Desert Review suggesting publication of the Protocol he and Dr. Brian Tyson have refined for their local patients that has been so successful. Fareed also included in his material what Dr. Zel
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